Picolinamides with fungicidal activity

ABSTRACT

The invention relates to picolinamides of Formula I and their use as fungicides.

CROSS REFERENCE TO RELATED APPLICATIONS

The application is a U.S. National Phase filing of International Application No. PCT/US2015/067199, filed Dec. 21, 2015, which claims the benefit of U.S. Provisional Patent Application Ser. No. 62/098,089 filed Dec. 30, 2014, 62/098,097 filed Dec. 30, 2014, 62/255,144 filed Nov. 13, 2015 and 62/255,152 filed Nov. 13, 2015, the disclosures of which are hereby expressly incorporated by reference herein in their entirety.

BACKGROUND & SUMMARY

Fungicides are compounds, of natural or synthetic origin, which act to protect and/or cure plants against damage caused by agriculturally relevant fungi. Generally, no single fungicide is useful in all situations. Consequently, research is ongoing to produce fungicides that may have better performance, are easier to use, and cost less.

The present disclosure relates to picolinamides and their use as fungicides. The compounds of the present disclosure may offer protection against ascomycetes, basidiomycetes, deuteromycetes and oomycetes.

One embodiment of the present disclosure may include compounds of Formula I:

-   -   X is hydrogen or C(O)R₅;     -   Y is hydrogen, C(O)R₅, or Q;     -   Q is

-   -   R₁ is CH₂OCH₃, or hydrogen or alkyl, where alkyl is optionally         substituted with 0, 1 or multiple R₈;     -   R₂ is methyl;     -   R₃ is chosen from C(O)OCH₃ or alkyl, alkenyl, or aryl, each         optionally substituted with 0, 1 or multiple R₈;     -   R₄ is chosen from alkyl or aryl, each optionally substituted         with 0, 1 or multiple R₈;     -   R₅ is alkoxy, optionally substituted with 0, 1, or multiple R₈;     -   R₆ is chosen from hydrogen or alkoxy, each optionally         substituted with 0, 1, or multiple R₈;     -   R₇ is chosen from hydrogen, —C(O)R₉, or —CH₂OC(O)R₉;     -   R₈ is chosen from hydrogen, alkyl, aryl, halo, alkenyl, or         phenoxy, each optionally substituted with 0, 1, or multiple R₁₀;     -   R₉ is chosen from alkyl, alkoxy, or aryl, each optionally         substituted with 0, 1, or multiple R₈;     -   R₁₀ is chosen from alkyl, aryl, halo, haloalkyl, haloaryl,         alkenyl, or alkoxy;     -   R₁₁ is chosen from hydrogen or methyl.

Another embodiment of the present disclosure may include a fungicidal composition for the control or prevention of fungal attack comprising the compounds described above and a phytologically acceptable carrier material.

Yet another embodiment of the present disclosure may include a method for the control or prevention of fungal attack on a plant, the method including the steps of applying a fungicidally effective amount of one or more of the compounds described above to at least one of the fungus, the plant, and an area adjacent to the plant.

It will be understood by those skilled in the art that the following terms may include generic “R”-groups within their definitions, e.g., “the term alkoxy refers to an —OR substituent”. It is also understood that within the definitions for the following terms, these “R” groups are included for illustration purposes and should not be construed as limiting or being limited by substitutions about Formula I.

The term “alkyl” refers to a saturated branched, unbranched, or cyclic carbon chain, including, but not limited to, methyl, ethyl, propyl, butyl, isopropyl, isobutyl, tertiary butyl, pentyl, hexyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and the like.

The term “alkenyl” refers to a branched, unbranched or cyclic carbon chain containing one or more double bonds including, but not limited to, ethenyl, propenyl, butenyl, isopropenyl, isobutenyl, cyclobutenyl, cyclopentenyl, cyclohexenyl, and the like.

The term “alkynyl” refers to a branched or unbranched carbon chain containing one or more triple bonds including, but not limited to, propynyl, butynyl and the like.

The term “aryl” refers to any aromatic, mono- or bi-cyclic, containing 0 heteroatoms.

The term “heterocycle” refers to any aromatic or non-aromatic ring, mono- or bi-cyclic, containing one or more heteroatoms

The term “alkoxy” refers to an —OR substituent.

The term “haloalkyl” refers to an alkyl, which is substituted with Cl, F, I, or Br or any combination thereof.

The term “halogen” or “halo” refers to one or more halogen atoms, defined as F, Cl, Br, and I.

Throughout the disclosure, reference to the compounds of Formula I is read as also including diastereomers, enantiomers, and mixtures thereof. In another embodiment, Formula (I) is read as also including salts or hydrates thereof. Exemplary salts include, but are not limited to: hydrochloride, hydrobromide, and hydroiodide.

It is also understood by those skilled in the art that additional substitution is allowable, unless otherwise noted, as long as the rules of chemical bonding and strain energy are satisfied and the product still exhibits fungicidal activity.

Another embodiment of the present disclosure is a use of a compound of Formula I, for protection of a plant against attack by a phytopathogenic organism or the treatment of a plant infested by a phytopathogenic organism, comprising the application of a compound of Formula I, or a composition comprising the compound to soil, a plant, a part of a plant, foliage, and/or roots.

Additionally, another embodiment of the present disclosure is a composition useful for protecting a plant against attack by a phytopathogenic organism and/or treatment of a plant infested by a phytopathogenic organism comprising a compound of Formula I and a phytologically acceptable carrier material.

DETAILED DESCRIPTION

The compounds of the present disclosure may be applied by any of a variety of known techniques, either as the compounds or as formulations comprising the compounds. For example, the compounds may be applied to the roots or foliage of plants for the control of various fungi, without damaging the commercial value of the plants. The materials may be applied in the form of any of the generally used formulation types, for example, as solutions, dusts, wettable powders, flowable concentrate, or emulsifiable concentrates.

Preferably, the compounds of the present disclosure are applied in the form of a formulation, comprising one or more of the compounds of Formula I with a phytologically acceptable carrier. Concentrated formulations may be dispersed in water, or other liquids, for application, or formulations may be dust-like or granular, which may then be applied without further treatment. The formulations can be prepared according to procedures that are conventional in the agricultural chemical art.

The present disclosure contemplates all vehicles by which one or more of the compounds may be formulated for delivery and use as a fungicide. Typically, formulations are applied as aqueous suspensions or emulsions. Such suspensions or emulsions may be produced from water-soluble, water-suspendible, or emulsifiable formulations which are solids, usually known as wettable powders; or liquids, usually known as emulsifiable concentrates, aqueous suspensions, or suspension concentrates. As will be readily appreciated, any material to which these compounds may be added may be used, provided it yields the desired utility without significant interference with the activity of these compounds as antifungal agents.

Wettable powders, which may be compacted to form water-dispersible granules, comprise an intimate mixture of one or more of the compounds of Formula I, an inert carrier and surfactants. The concentration of the compound in the wettable powder may be from about 10 percent to about 90 percent by weight based on the total weight of the wettable powder, more preferably about 25 weight percent to about 75 weight percent. In the preparation of wettable powder formulations, the compounds may be compounded with any finely divided solid, such as prophyllite, talc, chalk, gypsum, Fuller's earth, bentonite, attapulgite, starch, casein, gluten, montmorillonite clays, diatomaceous earths, purified silicates or the like. In such operations, the finely divided carrier and surfactants are typically blended with the compound(s) and milled.

Emulsifiable concentrates of the compounds of Formula I may comprise a convenient concentration, such as from about 1 weight percent to about 50 weight percent of the compound, in a suitable liquid, based on the total weight of the concentrate. The compounds may be dissolved in an inert carrier, which is either a water-miscible solvent or a mixture of water-immiscible organic solvents, and emulsifiers. The concentrates may be diluted with water and oil to form spray mixtures in the form of oil-in-water emulsions. Useful organic solvents include aromatics, especially the high-boiling naphthalenic and olefinic portions of petroleum such as heavy aromatic naphtha. Other organic solvents may also be used, for example, terpenic solvents, including rosin derivatives, aliphatic ketones, such as cyclohexanone, and complex alcohols, such as 2-ethoxyethanol.

Emulsifiers which may be advantageously employed herein may be readily determined by those skilled in the art and include various nonionic, anionic, cationic and amphoteric emulsifiers, or a blend of two or more emulsifiers. Examples of nonionic emulsifiers useful in preparing the emulsifiable concentrates include the polyalkylene glycol ethers and condensation products of alkyl and aryl phenols, aliphatic alcohols, aliphatic amines or fatty acids with ethylene oxide, propylene oxides such as the ethoxylated alkyl phenols and carboxylic esters solubilized with the polyol or polyoxyalkylene. Cationic emulsifiers include quaternary ammonium compounds and fatty amine salts. Anionic emulsifiers include the oil-soluble salts (e.g., calcium) of alkylaryl sulphonic acids, oil-soluble salts or sulfated polyglycol ethers and appropriate salts of phosphated polyglycol ether.

Representative organic liquids which may be employed in preparing the emulsifiable concentrates of the compounds of the present disclosure are the aromatic liquids such as xylene, propyl benzene fractions; or mixed naphthalene fractions, mineral oils, substituted aromatic organic liquids such as dioctyl phthalate; kerosene; dialkyl amides of various fatty acids, particularly the dimethyl amides of fatty glycols and glycol derivatives such as the n-butyl ether, ethyl ether or methyl ether of diethylene glycol, the methyl ether of triethylene glycol, petroleum fractions or hydrocarbons such as mineral oil, aromatic solvents, paraffinic oils, and the like; vegetable oils such as soy bean oil, rape seed oil, olive oil, castor oil, sunflower seed oil, coconut oil, corn oil, cotton seed oil, linseed oil, palm oil, peanut oil, safflower oil, sesame oil, tung oil and the like; esters of the above vegetable oils; and the like. Mixtures of two or more organic liquids may also be employed in the preparation of the emulsifiable concentrate. Organic liquids include xylene, and propyl benzene fractions, with xylene being most preferred in some cases. Surface-active dispersing agents are typically employed in liquid formulations and in an amount of from 0.1 to 20 percent by weight based on the combined weight of the dispersing agent with one or more of the compounds. The formulations can also contain other compatible additives, for example, plant growth regulators and other biologically active compounds used in agriculture.

Aqueous suspensions comprise suspensions of one or more water-insoluble compounds of Formula I, dispersed in an aqueous vehicle at a concentration in the range from about 1 to about 50 weight percent, based on the total weight of the aqueous suspension. Suspensions are prepared by finely grinding one or more of the compounds, and vigorously mixing the ground material into a vehicle comprised of water and surfactants chosen from the same types discussed above. Other components, such as inorganic salts and synthetic or natural gums, may also be added to increase the density and viscosity of the aqueous vehicle.

The compounds of Formula I can also be applied as granular formulations, which are particularly useful for applications to the soil. Granular formulations generally contain from about 0.5 to about 10 weight percent, based on the total weight of the granular formulation of the compound(s), dispersed in an inert carrier which consists entirely or in large part of coarsely divided inert material such as attapulgite, bentonite, diatomite, clay or a similar inexpensive substance. Such formulations are usually prepared by dissolving the compounds in a suitable solvent and applying it to a granular carrier which has been preformed to the appropriate particle size, in the range of from about 0.5 to about 3 mm. A suitable solvent is a solvent in which the compound is substantially or completely soluble. Such formulations may also be prepared by making a dough or paste of the carrier and the compound and solvent, and crushing and drying to obtain the desired granular particle.

Dusts containing the compounds of Formula I may be prepared by intimately mixing one or more of the compounds in powdered form with a suitable dusty agricultural carrier, such as, for example, kaolin clay, ground volcanic rock, and the like. Dusts can suitably contain from about 1 to about 10 weight percent of the compounds, based on the total weight of the dust.

The formulations may additionally contain adjuvant surfactants to enhance deposition, wetting and penetration of the compounds onto the target crop and organism. These adjuvant surfactants may optionally be employed as a component of the formulation or as a tank mix. The amount of adjuvant surfactant will typically vary from 0.01 to 1.0 percent by volume, based on a spray-volume of water, preferably 0.05 to 0.5 volume percent. Suitable adjuvant surfactants include, but are not limited to ethoxylated nonyl phenols, ethoxylated synthetic or natural alcohols, salts of the esters or sulphosuccinic acids, ethoxylated organosilicones, ethoxylated fatty amines, blends of surfactants with mineral or vegetable oils, crop oil concentrate (mineral oil (85%)+emulsifiers (15%)); nonylphenol ethoxylate; benzylcocoalkyldimethyl quaternary ammonium salt; blend of petroleum hydrocarbon, alkyl esters, organic acid, and anionic surfactant; C₉-C₁₁ alkylpolyglycoside; phosphated alcohol ethoxylate; natural primary alcohol (C₁₂-C₁₆) ethoxylate; di-sec-butylphenol EO-PO block copolymer; polysiloxane-methyl cap; nonylphenol ethoxylate+urea ammonium nitrate; emulsified methylated seed oil; tridecyl alcohol (synthetic) ethoxylate (8EO); tallow amine ethoxylate (15 EO); PEG(400) dioleate-99. The formulations may also include oil-in-water emulsions such as those disclosed in U.S. patent application Ser. No. 11/495,228, the disclosure of which is expressly incorporated by reference herein.

The formulations may optionally include combinations that contain other pesticidal compounds. Such additional pesticidal compounds may be fungicides, insecticides, herbicides, nematocides, miticides, arthropodicides, bactericides or combinations thereof that are compatible with the compounds of the present disclosure in the medium selected for application, and not antagonistic to the activity of the present compounds. Accordingly, in such embodiments, the other pesticidal compound is employed as a supplemental toxicant for the same or for a different pesticidal use. The compounds of Formula I and the pesticidal compound in the combination can generally be present in a weight ratio of from 1:100 to 100:1.

The compounds of the present disclosure may also be combined with other fungicides to form fungicidal mixtures and synergistic mixtures thereof. The fungicidal compounds of the present disclosure are often applied in conjunction with one or more other fungicides to control a wider variety of undesirable diseases. When used in conjunction with other fungicide(s), the presently claimed compounds may be formulated with the other fungicide(s), tank-mixed with the other fungicide(s) or applied sequentially with the other fungicide(s). Such other fungicides may include 2-(thiocyanatomethylthio)-benzothiazole, 2-phenylphenol, 8-hydroxyquinoline sulfate, ametoctradin, amisulbrom, antimycin, Ampelomyces quisqualis, azaconazole, azoxystrobin, Bacillus subtilis, Bacillus subtilis strain QST713, benalaxyl, benomyl, benthiavalicarb-isopropyl, benzylaminobenzene-sulfonate (BABS) salt, bicarbonates, biphenyl, bismerthiazol, bitertanol, bixafen, blasticidin-S, borax, Bordeaux mixture, boscalid, bromuconazole, bupirimate, calcium polysulfide, captafol, captan, carbendazim, carboxin, carpropamid, carvone, chlazafenone, chloroneb, chlorothalonil, chlozolinate, Coniothyrium minitans, copper hydroxide, copper octanoate, copper oxychloride, copper sulfate, copper sulfate (tribasic), cuprous oxide, cyazofamid, cyflufenamid, cymoxanil, cyproconazole, cyprodinil, dazomet, debacarb, diammonium ethylenebis-(dithiocarbamate), dichlofluanid, dichlorophen, diclocymet, diclomezine, dichloran, diethofencarb, difenoconazole, difenzoquat ion, diflumetorim, dimethomorph, dimoxystrobin, diniconazole, diniconazole-M, dinobuton, dinocap, diphenylamine, dithianon, dodemorph, dodemorph acetate, dodine, dodine free base, edifenphos, enestrobin, enestroburin, epoxiconazole, ethaboxam, ethoxyquin, etridiazole, famoxadone, fenamidone, fenarimol, fenbuconazole, fenfuram, fenhexamid, fenoxanil, fenpiclonil, fenpropidin, fenpropimorph, fenpyrazamine, fentin, fentin acetate, fentin hydroxide, ferbam, ferimzone, fluazinam, fludioxonil, flumorph, fluopicolide, fluopyram, fluoroimide, fluoxastrobin, fluquinconazole, flusilazole, flusulfamide, flutianil, flutolanil, flutriafol, fluxapyroxad, folpet, formaldehyde, fosetyl, fosetyl-aluminium, fuberidazole, furalaxyl, furametpyr, guazatine, guazatine acetates, GY-81, hexachlorobenzene, hexaconazole, hymexazol, imazalil, imazalil sulfate, imibenconazole, iminoctadine, iminoctadine triacetate, iminoctadine tris(albesilate), iodocarb, ipconazole, ipfenpyrazolone, iprobenfos, iprodione, iprovalicarb, isoprothiolane, isopyrazam, isotianil, kasugamycin, kasugamycin hydrochloride hydrate, kresoxim-methyl, laminarin, mancopper, mancozeb, mandipropamid, maneb, mefenoxam, mepanipyrim, mepronil, meptyl-dinocap, mercuric chloride, mercuric oxide, mercurous chloride, metalaxyl, metalaxyl-M, metam, metam-ammonium, metam-potassium, metam-sodium, metconazole, methasulfocarb, methyl iodide, methyl isothiocyanate, metiram, metominostrobin, metrafenone, mildiomycin, myclobutanil, nabam, nitrothal-isopropyl, nuarimol, octhilinone, ofurace, oleic acid (fatty acids), orysastrobin, oxadixyl, oxine-copper, oxpoconazole fumarate, oxycarboxin, pefurazoate, penconazole, pencycuron, penflufen, pentachlorophenol, pentachlorophenyl laurate, penthiopyrad, phenylmercury acetate, phosphonic acid, phthalide, picoxystrobin, polyoxin B, polyoxins, polyoxorim, potassium bicarbonate, potassium hydroxyquinoline sulfate, probenazole, prochloraz, procymidone, propamocarb, propamocarb hydrochloride, propiconazole, propineb, proquinazid, prothioconazole, pyraclostrobin, pyrametostrobin, pyraoxystrobin, pyrazophos, pyribencarb, pyributicarb, pyrifenox, pyrimethanil, pyriofenone, pyroquilon, quinoclamine, quinoxyfen, quintozene, Reynoutria sachalinensis extract, sedaxane, silthiofam, simeconazole, sodium 2-phenylphenoxide, sodium bicarbonate, sodium pentachlorophenoxide, spiroxamine, sulfur, SYP-Z048, tar oils, tebuconazole, tebufloquin, tecnazene, tetraconazole, thiabendazole, thifluzamide, thiophanate-methyl, thiram, tiadinil, tolclofos-methyl, tolylfluanid, triadimefon, triadimenol, triazoxide, tricyclazole, tridemorph, trifloxystrobin, triflumizole, triforine, triticonazole, validamycin, valifenalate, valiphenal, vinclozolin, zineb, ziram, zoxamide, Candida oleophila, Fusarium oxysporum, Gliocladium spp., Phlebiopsis gigantea, Streptomyces griseoviridis, Trichoderma spp., (RS)—N-(3,5-dichlorophenyl)-2-(methoxymethyl)-succinimide, 1,2-dichloropropane, 1,3-dichloro-1,1,3,3-tetrafluoroacetone hydrate, 1-chloro-2,4-dinitronaphthalene, 1-chloro-2-nitropropane, 2-(2-heptadecyl-2-imidazolin-1-yl)ethanol, 2,3-dihydro-5-phenyl-1,4-dithi-ine 1,1,4,4-tetraoxide, 2-methoxyethylmercury acetate, 2-methoxyethylmercury chloride, 2-methoxyethylmercury silicate, 3-(4-chlorophenyl)-5-methylrhodanine, 4-(2-nitroprop-1-enyl)phenyl thiocyanateme, ampropylfos, anilazine, azithiram, barium polysulfide, Bayer 32394, benodanil, benquinox, bentaluron, benzamacril; benzamacril-isobutyl, benzamorf, binapacryl, bis(methylmercury) sulfate, bis(tributyltin) oxide, buthiobate, cadmium calcium copper zinc chromate sulfate, carbamorph, CECA, chlobenthiazone, chloraniformethan, chlorfenazole, chlorquinox, climbazole, copper bis(3-phenylsalicylate), copper zinc chromate, cufraneb, cupric hydrazinium sulfate, cuprobam, cyclafuramid, cypendazole, cyprofuram, decafentin, dichlone, dichlozoline, diclobutrazol, dimethirimol, dinocton, dinosulfon, dinoterbon, dipyrithione, ditalimfos, dodicin, drazoxolon, EBP, ESBP, etaconazole, etem, ethirim, fenaminosulf, fenapanil, fenitropan, fluotrimazole, furcarbanil, furconazole, furconazole-cis, furmecyclox, furophanate, glyodine, griseofulvin, halacrinate, Hercules 3944, hexylthiofos, ICIA0858, isopamphos, isovaledione, mebenil, mecarbinzid, metazoxolon, methfuroxam, methylmercury dicyandiamide, metsulfovax, milneb, mucochloric anhydride, myclozolin, N-3,5-dichlorophenyl-succinimide, N-3-nitrophenylitaconimide, natamycin, N-ethylmercurio-4-toluenesulfonanilide, nickel bis(dimethyldithiocarbamate), OCH, phenylmercury dimethyldithiocarbamate, phenylmercury nitrate, phosdiphen, prothiocarb; prothiocarb hydrochloride, pyracarbolid, pyridinitril, pyroxychlor, pyroxyfur, quinacetol; quinacetol sulfate, quinazamid, quinconazole, rabenzazole, salicylanilide, SSF-109, sultropen, tecoram, thiadifluor, thicyofen, thiochlorfenphim, thiophanate, thioquinox, tioxymid, triamiphos, triarimol, triazbutil, trichlamide, urbacid, zarilamid, and any combinations thereof.

Additionally, the compounds described herein may be combined with other pesticides, including insecticides, nematocides, miticides, arthropodicides, bactericides or combinations thereof that are compatible with the compounds of the present disclosure in the medium selected for application, and not antagonistic to the activity of the present compounds to form pesticidal mixtures and synergistic mixtures thereof. The fungicidal compounds of the present disclosure may be applied in conjunction with one or more other pesticides to control a wider variety of undesirable pests. When used in conjunction with other pesticides, the presently claimed compounds may be formulated with the other pesticide(s), tank-mixed with the other pesticide(s) or applied sequentially with the other pesticide(s). Typical insecticides include, but are not limited to: 1,2-dichloropropane, abamectin, acephate, acetamiprid, acethion, acetoprole, acrinathrin, acrylonitrile, alanycarb, aldicarb, aldoxycarb, aldrin, allethrin, allosamidin, allyxycarb, alpha-cypermethrin, alpha-ecdysone, alpha-endosulfan, amidithion, aminocarb, amiton, amiton oxalate, amitraz, anabasine, athidathion, azadirachtin, azamethiphos, azinphos-ethyl, azinphos-methyl, azothoate, barium hexafluorosilicate, barthrin, bendiocarb, benfuracarb, bensultap, beta-cyfluthrin, beta-cypermethrin, bifenthrin, bioallethrin, bioethanomethrin, biopermethrin, bistrifluron, borax, boric acid, bromfenvinfos, bromocyclen, bromo-DDT, bromophos, bromophos-ethyl, bufencarb, buprofezin, butacarb, butathiofos, butocarboxim, butonate, butoxycarboxim, cadusafos, calcium arsenate, calcium polysulfide, camphechlor, carbanolate, carbaryl, carbofuran, carbon disulfide, carbon tetrachloride, carbophenothion, carbosulfan, cartap, cartap hydrochloride, chlorantraniliprole, chlorbicyclen, chlordane, chlordecone, chlordimeform, chlordimeform hydrochloride, chlorethoxyfos, chlorfenapyr, chlorfenvinphos, chlorfluazuron, chlormephos, chloroform, chloropicrin, chlorphoxim, chlorprazophos, chlorpyrifos, chlorpyrifos-methyl, chlorthiophos, chromafenozide, cinerin I, cinerin II, cinerins, cismethrin, cloethocarb, closantel, clothianidin, copper acetoarsenite, copper arsenate, copper naphthenate, copper oleate, coumaphos, coumithoate, crotamiton, crotoxyphos, crufomate, cryolite, cyanofenphos, cyanophos, cyanthoate, cyantraniliprole, cyclethrin, cycloprothrin, cyfluthrin, cyhalothrin, cypermethrin, cyphenothrin, cyromazine, cythioate, DDT, decarbofuran, deltamethrin, demephion, demephion-O, demephion-S, demeton, demeton-methyl, demeton-O, demeton-O-methyl, demeton-S, demeton-S-methyl, demeton-S-methylsulphon, diafenthiuron, dialifos, diatomaceous earth, diazinon, dicapthon, dichlofenthion, dichlorvos, dicresyl, dicrotophos, dicyclanil, dieldrin, diflubenzuron, dilor, dimefluthrin, dimefox, dimetan, dimethoate, dimethrin, dimethylvinphos, dimetilan, dinex, dinex-diclexine, dinoprop, dinosam, dinotefuran, diofenolan, dioxabenzofos, dioxacarb, dioxathion, disulfoton, dithicrofos, d-limonene, DNOC, DNOC-ammonium, DNOC-potassium, DNOC-sodium, doramectin, ecdysterone, emamectin, emamectin benzoate, EMPC, empenthrin, endosulfan, endothion, endrin, EPN, epofenonane, eprinomectin, esdepalléthrine, esfenvalerate, etaphos, ethiofencarb, ethion, ethiprole, ethoate-methyl, ethoprophos, ethyl formate, ethyl-DDD, ethylene dibromide, ethylene dichloride, ethylene oxide, etofenprox, etrimfos, EXD, famphur, fenamiphos, fenazaflor, fenchlorphos, fenethacarb, fenfluthrin, fenitrothion, fenobucarb, fenoxacrim, fenoxycarb, fenpirithrin, fenpropathrin, fensulfothion, fenthion, fenthion-ethyl, fenvalerate, fipronil, flonicamid, flubendiamide, flucofuron, flucycloxuron, flucythrinate, flufenerim, flufenoxuron, flufenprox, fluvalinate, fonofos, formetanate, formetanate hydrochloride, formothion, formparanate, formparanate hydrochloride, fosmethilan, fospirate, fosthietan, furathiocarb, furethrin, gamma-cyhalothrin, gamma-HCH, halfenprox, halofenozide, HCH, HEOD, heptachlor, heptenophos, heterophos, hexaflumuron, HHDN, hydramethylnon, hydrogen cyanide, hydroprene, hyquincarb, imidacloprid, imiprothrin, indoxacarb, iodomethane, IPSP, isazofos, isobenzan, isocarbophos, isodrin, isofenphos, isofenphos-methyl, isoprocarb, isoprothiolane, isothioate, isoxathion, ivermectin, jasmolin I, jasmolin II, jodfenphos, juvenile hormone I, juvenile hormone II, juvenile hormone III, kelevan, kinoprene, lambda-cyhalothrin, lead arsenate, lepimectin, leptophos, lindane, lirimfos, lufenuron, lythidathion, malathion, malonoben, mazidox, mecarbam, mecarphon, menazon, mephosfolan, mercurous chloride, mesulfenfos, metaflumizone, methacrifos, methamidophos, methidathion, methiocarb, methocrotophos, methomyl, methoprene, methoxychlor, methoxyfenozide, methyl bromide, methyl isothiocyanate, methylchloroform, methylene chloride, metofluthrin, metolcarb, metoxadiazone, mevinphos, mexacarbate, milbemectin, milbemycin oxime, mipafox, mirex, molosultap, monocrotophos, monomehypo, monosultap, morphothion, moxidectin, naftalofos, naled, naphthalene, nicotine, nifluridide, nitenpyram, nithiazine, nitrilacarb, novaluron, noviflumuron, omethoate, oxamyl, oxydemeton-methyl, oxydeprofos, oxydisulfoton, para-dichlorobenzene, parathion, parathion-methyl, penfluron, pentachlorophenol, permethrin, phenkapton, phenothrin, phenthoate, phorate, phosalone, phosfolan, phosmet, phosnichlor, phosphamidon, phosphine, phoxim, phoxim-methyl, pirimetaphos, pirimicarb, pirimiphos-ethyl, pirimiphos-methyl, potassium arsenite, potassium thiocyanate, pp'-DDT, prallethrin, precocene I, precocene II, precocene III, primidophos, profenofos, profluralin, promacyl, promecarb, propaphos, propetamphos, propoxur, prothidathion, prothiofos, prothoate, protrifenbute, pyraclofos, pyrafluprole, pyrazophos, pyresmethrin, pyrethrin I, pyrethrin II, pyrethrins, pyridaben, pyridalyl, pyridaphenthion, pyrifluquinazon, pyrimidifen, pyrimitate, pyriprole, pyriproxyfen, quassia, quinalphos, quinalphos-methyl, quinothion, rafoxanide, resmethrin, rotenone, ryania, sabadilla, schradan, selamectin, silafluofen, silica gel, sodium arsenite, sodium fluoride, sodium hexafluorosilicate, sodium thiocyanate, sophamide, spinetoram, spinosad, spiromesifen, spirotetramat, sulcofuron, sulcofuron-sodium, sulfluramid, sulfotep, sulfoxaflor, sulfuryl fluoride, sulprofos, tau-fluvalinate, tazimcarb, TDE, tebufenozide, tebufenpyrad, tebupirimfos, teflubenzuron, tefluthrin, temephos, TEPP, terallethrin, terbufos, tetrachloroethane, tetrachlorvinphos, tetramethrin, tetramethylfluthrin, theta-cypermethrin, thiacloprid, thiamethoxam, thicrofos, thiocarboxime, thiocyclam, thiocyclam oxalate, thiodicarb, thiofanox, thiometon, thiosultap, thiosultap-disodium, thiosultap-monosodium, thuringiensin, tolfenpyrad, tralomethrin, transfluthrin, transpermethrin, triarathene, triazamate, triazophos, trichlorfon, trichlormetaphos-3, trichloronat, trifenofos, triflumuron, trimethacarb, triprene, vamidothion, vaniliprole, XMC, xylylcarb, zeta-cypermethrin, zolaprofos, and any combinations thereof.

Additionally, the compounds described herein may be combined with herbicides that are compatible with the compounds of the present disclosure in the medium selected for application, and not antagonistic to the activity of the present compounds to form pesticidal mixtures and synergistic mixtures thereof. The fungicidal compounds of the present disclosure may be applied in conjunction with one or more herbicides to control a wide variety of undesirable plants. When used in conjunction with herbicides, the presently claimed compounds may be formulated with the herbicide(s), tank-mixed with the herbicide(s) or applied sequentially with the herbicide(s). Typical herbicides include, but are not limited to: 4-CPA; 4-CPB; 4-CPP; 2,4-D; 3,4-DA; 2,4-DB; 3,4-DB; 2,4-DEB; 2,4-DEP; 3,4-DP; 2,3,6-TBA; 2,4,5-T; 2,4,5-TB; acetochlor, acifluorfen, aclonifen, acrolein, alachlor, allidochlor, alloxydim, allyl alcohol, alorac, ametridione, ametryn, amibuzin, amicarbazone, amidosulfuron, aminocyclopyrachlor, aminopyralid, amiprofos-methyl, amitrole, ammonium sulfamate, anilofos, anisuron, asulam, atraton, atrazine, azafenidin, azimsulfuron, aziprotryne, barban, BCPC, beflubutamid, benazolin, bencarbazone, benfluralin, benfuresate, bensulfuron, bensulide, bentazone, benzadox, benzfendizone, benzipram, benzobicyclon, benzofenap, benzofluor, benzoylprop, benzthiazuron, bicyclopyrone, bifenox, bilanafos, bispyribac, borax, bromacil, bromobonil, bromobutide, bromofenoxim, bromoxynil, brompyrazon, butachlor, butafenacil, butamifos, butenachlor, buthidazole, buthiuron, butralin, butroxydim, buturon, butylate, cacodylic acid, cafenstrole, calcium chlorate, calcium cyanamide, cambendichlor, carbasulam, carbetamide, carboxazole chlorprocarb, carfentrazone, CDEA, CEPC, chlomethoxyfen, chloramben, chloranocryl, chlorazifop, chlorazine, chlorbromuron, chlorbufam, chloreturon, chlorfenac, chlorfenprop, chlorflurazole, chlorflurenol, chloridazon, chlorimuron, chlornitrofen, chloropon, chlorotoluron, chloroxuron, chloroxynil, chlorpropham, chlorsulfuron, chlorthal, chlorthiamid, cinidon-ethyl, cinmethylin, cinosulfuron, cisanilide, clethodim, cliodinate, clodinafop, clofop, clomazone, clomeprop, cloprop, cloproxydim, clopyralid, cloransulam, CMA, copper sulfate, CPMF, CPPC, credazine, cresol, cumyluron, cyanatryn, cyanazine, cycloate, cyclosulfamuron, cycloxydim, cycluron, cyhalofop, cyperquat, cyprazine, cyprazole, cypromid, daimuron, dalapon, dazomet, delachlor, desmedipham, desmetryn, di-allate, dicamba, dichlobenil, dichloralurea, dichlormate, dichlorprop, dichlorprop-P, diclofop, diclosulam, diethamquat, diethatyl, difenopenten, difenoxuron, difenzoquat, diflufenican, diflufenzopyr, dimefuron, dimepiperate, dimethachlor, dimethametryn, dimethenamid, dimethenamid-P, dimexano, dimidazon, dinitramine, dinofenate, dinoprop, dinosam, dinoseb, dinoterb, diphenamid, dipropetryn, diquat, disul, dithiopyr, diuron, DMPA, DNOC, DSMA, EBEP, eglinazine, endothal, epronaz, EPTC, erbon, esprocarb, ethalfluralin, ethametsulfuron, ethidimuron, ethiolate, ethofumesate, ethoxyfen, ethoxysulfuron, etinofen, etnipromid, etobenzanid, EXD, fenasulam, fenoprop, fenoxaprop, fenoxaprop-P, fenoxasulfone, fenteracol, fenthiaprop, fentrazamide, fenuron, ferrous sulfate, flamprop, flamprop-M, flazasulfuron, florasulam, fluazifop, fluazifop-P, fluazolate, flucarbazone, flucetosulfuron, fluchloralin, flufenacet, flufenican, flufenpyr, flumetsulam, flumezin, flumiclorac, flumioxazin, flumipropyn, fluometuron, fluorodifen, fluoroglycofen, fluoromidine, fluoronitrofen, fluothiuron, flupoxam, flupropacil, flupropanate, flupyrsulfuron, fluridone, flurochloridone, fluroxypyr, flurtamone, fluthiacet, fomesafen, foramsulfuron, fosamine, furyloxyfen, glufosinate, glufosinate-P, glyphosate, halosafen, halosulfuron, haloxydine, haloxyfop, haloxyfop-P, hexachloroacetone, hexaflurate, hexazinone, imazamethabenz, imazamox, imazapic, imazapyr, imazaquin, imazethapyr, imazosulfuron, indanofan, indaziflam, iodobonil, iodomethane, iodosulfuron, ioxynil, ipazine, ipfencarbazone, iprymidam, isocarbamid, isocil, isomethiozin, isonoruron, isopolinate, isopropalin, isoproturon, isouron, isoxaben, isoxachlortole, isoxaflutole, isoxapyrifop, karbutilate, ketospiradox, lactofen, lenacil, linuron, MAA, MAMA, MCPA, MCPA-thioethyl, MCPB, mecoprop, mecoprop-P, medinoterb, mefenacet, mefluidide, mesoprazine, mesosulfuron, mesotrione, metam, metamifop, metamitron, metazachlor, metazosulfuron, metflurazon, methabenzthiazuron, methalpropalin, methazole, methiobencarb, methiozolin, methiuron, methometon, methoprotryne, methyl bromide, methyl isothiocyanate, methyldymron, metobenzuron, metobromuron, metolachlor, metosulam, metoxuron, metribuzin, metsulfuron, molinate, monalide, monisouron, monochloroacetic acid, monolinuron, monuron, morfamquat, MSMA, naproanilide, napropamide, naptalam, neburon, nicosulfuron, nipyraclofen, nitralin, nitrofen, nitrofluorfen, norflurazon, noruron, OCH, orbencarb, ortho-dichlorobenzene, orthosulfamuron, oryzalin, oxadiargyl, oxadiazon, oxapyrazon, oxasulfuron, oxaziclomefone, oxyfluorfen, parafluron, paraquat, pebulate, pelargonic acid, pendimethalin, penoxsulam, pentachlorophenol, pentanochlor, pentoxazone, perfluidone, pethoxamid, phenisopham, phenmedipham, phenmedipham-ethyl, phenobenzuron, phenylmercury acetate, picloram, picolinafen, pinoxaden, piperophos, potassium arsenite, potassium azide, potassium cyanate, pretilachlor, primisulfuron, procyazine, prodiamine, profluazol, profluralin, profoxydim, proglinazine, prometon, prometryn, propachlor, propanil, propaquizafop, propazine, propham, propisochlor, propoxycarbazone, propyrisulfuron, propyzamide, prosulfalin, prosulfocarb, prosulfuron, proxan, prynachlor, pydanon, pyraclonil, pyraflufen, pyrasulfotole, pyrazolynate, pyrazosulfuron, pyrazoxyfen, pyribenzoxim, pyributicarb, pyriclor, pyridafol, pyridate, pyriftalid, pyriminobac, pyrimisulfan, pyrithiobac, pyroxasulfone, pyroxsulam, quinclorac, quinmerac, quinoclamine, quinonamid, quizalofop, quizalofop-P, rhodethanil, rimsulfuron, saflufenacil, S-metolachlor, sebuthylazine, secbumeton, sethoxydim, siduron, simazine, simeton, simetryn, SMA, sodium arsenite, sodium azide, sodium chlorate, sulcotrione, sulfallate, sulfentrazone, sulfometuron, sulfosulfuron, sulfuric acid, sulglycapin, swep, TCA, tebutam, tebuthiuron, tefuryltrione, tembotrione, tepraloxydim, terbacil, terbucarb, terbuchlor, terbumeton, terbuthylazine, terbutryn, tetrafluron, thenylchlor, thiazafluron, thiazopyr, thidiazimin, thidiazuron, thiencarbazone-methyl, thifensulfuron, thiobencarb, tiocarbazil, tioclorim, topramezone, tralkoxydim, triafamone, tri-allate, triasulfuron, triaziflam, tribenuron, tricamba, triclopyr, tridiphane, trietazine, trifloxysulfuron, trifluralin, triflusulfuron, trifop, trifopsime, trihydroxytriazine, trimeturon, tripropindan, tritac, tritosulfuron, vernolate, and xylachlor.

Another embodiment of the present disclosure is a method for the control or prevention of fungal attack. This method comprises applying to the soil, plant, roots, foliage, or locus of the fungus, or to a locus in which the infestation is to be prevented (for example applying to cereal or grape plants), a fungicidally effective amount of one or more of the compounds of Formula I. The compounds are suitable for treatment of various plants at fungicidal levels, while exhibiting low phytotoxicity. The compounds may be useful both in a protectant and/or an eradicant fashion.

The compounds have been found to have significant fungicidal effect particularly for agricultural use. Many of the compounds are particularly effective for use with agricultural crops and horticultural plants.

It will be understood by those in the art that the efficacy of the compound for the foregoing fungi establishes the general utility of the compounds as fungicides.

The compounds have broad ranges of activity against fungal pathogens. Exemplary pathogens may include, but are not limited to, causing agent of wheat leaf blotch (Zymoseptoria tritici), wheat brown rust (Puccinia triticina), wheat stripe rust (Puccinia striiformis), scab of apple (Venturia inaequalis), powdery mildew of grapevine (Uncinula necator), barley scald (Rhynchosporium secalis), blast of rice (Pyricularia oryzae), rust of soybean (Phakopsora pachyrhizi), glume blotch of wheat (Leptosphaeria nodorum), powdery mildew of wheat (Blumeria graminis f. sp. tritici), powdery mildew of barley (Blumeria graminis f. sp. hordei), powdery mildew of cucurbits (Erysiphe cichoracearum), anthracnose of cucurbits (Colletotrichum lagenarium), leaf spot of beet (Cercospora beticola), early blight of tomato (Alternaria solani), and spot blotch of barley (Cochliobolus sativus). The exact amount of the active material to be applied is dependent not only on the specific active material being applied, but also on the particular action desired, the fungal species to be controlled, and the stage of growth thereof, as well as the part of the plant or other product to be contacted with the compound. Thus, all the compounds, and formulations containing the same, may not be equally effective at similar concentrations or against the same fungal species.

The compounds are effective in use with plants in a disease-inhibiting and phytologically acceptable amount. The term “disease-inhibiting and phytologically acceptable amount” refers to an amount of a compound that kills or inhibits the plant disease for which control is desired, but is not significantly toxic to the plant. This amount will generally be from about 0.1 to about 1000 ppm (parts per million), with 1 to 500 ppm being preferred. The exact concentration of compound required varies with the fungal disease to be controlled, the type of formulation employed, the method of application, the particular plant species, climate conditions, and the like. A suitable application rate is typically in the range from about 0.10 to about 4 pounds/acre (about 0.01 to 0.45 grams per square meter, g/m²).

Any range or desired value given herein may be extended or altered without losing the effects sought, as is apparent to the skilled person for an understanding of the teachings herein.

The compounds of Formula I may be made using well-known chemical procedures. Intermediates not specifically mentioned in this disclosure are either commercially available, may be made by routes disclosed in the chemical literature, or may be readily synthesized from commercial starting materials utilizing standard procedures.

GENERAL SCHEMES

The following schemes illustrate approaches to generating picolinamide compounds of Formula (I). The following descriptions and examples are provided for illustrative purposes and should not be construed as limiting in terms of substituents or substitution patterns.

Compounds of Formula 1.3, wherein R₄ is as originally defined, but not alkoxyaryl, can be prepared according to the methods outlined in Scheme 1, steps a-c. Compounds of Formula 1.1, wherein R₄ is as originally defined, but not alkoxyaryl, can be obtained by reaction of the dianion of an ester of Formula 1.0, formed by treatment with lithium diisopropylamide (LDA) at −50° C., with an alkyl halide, such as benzyl bromide, or allyl halide in a solvent such as tetrahydrofuran (THF) at cryogenic temperatures, such as −78° C., as shown in step a. Compounds of Formula 1.2, wherein R₄ is alkyl, can be obtained by treating compounds of Formula 1.1, wherein R₄ is an alkenyl functionality, with hydrogen gas in the presence of a catalyst, such as palladium on carbon (Pd/C), in a solvent such as ethyl acetate (EtOAc), as shown in step b. Compounds of Formula 1.3, wherein R₄ is as originally defined, but not alkoxyaryl, can be prepared from compounds of Formula 1.1, wherein R₄ is as defined above, but not alkoxyaryl, and Formula 1.2, wherein R₄ is as defined above, but not alkoxyaryl, by treating with an alkylating agent such as 4-methoxybenzyl 2,2,2-trichloroacetimidate, or benzyl 2,2,2-trichloroacetimidate, in the presence of an acid such as camphor sulfonic acid (CSA), or triflic acid, in a solvent such as dichloromethane (DCM), as depicted in step c.

Compounds of Formulas 2.2 and 2.3 can be prepared according to the methods outlined in Scheme 2, steps a-b. Compound 2.1 can be obtained by reaction of the dianion of an ester of Formula 2.0, formed by treatment with LDA at −50° C., with alkyl halide such as 4-methoxybenzyl bromide, in a solvent such as THF at cryogenic temperatures such as −78° C., as shown in step a. Compounds of Formulas 2.2 and 2.3 can be prepared from compounds of Formula 2.1, by treating with an alkylating agent such as benzyl 2,2,2-trichloroacetimidate, in the presence of an acid such as triflic acid, in a solvent such as DCM, as depicted in step b.

Compounds of Formulas 3.2, 3.3, 3.4, and 3.5 wherein R₄ is as originally defined, can be prepared according to the methods outlined in Scheme 3, steps a-d. Compounds of Formula 3.1, wherein R₄ is as originally defined, can be obtained by the reaction of compounds of the Formula 3.0, wherein R₄ is as originally defined, with a reducing agent such as diethylsilane in the presence of a transition metal catalyst such as chlorobis(cyclooctene)iridium(I) dimer in a solvent such as DCM at a temperature such as 0° C., as depicted in step a. Compounds of Formulas 3.2 and 3.3, wherein R₄ is as originally defined, can be prepared from compounds of the Formula 3.1, wherein R₄ is as originally defined, by treating with vinylmagnesium bromide at cryogenic temperatures such as −78° C. in a solvent such as THF, as shown in step b. Compounds of the Formula 3.4, wherein R₄ is as originally defined, can be obtained by a reaction of compounds of the Formula 3.0, wherein R₄ is as originally defined, with a reducing agent such as lithium aluminum hydride (LAH) in a solvent such as THF at a temperature of about −78° C. to about 23° C., as shown in step c. Additionally, compounds of Formula 3.0, wherein R₄ is as originally defined, can be treated with a nucleophile such as methyllithium in a solvent such as THF at a temperature of about −78° C. to about 23° C., as described is step d, to afford compounds of Formula 3.5, wherein R₄ is as originally defined.

Compounds of Formulas 4.2, 4.4, and 4.7, wherein R₄ is as originally defined, R₈ is alkyl or aryl, and R₁₀ is alkyl, can be prepared according to the methods described in Scheme 4, steps a-g. Compounds of the Formula 4.0 can be treated with a base such as potassium t-butoxide and alkylating agent such as n-propyltosylate, in a solvent such as dimethoxyethane (DME) at a temperature of about 40° C., to afford compounds of Formula 4.1, wherein R₄ is as originally described and R₈ is alkyl, as depicted in step a. Compounds of Formula 4.2, wherein R₄ is as originally described and R₈ is alkyl, can be obtained upon treating compounds of the Formula 4.1, wherein R₄ is as originally described and R₈ is alkyl, with a transition metal catalyst, such as Pd/C, under a hydrogen (H₂) atmosphere in a polar solvent such as EtOAc or methanol (MeOH), as shown in step b. Additionally, compounds of the Formula 4.0, wherein R₄ is as originally described, can be arylated to provide compounds of the Formula 4.3, wherein R₄ is as originally described and R₈ is aryl, using a reagent such as tris(o-tolyl)bismuth(V) diacetate in the presence of an amine base such as N,N-dicyclohexyl-N-methylamine and a catalyst such as copper(II) acetate, in a solvent such as toluene at a temperature of about 65° C., as shown in step c. Compounds of Formula 4.4, wherein R₄ is as originally described and R₈ is aryl, can be obtained via hydrogenation of compounds of Formula 4.3, wherein R₄ is as originally described and R₈ is aryl, in the presence of a transition metal catalyst, such as Pd/C, under a H₂ atmosphere in a polar solvent such as EtOAc or MeOH, as shown in step d. Furthermore, compounds of Formula 4.3, wherein R₄ is as originally described and R₈ is aryl, can be subjected to ozone (O₃) in the presence of an acid scavenger, such as sodium bicarbonate (NaHCO₃), and an indicator, such as Sudan III, in a solvent like DCM at a temperature of about −78° C., followed by addition of a reducing agent, such as sodium borohydride, in a solvent such as methanol at a temperature of about −78° C. to about 23° C., to provide compounds of Formula 4.5, wherein R₄ is as originally described and R₈ is aryl, as shown in step e. Alkylation of compounds of Formula 4.5, wherein R₄ is as originally described and R₈ is aryl, using a base, such as sodium hydride, and an alkylating agent, such as ethyl iodide, in a solvent such as THF at temperatures from about 0° C. to 23° C., afford compounds of Formula 4.6, wherein R₄ is as originally described, R₈ is aryl and R₁₀ is alkyl, as depicted in step f. Compounds of Formula 4.7, wherein R₄ is as originally described, R₈ is aryl and R₁₀ is alkyl, can be obtained upon treating compounds of the Formula 4.6, wherein R₄ is as originally described, R₈ is aryl and R₁₀ is alkyl, with a 2,3-dichloro-5,6-dicyanoquinone (DDQ) in a solvent such as DCM at a temperature of about 0° C., as shown in step g.

Compounds of Formulas 5.1, 5.2, and 5.3, wherein R₄ is as originally defined and R₈ is hydrogen or alkyl, and R₁₀ is alkyl or aryl, can be prepared according to the methods outlined in Scheme 5, steps a-c. Treatment of compounds of Formula 5.0, wherein R₄ is as originally defined and R₈ is hydrogen or methyl, with a methylating agent, trimethyloxonium tetrafluoroborate, in the presence of a base, such as 1,8-bis(dimethylamino)naphthalene, in a solvent such as DCM at a temperature of about 0° C. to 23° C., affords compounds of Formula 5.1, wherein R₄ is as originally defined, R₈ is hydrogen or methyl, and R₁₀ is methyl, as shown in step a. Compounds of Formula 5.2, wherein R₄ is as originally defined, R₈ is hydrogen or methyl, and R₁₀ is either alkyl or alkenyl, can be obtained from the reaction between compounds of a Formula 5.0, wherein R₄ is as originally defined and R₈ is hydrogen or methyl, and an appropriate alkyl or alkenyl halide, such as benzyl bromide or allyl bromide, in the presence of a base, such as sodium hydride, and a catalyst such as tetrabutylammonium iodide, in a solvent such as DMF at a temperatures of about 0° C. to 23° C., as shown in step b. Additionally, compounds of Formula 5.0, wherein R₄ is as originally defined and R₈ is hydrogen or methyl, can be treated with a base, such as sodium hydride or potassium t-butoxide, and an aryl fluoride such as 1,2,4-trifluorobenzene, with or without a crown ether such as 15-crown-5, in a solvent such as DMF at temperatures of about 0° C. to about 70° C., to provide compounds of Formula 5.3, wherein R₄ is as originally defined, R₈ is hydrogen or methyl, and R₁₀ is aryl, as shown in step c.

Compounds of Formula 6.2, wherein R₄ is as originally defined and R₈ is alkyl or aryl, can be prepared according to the methods depicted in Scheme 6, steps a-c. Hydrogenolysis of compounds of Formula 6.0, wherein R₄ is as originally defined and R₈ is aryl, alkenyl, or alkyl, but not benzyl, in the presence of a catalyst such as Pd/C under an atmosphere of H₂ in a polar solvent such as EtOAc or EtOH, or with an alternate source of hydrogen, such as cyclohexene, in a polar solvent such as EtOH, provides products of Formula 6.2, wherein R₄ is as originally defined and R₈ is alkyl or aryl, but not alkenyl, benzyl or aryl chloride, as shown in step a. Compounds of Formula 6.1, wherein R₄ is as originally defined and R₈ is alkyl, alkenyl, or aryl, but not benzyl, upon treatment with a catalyst such as Pd/C under an atmosphere of H₂ in a polar solvent such as EtOAc or EtOH, afford compounds of Formula 6.2, wherein R₄ is as originally defined and R₈ is alkyl or aryl, but not alkenyl, benzyl or aryl chloride, as shown in step b. Alternatively, compounds of Formula 6.2, wherein R₄ is as originally defined and R₈ is alkyl, benzyl or aryl, may be obtained by treating compounds of Formula 6.1, where R₄ is as originally defined and R₈ is alkyl, benzyl or aryl, with an oxidant, such as ceric ammonium nitrate (CAN) in a solvent such as wet acetonitrile at a temperature of about 0° C. to 23° C., as shown in step c.

Compounds of Formula 7.2, wherein R₄ is as originally defined and R₈ is alkyl or aryl, can be prepared according to the methods depicted in Scheme 7, steps a-c. Hydrogenolysis of compounds of Formula 7.0, wherein R₄ is as originally defined and R₈ is aryl, alkenyl, or alkyl, but not benzyl, in the presence of a catalyst such as Pd/C under an atmosphere of H₂ in a polar solvent such as EtOAc or EtOH, provides products of Formula 7.2, wherein R₄ is as originally defined and R₈ is alkyl or aryl, but not alkenyl, benzyl or aryl chloride, as shown in step a. Compounds of Formula 7.1, wherein R₄ is as originally defined and R₈ is alkyl or alkenyl, but not benzyl, upon treatment with a catalyst such as Pd/C, under an atmosphere of H₂ in a polar solvent such as EtOAc or EtOH, afford compounds of Formula 7.2, wherein R₄ is as originally defined and R₈ is alkyl or aryl, but not alkenyl or benzyl, as shown in step b. Alternatively, compounds of Formula 7.2, wherein R₄ is as originally defined and R₈ is alkyl, alkenyl, benzyl or aryl, may be obtained by treating compounds of Formula 7.1, where R₄ is as originally defined and R₈ is alkyl, alkenyl, benzyl or aryl, with an oxidant, such as CAN, in a solvent such as wet acetonitrile at a temperature of about 0° C. to 23° C., as shown in step c.

Compounds of Formula 8.3, wherein R₄ is as originally defined and R₈ is alkyl, allyl, or benzyl, can be prepared according to the methods outlined in Scheme 8, steps a-c. Compounds of Formula 8.1, wherein R₄ is as originally defined, can be obtained by reaction of (S)-5-methylfuran-2(5H)-one, a compound of Formula 8.0 (prepared as in Kobayashi et al. Tetrahedron 2003, 59, 9743-9758) with an organolithium reagent, such as R₄CH₂Li, or a Grignard reagent, such as R₄CH₂MgX, wherein R₄ is as originally defined and X is bromide or chloride, and copper (I) iodide in a solvent such as THF at cryogenic temperatures such as −78° C., as shown in step a. Compounds of Formula 8.2, wherein R₄ is as originally defined and R₈ is alkyl, alkenyl, or benzyl, can be obtained by treating compounds of Formula 8.1, wherein R₄ is as originally defined, with lithium diisopropylamide (LDA), which was generated in situ from n-butyllithium (n-BuLi) and diisopropylamine (i-Pr₂NH) at −20° C., followed by reacting with alkyl, allyl, or benzyl bromide or alkyl, allyl, or benzyl chloride, such as R₈Br, wherein R₈ is alkyl, allyl, or benzyl, in a solvent such as THF from −78° C. to ambient temperature, as shown in step b. Compounds of Formula 8.3, wherein R₄ is as originally defined and R₈ is alkyl, allyl, or benzyl, can be prepared from compounds of Formula 8.2, wherein R₄ is as originally defined and R₈ is alkyl, allyl, or benzyl, by treating with a reducing agent such as LAH, in a solvent such as THF from 0° C. to ambient temperature, as depicted in step c.

Compounds of Formula 9.3, wherein R₄ is as originally defined and R₈ is alkyl or benzyl, can be prepared as shown in Scheme 9, steps a-d. Diols of Formula 9.3, wherein R₄ is as originally defined and R₈ is alkyl, allyl, or benzyl, can be protected as bis-trimethylsilyl (TMS) ethers to give compounds of Formula 9.0, wherein R₄ is as originally defined and R₈ is alkyl, allyl, or benzyl, by reacting with a base such as triethylamine (Et₃N) and silylating reagent, such as chloro trimethylsilane (TMSCl), in an aprotic solvent, such as DCM, at ambient temperature, as shown in step a. Compounds of Formula 9.1, wherein R₄ is as originally defined and R₈ is alkyl, allyl, or benzyl, can be obtained by reacting compounds of Formula 9.0, wherein R₄ is as originally defined and R₈ is alkyl, allyl, or benzyl, with an oxidant, such as a solution of chromium trioxide (CrO₃) and pyridine in DCM, in a solvent such as DCM at low temperatures such as from about −25° C. to about −10° C., as shown in step b. Compounds of Formula 9.2, wherein R₄ is as originally defined and R₇ is alkyl, allyl, or benzyl, can be prepared by addition of compounds of Formula 9.1, is as originally defined and R₈ is alkyl, allyl, or benzyl, into a mixture of n-BuLi and triphenylmethylphosphonium bromide (Ph₃PCH₃Br), in a solvent such as THF at cryogenic temperatures such as −78° C., and slowly warming to ambient temperature, as shown in step c. Compounds of Formula 9.3, wherein R₄ is as originally defined and R₈ is alkyl or benzyl, can be obtained from compounds of Formula 9.2, is as originally defined and R₈ is alkyl, allyl, or benzyl, via hydrogenation in the presence of a catalyst, such as Pd/C, under an atmosphere of H₂ in a polar solvent such as EtOAc or EtOH, as shown in step d.

Compounds of Formula 10.1, wherein R₄ is as originally defined, can be prepared from the reaction between trans-2-methyl-3-phenyloxirane, a compound of Formula 10.0, with an organolithium reagent, such as R₄CH₂Li, or a Grignard reagent, such as R₄CH₂MgX, wherein R₄ is as originally defined and X is bromide or chloride, and copper (I) iodide in a solvent such as THF at cryogenic temperatures such as −78° C., as shown in step a.

Compounds of Formula 11.3, wherein R₄ is aryl, can be prepared as shown in Scheme 11, steps a-c. Methyl acetoacetate, a compound of Formula 11.0, can be reacted with benzylic halides, such as R₄CH₂X, wherein R₄ is aryl and X is Br or Cl, in the presence of a base, such as potassium carbonate (K₂CO₃) and a phase transfer catalyst, such as 1-butyl-3-methylimidazolium tetrafluoroborate, in a polar aprotic solvent like DMF at a temperature of about 23° C. to afford compounds of Formula 11.1, wherein R₄ is aryl, as depicted in step a. Treatment of compounds such as 11.1, wherein R₄ is aryl, with a nucleophile such as 4-aminobenzenethiol in the presence of a base, such as cesium carbonate (Cs₂CO₃) in a solvent like DMF at a temperature of about 85° C. provides compounds of Formula 11.2, wherein R₄ is aryl, as in step b. Compounds of Formula 11.3, wherein R₄ is aryl, can be generated by a reduction of ketones of Formula 11.2, wherein R₄ is aryl, using a reductant such as borane-dimethylsulfide complex (BH₃·SMe₂) in the presence of a chiral catalyst like (R)-(+)-2-Methyl-CBS-oxazaborolidine in nonpolar solvent such as toluene at temperatures of about −78° C. to about 23° C., as shown in step c.

Compounds of Formula 12.3, wherein R₁, R₂, R₃, R₄, and R₁₁ are as originally defined, can be prepared according to the methods shown in Scheme 12, steps a-b. Alcohols of Formula 12.0, wherein R₂, R₃, and R₄ are as originally defined, can be treated with compounds of Formula 12.1, wherein R₁ and R₁₁ are as originally defined, a coupling reagent, such as 3-ethyliminomethyleneamino)-N,N-dimethylpropan-1-amine hydrochloride (EDC) or a polymer-supported carbodiimide (PS-CDI), and a catalyst, such as N,N-dimethylaminopyridine (DMAP), in a halogenated solvent such as DCM to afford compounds of Formula 12.3, wherein R₁, R₂, R₃, R₄, and R₁₁ are as originally defined, as shown in step a. Alternatively, compounds of Formula 12.3, wherein R₁, R₂, R₃, R₄, and R₁₁ are as originally defined, can be prepared by reacting compounds of Formula 12.2, wherein R₂, R₃, and R₄ are as originally defined, with an activating agent, such as diisopropyl azodicarboxylate (DIAD), in the presence of phosphine reagent, such as triphenylphosphine, and a nucleophile such as compounds of Formula 12.1, wherein R₁ and R₁₁ are as originally defined, in a solvent such as tetrahydrofuran (THF) at temperatures of about 0° C. to about 23° C., as depicted in step b.

Compounds of Formula 13.4, wherein R₁ and R₁₁ are as originally defined, can be prepared according to the methods described in Scheme 13, steps a-c. Treatment of compound of Formula 13.1 (see: Hayashi, T. et al. Tetrahedron 1994, 50, 335) with amino acids of Formula 13.0, wherein R₁ and R₁₁ are as originally defined, under coupling conditions outlined in Scheme 12, step a, affords compounds of Formula 13.2, wherein R₁ and R₁₁ are as originally defined, as depicted in step a. Ketones of Formula 13.2, wherein R₁ and R₁₁ are as originally defined, can be treated with an olefinating reagent, such as bis(cyclopentadienyl)-μ-chloro(dimethylaluminum)-μ-methylenetitanium (Tebbe reagent), in a nonpolar solvent like toluene at temperatures of about 0° C. to about 23° C., to afford compounds of Formula 13.3, R₁ and R₁₁ are as originally defined, as shown in step b. Compounds of Formula 13.3, wherein R₁ and R₁₁ are as originally defined, can be hydrogenated under conditions outlined in Scheme 9, step d, to afford compounds of the Formula 13.4, R₁ and R₁₁ are as originally defined, as depicted in step c.

Compounds of Formula 14.4, wherein R₁, R₂, R₃, R₄, R₆ and R₁₁ are as originally defined, can be prepare according to the methods outlined in Scheme 14, steps a-c. Compounds of Formula 14.0, wherein R₁, R₂, R₃, R₄, R₆ and R₁₁ are as originally defined, but not alkenyl, can be treated with an acid, such as a 4 N solution of HCl in dioxane, to afford compounds of Formula 14.1, wherein R₁, R₂, R₃, R₄, R₆ and R₁₁ are as originally defined, but not alkenyl, as shown in step a. Alternatively, compounds of Formula 14.2, wherein R₁, R₂, R₃, R₄, R₆ and R₁₁ are as originally defined, can be obtained via treatment of compounds of Formula 14.0, wherein R₁, R₂, R₃, R₄, R₆ and R₁₁ are as originally defined, with an acid, such as 2,2,2-trifluoroacetic acid, in a solvent such as DCM, as depicted in step b. Compounds of Formulas 14.1 and 14.2, wherein R₁, R₂, R₃, R₄, R₆ and R₁₁ are as originally defined, can be treated with compound of Formula 14.3, in the presence of a base, such as diisopropylethylamine, and a peptide coupling reagent, such as benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate (PyBOP) or O-(7-azabenzo-triazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (HATU), in a halogenated solvent such as DCM, to afford compounds of Formula 14.4, wherein R₁, R₂, R₃, R₄, R₆ and R₁₁ are as originally defined, as shown step c.

Compounds of Formula 15.1, wherein R₁, R₂, R₃, R₄, R₆, R₇, and R₁₁ are as originally defined, can be prepared according to the method outlined in Scheme 15, step a. Compounds of Formula 15.0, wherein R₁, R₂, R₃, R₄, R₆, R₇, and R₁₁ are as previously defined, can be treated with an appropriate alkyl halide, with or without a reagent such as sodium iodide (NaI), and an alkali carbonate base, such as Na₂CO₃ or potassium carbonate (K₂CO₃), in a solvent like acetone or by treatment with an acyl halide in the presence of an amine base, such as pyridine, NEt₃, DMAP, or mixtures thereof, in an aprotic solvent such as DCM, to afford compounds of Formula 15.1, wherein R₁, R₂, R₃, R₄, R₆, R₇, and R₁₁ are as previously defined, as shown in step a.

The following examples are presented to illustrate the various aspects of the compounds of the present disclosure and should not be construed as limitations to the claims.

EXAMPLES Example 1, Step 1: Preparation of (S)-methyl 2-((S)-1-hydroxyethyl)-5-methylhex-4-enoate

To a solution of diisopropylamine (19.93 mL, 142 mmol) in anhydrous THF (99 mL) at −50° C. (deficient dry ice/acetone bath) was added butyllithium (54.3 mL, 130 mmol). This solution was removed from the cold bath for 15 min, then re-cooled to −50° C. To this solution was added a solution of (S)-methyl 3-hydroxybutanoate (6.64 mL, 59.3 mmol) in THF (20 mL) dropwise over 15 minutes using a Teflon canula. This solution was allowed to warm to −30° C. over 30 min, then stirred at this temperature for another 1 h and cooled to −78° C. To this solution was added a solution of 1-bromo-3-methylbut-2-ene (13.69 mL, 119 mmol) in anhydrous 1,2-dimethoxyethane (20.00 mL, 193 mmol) dropwise over 15 minutes using a Teflon canula. This reaction was at −60° C. after 1 h. Removed the cold bath and stirred at room temperature for 1.5 h. The reaction was quenched with addition of sat aq. NH₄Cl (50 mL) then added EtOAc (50 mL) and the phases were transferred to a separatory funnel and separated. The aqueous phase was further extracted with EtOAc (2×50 mL) and the combined organic extracts were washed with brine (50 mL), dried (Na₂SO₄), filtered and concentrated to dryness. The crude residue was purified using flash chromatography on silica (120 g column, 85 mL/min, 0% EtOAc 1 min, ramp to 40% EtOAc/hexanes over 28 min) to afford (S)-methyl 2-((S)-1-hydroxyethyl)-5-methylhex-4-enoate (9.5 g, 86%) as a slightly yellow oil. ¹H NMR (400 MHz, CDCl₃) δ 5.11-5.01 (m, 1H), 3.92 (p, J=6.3 Hz, 1H), 3.70 (s, 3H), 2.78 (s, 1H), 2.46-2.28 (m, 3H), 1.69 (d, J=1.4 Hz, 3H), 1.62 (s, 3H), 1.23 (d, J=6.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 175.54, 134.14, 120.30, 67.78, 52.72, 51.52, 27.90, 25.73, 21.46, 17.64; (Thin film) 3452, 2971, 2929, 1730, 1437, 1198, 1160 cm⁻¹.

Example 1, Step 2: Preparation of (S)-methyl 2-((S)-1-hydroxyethyl)-5-methylhexanoate

Palladium on carbon (Pd/C) (0.543 g, 5.10 mmol) (1 mol %) was added to a well stirred solution of (S)-methyl 2-((S)-1-hydroxyethyl)-5-methylhex-4-enoate (9.5 g, 51.0 mmol) in MeOH (51.0 mL). The reaction was placed under a hydrogen atmosphere (balloon) and stirred at room temperature for 20 h. The suspension was filtered through plug of celite, and the plug was washed with MeOH (20 mL). The solvent was removed under reduced pressure and then CH₂Cl₂ (50 mL) was added to the residue and the solution was passed through a phase separator. Then the solvent was removed under reduced pressure to afford (s)-methyl 2-((S)-1-hydroxyethyl)-5-methylhexanoate (9.45 g, 98%) as a slightly yellow oil. ¹H NMR (400 MHz, CDCl₃) δ 3.91 (p, J=6.4 Hz, 1H), 3.72 (s, 3H), 2.77 (s, 1H), 2.36 (ddd, J=9.2, 6.3, 5.0 Hz, 1H), 1.72-1.45 (m, 3H), 1.28-1.05 (m, 5H), 0.88 (dd, J=6.6, 3.2 Hz, 6H). ¹³C NMR (75 MHz, CDCl₃) δ 176.13, 68.55, 53.29, 51.67, 36.55, 28.16, 27.37, 22.74, 22.44, 21.68. (Thin film) 3451, 2954, 2871, 1736, 1719, 1169 cm⁻¹.

Example 1, Step 3: Preparation of (S)-methyl 2-((S)-1-((4-methoxybenzyl)oxy)ethyl)-5-methylhexanoate

To a solution of (S)-methyl 2-((S)-1-hydroxyethyl)-5-methylhexanoate (5 g, 26.6 mmol) and ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid (0.617 g, 2.66 mmol) in CH₂Cl₂ (53.1 mL) at 0° C. was added 4-methoxybenzyl 2,2,2-trichloroacetimidate (8.27 mL, 39.8 mmol). The reaction mixture was removed from the cold bath and stirred at room temperature for 17 h. To the mixture was added hexanes (50 mL) and the precipitates were removed by filtration through a phase separator. The solids were washed with hexanes (2×10 mL). Celite™ (2 scoopula tip-fulls) was then added to the organic phase then the solvent was removed under reduced pressure and the resulting solid material was directly loaded onto a column and purified using flash chromatography on silica (80 g column, 60 mL/min, 0% EtOAc 1 min, ramp to 35% EtOAc/hexanes over 33 min and hold at 35% for 2 mins) to afford (S)-methyl 2-((S)-1-((4-methoxybenzyl)oxy)ethyl)-5-methylhexanoate (6.3 g, 77%) as a colorless oil. ¹H NMR (400 MHz, CDCl₃) δ 7.24-7.16 (m, 2H), 6.89-6.79 (m, 2H), 4.49 (d, J=11.2 Hz, 1H), 4.33 (d, J=11.1 Hz, 1H), 3.75 (s, 3H), 3.74-3.62 (m, 4H), 2.49 (ddd, J=10.7, 8.2, 4.0 Hz, 1H), 1.62-1.40 (m, 3H), 1.23-1.16 (m, 3H), 1.16-1.03 (m, 2H), 0.87 (d, J=3.9 Hz, 3H), 0.85 (d, J=3.9 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 175.03, 159.10, 130.63, 129.14, 113.62, 76.16, 70.71, 55.11, 52.64, 51.25, 36.58, 27.97, 26.00, 22.69, 22.17, 17.08. ESIMS (m/z) 331 ([M+Na]⁺).

Example 2: Preparation of (2S,3S)-methyl 3-(benzyloxy)-2-(4-methoxybenzyl)butanoate and (2S,3S)-methyl 2-(3-benzyl-4-methoxybenzyl)-3-(benzyloxy)butanoate

To a solution of (2S,3S)-methyl 3-hydroxy-2-(4-methoxybenzyl)butanoate (7.6 g, 31.9 mmol) in DCM (100 mL) at 0° C. was added benzyl 2,2,2-trichloroacetimidate (12.08 g, 47.8 mmol). To the mixture was then added trifluoromethanesulfonic acid (0.282 mL, 3.19 mmol) dropwise. The mixture was allowed to slowly warm to room temperature and stirred overnight. To the mixture was then added hexanes. The solution was stirred for 20 min, filtered through celite and the filter cake washed with hexanes. The filtrate was then treated with sat. NaHCO₃, and the products extracted with DCM. The organics were then washed with water and brine, dried with Na₂SO₄, filtered and concentrated. Purification via flash chromatography (120 g silica column, 0-30% acetone/hexanes) provided 5.76 g of a pale yellow oil. Subsequent reverse phase chromatography (C18 stationary phase column, 5-100% acetonitrile/water) provided (2S,3S)-methyl 3-(benzyloxy)-2-(4-methoxybenzyl)butanoate (3.009 g, 28%) as viscous yellow/orange oil. ¹N HMR (400 MHz, CDCl₃) δ 7.38-7.20 (m, 5H), 7.13-6.97 (m, 2H), 6.88-6.70 (m, 2H), 4.59 (d, J=11.7 Hz, 1H), 4.46 (d, J=11.6 Hz, 1H), 3.80 (dq, J=10.8, 6.3 Hz, 1H), 3.76 (s, 3H), 3.53 (s, 3H), 2.93-2.71 (m, 3H), 1.28 (d, J=6.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 174.13, 158.09, 138.48, 131.28, 129.76, 128.33, 127.63, 127.54, 113.82, 75.98, 71.04, 55.20, 54.37, 51.44, 33.09, 17.23. (Thin film) 2948.79, 1731.78, 1511.90, 1244.97, 1028.55 cm⁻¹. HRMS-ESI (m/z) ([M+H]⁺) calcd for C₂₀H₂₅O₄, 329.1747; found, 329.1731. And, (2S,3S)-methyl 2-(3-benzyl-4-methoxybenzyl)-3-(benzyloxy)butanoate (1.314 g, 2.51 mmol, 8%, ˜80% purity) as a viscous orange oil. ¹N HMR (400 MHz, CDCl₃) δ 7.40-7.21 (m, 6H), 7.21-7.00 (m, 3H), 6.96 (dt, J=8.3, 1.6 Hz, 1H), 6.93-6.81 (m, 1H), 6.81-6.61 (m, 2H), 4.57 (d, J=11.6 Hz, 1H), 4.43 (d, J=11.5 Hz, 1H), 4.06 3.84 (m, 2H), 3.77 (s, 3H), 3.54-3.49 (m, 1H), 3.46 (s, 3H), 2.87-2.70 (m, 3H), 1.25 (d, J=6.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 174.14, 155.90, 141.13, 138.48, 130.87, 129.47, 128.85, 128.45, 128.30, 128.21, 127.63, 127.55, 127.52, 125.73, 110.46, 76.03, 71.04, 55.43, 54.42, 51.36, 35.83, 33.21, 17.25. (Thin film) 2947, 1732, 1495, 1248, 1028 cm⁻¹. HRMS-ESI (m/z) ([M+H]⁺) calcd for C₂₇H₃₁O₄, 419.2217; found, 419.2219.

Example 3A, Step 1: Preparation of (2S,3S)-2-benzyl-3-((4-methoxybenzyl)oxy)butanal

To a magnetically stirred 50 mL RB flask was added (2S,3S)-methyl 2-benzyl-3-((4-methoxybenzyl)oxy)butanoate (5 g, 15.23 mmol) and DCM (7.61 mL). Then, Ir₂Cl₂(coe)₄ (0.273 g, 0.305 mmol) was added and the flask was cooled to 0° C. Over 5 min, diethylsilane (2.95 mL, 22.84 mmol) was added via syringe with much gas evolution. Once the addition was complete, the flask was removed from the cold bath and allowed to warm to rt overnight. The reaction was poured into a well-stirred Erlenmeyer flask containing a mixture of 50 mL Et₂O and 15 mL 2 N HCl at 0° C. The flask was stirred vigorously at 0° C. for 1.5 h, then the mixture was transferred to a separatory funnel and diluted with 25 mL H₂O. The phases were separated and the aqueous phase was extracted with Et₂O×3. The organic phases were washed with sat. NaHCO₃ and then brine. The solvent was removed and the resulting oil was purified by flash chromatography on silica (gradient eluent: 1-15% acetone in hexanes) to afford (2S,3S)-2-benzyl-3-((4-methoxybenzyl)-oxy)butanal (4.25 g, 94%) as a colorless oil. ¹H NMR (400 MHz, CDCl₃) δ 9.78 (d, J=2.8 Hz, 1H), 7.29-7.22 (m, 4H), 7.22-7.14 (m, 1H), 7.11-7.05 (m, 2H), 6.93-6.85 (m, 2H), 4.56 (d, J=11.3 Hz, 1H), 4.34 (d, J=11.3 Hz, 1H), 3.81 (s, 3H), 3.81-3.75 (m, 1H), 3.03 (dd, J=14.0, 8.2 Hz, 1H), 2.87 (dd, J=14.0, 6.3 Hz, 1H), 2.70 (dddd, J=8.2, 6.4, 4.5, 2.8 Hz, 1H), 1.29 (d, J=6.4 Hz, 3H).

Example 3A, Step 2: Preparation of (3S,4R,5S)-4-benzyl-5-((4-methoxybenzyl)oxy)hex-1-en-3-ol and (3R,4R,5S)-4-benzyl-5((4-methoxybenzyl)oxy)hex-1-en-3-ol

To a magnetically stirred 100 mL round-bottomed (rb) flask was added (2S,3S)-2-benzyl-3-((4-methoxybenzyl)oxy)butanal (1.987 g, 6.66 mmol) and THF (13 mL). The flask was cooled to −78° C. and vinylmagnesium bromide (1.0 M in THF) (13.3 mL, 13.3 mmol) was added in a slow stream via syringe. The reaction was maintained at −78° C. for 1.5 h. The reaction was quenched with sat. NH₄Cl at −78° C. (20 mL) and then removed from the cold bath. After warming to rt, the biphasic solution was diluted with EtOAc (50 mL). The solution was washed with brine (15 mL), dried over MgSO₄, filtered and concentrated. The oil was purified by flash chromatography on silica (40 g column, 40 mL/min, gradient eluent: 0-15% acetone in hexanes over 20 min) to afford clean separation of the two isomers: (3S,4R,5S)-4-benzyl-5-((4-methoxy-benzyl)oxy)hex-1-en-3-ol (1.15 g, 51%). ¹H NMR (400 MHz, CDCl₃) δ 7.28-7.17 (m, 5H), 7.05-6.98 (m, 2H), 6.92-6.84 (m, 2H), 5.91 (ddd, J=17.1, 10.6, 4.4 Hz, 1H), 5.36 (dt, J=17.2, 1.9 Hz, 1H), 5.23 (dt, J=10.6, 1.8 Hz, 1H), 4.65-4.59 (m, 1H), 4.56 (d, J=10.9 Hz, 1H), 4.21 (d, J=11.0 Hz, 1H), 3.89 (d, J=2.7 Hz, 1H), 3.78 (s, 3H), 3.65 (qd, J=6.3, 3.7 Hz, 1H), 2.72 (d, J=7.3 Hz, 2H), 1.78-1.70 (m, 1H), 1.25 (d, J=6.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 159.46, 141.10, 139.22, 130.09, 129.57, 129.23, 128.39, 125.91, 115.02, 114.01, 75.38, 70.99, 70.74, 55.33, 50.95, 31.46, 17.72. ESIMS (m/z) 349 ([M+Na]⁺). And, (3R,4R,5S)-4-benzyl-5-((4-methoxybenzyl)oxy)hex-1-en-3-ol (0.5 g, 22%). ¹H NMR (400 MHz, CDCl₃) δ 7.29-7.22 (m, 5H), 7.16-7.10 (m, 2H), 6.92-6.85 (m, 2H), 5.95 (ddd, J=17.2, 10.5, 5.5 Hz, 1H), 5.24 (dt, J=17.2, 1.7 Hz, 1H), 5.10 (dt, J=10.5, 1.6 Hz, 1H), 4.55 (d, J=11.3 Hz, 1H), 4.30 (d, J=11.3 Hz, 1H), 4.28-4.20 (m, 1H), 3.81 (s, 3H), 3.69 (qd, J=6.4, 4.1 Hz, 1H), 2.85 (dd, J=5.4, 1.1 Hz, 1H), 2.80 (dd, J=14.0, 7.1 Hz, 1H), 2.71 (dd, J=14.0, 7.0 Hz, 1H), 2.04-1.96 (m, 1H), 1.26 (d, J=6.4 Hz, 3H).

Example 3B: Preparation of (2R,3S)-2-benzyl-3-((4-methoxybenzyl)oxy)butan-1-ol

To a suspension of lithium aluminum hydride (0.844 g, 22.23 mmol) in THF (50 mL) at −78° C. was added a solution of (2S,3S)-methyl 2-benzyl-3-((4-methoxybenzyl)oxy)butanoate (3.65 g, 11.11 mmol) in THF (5 mL) dropwise. The mixture was then warmed to room temperature and stirred overnight. The mixture was cooled to 0° C. and the reaction was quenched via the CAREFUL addition of water (0.84 mL) followed by the addition of 15% NaOH (0.84 mL), and then more water (2.52 mL). The solution was then allowed to warm to room temperature and stirred an additional 1 h. The solids were then filtered off and the filter cake washed with ether. The collected filtrate was then concentrated and the residue purified via flash chromatography (80 g silica column, 0-30% acetone/hexanes) to provide (2R,3S)-2-benzyl-3-((4-methoxybenzyl)oxy)butan-1-ol (2.94 g, 88%) as a clear colorless oil. ¹N HMR (400 MHz, CCDCl₃) δ 7.30-7.23 (m, 4H), 7.21-7.12 (m, 3H), 6.92-6.86 (m, 2H), 4.60 (d, J=11.2 Hz, 1H), 4.31 (d, J=11.2 Hz, 1H), 3.90 (ddd, J=11.3, 3.9, 2.6 Hz, 1H), 3.81 (s, 3H), 3.66 (qd, J=6.2, 4.3 Hz, 1H), 3.56-3.43 (m, 1H), 2.86 (ddd, J=7.6, 3.9, 1.3 Hz, 1H), 2.84-2.68 (m, 2H), 1.82-1.71 (m, 1H), 1.30 (d, J=6.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 159.30, 140.56, 130.31, 129.36, 129.17, 128.34, 125.95, 113.90, 70.68, 62.36, 55.29, 47.79, 35.13, 17.66. (Thin film) 3432.14, 2932.00, 1611.60, 1512.16, 1245.18, 1030.65 cm⁻¹. HRMS-ESI (m/z) ([M+Na]⁺) calcd for C₁₉H₂₄NaO₃, 323.1623; found, 323.1625.

Example 3C: Preparation of (3S,4S)-3-(4-fluorobenzyl)-4-((4-methoxybenzyl)oxy)-2-methylpentan-2-ol

In a 250 mL round-bottom flask, a solution of (2S,3S)-methyl 2-(4-fluorobenzyl)-3-((4-methoxybenzyl)oxy)butanoate (3.55 g, 10.25 mmol) was prepared in THF (41.0 mL) and cooled to −78° C. in an acetone/dry ice bath. After ˜15 min, methyllithium (1.6 M in Et₂O) (19.22 mL, 30.7 mmol) was added via syringe over 1 h. The reaction was allowed to slowly warm to room temperature and stirred overnight. The reaction was cooled to 0° C. and carefully quenched with sat. aq. NH₄Cl (60 mL) and extracted with EtOAc (3×60 mL). The combined organic phases were dried over Na₂SO₄, filtered and concentrated to afford a yellow oil. The oil was purified via flash chromatography on silica (120 g column, 85 mL/min, 100% hexanes for 2 column volumes, 100% hexanes to 40% acetone:hexanes over 12 column volumes, hold at 40% acetone:hexanes for 2 column volumes) to afford (3S,4S)-3-(4-fluorobenzyl)-4-((4-methoxybenzyl)oxy)-2-methylpentan-2-ol (1.706 g, 48%) as a yellow oil. ¹H NMR (400 MHz, CDCl₃) δ 7.30-7.21 (m, 2H), 7.11-7.01 (m, 2H), 6.99-6.82 (m, 4H), 4.60 (d, J=10.9 Hz, 1H), 4.45 (s, 1H), 4.30 (d, J=11.0 Hz, 1H), 3.80 (s, 3H), 3.75-3.65 (m, 1H), 2.76-2.65 (m, 1H), 2.39 (dd, J=15.3, 7.2 Hz, 1H), 1.95 (td, J=7.0, 4.1 Hz, 1H), 1.27-1.20 (m, 9H). ¹³C NMR (101 MHz, CDCl₃) δ 161.15 (d, J=243.8 Hz), 159.42, 137.58 (d, J=3.2 Hz), 129.99 (d, J=7.7 Hz), 129.73, 129.65, 115.10 (d, J=21.1 Hz), 113.96, 78.02, 73.70, 70.27, 55.30, 55.14, 34.78, 30.31, 26.29, 18.99. ¹⁹F NMR (376 MHz, CDCl₃) δ−117.71. (Thin film) 3441, 2971, 2935, 1612, 1586, 1509, 1464, 1377, 1302, 1247, 1218, 1172, 1157, 1071, 986, 942, 900, 819, 749 cm⁻¹. HRMS-ESI (m/z) ([M+Na]⁺) calcd for C₂₁H₂₇FNaO₃, 369.1836; found, 369.1845.

Example 4A: Preparation of 1-((((2S,3S,4S)-3-benzyl-4-propoxyhex-5-en-2-yl)oxy)-methyl)-4-methoxybenzene

To a solution of (3S,4R,5S)-4-benzyl-5-((4-methoxybenzyl)oxy)hex-1-en-3-ol (390 mg, 1.195 mmol) in THF (7965 μl) at room temperature was added t-BuOK (161 mg, 1.434 mmol). The mixture then became orange. After stirring at this temperature for 10 min n-propyl tosylate (337 μl, 1.792 mmol) was added to the solution and the mixture was stirred at room temperature for 20 h. The mixture became slurry-like. Alcohol remained so additional tosylate (100 μL) and potassium t-BuOK (40.2 mg, 0.358 mmol) were added and the reaction was allowed to stir at room temperature for 14 h. H₂O (10 mL) was added and the reaction was transferred to a separtory funnel. The aq. phase was extracted with EtOAc (3×10 mL), and the combined organics were dried (Na₂SO₄), filtered, and concentrated to dryness. Took up in CH₂Cl₂ (10 mL) then Celite™ (2 scoopula tip-fulls) was added to the organic phase then the solvent was removed under reduced pressure and the resulting solid material was directly loaded onto a column and purified via flash chromatography on silica (24 g column, 35 mL/min, 0% EtOAc 1 min, ramp to 30% EtOAc/hexanes over 12 min and hold at 30% for 2 mins) to afford recovered (3S,4R,5S)-4-benzyl-5((4-methoxybenzyl)oxy)hex-1-en-3-ol (60 mg, 15%) and 1-((((2S,3S,4S)-3-benzyl-4-propoxyhex-5-en-2-yl)oxy)methyl)-4-methoxybenzene (315 mg, 72%). ¹H NMR (400 MHz, CDCl₃) δ 7.27-7.16 (m, 6H), 7.16-7.08 (m, 1H), 6.90-6.80 (m, 2H), 5.67 (ddd, J=17.4, 10.3, 7.2 Hz, 1H), 5.21-5.10 (m, 2H), 4.43 (d, J=11.3 Hz, 1H), 4.33 (d, J=11.3 Hz, 1H), 3.87-3.79 (m, 1H), 3.77 (s, 3H), 3.73-3.62 (m, 1H), 3.40 (app dt, J=9.1, 6.6 Hz, 1H), 3.11 (app dt, J=9.1, 6.6 Hz, 1H), 2.83 (dd, J=14.4, 6.1 Hz, 1H), 2.68 (dd, J=14.4, 6.2 Hz, 1H), 2.16 (qd, J=6.0, 4.7 Hz, 1H), 1.60-1.46 (m, 2H), 1.13 (d, J=6.4 Hz, 3H), 0.90 (t, J=7.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 159.06, 142.74, 138.35, 131.27, 129.22, 129.20, 128.12, 125.44, 116.55, 113.74, 81.12, 75.17, 70.52, 70.13, 55.28, 49.99, 32.01, 23.25, 17.35, 10.92. ESIMS (m/z) 391 ([M+Na]⁺).

Example 4B, Step 1: Preparation of 1-fluoro-4-((2S,3S)-2-((S)-1-((4-methoxybenzyl)oxy)ethyl)-3-(p-tolyloxy)pent-4-en-1-yl)benzene

To a magnetically stirred 100 mL Schlenk tube was added (3S,4R,5S)-4-(4-fluorobenzyl)-5-((4-methoxybenzyl)oxy)hex-1-en-3-ol (1.2 g, 3.48 mmol) and toluene (11.61 mL), followed by copper(II) acetate (0.127 g, 0.697 mmol), tri(p-tolyl)bismuth(V) acetate (2.51 g, 4.18 mmol), and N-cyclohexyl-N-methylcyclohexanamine (0.887 mL, 4.18 mmol). The flask was evacuated under vacuum and backfilled with N₂ four times, then heated to 65° C. and left to stir over the weekend. The reaction was filtered through Celite™ with EtOAc and then concentrated. The crude green oil was purified via flash chromatography on silica (gradient eluent: 1-10% acetone in hexanes) to afford 1-fluoro-4-((2S,3S)-2-((S)-1-((4-methoxybenzyl)oxy)ethyl)-3-(p-tolyloxy)pent-4-en-1-yl)benzene (798 mg, 53%). ¹H NMR (400 MHz, CDCl₃) δ 7.17-7.11 (m, 2H), 7.08-7.00 (m, 4H), 6.99-6.89 (m, 2H), 6.80-6.71 (m, 4H), 5.78 (ddd, J=17.3, 10.7, 5.2 Hz, 1H), 5.22 (dt, J=17.5, 1.6 Hz, 1H), 5.18 (dt, J=10.6, 1.5 Hz, 1H), 4.99 (td, J=3.6, 1.8 Hz, 1H), 4.40 (d, J=10.8 Hz, 1H), 4.15 (d, J=10.9 Hz, 1H), 3.78 (s, 3H), 3.69 (p, J=6.4 Hz, 1H), 2.95 (dd, J=15.0, 5.8 Hz, 1H), 2.68 (dd, J=14.8, 6.3 Hz, 1H), 2.28 (s, 3H), 2.17 (qd, J=6.4, 3.5 Hz, 1H), 1.15 (d, J=6.2 Hz, 3H). ¹⁹F NMR (376 MHz, CDCl₃) δ−117.98.

Example 4B, Step 2: Preparation of (2R,3S,4S)-3-(4-fluorobenzyl)-4-((4-methoxybenzyl)oxy)-2-(p-tolyloxy)pentan-1-ol

To a magnetically stirred 100 mL three-necked flask was added 1-fluoro-4-((2S,3S)-2-((S)-1-((4-methoxybenzyl)oxy)ethyl)-3-(p-tolyloxy)pent-4-en-1-yl)benzene (748 mg, 1.721 mmol), DCM (20 mL), MeOH (5 mL), and 2 drops of 0.1% Sudan III in DCM. Then, the flask was connected to the ozonator and cooled to −78° C. Ozone was bubbled into the flask (ozone pressure=1.0, 6 psi) for ˜10 min until the color turned from red to colorless. Then, the ozone was shut off and O₂ was bubbled through the reaction to purge remaining ozone for ˜5 min. While still at −78° C., sodium borohydride (195 mg, 5.16 mmol) was added in one portion, and then the flask was removed from the cold bath, fitted to a nitrogen inlet, and let warm to rt. Another 10 mL MeOH was added and the reaction was left to stir overnight. The reaction was quenched with sat. NH₄Cl and extracted with DCM×3. The organic phases were passed through a phase separator and then the solvent was removed. The crude oil was purified via flash chromatography on silica (gradient eluent: 1-25% acetone in hexanes) to afford (2R,3S,4S)-3-(4-fluorobenzyl)-4-((4-methoxybenzyl)oxy)-2-(p-tolyloxy)pentan-1-ol (602 mg, 80%) as a colorless oil. ¹N NMR (400 MHz, CDCl₃) δ 7.19 (d, J=8.5 Hz, 2H), 7.10 (dd, J=8.3, 5.7 Hz, 2H), 7.03-6.99 (m, 2H), 6.95 (t, J=8.6 Hz, 2H), 6.87 (d, J=8.6 Hz, 2H), 6.69 (dd, J=8.4, 1.4 Hz, 2H), 4.51 (d, J=11.0 Hz, 1H), 4.52-4.47 (m, 1H), 4.18 (d, J=11.1 Hz, 1H), 3.81 (s, 3H), 3.81-3.74 (m, 2H), 3.64-3.55 (m, 1H), 2.83 (dd, J=14.3, 7.3 Hz, 1H), 2.74 (dd, J=14.2, 6.9 Hz, 1H), 2.47-2.35 (m, 1H), 2.27 (s, 3H), 2.27-2.20 (m, 1H), 1.29 (d, J=6.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 161.36 (d, J=244.0 Hz), 159.20, 155.88, 136.70 (d, J=2.2 Hz), 130.51 (d, J=7.8 Hz), 130.46, 130.31, 130.00, 129.28, 115.80, 115.14 (d, J=21.0 Hz), 113.83, 78.80, 74.95, 70.40, 62.78, 55.30, 46.83, 33.68, 20.49, 17.68. ¹⁹F NMR (376 MHz, CDCl₃) δ−117.22.

Example 4B, Step 3: Preparation of 1-((2S,3R)-4-ethoxy-2-((S)-1-((4-methoxy-benzyl)oxy)ethyl)-3-(p-tolyloxy)butyl)-4-fluorobenzene

To a magnetically stirred 25 mL screw-cap vial was added (2R,3S,4S)-3-(4-fluorobenzyl)-4-((4-methoxybenzyl)oxy)-2-(p-tolyloxy)pentan-1-ol (142 mg, 0.324 mmol) and THF (3238 μL). Then, the vial was cooled to 0° C. and sodium hydride (32.4 mg, 0.810 mmol) was added. The reaction was stirred for 30 min at 0° C., then ethyl iodide (78 μL, 0.971 mmol) was added. The reaction was removed from the cold bath and allowed to warm to rt overnight. In the morning, a small amount of alcohol remained by TLC, so another 15 mg NaH and 40 μL ethyl iodide was added. The reaction was left for another 3 h, then quenched with sat. NH₄Cl. The aqueous phase was extracted with EtOAc (3×) and then the organic phase was washed with brine and dried over Na₂SO₄. The solvent was removed and the crude oil was purified via flash chromatography on silica (gradient eluent: 1-15% acetone in hexanes) to afford 1-((2S,3R)-4-ethoxy-2-((S)-1-((4-methoxybenzyl)oxy)ethyl)-3-(p-tolyloxy)butyl)-4-fluorobenzene (108 mg, 72%) as a colorless oil. ¹H NMR (400 MHz, CDCl₃) δ 7.17 (dd, J=8.5, 5.6 Hz, 2H), 7.12 (d, J=8.6 Hz, 2H), 7.05-7.01 (m, 2H), 6.94 (t, J=8.7 Hz, 2H), 6.80 (t, J=8.9 Hz, 4H), 4.65 (td, J=5.9, 3.1 Hz, 1H), 4.41 (d, J=11.1 Hz, 1H), 4.14 (d, J=11.2 Hz, 1H), 3.79 (s, 3H), 3.59 (p, J=6.2 Hz, 1H), 3.51 (dd, J=10.3, 5.7 Hz, 1H), 3.44-3.33 (m, 2H), 3.33-3.25 (m, 1H), 2.92 (dd, J=14.5, 6.9 Hz, 1H), 2.73 (dd, J=14.5, 5.9 Hz, 1H), 2.34 (dtd, J=7.0, 5.9, 3.1 Hz, 1H), 2.27 (s, 3H), 1.19 (d, J=6.2 Hz, 3H), 1.10 (t, J=7.0 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 161.22 (d, J=243.3 Hz), 159.01, 156.47, 137.70 (d, J=3.2 Hz), 130.97, 130.50 (d, J=7.7 Hz), 130.02, 129.87, 129.21, 115.97, 114.92 (d, J=21.0 Hz), 113.65, 76.76, 75.17, 70.36, 70.16, 66.62, 55.27, 46.88, 31.49, 20.52, 17.54, 15.16. ESIMS (m/z) 467 [(M+H)⁺].

Example 4C: Preparation of 1-fluoro-4-((S)-3-methoxy-2-((S)-1-((4-methoxybenzyl)oxy)ethyl)-3-methylbutyl)benzene

To a solution of (3S,4S)-3-(4-fluorobenzyl)-4-((4-methoxybenzyl)oxy)-2-methylpentan-2-ol (300 mg, 0.866 mmol) in DCM (4330 μL) was added N,N,N′,N′-tetramethylnaphthalene-1,8-diamine (371 mg, 1.732 mmol), in one portion, followed by the addition of trimethyloxonium tetrafluoroborate (167 mg, 1.126 mmol). The resulting clear, colorless solution was stirred at room temperature overnight. The reaction was carefully quenched with sat. aq. NaHCO₃ (20 mL) and extracted with DCM (3×20 mL). The combined organic layers were washed with 1 N HCl (2×20 mL) and then brine (20 mL). The organic layer was filtered through a phase separator and concentrated to afford a pale yellow oil. The oil was purified via flash chromatography on silica (40 g column, 40 mL/min, 100% hexanes for 2 column volumes, 100% hexanes to 30% ethyl acetate:hexanes over 12 column volumes, hold at 30% ethyl acetate:hexanes for 2 column volumes) to afford 1-fluoro-4-((S)-3-methoxy-2-((S)-1-((4-methoxybenzyl)oxy)ethyl)-3-methylbutyl)benzene (232.6 mg, 74%) as a clear, colorless oil. ¹H NMR (400 MHz, CDCl₃) δ 7.15 (dt, J=8.5, 2.7 Hz, 4H), 6.95-6.80 (m, 4H), 4.41 (d, J=11.4 Hz, 1H), 4.29 (d, J=11.5 Hz, 1H), 3.86-3.72 (m, 4H), 3.12 (s, 3H), 2.76 (dd, J=6.1, 2.8 Hz, 2H), 2.23 (ddd, J=6.4, 5.6, 2.9 Hz, 1H), 1.24 (d, J=6.4 Hz, 3H), 1.17 (s, 3H), 1.14 (s, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 160.94 (d, J=242.6 Hz), 158.96, 139.33 (d, J=3.3 Hz), 131.28, 130.36 (d, J=7.7 Hz), 128.90, 114.72 (d, J=20.9 Hz), 113.66, 76.80, 74.64, 69.84, 55.26, 52.32, 48.73, 30.83, 24.31, 24.25, 17.52. ¹⁹F NMR (376 MHz, CDCl₃) δ−118.64. (Thin film) 2972, 2936, 2833, 1612, 1586, 1509, 1464, 1381, 1365, 1301, 1245, 1219, 1172, 1156, 1143, 1109, 1069, 1035, 929, 895, 812, 772, 753 cm⁻¹. HRMS-ESI (m/z) ([M+Na]⁺) calcd for C₂₂H₂₉FNaO₃, 383.1993; found, 383.1997.

Example 4D: Preparation of 1-((((2S,3S)-4-(allyloxy)-3-benzyl-4-methylpentan-2-yl)-oxy)methyl)-4-methoxybenzene

To a suspension of sodium hydride (0.046 g, 1.142 mmol) in THF (3.04 mL) was added a solution of ((3S,4S)-3-benzyl-4-((4-methoxybenzyl)oxy)-2-methylpentan-2-ol (0.250 g, 0.761 mmol) in THF (1 mL). To the mixture was added tetrabutylammonium iodide (0.028 g, 0.076 mmol) followed by allyl bromide (0.079 mL, 0.913 mmol). The mixture was then heated to reflux and stirred overnight. The reaction was quenched with NH₄Cl and extracted with ether (2×). The combined organics were then washed with water and brine (2×), dried with Na₂SO₄, filtered and concentrated. The crude mixture was purified via flash chromatography on silica (12 g silica column, 0-30% acetone in hexanes) to provide 1-((((2S,3S)-4-(allyloxy)-3-benzyl-4-methylpentan-2-yl)oxy)methyl)-4-methoxybenzene (132 mg, 47%) as a pale yellow oil. ¹H NMR (400 MHz, CDCl₃) δ 7.29-7.21 (m, 4H), 7.21-7.08 (m, 3H), 6.91-6.80 (m, 2H), 5.94-5.80 (m, 1H), 5.32-5.18 (m, 1H), 5.14-5.02 (m, 2H), 4.41 (d, J=11.5 Hz, 1H), 4.33 (d, J=11.4 Hz, 1H), 3.90-3.85 (m, 2H), 3.80 (s, 3H), 2.85 (dd, J=6.0, 1.1 Hz, 2H), 2.37-2.29 (m, 1H), 1.26 (d, J=6.4 Hz, 3H), 1.21 (s, 3H), 1.17 (s, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 158.88, 143.75, 136.14, 131.40, 129.11, 128.89, 128.09, 125.21, 115.10, 113.64, 77.18, 74.74, 69.84, 62.15, 55.28, 52.46, 31.67, 25.07, 24.86, 17.70. (Thin film) 2972.71, 1611.99, 1512.34, 1245.18, 1062.24, 1033.31 cm⁻¹. HRMS-ESI (m/z) ([M+Na]⁺) calcd for C₂₄H₃₂NaO₃, 391.2244; found, 391.2249.

Example 4E: Preparation of 1-(((3S,4S)-3-benzyl-4-((4-methoxybenzyl)oxy)-2-methylpentan-2-yl)oxy)-2,4-dichlorobenzene

To a solution of (3S,4S)-3-benzyl-4-((4-methoxybenzyl)oxy)-2-methylpentan-2-ol (0.445 g, 1.355 mmol) in DMF (6.77 mL) was added 15-crown-5 (0.030 g, 0.135 mmol), 2,4-dichloro-1-fluorobenzene (0.476 mL, 4.06 mmol), and sodium hydride (0.081 g, 2.032 mmol). The mixture was then warmed to 70° C. and stirred overnight. The reaction was quenched with NH₄Cl and extracted with ether (2×). The combined organics were then washed with water and brine (2×), dried with Na₂SO₄, filtered and concentrated. The crude mixture was purified via flash chromatography on silica (24 g silica column, 0-30% acetone in hexanes) to provide 1-(((3S,4S)-3-benzyl-4-((4-methoxybenzyl)oxy)-2-methylpentan-2-yl)oxy)-2,4-dichlorobenzene (318 mg, 50%) as a pale yellow oil. ¹H NMR (400 MHz, CDCl₃) δ 7.37 (d, J=2.6 Hz, 1H), 7.28-7.23 (m, 4H), 7.21-7.13 (m, 3H), 7.09 (dd, J=8.8, 2.6 Hz, 1H), 6.95 (d, J=8.8 Hz, 1H), 6.89-6.83 (m, 2H), 4.48 (d, J=11.5 Hz, 1H), 4.36 (d, J=11.6 Hz, 1H), 4.02 (qd, J=6.5, 3.0 Hz, 1H), 3.80 (s, 3H), 3.08 (dd, J=14.5, 5.7 Hz, 1H), 2.97 (dd, J=14.6, 6.3 Hz, 1H), 2.53 (td, J=6.0, 3.0 Hz, 1H), 1.35 (d, J=6.4 Hz, 3H), 1.33 (s, 3H), 1.31 (s, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 158.97, 150.31, 143.27, 131.22, 130.09, 129.93, 129.07, 129.01, 128.21, 128.19, 127.11, 125.43, 125.16, 113.69, 86.22, 74.55, 69.96, 55.29, 54.62, 32.10, 26.26, 25.93, 17.86. (Thin film) 2975.24, 1512.04, 1494.87, 1471.70, 1245.00, 1055.68 cm ⁻¹. HRMS-ESI (m/z) ([M+Na]⁺) calcd for C₂₇H₃₀Cl₂ NaO₃, 495.1464; found, 495.146.

Example 5A: Preparation of (2S,3S)-3-(4-methoxybenzyl)-4-methyl-4-propoxypentan-2-ol

To a solution of 1-((S)-3-(allyloxy)-2-((S)-1-(benzyloxy)ethyl)-3-methylbutyl)-4-methoxybenzene (0.300 g, 0.814 mmol) in EtOAc (4.07 mL) was added palladium (5% wt on carbon, dry basis) (0.347 g, 0.081 mmol). The mixture was then stirred overnight under an atmosphere of hydrogen. The mixture was filtered through Celite™, and the filter cake was washed with EtOAc. The combined filtrate was concentrated and the residue purified via flash chromatography (12 g silica column, 0-30% acetone in hexanes) to provide (2S,3S)-3-(4-methoxybenzyl)-4-methyl-4-propoxypentan-2-ol (90 mg, 39%) as a clear oil. ¹H NMR (400 MHz, CDCl₃) δ 7.19-7.09 (m, 2H), 6.87-6.65 (m, 2H), 5.42 (s, 1H), 4.00 3.90 (m, 1H), 3.79 (s, 3H), 3.41 (ddt, J=28.2, 8.5, 6.6 Hz, 2H), 2.52 (dd, J=15.6, 4.0 Hz, 1H), 2.35 (dd, J=15.7, 6.3 Hz, 1H), 2.02 (ddd, J=8.7, 6.3, 4.0 Hz, 1H), 1.61-1.51 (m, 2H), 1.29 (s, 3H), 1.25 (s, 3H), 1.13 (d, J=6.2 Hz, 3H), 0.92 (t, J=7.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 157.69, 133.99, 129.41, 113.78, 80.84, 70.43, 62.83, 55.24, 54.15, 34.13, 25.10, 23.48, 22.96, 20.42, 10.76. (Thin film) 3418.41, 2967.62, 1511.47, 1245.36, 1069.93, 1035.76 cm⁻¹.

Example 5B: Preparation of (2S,3R)-3-benzyl-4-phenoxybutan-2-ol

To a solution of 1-((2R,3S)-2-benzyl-3-((4-methoxybenzyl)oxy)butoxy)-2,4-dichlorobenzene (0.275 g, 0.617 mmol) in MeOH (1.544 mL) and ethyl acetate (1.544 mL) was added palladium (5% wt on carbon, dry basis) (0.131 g, 0.031 mmol). The mixture was then stirred under an atmosphere of hydrogen overnight. The reaction was incomplete as determined by UPLC. An additional portion of palladium (5% wt on carbon, dry basis) (0.131 g, 0.031 mmol) was then added and the mixture was warmed to 50° C. and stirred under hydrogen for an additional 8 h. The mixture was cooled to rt and filtered through Celite™. The filter cake was washed with EtOAc and the filtrate concentrated. The residue was then purified via flash chromatography on silica (4 g silica column, 0-20% acetone in hexanes) to provide (2S,3R)-3-benzyl-4-phenoxybutan-2-ol (110 mg, 70%) as a clear oil. ¹H NMR (400 MHz, CDCl₃) δ 7.32-7.23 (m, 4H), 7.23-7.16 (m, 3H), 6.98-6.91 (m, 1H), 6.89-6.82 (m, 2H), 4.09 (dd, J=9.5, 3.9 Hz, 1H), 4.06-3.97 (m, 1H), 3.91 (ddd, J=9.6, 4.9, 1.0 Hz, 1H), 2.92 (dd, J=13.7, 6.0 Hz, 1H), 2.79 (dd, J=13.7, 9.2 Hz, 1H), 2.28 (s, 1H), 2.11-1.98 (m, 1H), 1.32 (dd, J=6.4, 0.9 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 158.59, 140.19, 129.49, 129.22, 128.49, 126.14, 121.03, 114.54, 68.92, 67.07, 46.84, 34.62, 21.54. (Thin film) 3382.25, 2929.09, 1598.48, 1495.02, 1240.62 cm ⁻¹. HRMS-ESI (m/z) ([M+Na]⁺) calcd for C₁₇H₂₀NaO₂, 279.1356; found, 279.1351.

Example 5C: (2S,3R)-4-(2,4-difluorophenoxy)-3-(4-methoxybenzyl)butan-2-ol

To a solution of 1-((2R,3S)-3-(benzyloxy)-2-(4-methoxybenzyl)butoxy)-2,4-difluorobenzene (0.298 g, 0.722 mmol) in EtOH (4.82 mL) and cyclohexene (2.408 mL) was added palladium (5% wt on carbon, dry basis) (0.154 g, 0.036 mmol). The mixture was then heated to 65° C. and stirred for 3 h. The mixture was filtered through Celite™ and the filter cake washed with EtOAc. The filtrate was then concentrated to provide (2S,3R)-4-(2,4-difluorophenoxy)-3-(4-methoxybenzyl)butan-2-ol (232 mg, 100%) as a clear oil. ¹H NMR (400 MHz, CDCl₃) δ 7.14-7.08 (m, 2H), 7.04-6.96 (m, 1H), 6.85-6.79 (m, 2H), 6.62-6.51 (m, 2H), 4.09 (dd, J=9.3, 3.9 Hz, 1H), 4.06-3.98 (m, 1H), 3.91 (dd, J=9.3, 4.7 Hz, 1H), 3.78 (s, 3H), 2.87 (dd, J=13.8, 6.0 Hz, 1H), 2.74 (dd, J=13.8, 9.4 Hz, 1H), 2.12 (s, 1H), 2.07-1.98 (m, 1H), 1.34 (d, J=6.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 158.70 (dd, J=242.1, 2.5 Hz), 158.06, 148.94 (dd, J=241.1, 3.3 Hz), 147.44 (dd, J=12.7, 10.4 Hz), 131.74, 130.06, 116.07 (dd, J=20.6, 10.2 Hz), 113.96, 106.68 (dd, J=23.8, 6.9 Hz), 102.58 (dd, J=27.7, 1.9 Hz), 68.41, 68.35, 55.24, 47.02, 33.43, 21.59. HRMS-ESI (m/z) (([M+Na]⁺)) calcd for C₁₈H₂₀F₂NaO₃, 345.1273; found, 345.126.

Example 5D: Preparation of (2S,3R)-3-benzyl-4-(2,4-dichlorophenoxy)butan-2-ol

To a solution of 1-((2R,3S)-2-benzyl-3-((4-methoxybenzyl)oxy)butoxy)-2,4-dichlorobenzene (0.280 g, 0.629 mmol) in acetonitrile (5.72 mL) and water (0.572 mL) was added ceric ammonium nitrate (0.758 g, 1.383 mmol) at room temperature. The mixture was stirred for 45 min and then was quenched with NaHCO₃ (some gas evolution). The mixture was then diluted with water and ether. The products were extracted with Et₂O (2×), and the combined organics were washed with water and brine (2×), dried with Na₂SO₄, filtered and concentrated. The crude was purified via flash chromatography on silica (24 g silica column, 0-25% acetone in hexanes) to afford (2S,3R)-3-benzyl-4-(2,4-dichlorophenoxy)butan-2-ol (172 mg, 84%) as a clear, slightly pink oil. ¹N NMR (400 MHz, CDCl₃) δ 7.37 (d, J=2.5 Hz, 1H), 7.31-7.26 (m, 2H), 7.24-7.16 (m, 3H), 7.13 (dd, J=8.8, 2.6 Hz, 1H), 6.71 (d, J=8.8 Hz, 1H), 4.13 (dd, J=9.2, 3.7 Hz, 1H), 4.09-3.99 (m, 1H), 3.89 (dd, J=9.3, 4.4 Hz, 1H), 2.95 (dd, J=13.6, 6.0 Hz, 1H), 2.85 (dd, J=13.6, 9.5 Hz, 1H), 2.30 (s, 1H), 2.12-1.99 (m, 1H), 1.36 (d, J=6.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 152.96, 139.92, 129.86, 129.16, 128.53, 127.61, 126.23, 125.91, 123.57, 113.65, 68.69, 68.12, 46.86, 34.57, 21.74. (Thin film) 3377.21, 2929.96, 1483.11, 1461.63, 1245.26, 1058.96 cm⁻¹. HRMS-ESI (m/z) ([M+H]⁺) calcd for C₁₇H₁₉Cl₂O₂, 325.0757; found, 325.0756.

Example 6, Step 1: Preparation of (4R,5S)-4-(4-fluorobenzyl)-5-methyldihydrofuran-2(3H)-one

To a flame-dried 3-neck 2 L rb flask charged with Mg-turnings (66.9 g, 2752.2 mmol) that were activated by stirring half an hour under nitrogen, was added dry ether (900 mL). This was allowed to stir for 15 min. Para-fluorobenzyl chloride (66.4 g, 458.7 mmol) was then added as an ether (200 mL) solution drop-wise over ˜1.5 h, maintaining an internal temperature below 30° C. A water cooling bath was applied when required. After completion of the addition, the reaction mixture was stirred for a further 2 h at room temperature. A separate flame dried 3-neck flask was charged with CuI (dried in a vac oven at 60° C. overnight, 40.8 g, 214.06 mmol) under nitrogen to which was added dry ether (450 mL), stirred for 10 min, and cooled to −78° C. The Grignard reagent (prepared above) was transferred to the dropping funnel using a cannula and added slowly over 1 h (the temperature increased to −63° C.) and the reaction mixture was stirred for a further 2.5 h. The reaction mixture was also allowed to warm up to −33° C. and the gray color reaction mixture turned to a black solution with black suspension indicating the formation of the organo-copper reagent. A pre-mixed mixture of compound 8 and TMSCl (16.6 g, 152.9 mmol) in ether (100 mL) was added using a addition funnel over 20 min. The reaction mixture was stirred for 2 h at −78° C. and the HPLC showed no starting material (confirmed by TLC 40% EA in hexane). The formation of the product was confirmed by GC. The reaction mixture was quenched with a saturated NH₄Cl solution and extracted with ethyl acetate (3 times). The combined organic layers were further washed with a NH₄Cl solution (3 times) to remove CuI. The organic layers were dried over Na₂SO₄, filtered, and evaporated to give a crude material (41 g), which was purified by silica gel flash chromatography (0-30% ethyl acetate in hexanes) to give (4R,5S)-4-(4-fluorobenzyl)-5-methyldihydrofuran-2(3H)-one (17.0 g, 53%). ¹H NMR (400 MHz, CDCl₃) δ 7.14-7.08 (m, 2H), 7.01-6.97 (m, 2H), 4.31 (m, 1H), 2.80 (m, 1H), 2.71-2.52 (m, 2H), 2.39-2.23 (m, 2H), 1.31 (d, J=4 Hz, 3H).

Example 6, Step 2: Preparation of (3R,4R,5S)-3-benzyl-4-(4-fluorobenzyl)-5-methyl-dihydrofuran-2(3H)-one

To a solution of (4R,5S)-4-(4-fluorobenzyl)-5-methyldihydrofuran-2(3H)-one (1.2 g, 5.76 mmol) in dry THF (30 mL) at −78° C. was added LDA (2.0 M, 17.29 mmol, 8.15 mL) drop-wise. After complete addition, the reaction mixture was stirred for a further 30 min at −78° C. Hexamethylphosphoramide (155 mg, 0.864 mmol) was added and the reaction was stirred for 0.5 h. Benzylbromide (2.9 g, 17.29 mmol) was added drop-wise as a THF (10 mL) solution at −78° C. The reaction mixture was then stirred at −78° C. for 30 min. The cooling bath was then removed to allow the mixture to come up to room temperature and stirred overnight. The reaction mixture was quenched with a saturated aq. NH₄Cl solution and extracted with ethyl acetate (3 times). The combined organic layers were washed with brine, dried (Na₂SO₄), filtered, and evaporated to give a crude product which was purified via flash chromatography on silica to give the (3R,4R,5S)-3-benzyl-4-(4-fluorobenzyl)-5-methyldihydrofuran-2(3H)-one (0.99 g, 58%). ¹H NMR (400 MHz, CDCl₃) δ 7.34-7.26 (m, 3H), 7.15 (d, J=8 Hz, 2H), 7.01-6.92 (m, 4H), 4.17 (m, 1H), 3.06-2.95 (m, 2H), 2.67 (m, 1H), 2.51 (m, 1H), 2.04 (m, 1H), 1.01 (d, J=4 Hz, 3H).

Example 6, Step 3: Preparation of (2R,3R,4S)-2-benzyl-3-(4-fluorobenzyl)pentane-1,4-diol

To a solution of (3R,4R,5S)-3-benzyl-4-(4-fluorobenzyl)-5-methyldihydrofuran-2(3H)-one (1.2 g, 4.02 mmol) in dry THF (30 mL) at 0° C. in an ice-water bath was added LiAlH₄ (2.0 M in THF, 4.43 mmol, 2.2 mL) drop-wise. The reaction mixture was stirred cold for 30 min and then for an additional 30 min at room temperature. The reaction mixture was quenched with water (0.6 mL) and NaOH (1 N, 1.2 mL) and stirred for a further 15 min. Na₂SO₄ was added and the reaction mixture was filtered and washed with excess DCM. The filtrate was evaporated to give the crude material which was purified via flash chromatography on silica to afford (2R,3R,4S)-2-benzyl-3-(4-fluorobenzyl)pentane-1,4-diol (1.2 g, 98%) which was used in the next step without further purification. ¹H NMR (400 MHz, CDCl₃) δ 7.23-7.21 (m, 2H), 7.16 (m, 1H), 7.05-7.01 (m, 4H), 6.92-6.90 (m, 2H), 3.91 (m, 1H), 3.79 (m, 1H), 3.57 (m, 1H), 2.87 (dd, J=8 Hz, 4 Hz, 1H), 2.74-2.70 (m, 2H), 2.61-2.54 (m, 2H), 2.26 (br-s, 1H), 2.03 (m, 1H), 1.88 (m, 1H), 1.33 (d, J=8 Hz, 3H).

Example 6, Step 4: Preparation of (4S,5S,6S)-6-benzyl-5-(4-fluorobenzyl)-2,2,4,9,9-pentamethyl-3,8-dioxa-2,9-disiladecane

(2R,3R,4S)-2-benzyl-3-(4-fluorobenzyl)pentane-1,4-diol (2.6 g, 8.6 mmol) was dissolved in dry DCM (90 mL) to which was added Et₃N (4.4 g, 43.0 mmol) followed by TMSCl (2.3 g, 21.5 mmol) drop-wise. The reaction mixture was stirred at room temperature for 1 h. Hexane was added to precipitate the triethyl amine salt, which was filtered through a Celite™ pad and washed with hexane-ethyl acetate (440 mL, 10:1). The filtrate was evaporated to give (4S,5S,6S)-6-benzyl-5-(4-fluorobenzyl)-2,2,4,9,9-pentamethyl-3,8-dioxa-2,9-disiladecane (3.6 g) as an colorless oil which was used in the next step without further purification or characterization.

Example 6, Step 5: Preparation of (2S,3S,4S)-2-benzyl-3-(4-fluorobenzyl)-4-((trimethyl silyl)oxy)pentanal

Dry chromium(VI) oxide (3.9 g, 38.7 mmol) was dissolved in dry DCM (80 mL) at room temperature, to which pyridine (6.1 g, 77.4 mmol) was added slowly and stirred at room temperature for 30 min. The reaction mixture was then cooled to −20° C. The (4S,5S,6S)-6-benzyl-5-(4-fluorobenzyl)-2,2,4,9,9-pentamethyl-3,8-dioxa-2,9-disiladecane (3.6 g crude) was added as a DCM (30 mL) solution slowly. The reaction mixture was allowed to stir at a temperature of between −10° C. and −20° C. for 2 h. The cold reaction mixture was filtered quickly through a pad of silica gel and the silica was further washed with Hex-EA (5:1, checked by TLC). The clear filtrate was evaporated to give (2S,3S,4S)-2-benzyl-3-(4-fluorobenzyl)-4-((trimethylsilyl)oxy)pentanal (2.9 g) which was used in the next step without further purification or characterization.

Example 6, Step 6: Preparation of (2S,3S,4R)-4-benzyl-3-(4-fluorobenzyl)hex-5-en-2-ol

To a suspension of bromo(methyl)triphenylphosphorane (10.4 g, 29.24 mmol) in dry THF (110 mL) was added n-BuLi (2.5 M, 28.38 mmol, 11.4 mL) drop-wise at 0° C. and stirred for 30 min (colour changed from white to yellow). The reaction mixture was then cooled to −78° C. and (2S,3S,4S)-2-benzyl-3-(4-fluorobenzyl)-4-((trimethylsilyl)oxy)pentanal (2.9 g) was added as a THF (30 mL) solution drop-wise. The reaction mixture was allowed to warm up to room temperature overnight. The reaction mixture was quenched with water, then the pH was adjusted to 1 using 1 N HCl, stirred for 15 min and then extracted with EtOAc (3 times). The organic layers were washed with brine, dried over Na₂SO₄ and evaporated to give an colorless oil which was purified via flash chromatography on silica to afford (2S,3S,4R)-4-benzyl-3-(4-fluorobenzyl)hex-5-en-2-ol (1.2 g, 47%). ¹N NMR (400 MHz, CDCl3) δ 7.25-7.22 (m, 2H), 7.14 (m, 1H), 7.05-7.02 (m, 2H), 7.00-6.98 (m, 2H), 6.94-6.90 (m, 2H), 5.85 (m, 1H), 5.03 (dd, J=8 Hz, 0.8 Hz, 1H), 4.88 (dd, J=12 Hz, 0.8 Hz, 1H), 3.92 (m, 1H), 2.95 (dd, J=8 Hz, 4 Hz, 1H), 2.72 (dd, J=8 Hz, 4 Hz, 1H), 2.64 (dd, J=8 Hz, 4 Hz, 1H), 2.54 (dd, J=8 Hz, 4 Hz, 1H), 1.84 (m, 1H), 1.29 (d, J=4 Hz, 1H), 1.23 (d, J=8 Hz, 3H).

Example 7: (2S,3R)-4-(3,4-dichlorophenyl)-3-phenylbutan-2-ol

To magnesium turnings (219 mg, 9.00 mmol) in 2 mL Et₂O was added a solution of 4-(bromomethyl)-1,2-dichlorobenzene (1080 mg, 4.50 mmol) in 2 mL Et₂O at rt, followed by 5 μL of MeI. The mixture was warmed to rt, heated by heat gun to gentle boil, and then stirred at rt for 1 hr. The clear solution was transferred into a suspension of copper(I) iodide (429 mg, 2.250 mmol) in 3.5 mL Et₂O at −78° C. The reaction was stirred at −30° C. for 30 min, then cooled to −78° C., (2S,3S)-2-methyl-3-phenyloxirane (201 μl, 1.5 mmol) was added. The reaction was slowly warmed to rt overnight. The reaction was then quenched with saturated aq. NH₄Cl and extracted with EtOAc. Combined organic phases dried over Na₂SO₄, concentrated and purified by flash chromatography on silica (0-10% acetone in hexanes) to provide (2S,3R)-4-(3,4-dichlorophenyl)-3-phenylbutan-2-ol (370 mg, 79%) as a colorless oil. ¹N HMR (400 MHz, CDCl₃) δ 7.32-7.25 (m, 2H), 7.25-7.19 (m, 2H), 7.19-7.11 (m, 3H), 6.85 (dd, J=8.2, 2.1 Hz, 1H), 4.03-3.91 (m, 1H), 3.11 (dd, J=13.6, 6.3 Hz, 1H), 2.88 (dd, J=13.5, 9.0 Hz, 1H), 2.76 (ddd, J=9.1, 6.4, 5.2 Hz, 1H), 1.35 (s, 1H), 1.16 (d, J=6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 140.70, 139.68, 131.98, 130.97, 130.00, 129.80, 129.05, 128.55, 128.52, 127.10, 69.48, 54.91, 37.66, 21.63. ESIMS m/z 318.2 ([M+Na]⁺).

Example 8, Step 1: Preparation of methyl 2,2-bis(4-fluorobenzyl)-3-oxobutanoate

To a stirred solution of methyl 3-oxobutanoate (0.929 mL, 8.61 mmol) in DMF (20 mL) was added potassium carbonate (2.98 g, 21.53 mmol), 1-(bromomethyl)-4-fluorobenzene (2.361 mL, 18.95 mmol) and 1-butyl-3-methyl-1H-imidazolium tetrafluoroborate (0.161 mL, 0.861 mmol). The reaction was stirred at rt for two hours at room temperature. The reaction was filtered and the solid was washed with diethyl ether. The filtrate was diluted with water and extracted with diethyl ether. The organic layers were combined and washed with brine solution and dried over Mg₂SO₄. The residue is purified via flash chromatography on silica to yield methyl 2,2-bis(4-fluorobenzyl)-3-oxobutanoate (2.786 g, 97%) as a white solid. ¹H NMR (400 MHz, CDCl₃) δ 7.14-7.01 (m, 4H), 7.01-6.89 (m, 4H), 3.66 (s, 3H), 3.15 (s, 4H), 1.93 (s, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 205.44, 172.01, 161.93 (d, J=245.7 Hz), 131.76 (d, J=3.4 Hz), 131.48 (d, J=7.9 Hz), 115.24 (d, J=21.2 Hz), 66.14, 52.12, 39.31, 29.32. HRMS-ESI (m/z) (([M+H]⁺)) calcd for C₁₉H₁₈F₂O₃, 332.341; found, 355.1115.

Example 8, Step 2: Preparation of 3-(4-fluorobenzyl)-4-(4-fluorophenyl)butan-2-one

To a stirred solution of methyl 2,2-bis(4-fluorobenzyl)-3-oxobutanoate (2.736 g, 8.23 mmol) and cesium carbonate (0.805 g, 2.470 mmol) in DMF (10 mL) was added 4-aminobenzenethiol (2.061 g, 16.47 mmol). The reaction was partitioned between ether and water, and the aqueous layer was thoroughly extracted with ether. The organic layers were combined and washed with brine solution, and dried over Na₂SO₄. The ether was evaporated to yield an oil, which was purified via flash chromatography on silica to yield 3-(4-fluorobenzyl)-4-(4-fluorophenyl)butan-2-one (2.235 g, 99%) as an oil. ¹H NMR (400 MHz, CDCl₃) δ 7.12-7.04 (m, 4H), 7.01-6.92 (m, 4H), 3.08 (tt, J=8.8, 5.9 Hz, 1H), 2.88 (dd, J=13.6, 8.9 Hz, 2H), 2.68 (dd, J=13.6, 5.8 Hz, 2H), 1.78 (s, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 211.68, 161.56 (d, J=244.6 Hz), 134.79 (d, J=3.3 Hz), 130.26 (d, J=7.9 Hz), 115.38 (d, J=21.2 Hz), 56.62, 37.24, 31.68. ¹⁹F NMR (376 MHz, CDCl₃) δ−116.54.

Example 8, Step 3: Preparation of (S)-3-(4-fluorobenzyl)-4-(4-fluorophenyl)butan-2-ol

To a stirred solution of 3-(4-fluorobenzyl)-4-(4-fluorophenyl)butan-2-one (2.195 g, 8.00 mmol) and (R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole (0.800 mL, 0.800 mmol) in toluene (53.3 mL) under nitrogen at −78° C. was added 1 M borane-THF complex in THF (8.80 mL, 8.80 mmol) dropwise. The reaction was allowed to warm to rt and was stirred for 1 h. The reaction mixture was partitioned between EtOAc (50 mL) and water (50 mL), and the aqueous phase was extracted with EtOAc (2×, 40 mL). The organic layers were combined, washed with brine, and dried over Na₂SO₄. The organic phase was concentrated to yield a semi-solid which was purified via flash chromatography on silica to yield (S)-3-(4-fluorobenzyl)-4-(4-fluorophenyl)butan-2-ol (2.127 g, 96%) as an oil. ¹H NMR (400 MHz, CDCl₃) δ 7.12-7.02 (m, 4H), 7.02-6.89 (m, 4H), 3.84-3.72 (m, 1H), 2.75 (dd, J=13.8, 7.4 Hz, 1H), 2.67 (dd, J=14.0, 6.6 Hz, 1H), 2.53 (dd, J=14.0, 7.8 Hz, 1H), 2.43 (dd, J=13.8, 7.1 Hz, 1H), 1.95 (ddq, J=11.1, 7.3, 3.7 Hz, 1H), 1.22 (d, J=6.4 Hz, 3H). ¹⁹F NMR (471 MHz, CDCl₃) δ−117.48. (Thin film) 3353, 2929, 1600, 1507, 1218, 823 cm⁻¹.

Example 9A: Preparation of (S)-(2S,3S)-3-benzyl-4-methyl-4-propoxypentan-2-yl 2-((tert-butoxycarbonyl)amino)propanoate

To a solution of (2S,3S)-3-benzyl-4-methyl-4-propoxypentan-2-ol (0.044 g, 0.176 mmol) in DCM (0.879 mL) at rt was added N-ethyl-N-isopropylpropan-2-amine (0.061 ml, 0.351 mmol), N,N-dimethylpyridin-4-amine (2.147 mg, 0.018 mmol), (S)-2-((tert-butoxycarbonyl)-amino)propanoic acid (0.037 g, 0.193 mmol), and 3-(((ethylimino)methylene)amino)-N,N-dimethylpropan-1-aminium chloride (EDC) (0.040 g, 0.211 mmol), in that order. The mixture was stirred at room temperature overnight. The mixture was concentrated onto Celite™ and purified via flash chromatography on silica to provide (S)-(2S,3S)-3-benzyl-4-methyl-4-propoxypentan-2-yl 2-((tert-butoxycarbonyl)amino)propanoate (55 mg, 53% yield) (˜71% pure by wt) as a clear oil. ¹H NMR (400 MHz, CDCl₃) δ 7.31-7.12 (m, 5H), 5.35 (qd, J=6.6, 2.8 Hz, 1H), 4.84 (s, 1H), 4.12-3.99 (m, 1H), 3.29 (td, J=6.5, 1.0 Hz, 2H), 2.96 (dd, J=14.7, 4.7 Hz, 1H), 2.74 (dd, J=14.7, 7.8 Hz, 1H), 2.23 (ddd, J=7.7, 4.8, 2.8 Hz, 1H), 1.61-1.48 (m, 2H), 1.44 (s, 9H), 1.34 (d, J=6.5 Hz, 3H), 1.23 (s, 3H), 1.18 (s, 3H), 1.07 (d, J=7.2 Hz, 3H), 0.92 (t, J=7.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.4, 155.0, 143.0, 128.9, 128.2, 125.5, 79.6, 75.9, 73.0, 62.5, 52.9, 49.5, 31.0, 28.4, 24.8, 24.6, 23.7, 18.4, 17.0, 11.0. (Thin film) 3432, 2974, 1715, 1496, 1366, 1167 cm ⁻¹. HRMS-ESI (m/z) ([M+Na]⁺) calcd for C₂₄H₃₉NNaO₅, 444.272; found, 444.2723.

Example 9B: (S)-(2S,3S)-3-phenylpentan-2-yl 2-((tert-butoxycarbonyl)amino)propanoate

To a solution of triphenylphosphine (399 mg, 1.522 mmol) in 4 mL of THF at 0° C. was added (E)-diisopropyl diazene-1,2-dicarboxylate (300 μl, 1.522 mmol). The solution was stirred at 0° C. for 30 min. A mixture of (S)-2-((tert-butoxycarbonyl)amino)propanoic acid (288 mg, 1.522 mmol) and (2R,3S)-3-phenylpentan-2-ol (125 mg, 0.761 mmol) in 4 mL THF was added dropwise. The reaction was slowly warmed to rt overnight. The reaction was quenched with saturated aq. NaHCO₃ and was extracted with Et₂O. The organic phases were combined, dried over Na₂SO₄, concentrated and purified via flash chromatography on silica to provide (S)-(2S,3S)-3-phenylpentan-2-yl 2-((tert-butoxycarbonyl)amino)propanoate (94 mg, 36%) as a colorless oil. ¹H NMR (300 MHz, CDCl₃) δ 7.34-7.19 (m, 3H), 7.17-7.11 (m, 2H), 5.21-5.01 (m, 2H), 4.42-4.22 (m, 1H), 2.63 (ddd, J=11.0, 8.6, 3.8 Hz, 1H), 1.84 (dqd, J=13.4, 7.5, 3.9 Hz, 1H), 1.69-1.51 (m, 1H), 1.45 (s, 9H), 1.41 (d, J=7.2 Hz, 3H), 1.04 (d, J=6.3 Hz, 3H), 0.72 (t, J=7.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.91, 155.04, 140.84, 128.60, 128.42, 126.76, 79.72, 75.34, 53.05, 49.54, 28.34, 24.58, 18.83, 18.38, 11.84. ESIMS m/z 336 [(M+H)⁺].

Example 10, Step 1: Preparation of (S)-(2S,3S)-3-benzyl-4-oxopentan-2-yl 2-((tert-butoxycarbonyl)amino)propanoate

To a solution of (3S,4S)-3-benzyl-4-hydroxypentan-2-one (300 mg, 1.560 mmol) (for preparation see: see: Hayashi, T. et al. Tetrahedron 1994, 50, 335) in DCM (7.80 mL) at 0° C. was added (S)-2-((tert-butoxycarbonyl)amino)propanoic acid (354 mg, 1.873 mmol), EDC (598 mg, 3.12 mmol), and N,N-dimethylpyridin-4-amine (19.06 mg, 0.156 mmol). The mixture was then slowly warmed to room temperature overnight. The reaction was quenched with saturated aq. NH₄Cl and the product was extracted with DCM. The organics were then washed with saturated aq. NaHCO₃ and brine, dried with Na₂SO₄, filtered and concentrated to provide a yellow oil. The crude material was purified via flash chromatography on silica to provide (S)-(2S,3S)-3-benzyl-4-oxopentan-2-yl 2-((tert-butoxycarbonyl)amino)propanoate (540 mg, 81%) (˜85% purity) as a colorless oil. ¹H MR (400 MHz, CDCl₃) δ 7.34-7.23 (m, 2H), 7.24-7.17 (m, 1H), 7.16-7.09 (m, 2H), 5.16 (dq, J=7.3, 6.3 Hz, 1H), 5.02 (d, J=8.0 Hz, 1H), 4.33-4.18 (m, 1H), 3.11 (ddd, J=10.0, 7.4, 5.1 Hz, 1H), 2.93-2.75 (m, 2H), 1.92 (s, 3H), 1.44 (s, 9H), 1.34 (d, J=6.4 Hz, 3H), 1.33 (d, J=7.2 Hz, 3H). ESIMS (m/z) 387 ([M+Na]⁺).

Example 10, Step 2: Preparation of (S)-(2S,3R)-3-benzyl-4-methylpent-4-en-2-yl 2-((tert-butoxycarbonyl)amino)propanoate

To a solution of (S)-(2S,3S)-3-benzyl-4-oxopentan-2-yl 2-((tert-butoxycarbonyl)-amino)propanoate (350 mg, 0.963 mmol) in THF (9.63 mL) at −78° C. was added pyridine (15.51 μL, 0.193 mmol) and Tebbe reagent (0.5 M in toluene) (3.85 mL, 1.926 mmol). The reaction was stirred at 0° C. for 3 hr. The reaction was quenched carefully with 1 N NaOH at 0° C., and was extracted with EtOAc. The organic phases were combined, concentrated and purified via flash chromatography on silica to provide (S)-(2S,3R)-3-benzyl-4-methylpent-4-en-2-yl 2-((tert-butoxycarbonyl)amino)propanoate (144 mg, 35%) as a colorless oil. ¹H NMR (400 MHz, CDCl₃) δ 7.29-7.22 (m, 2H), 7.21-7.08 (m, 3H), 5.15-4.96 (m, 2H), 4.84-4.76 (m, 1H), 4.71-4.61 (m, 1H), 4.29 (p, J=7.6 Hz, 1H), 2.80 (dd, J=13.6, 5.6 Hz, 1H), 2.64 (dd, J=13.6, 9.5 Hz, 1H), 2.53 (dt, J=9.5, 5.8 Hz, 1H), 1.68 (dd, J=1.5, 0.8 Hz, 3H), 1.45 (s, 9H), 1.39 (d, J=7.2 Hz, 3H), 1.27 (d, J=6.3 Hz, 3H). ESIMS (m/z) 362.4 ([M+H]⁺).

Example 10, Step 3: Preparation of (S)-(2S,3R)-3-benzyl-4-methylpentan-2-yl 2-((tert-butoxycarbonyl)amino)propanoate

A mixture of (S)-(2S,3R)-3-benzyl-4-methylpent-4-en-2-yl 2-((tert-butoxycarbonyl)-amino)propanoate (160 mg, 0.443 mmol) and palladium on carbon (5% w/w) (94 mg, 0.044 mmol) in EtOAc (4.43 mL) was stirred under H₂ (100 psi) at rt overnight. The crude material was used directly in next step. ¹H NMR (400 MHz, CDCl₃) δ 7.31-7.24 (m, 2H), 7.22-7.12 (m, 3H), 5.06-4.95 (m, 2H), 4.32-4.20 (m, 1H), 2.68 (dd, J=14.3, 5.2 Hz, 1H), 2.52 (dd, J=14.2, 8.2 Hz, 1H), 2.03-1.89 (m, 1H), 1.83-1.73 (m, 1H), 1.45 (s, 9H), 1.36 (d, J=7.2 Hz, 3H), 1.19 (d, J=6.5 Hz, 3H), 1.01 (d, J=6.9 Hz, 3H), 0.95 (d, J=6.8 Hz, 3H). ESIMS (m/z) 364 [(M+H)⁺].

Example 11A, Step 1: Preparation of (S)-(2S,3R)-3-benzyl-4-phenoxybutan-2-yl 2-aminopropanoate hydrochloride

To neat (S)-(2S,3R)-3-benzyl-4-phenoxybutan-2-yl 2-((tert-butoxycarbonyl)amino)propanoate (0.111 g, 0.260 mmol) was added hydrogen chloride (4 M in dioxane) (1.298 mL, 5.19 mmol). The mixture was then stirred for 2 h. The solution was concentrated under a stream of nitrogen to provide (S)-(2S,3R)-3-benzyl-4-phenoxybutan-2-yl 2-aminopropanoate hydrochloride (0.094 g, 100%) as a clear glass. The solid was used in the next step without further purification or characterization. ESIMS (m/z) 328.4 [(M+H)⁺].

Example 11A, Step 2: Preparation of (S)-(2S,3R)-3-benzyl-4-phenoxybutan-2-yl 2-(3-hydroxy-4-methoxypicolinamido)propanoate

To a solution of (S)-(2S,3R)-3-benzyl-4-phenoxybutan-2-yl 2-aminopropanoate hydrochloride (0.094 g, 0.258 mmol) in DCM (2.58 mL) was added N-ethyl-N-isopropylpropan-2-amine (0.135 mL, 0.775 mmol), 3-hydroxy-4-methoxypicolinic acid (0.048 g, 0.284 mmol), and ((1H-benzo[d][1,2,3]triazol-1-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (PyBOP) (0.148 g, 0.284 mmol). The mixture was then stirred at room temperature overnight. The mixture was concentrated and purified via flash chromatography on silica to provide (S)-(2S,3R)-3-benzyl-4-phenoxybutan-2-yl 2-(3-hydroxy-4-methoxypicolinamido)propanoate (80 mg, 62%) (˜95% pure) as a white foam. ¹H NMR (400 MHz, CDCl₃) δ 12.13 (s, 1H), 8.49 (d, J=8.0 Hz, 1H), 7.97 (d, J=5.2 Hz, 1H), 7.30-7.17 (m, 5H), 7.17-7.12 (m, 2H), 6.92 (tt, J=7.4, 1.1 Hz, 1H), 6.85 (d, J=4.7 Hz, 1H), 6.83 6.79 (m, 2H), 5.26 (qd, J=6.4, 5.0 Hz, 1H), 4.78 4.61 (m, 1H), 3.93 (s, 3H), 3.91-3.86 (m, 2H), 2.84-2.75 (m, 2H), 2.36-2.25 (m, 1H), 1.50 (d, J=7.2 Hz, 3H), 1.40 (d, J=6.5 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.35, 168.74, 158.67, 155.38, 148.77, 140.51, 139.41, 130.42, 129.40, 129.15, 128.52, 126.30, 120.80, 114.44, 109.47, 72.36, 65.70, 56.06, 48.12, 45.32, 33.66, 18.36, 17.53. (Thin film) 3368.01, 2937.00, 1734.91, 1648.24, 1527.51, 1240.25, 1147.60 cm⁻¹. HRMS-ESI (m/z) ([M+H]⁺) calcd for C₂₇H₃₁N₂O₆, 480.2209; found, 480.221.

Example 11B, Step 1: Preparation of (2S,3R,4S)-3-(4-fluorobenzyl)-4-(4-(trifluoro-methyl)benzyl)hex-5-en-2-yl L-alaninate 2,2,2-trifluoroacetate

To a solution of (2S,3R,4S)-3-(4-fluorobenzyl)-4-(4-(trifluoromethyl)benzyl)hex-5-en-2-yl (tert-butoxycarbonyl)-L-alaninate (328 mg, 0.595 mmol) in DCM (3 mL) was added trifluoroacetic acid (0.46 mL, 5.95 mmol). After stirring at room temperature for 4 h, the mixture was concentrated in vacuo, to provide (2S,3R,4S)-3-(4-fluorobenzyl)-4-(4-(trifluoromethyl)-benzyl)hex-5-en-2-yl L-alaninate 2,2,2-trifluoroacetate (328 mg, 100%) as a clear, light yellow oil. ¹H NMR (400 MHz, d₆-DMSO) δ 8.30 (bs, 3H), 7.55 (d, J=7.9 Hz, 2H), 7.24 (d, J=7.9 Hz, 2H), 7.17 (dd, J=8.7, 5.6 Hz, 2H), 7.08 (t, J=8.9 Hz, 2H), 5.75 (m, 1H), 5.10 (m, 1H), 4.98 (dd, J=10.3, 1.6 Hz, 1H), 4.83 (d, J=17.2 Hz, 1H), 4.10 (m, 1H), 2.94 (dd, J=13.6, 4.4 Hz, 1H), 2.73 (m, 2H), 2.65 (m, 1H), 2.46 (m, 1H), 2.05 (m, 1H), 1.36 (d, J=7.3 Hz, 3H), 1.25 (d, J=6.4 Hz, 3H). ¹⁹F NMR (376 MHz, d₆-DMSO)) δ−55.96, −69.59, −112.58. ESIMS (m/z) 438 [(M+H)⁺].

Example 11B, Step 2: Preparation of (2S,3R,4S)-3-(4-fluorobenzyl)-4-(4-(trifluoro-methyl)benzyl)hex-5-en-2-yl (3-hydroxy-4-methoxypicolinoyl)-L-alaninate

To a mixture of (2S,3R,4S)-3-(4-fluorobenzyl)-4-(4-(trifluoromethyl)benzyl)hex-5-en-2-yl L-alaninate 2,2,2-trifluoroacetate (328 mg, 0.595 mmol), 3-hydroxy-4-methoxypicolinic acid (126 mg, 0.744 mmol), and PyBOP (465 mg, 0.893 mmol) were added DCM (3 mL) and N,N-diisopropyl-N-ethylamine (0.31 mL, 1.79 mmol). The mixture was stirred for ˜40 h. The mixture was concentrated in vacuo, and the residue partitioned between water and EtOAc. The layers were separated and the organics dried with Na₂SO₄, filtered and concentrated. The crude residue was purified via silica gel column chromatography (CH₂Cl₂/MeOH 100:1) to provide (2S,3R,4S)-3-(4-fluorobenzyl)-4-(4-(trifluoromethyl)benzyl)hex-5-en-2-yl (3-hydroxy-4-methoxypicolinoyl)-L-alaninate (233 mg, 67%) as a clear colorless oil. ¹H NMR (400 MHz, CDCl₃) δ 12.09 (s, 1H), 8.43 (d, J=7.9 Hz, 1H), 7.87 (d, J=5.1 Hz, 1H), 7.39 (d, J=7.9 Hz, 2H), 7.04-6.96 (m, 4H), 6.91 (t, J=8.7 Hz, 2H), 6.77 (d, J=5.1 Hz, 1H), 5.69 (ddd, J=17.2, 10.3, 8.5 Hz, 1H), 5.17 (m, 1H), 5.03 (dd, J=10.3, 1.3 Hz, 1H), 4.84 (d, J=20 Hz, 1H), 4.73 (m, 1H), 3.91 (s, 3H), 2.90 (dd, J=13.1, 5.1 Hz, 1H), 2.72 (dd, J=14.1, 6.3 Hz, 1H), 2.60 (dd, J=14.1, 7.8 Hz, 1H), 2.56 2.48 (m, 1H), 2.46 (m, 1H), 1.97 (m, 1H), 1.56 (d, J=7.3 Hz, 3H), 1.31 (d, J=6.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.33, 168.83, 161.34 (d, J=243 Hz), 155.36, 148.76, 144.44, 140.49, 138.45, 135.83 (d, J=3 Hz), 130.23, 130.22 (d, J=7 Hz), 129.32, 127.93 (q, J=32 Hz), 124.81 (q, J=4 Hz), 124.36 (q, J=270 Hz), 116.99, 115.18, (d, J=21 Hz), 109.40, 72.63, 56.02, 48.13, 45.33, 37.96, 32.69, 18.10, 17.63. ¹⁹F NMR (376 MHz, CDCl₃) δ−62.27, −117.06. ESIMS (m/z) 589 [(M+H)⁺].

Example 11C, Step 1: Preparation of (S)-(2S,3S)-3-benzyl-4-(2,4-dichlorophenoxy)-4-methylpentan-2-yl 2-aminopropanoate hydrochloride and (S)-(2S,3R)-3-benzyl-4-methylpent-4-en-2-yl 2-aminopropanoate hydrochloride

To neat (S)-(2S,3S)-3-benzyl-4-(2,4-dichlorophenoxy)-4-methylpentan-2-yl 2-((tert-butoxycarbonyl)amino)propanoate (0.095 g, 0.181 mmol) was added hydrogen chloride (4 M in dioxane) (0.906 ml, 3.62 mmol). The mixture was stirred at room temperature for 2.5 h. The mixture was concentrated under a stream of nitrogen to provide a 2:3 mixture of compounds (S)-(2S,3R)-3-benzyl-4-methylpent-4-en-2-yl 2-aminopropanoate hydrochloride (21 mg, 40%). ESIMS (m/z) 424.4 ([M+H]⁺), and

(S)-(2S,3S)-3-benzyl-4-(2,4-dichlorophenoxy)-4-methylpentan-2-yl 2-aminopropanoate hydrochloride (50 mg, 60%). ESIMS (m/z) 262.4 ([M+H]⁺).

Example 11C, Step 2: Preparation of (S)-(2S,3S)-3-benzyl-4-(2,4-dichlorophenoxy)-4-methylpentan-2-yl 2-(3-hydroxy-4-methoxypicolinamido)propanoate and (S)-(2S,3R)-3-benzyl-4-methylpent-4-en-2-yl 2-(3-hydroxy-4-methoxypicolinamido)propanoate

To a solution of a mixture of (S)-(2S,3S)-3-benzyl-4-(2,4-dichlorophenoxy)-4-methylpentan-2-yl 2-aminopropanoate hydrochloride (0.050 g, 0.109 mmol) and (S)-(2S,3R)-3-benzyl-4-methylpent-4-en-2-yl 2-aminopropanoate hydrochloride (21 mg, 0.071 mmol) in DCM (1.085 ml) were added N-ethyl-N-isopropylpropan-2-amine (0.094 ml, 0.543 mmol), 3-hydroxy-4-methoxypicolinic acid (0.032 g, 0.189 mmol), and PyBOP (0.098 g, 0.189 mmol). The mixture was stirred overnight at room temperature. The mixture was then concentrated and purified via reverse phase chromatography (5.5 g C18 column, 5-100% acetonitrile in water) to afford: (S)-(2S,3R)-3-benzyl-4-methylpent-4-en-2-yl 2-(3-hydroxy-4-methoxypicolinamido)propanoate (18 mg, 62%) as a sticky wax. ¹H NMR (400 MHz, CDCl₃) δ 12.15 (s, 1H), 8.50 (d, J=7.9 Hz, 1H), 7.99 (d, J=5.2 Hz, 1H), 7.28-7.22 (m, 2H), 7.20-7.14 (m, 1H), 7.14-7.07 (m, 2H), 6.87 (d, J=5.3 Hz, 1H), 5.08 (p, J=6.3 Hz, 1H), 4.78-4.76 (m, 1H), 4.75-4.66 (m, 1H), 4.66-4.63 (m, 1H), 3.94 (s, 3H), 2.81 (dd, J=13.5, 5.4 Hz, 1H), 2.68-2.60 (m, 1H), 2.59-2.50 (m, 1H), 1.65 (dd, J=1.5, 0.8 Hz, 3H), 1.56 (d, J=7.2 Hz, 3H), 1.30 (d, J=6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.54, 168.73, 155.38, 148.76, 143.19, 140.46, 139.73, 130.50, 128.85, 128.22, 126.04, 114.84, 109.45, 73.11, 56.08, 53.85, 48.20, 35.81, 20.59, 18.37, 18.15. (Thin film) 3368.25, 2978.89, 1732.44, 1647.36, 1526.67, 1451.05, 1262.62 cm⁻¹. HRMS-ESI (m/z)([M+H]⁺) calcd for C₂₃H₂₉N₂O₅, 413.2071; found, 413.2071, and (S)-(2S,3S)-3-benzyl-4-(2,4-dichlorophenoxy)-4-methylpentan-2-yl 2-(3-hydroxy-4-methoxypicolinamido)propanoate (31 mg, 50%) as a sticky wax. ¹H NMR (400 MHz, CDCl₃) δ 12.14 (s, 1H), 8.40 (d, J=7.9 Hz, 1H), 7.97 (d, J=5.2 Hz, 1H), 7.39 (d, J=2.6 Hz, 1H), 7.30-7.18 (m, 4H), 7.18-7.11 (m, 2H), 7.01 (d, J=8.8 Hz, 1H), 6.86 (d, J=5.2 Hz, 1H), 5.60 (qd, J=6.5, 2.9 Hz, 1H), 4.56-4.44 (m, 1H), 3.94 (s, 3H), 3.24 (dd, J=14.9, 5.2 Hz, 1H), 2.93 (dd, J=14.9, 7.0 Hz, 1H), 2.51 (ddd, J=7.0, 5.2, 3.0 Hz, 1H), 1.49 (d, J=6.5 Hz, 3H), 1.43 (s, 3H), 1.31 (s, 3H), 1.29 (d, J=7.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.44, 168.67, 155.37, 149.85, 148.75, 142.20, 140.46, 130.47, 130.21, 129.94, 128.75, 128.63, 128.42, 127.24, 125.80, 125.27, 109.44, 85.33, 73.24, 56.08, 54.16, 48.09, 31.34, 26.30, 25.82, 17.88, 17.30. (Thin film) 3366.01, 2977.63, 1732.01, 1648.45, 1472.90, 1261.08, cm⁻¹. HRMS-ESI (m/z) ([M+H]⁺) calcd for C₂₉H₃₃Cl₂N₂O₆, 575.171; found, 575.171.

Example 11D, Step 1: Preparation of (S)-(2S,3S)-3-(4-fluorobenzyl)-4-((4-fluorobenzyl)oxy)-4-methylpentan-2-yl 2-aminopropanoate

To a solution of (S)-(2S,3S)-3-(4-fluorobenzyl)-4-((4-fluorobenzyl)oxy)-4-methylpentan-2-yl 2-((tert-butoxycarbonyl)amino)propanoate (213.1 mg, 0.421 mmol) in DCM (4.215 mL) was added 2,6-dimethylpyridine (292 μL, 2.53 mmol) in one portion via syringe, followed by trimethylsilyl trifluoromethanesulfonate (305 μL, 1.686 mmol). The resulting clear, colorless solution was then stirred at room temperature for 3 h. Methanol (3 mL) was then added, and the solution was stirred at room temperature for 30 min. After 30 min, the solution was concentrated under a stream of N₂ to yield the title compound as a pale orange oil that was used directly in the next step without further purification. ¹⁹F NMR (376 MHz, CDCl₃) δ−115.97, −118.05; (Thin film) 3488, 2981, 1742, 1647, 1510, 1222, 1158, 1027 cm⁻¹; HRMS-ESI (m/z) calc'd for [C₂₃H₃₀F₂NO₃]⁺, 406.2188; found, 406.2196.

Example 11D, Step 2: Preparation of (S)-(2S,3R)-3-benzyl-4-phenoxybutan-2-yl 2-(3-hydroxy-4-methoxypicolinamido)propanoate

To a solution of (S)-(2S,3S)-3-(4-fluorobenzyl)-4-((4-fluorobenzyl)oxy)-4-methylpentan-2-yl 2-aminopropanoate (173.0 mg, 0.427 mmol) was added 3-hydroxy-4-methoxypicolinic acid (87 mg, 0.512 mmol) and ((1H-benzo[d][1,2,3]triazol-1-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (266 mg, 0.512 mmol) in DCM (4.27 mL) was added N-ethyl-N-isopropylpropan-2-amine (297 μL, 1.707 mmol) dropwise over 45 seconds. The resultant pale orange colored reaction was stirred at rt overnight. The reaction was concentrated under reduced pressure to yield an orange colored oil which was purified via flash chromatography on silica to afford the title compound (174.6 mg, 73% yield over two steps) as a clear, colorless oil. ¹H NMR (400 MHz, CDCl₃) δ 12.13 (s, 1H), 8.38 (d, J=7.9 Hz, 1H), 7.96 (d, J=5.2 Hz, 1H), 7.36-7.20 (m, 2H), 7.20-7.06 (m, 2H), 7.06-6.95 (m, 2H), 6.94-6.87 (m, 2H), 6.85 (d, J=5.3 Hz, 1H), 5.45 (qd, J=6.5, 2.8 Hz, 1H), 4.59-4.46 (m, 1H), 4.45-4.32 (m, 2H), 3.93 (d, J=2.0 Hz, 3H), 2.96 (dd, J=14.8, 5.3 Hz, 1H), 2.78 (dd, J=14.9, 7.0 Hz, 1H), 2.29 (ddd, J=7.0, 5.4, 2.8 Hz, 1H), 1.93 (dddd, J=31.2, 13.0, 7.3, 5.9 Hz, 1H), 1.36 (d, J=6.6 Hz, 3H), 1.33 (s, 3H), 1.30 (d, J=7.2 Hz, 3H), 1.26 (s, 3H); ¹⁹F NMR (376 MHz, CDCl₃) δ−115.67, −117.79; (Thin film) 3369, 2976, 1732, 1649, 1528, 1218, 1141, 1040, 729 cm⁻¹; HRMS-ESI (m/z) calc'd for [C₃₀H₃₅F₂N₂O₆]⁺, 557.2458; found, 557.2471.

Example 12A: Preparation of (S)-(2S,3R)-3-phenylheptan-2-yl 2-(3-(acetoxymethoxy)-4-methoxypicolinamido)propanoate

To a solution of (S)-(2S,3R)-3-phenylheptan-2-yl 2-(3-hydroxy-4-methoxypicolinamido)propanoate (98 mg, 0.236 mmol) and K₂CO₃ (98 mg, 0.709 mmol) in acetone (4.73 mL) was added bromomethyl acetate (34.8 μL, 0.355 mmol). The solution was heated to 50° C. for 3 hr. The solution was cooled to rt and concentrated. Purification via flash chromatography on silica yielded (S)-(2S,3R)-3-phenylheptan-2-yl 2-(3-(acetoxymethoxy)-4-methoxypicolinamido)propanoate (84 mg, 69%) as a colorless oil. ¹H NMR (400 MHz, CDCl₃) δ 8.43-8.14 (m, 2H), 7.31-7.21 (m, 2H), 7.22-7.11 (m, 3H), 6.94 (d, J=5.4 Hz, 1H), 5.86-5.60 (m, 2H), 5.31-5.14 (m, 1H), 4.75-4.49 (m, 1H), 3.90 (s, 3H), 2.71 (ddd, J=10.3, 7.0, 4.6 Hz, 1H), 2.06 (s, 3H), 1.73-1.58 (m, 2H), 1.37-1.19 (m, 2H), 1.24 (d, J=6.3 Hz, 3H), 1.17-1.04 (m, 2H), 1.14 (d, J=7.1 Hz, 3H). 0.81 (t, J=7.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) d 172.23, 170.23, 162.87, 160.26, 145.68, 143.96, 142.56, 141.28, 128.62, 128.18, 126.49, 109.54, 89.55, 74.79, 56.17, 51.14, 48.18, 31.40, 29.46, 22.60, 20.85, 18.35, 18.12, 13.89. HRMS-ESI (m/z) ([M+H]⁺) calcd for C₂₆H₃₅N₂O₇, 487.2444; found, 487.2437.

Example 12B: Preparation of ((4-methoxy-2-(((S)-1-oxo-1-(((2S,3R)-3-phenylheptan-2-yl)oxy)propan-2-yl)carbamoyl)pyridin-3-yl)oxy)methyl isobutyrate

To a solution of (S)-(2S,3R)-3-phenylheptan-2-yl 2-(3-hydroxy-4-methoxy-picolinamido)propanoate (98 mg, 0.236 mmol), sodium iodide (7.09 mg, 0.047 mmol) and sodium carbonate (75 mg, 0.709 mmol) in acetone (4729 μl) was added chloromethyl isobutyrate (48.4 mg, 0.355 mmol). The solution was heated to 55° C. and stirred overnight. The solution was cooled to room temperature and concentrated. Purification via flash chromatography on silica yielded ((4-methoxy-2-(((S)-1-oxo-1-(((2S,3R)-3-phenylheptan-2-yl)oxy)propan-2-yl)carbamoyl)pyridin-3-yl)-oxy)methyl isobutyrate (94 mg, 73%) as a colorless oil. ¹N HMR (400 MHz, CDCl₃) δ 8.34 (d, J=7.8 Hz, 1H), 8.26 (d, J=5.4 Hz, 1H), 7.27-7.15 (m, 5H), 6.94 (d, J=5.4 Hz, 1H), 5.76 (q, J=6.4 Hz, 2H), 5.33-5.10 (m, 1H), 4.65-4.51 (m, 1H), 3.88 (s, 3H), 2.72 (ddd, J=10.3, 7.0, 4.7 Hz, 1H), 2.54 (hept, J=7.0 Hz, 1H), 1.76-1.55 (m, 2H), 1.32-1.21 (m, 2H), 1.24 (d, J=6.3 Hz, 3H), 1.20-1.02 (m, 2H), 1.14 (d, J=7.2 Hz, 3H), 1.14 (d, J=7.0 Hz, 6H), 0.81 (t, J=7.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 176.19, 172.23, 162.84, 160.25, 145.53, 144.19, 142.19, 141.27, 128.62, 128.17, 126.48, 109.48, 89.91, 74.77, 56.12, 51.13, 48.17, 33.84, 31.39, 29.46, 22.60, 18.66, 18.34, 18.12, 13.88. HRMS-ESI (m/z) ([M+H]⁺) calcd for C₂₈H₃₉N₂O₇, 515.2764; found, 515.2759.

Example 12C: Preparation of (S)-(2S,3R)-3-phenylheptan-2-yl 2-(3-acetoxy-4-methoxypicolinamido)propanoate

To (S)-(2S,3R)-3-phenylheptan-2-yl 2-(3-hydroxy-4-methoxypicolinamido)propanoate (98 mg, 0.236 mmol), N,N-dimethylpyridin-4-amine (5.78 mg, 0.047 mmol) and triethylamine (99 μL, 0.709 mmol) in DCM (4.73 mL) was added acetyl chloride (33.6 μl, 0.473 mmol) at rt. The reaction gradually turned orange. The reaction was stirred at rt for 2 hr. The reaction mixture was purified via flash chromatography on silica to provide (S)-(2S,3R)-3-phenylheptan-2-yl 2-(3-acetoxy-4-methoxypicolinamido)propanoate (85 mg, 71%) as a colorless oil. ¹H NMR (400 MHz, CDCl₃) δ 8.46 (d, J=8.3 Hz, 1H), 8.32 (d, J=5.4 Hz, 1H), 7.33-7.14 (m, 5H), 6.99 (d, J=5.5 Hz, 1H), 5.20 (p, J=6.4 Hz, 1H), 4.58 (dq, J=8.2, 7.2 Hz, 1H), 3.89 (s, 3H), 2.70 (ddd, J=10.3, 6.9, 4.9 Hz, 1H), 2.38 (s, 3H), 1.75-1.56 (m, 2H), 1.33-1.23 (m, 2H), 1.22 (d, J=6.3 Hz, 3H), 1.13 (d, J=7.2 Hz, 3H), 1.12-0.99 (m, 2H), 0.81 (t, J=7.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.13, 168.87, 162.28, 159.44, 146.64, 141.56, 141.22, 137.47, 128.65, 128.17, 126.50, 109.73, 74.81, 56.27, 51.11, 47.97, 31.39, 29.48, 22.61, 20.73, 18.32, 18.30, 13.90. HRMS-ESI (m/z) ([M+H]⁺) calcd for C₂₅H₃₃N₂O₆, 457.2338; found, 457.2345.

Example A: Evaluation of Fungicidal Activity: Leaf Blotch of Wheat (Zymoseptoria tritici; Bayer code SEPTTR)

Technical grades of materials were dissolved in acetone, which were then mixed with nine volumes of water containing 110 ppm Triton X-100. The fungicide solutions were applied onto wheat seedlings using an automated booth sprayer to run-off. All sprayed plants were allowed to air dry prior to further handling. All fungicides were evaluated using the aforementioned method for their activity vs. all target diseases. Wheat leaf blotch and brown rust activity were also evaluated using track spray applications, in which case the fungicides were formulated as EC formulations, containing 0.1% Trycol 5941 in the spray solutions.

Wheat plants (variety Yuma) were grown from seed in a greenhouse in 50% mineral soil/50% soil-less Metro mix until the first leaf was fully emerged, with 7-10 seedlings per pot. These plants were inoculated with an aqueous spore suspension of Zymoseptoria tritici either prior to or after fungicide treatments. After inoculation the plants were kept in 100% relative humidity (one day in a dark dew chamber followed by two to three days in a lighted dew chamber at 20° C.) to permit spores to germinate and infect the leaf. The plants were then transferred to a greenhouse set at 20° C. for disease to develop. When disease symptoms were fully expressed on the 1^(st) leaves of untreated plants, infection levels were assessed on a scale of 0 to 100 percent disease severity. Percent disease control was calculated using the ratio of disease severity on treated plants relative to untreated plants.

Example B: Evaluation of Fungicidal Activity: Wheat Brown Rust (Puccinia triticina; Synonym: Puccinia recondita f. sp. tritici; Bayer code PUCCRT)

Wheat plants (variety Yuma) were grown from seed in a greenhouse in 50% mineral soil/50% soil-less Metro mix until the first leaf was fully emerged, with 7-10 seedlings per pot. These plants were inoculated with an aqueous spore suspension of Puccinia triticina either prior to or after fungicide treatments. After inoculation the plants were kept in a dark dew room at 22° C. with 100% relative humidity overnight to permit spores to germinate and infect the leaf. The plants were then transferred to a greenhouse set at 24° C. for disease to develop. Fungicide formulation, application and disease assessment followed the procedures as described in the Example A.

Example C: Evaluation of Fungicidal Activity: Asian Soybean Rust (Phakopsora pachyrhizi; Bayer code PHAKPA)

Technical grades of materials were dissolved in acetone, which were then mixed with nine volumes of water containing 0.011% Tween 20. The fungicide solutions were applied onto soybean seedlings using an automated booth sprayer to run-off. All sprayed plants were allowed to air dry prior to further handling.

Soybean plants (variety Williams 82) were grown in soil-less Metro mix, with one plant per pot. Two weeks old seedlings were used for testing. Plants were inoculated either 3 days prior to or 1 day after fungicide treatments. Plants were incubated for 24 h in a dark dew room at 22° C. and 100% RH then transferred to a growth room at 23° C. for disease to develop. Disease severity was assessed on the sprayed leaves.

TABLE 1 Compound Structure and Appearance Prepared According *Cmpd. to No. Structure Example Appearance 1

Example 6, Step 1-6; Example 5A; Example 9A Colorless Oil 2

Example 6, Step 1, 3-6; Example 5A; Example 9A Colorless Oil 3

Example 6, Steps 1-6; Example 9A Colorless Oil 4

Example 6, Steps 1-6; Example 9A Colorless Oil 5

Example 6, Step 1, 3-6; Example 5A; Example 9A Colorless Oil 6

Example 1, Step 1; Example 9A Colorless Oil 7

Example 6, Steps 1-6; Example 9A; Example 10B, Step 3 Colorless Oil 8

Example 1, Steps 1-3; Example 3A, Steps 1-2; Example 4B; Example 5A; Example 9A Colorless Oil 9

Example 1, steps 1-3; Example 3A steps 1-2; Example 4B; Example 5A; Example 9A Red Oil 10

Example 1, steps 1 and 3; Example 3A steps 1-2; Example 4B; Example 5A; Example 9A Light Yellow Oil 11

Example 1, steps 1 and 3; Example 3A steps 1-2; Example 4B; Example 5A; Example 9A Light Yellow Oil 12

Example 7; Example 9A Colorless Oil 13

Example 10, Step 1-3 Colorless Oil 14

Example 7; Example 9A Colorless Oil 15

Example 7; Example 9A Colorless Oil 16

Example 7; Example 9A Colorless Oil 17

Example 7; Example 9A Colorless Oil 18

Example 7; Example 9A Colorless Oil 19

Example 7; Example 9A Colorless Oil 20

Example 1, Steps 1 and 3; Example 3B; Example 4D; Example 5D; Example 9A Clear, Colorless Oil 21

Example 1, Steps 1 and 3; Example 3B; Example 4D; Example 5D; Example 9A Clear, Colorless Oil 22

Example 1, Steps 1 and 3; Example 3C; Example 4D; Example 5D; Example 9A Clear, Colorless Oil 23

Example 1, Steps 1 and 3; Example 3C; Example 4D; Example 5D; Example 9A Clear, Colorless Oil 24

Example 1, Steps 1 and 3; Example 3B; Example 4C; Example 5D; Example 9A White Semi-Solid 25

Example 1, Steps 1 and 3; Example 3C; Example 4C; Example 5D; Example 9A Clear, Colorless Oil 26

Example 1, steps 1 and 3; Example 3C; Example 4D; Example 5A; Example 9A Clear Oil 27

Example 1, steps 1 and 3; Example 3B; Example 4E; Example 5B; Example 9A White Solid 28

Example 1, steps 1 and 3; Example 3B; Example 4E; Example 5D; Example 9A Sticky Wax 29

Example 7; Example 9A Colorless Oil 30

Example 1, Step 1, 3; Example 3C; Example 4C; Example 5D; Example 9A Colorless Oil 31

Example 1, Steps 1 and 3; Example 3B; Example 4D; Example 5D; Example 9A Clear, Colorless Oil 32

Example 1, Steps 1 and 3; Example 3C; Example 4D; Example 5D; Example 9A Clear, Colorless Oil 33

Example 1, Steps 1 and 3; Example 3B; Example 4D; Example 5B; Example 9A Clear, Colorless Oil 34

Example 1, Steps 1 and 3; Example 3B; Example 4D; Example 5B; Example 9A Clear, Colorless Oil 35

Example 1, steps 1 and 3; Example 3C; Example 4E; Example 5D; Example 9A Sticky Wax 36

Example 1, step 1; Example 2; Example 3B; Example 4D; Example 5A; Example 9A Clear Oil 37

Example 1, step 1; Example 2; Example 3C; Example 4D; Example 5A; Example 9A Clear Oil 38

Example 1, step 1; Example 2; Example 3B; Example 4D; Example 5A; Example 9A Clear Oil 39

Example 1, step 1; Example 2; Example 3C; Example 4D; Example 5A; Example 9A Colorless Oil 40

Example 8, steps 1-3; Example 9A Oil 41

Example 8, steps 1-3; Example 9A Oil 42

Example 1, step 1; Example 2; Example 3C; Example 4D; Example 5A; Example 9A Clear Oil 43

Example 1, step 1; Example 2; Example 3C; Example 4E; Example 5A; Example 9A Clear Oil 44

Example 1, step 1; Example 2; Example 3B; Example 4D; Example 5A; Example 9A Clear Oil 45

Example 1, step 1; Example 2; Example 3B; Example 4D; Example 5A; Example 9A Clear Oil 46

Example 1, step 1; Example 2; Example 3B; Example 4E; Example 5A; Example 9A As A White Semi-Solid 47

Example 1, step 1; Example 2; Example 3C; Example 5A; Example 9A Clear Oil 48

Example 7; Example 9B Colorless Oil 49

Example 11A, Step 1 White Solid 50

Example 1, Steps 1 and 3; Example 3A, Steps 1-2; Example 4B, Steps 1-3; Example 5D; Example 9A; Example 11A, Step 1 White Solid 51

Example 11B, Step 1 Colorless Oil 52

Example 11B, Step 1 Light Yellow Oil 53

Example 11B, Step 1 Light Yellow Oil 54

Example 11A, step 1 White Solid 55

Example 11A, Step 1 White Solid 56

Example 11A, Step 1 White Solid 57

Example 11A, Step 1 Colorless Oil 58

Example 11A, Step 1 Colorless Oil 59

Example 11A, Step 1 Colorless Oil 60

Example 11A, Step 1 Pale Yellow Oil 61

Example 11A, Step 1 Colorless Oil 62

Example 11A, step 1 Clear Glass 63

Example 11A, Step 1 Clear, Colorless Oil 64

Example 11A, Step 1 Clear, Colorless Oil 65

Example 11A, Step 1 Clear, Colorless Oil 66

Example 11A Step 1 Clear, Colorless Oil 67

Example 11A, Step 1 White Solid 68

Example 11A, Step 1 Clear, Colorless Oil 69

Example 11A, Step 1 Colorless Oil 70

Example 11A, Step 1 Colorless Oil 71

Example 11A, Step 1 Colorless Oil 72

Example 11A, Step 1 White Foam 73

Example 11A, Step 1 Colorless Oil 74

Example 11A, Step 1 Clear, Colorless Oil 75

Example 11A, Step 1 Pale Orange Oil 76

Example 11A, Step 1 Clear, Colorless Oil 77

Example 11A, Step 1 Clear, Colorless Oil 78

Example 11A, step 1 Sticky Wax 79

Example 11C, step 1 Sticky Wax 80

Example 11A, step 1 Yellow/Orange Oil 81

Example 11A, step 1 Yellow/Orange Oil 82

Example 8, steps 1-3; Example 9A; Example 11A, step 1 Oil 83

Example 11A, step 1 84

Example 8, steps 1-3; Example 9A; Example 11A, step 1 Oil 85

Example 11A, step 1 Oil 86

Example 8, steps 1-3; Example 9A; Example 11A, step 1 Oil 87

Example 11A, step 1 Sticky Wax 88

Example 11A, step 1 Yellow Oil 89

Example 11C, step 1 Sticky Wax 90

Example 11A, Step 1 Colorless Oil 91

Example 1, steps 1 and 3; Example 3A steps 1-2; Example 4A; Example 5A; Example 9A; Example 11A, steps 1-2 Colorless Oil 92

Example 1, steps 1 and 3; Example 3A steps 1-2; Example 4A; Example 5A; Example 9A; Example 11A, steps 1-2 Colorless Oil 93

Example 1, steps 1 and 3; Example 3B; Example 4A; Example 5A; Example 9A; Example 11A, steps 1-2 Colorless Oil 94

Example 1, steps 1 and 3; Example 3A steps 1-2; Example 4A; Example 5A; Example 9A; Example 11A, steps 1-2 Colorless Oil 95

Example 1, steps 1 and 3; Example 3A steps 1-2; Example 4A; Example 5A; Example 9A; Example 11A, steps 1-2 Colorless Oil 96

Example 1, steps 1 and 3; Example 3A steps 1-2; Example 4A; Example 5A; Example 9A; Example 11A, steps 1-2 Colorless Oil 97

Example 1, step 1 and 3; Example 3B; Example 4A; Example 5A; Example 9A; Example 11A, steps 1-2 Colorless Oil 98

Example 1, steps 1 and 3; Example 3B; Example 4A; Example 5A; Example 9A; Example 11A, steps 1-2 Colorless Oil 99

Example 1, steps 1 and 3; Example 3B; Example 4A; Example 5A; Example 9A; Example 11A, steps 1-2 Colorless Oil 100

Example 1, steps 1 and 3; Example 3A steps 1-2; Example 4A; Example 5A; Example 9A; Example 11A, steps 1-2 Colorless Oil 101

Example 11A, Step 2 Colorless Oil 102

Example 6, steps 1-6, Example 5A, Example 9A; Example 11A, steps 1-2 Slightly Red Oil 103

Example 6, steps 1-6, Example 5A, Example 9A; Example 11A, steps 1-2 Colorless Oil 104

Example 1, steps 1 and 3; Example 3B; Example 4A; Example 5A; Example 9A; Example 11A, steps 1-2 Colorless Oil 105

Example 11A, Step 2 Colorless Tacky Oil 106

Example 1, steps 1 and 3; Example 3B; Example 4A; Example 5A; Example 9A; Example 11A, steps 1-2 Colorless Oil 107

Example 11B, Step 2 White Foam 108

Example 11B, Step 2 Colorless Oil 109

Example 11B, Step 2 White Foam 110

Example 10, Step 3 Sticky White Foam 111

Example 10, Step 3 Off White Foam 112

Example 11A, step 2 Thick Colorless Oil 113

Example 11A, Step 2 White Solid 114

Example 11A, Step 2 White Solid 115

Example 11A, steps 1-2 Colorless Oil 116

Example 11A, steps 1-2 Colorless Oil 117

Example 11A, steps 1-2 Colorless Oil 118

Example 11A, steps 1-2 Colorless Oil 119

Example 11A, Step 2 Colorless Oil 120

Example 11A, Step 2 Colorless Foam 121

Example 11A, Step 2 Colorless Foam 122

Example 11A, Step 2 Colorless Oil 123

Example 11A, Step 2 Colorless Oil 124

Example 11A, step 2 Sticky Wax 125

Example 11A, step 2 White Foam 126

Example 11A, step 2 White Foam 127

Example 11A, Step 2 White Foam 128

Example 11A, Step 2 White Foam 129

Example 11A, Step 2 White Foam 130

Example 11A, Step 2 White Foam 131

Example 11A, Step 2 Clear, Colorless Oil 132

Example 11A, Step 2 Clear, Colorless Oil 133

Example 11A, Step 2 Clear, Colorless Oil 134

Example 11A, Step 2 Clear, Colorless Oil 135

Example 11A, Step 2 Clear, Colorless Oil 136

Example 11A, Step 2 Clear, Colorless Oil 137

Example 11A, Step 2 Colorless Oil 138

Example 11A, Step 2 Pale Yellow Oil 139

Example 11A, Step 2 Clear, Colorless Oil 140

Example 11A, Step 2 Clear, Colorless Oil 141

Example 11A, Step 2 Clear, Colorless Oil 142

Example 11A, step 2 Sticky Wax 143

Example 11A, step 2 Clear Sticky Wax 144

Example 11A, step 2 Clear Sticky Oil 145

Example 11A, step 2 Clear Sticky Wax 146

Example 11A, step 2 Clear Sticky Wax 147

Example 11A, step 2 Oil 148

Example 11A, step 2 Oil 149

Example 11A, step 2 Oil 150

Example 11A, step 2 Oil 151

Example 11A, step 2 Oil 152

Example 8, steps 1-3; Example 9A; Example 11A, step 1-2 Oil 153

Example 8, steps 1-3; Example 9A; Example 11A, step 1-2 Oil 154

Example 8, steps 1-3; Example 9A; Example 11A, step 1-2 Oil 155

Example 8, steps 1-3; Example 9A; Example 11A, step 1-2 Oil 156

Example 11A, step 2 Sticky Wax 157

Example 11A, step 2 Sticky Wax 158

Example 11A, step 2 Sticky Wax 159

Example 11A, step 2 Sticky Wax 160

Example 11A, step 2 Sticky Wax 161

Example 11A, step 2 Colorless Oil 162

Example 12A Colorless Oil 163

Example 12A Colorless Oil 164

Example 12A Colorless Oil 165

Example 12A Colorless Oil 166

Example 12A Colorless Oil 167

Example 12A Colorless Oil 168

Example 12A Colorless Oil 169

Example 12A Colorless Oil 170

Example 12A Colorless Oil 171

Example 12A Colorless Oil 172

Example 12C Colorless Oil 173

Example 12A Slight Yellow Oil 174

Example 12A Colorless Oil 175

Example 12A Slight Yellow Oil 176

Example 12C Slight Yellow Oil 177

Example 12A Clear Tacky Oil 178

Example 12C Sticky White Foam 179

Example 12C Light Yellow Oily Foam 180

Example 12C Sticky Off White Foam 181

Example 12C Light Orange Foam 182

Example 12C Light Orange Foam 183

Example 12C Off White Foam 184

Example 12A Light Yellow Oil 185

Example 12A Light Yellow Oil 186

Example 12C Light Yellow Oil 187

Example 12A Colorless Oil 188

Example 12A Colorless Oil 189

Example 12A Colorless Oil 190

Example 12C Red- Orange Oil 191

Example 12A Colorless Oil 192

Example 12A Colorless Oil 193

Example 12C Yellow Oil 194

Example 12C Yellow Oil 195

Example 12A Colorless Oil 196

Example 12C Colorless Oil 197

Example 12C Colorless Oil 198

Example 12C Colorless Oil 199

Example 12A Colorless Oil 200

Example 12B Colorless Oil 201

Example 12C Colorless Oil 202

Example 12C Colorless Oil 203

Example 12A Colorless Oil 204

Example 12B Colorless Oil 205

Example 12C Colorless Oil 206

Example 12A Colorless Oil 207

Example 12A Sticky Wax 208

Example 12A Clear Glass 209

Example 12A White Foam 210

Example 12C Colorless Oil 211

Example 12C Colorless Oil 212

Example 12C Colorless Oil 213

Example 12A Colorless Oil 214

Example 12B Colorless Oil 215

Example 12B Colorless Oil 216

Example 12C White Foam 217

Example 12C White Foam 218

Example 12A White Foam 219

Example 12B White Foam 220

Example 12C White Foam 221

Example 12A White Foam 222

Example 12A White Foam 223

Example 12B White Foam 224

Example 12C White Foam 225

Example 12A White Foam 226

Example 12B White Foam 227

Example 12C Yellow Oil 228

Example 12C Yellow Oil 229

Example 12C Yellow Oil 230

Example 12C Yellow Oil 231

Example 12C Yellow Oil 232

Example 12C Yellow Oil 233

Example 12B Clear, Colorless Oil 234

Example 12B Clear, Colorless Oil 235

Example 12B Clear, Colorless Oil 236

Example 12B Clear, Colorless Oil 237

Example 12B Clear, Colorless Oil 238

Example 12B Clear, Colorless Oil 239

Example 12A Clear, Colorless Oil 240

Example 12A Clear, Colorless Oil 241

Example 12A Clear, Colorless Oil 242

Example 12A Clear, Colorless Oil 243

Example 12A Clear, Colorless Oil 244

Example 12A Clear, Colorless Oil 245

Example 12A Colorless Oil 246

Example 12C Yellow Oil 247

Example 12C Pale, Yellow Oil 248

Example 12C Yellow Oil 249

Example 12A Clear, Colorless Oil 250

Example 12A Clear, Colorless Oil 251

Example 12A Clear, Colorless Oil 252

Example 12A Clear, Colorless Oil 253

Example 12B Clear, Colorless Oil 254

Example 12A Sticky Wax 255

Example 12A Sticky Wax 256

Example 12A Sticky Wax 257

Example 12A Sticky Wax 258

Example 12A Sticky Wax 259

Example 12A Sticky Wax 260

Example 12C Semi-Soild 261

Example 12C Semi-Solid 262

Example 12C Oil 263

Example 12C Oil 264

Example 12C Oil 265

Example 12A Oil 266

Example 12A Oil 267

Example 12A Oil 268

Example 12A Oil 269

Example 12A Oil 270

Example 12C Oil 271

Example 12C Oil 272

Example 12C Oil 273

Example 12C Oil 274

Example 12A Oil 275

Example 12A Oil 276

Example 12A Oil 277

Example 12A Oil 278

Example 12A Sticky Wax 279

Example 12A Sticky Wax 280

Example 12A Sticky Wax 281

Example 12A Sticky Wax 282

Example 12A Sticky White Foam 283

Example 12C Colorless Oil 284

Example 10, Step 3 White foam *Cmpd. No.—Compound Number

TABLE 2 Analytical Data *Cmpd. NMR No. IR (cm⁻¹) MASS (¹H, ¹³C or ¹⁹F) 1 ESIMS m/z 470 ¹H NMR (400 MHz, CDCl₃) δ ([M + Na]⁺) 7.31-7.26 (m, 2H), 7.21-7.14 (m, 3H), 5.15-4.94 (m, 2H), 4.35- 4.15 (m, 1H), 2.72-2.52 (m, 2H), 1.73-1.49 (m, 4H), 1.45 (s, 9H), 1.38-1.28 (m, 3H), 1.33 (d, J = 7.0 Hz, 3H), 1.20 (d, J = 6.4 Hz, 3H), 1.18-0.97 (m, 2H), 0.95- 0.78 (m, 11H). ¹³C NMR (101 MHz, CDCl₃) δ 172.83, 155.01, 142.66, 128.34, 128.27, 125.64, 80.65, 73.59, 49.46, 41.07, 40.21, 36.38, 35.71, 30.33, 30.16, 28.36, 26.11, 24.12, 23.47, 22.31, 18.94, 17.93, 12.50. 2 ESIMS m/z 590 ¹H NMR (400 MHz, CDCl₃) δ ([M + Na]⁺) 7.44 (d, J = 8.0 Hz, 2H), 7.09 (d, J = 7.9 Hz, 2H), 7.00 (dd, J = 8.6, 5.5 Hz, 2H), 6.95-6.87 (m, 2H), 5.73 (m, 1H), 5.42 (d, J = 8.6 Hz, 1H), 5.19 (m, 1H), 5.05 (d, J = 11.4 Hz, 1H), 4.86 (d, J = 17.1 Hz, 1H), 4.43 (s, 1H), 3.84 (dd, J = 9.2, 2.9 Hz, 1H), 3.58 (dd, J = 9.2, 3.2 Hz, 1H), 3.29 (s, 3H), 2.99 (dd, J = 13.4, 5.5 Hz, 1H), 2.71 (dd, J = 14.0, 6.1 Hz, 1H), 2.59 (ddd, J = 13.8, 8.6, 4.1 Hz, 2H), 2.45 (m, 1H), 2.00 (m, 1H), 1.44 (s, 9H), 1.28 (d, J = 6.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 170.06, 161.32 (d, J = 243 Hz), 155.43, 144.59, 138.67, 135.97 (d, J = 4 Hz), 130.28 (d, J = 8 Hz), 129.47, 128.13 (q, J = 34 Hz), 124.96 (q, J = 4 Hz), 124.34 (q, J = 271 Hz), 117.06, 115.18, (d, J = 21 Hz), 80.05, 72.76, 72.46, 59.22, 54.24, 47.94, 45.44, 37.96, 32.57, 28.32, 17.66. 3 ESIMS m/z 560 ¹H NMR (400 MHz, CDCl₃) δ ([M + Na]⁺) 7.44 (d, J = 8.0 Hz, 2H), 7.07 (d, J = 7.9 Hz, 2H), 7.02-6.88 (m, 4H), 5.70 (ddd, J = 17.1, 10.2, 8.9 Hz, 1H), 5.15 (m, 1H), 5.06 (dd, J = 8.0, 2.0 Hz, 1H), 5.03 (d, J = 7.7 Hz, 1H), 4.87 (dd, J = 17.1, 1.0 Hz, 1H), 4.30 (m, 1H), 2.96 (dd, J = 13.6, 5.8 Hz, 1H), 2.73 (dd, J = 14.1, 5.7 Hz, 1H), 2.60 (m, 2H), 2.43 (m, 1H), 1.97 (td, J = 8.4, 5.6 Hz, 1H), 1.44 (s, 9H), 1.37 (d, J = 7.3 Hz, 3H), 1.28 (d, J = 6.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.62, 161.33 (d, J = 243 Hz), 155.01, 144.43, 138.38, 135.94 (d, J = 3 Hz), 130.22 (d, J = 8 Hz), 129.39, 128.23 (q, J = 32 Hz), 124.00 (q, J = 3 Hz), 124.29 (q, J = 270 Hz), 117.06, 115.24, (d, J = 22 Hz), 79.94, 72.25, 49.49, 47.76, 45.56, 38.22, 32.88, 28.33, 18.72, 17.52. 4 ESIMS m/z 546 ¹H NMR (400 MHz, CDCl₃) δ ([M + Na]⁺) 7.45 (bd, J = 8.0 Hz, 2H), 7.07 (bd, J = 8.0 Hz, 2H), 7.00 (td, J = 5.6, 2.3 Hz, 2H), 6.95 (m, 2H), 5.70 (ddd, J = 17.1, 10.2, 8.8 Hz, 1H), 5.14 (p, J = 6.1 Hz, 1H), 5.06 (dd, J = 10.3, 1.1 Hz, 1H), 4.99 (bs, 1H), 4.87 (dt, J = 17.1, 1.3 Hz, 1H), 3.87 (m, 2H), 2.94 (dd, J = 13.6, 5.9 Hz, 1H), 2.73 (dd, J = 14.2, 5.9 Hz, 1H), 2.60 (m, 2H), 2.41 (m, 1H), 2.01 (m, 1H), 1.46 (s, 9H), 1.28 (d, J = 6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.13, 161.32 (d, J = 243 Hz), 155.66, 144.43, 138.26, 135.96 (d, J = 4 Hz), 130.26 (d, J = 8 Hz), 129.41, 128.21 (q, J = 32 Hz), 125.01 (q, J = 4 Hz), 124.31 (q, J = 270 Hz), 117.26, 115.22, (d, J = 21 Hz), 80.10, 72.68, 47.56, 45.72, 42.78, 38.48, 33.09, 28.30, 17.57. 5 ESIMS m/z 364 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 7.32-7.22 (m, 2H), 7.21-7.14 (m, 1H), 7.14-7.08 (m, 2H), 5.16- 5.05 (m, 1H), 5.00 (qd, J = 6.5, 3.7 Hz, 1H), 4.43-4.21 (m, 1H), 2.65 (dd, J = 13.6, 6.6 Hz, 1H), 2.50 (dd, J = 13.6, 7.6 Hz, 1H), 1.90-1.78 (m, 1H), 1.45 (s, 9H), 1.39 (d, J = 7.2 Hz, 3H), 1.36- 1.28 (m, 4H), 1.21 (d, J = 6.5 Hz, 3H), 0.92-0.80 (m, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.78, 155.08, 140.77, 129.10, 128.33, 125.93, 79.68, 72.93, 49.48, 44.51, 36.23, 31.54, 28.36, 20.30, 18.93, 16.20, 14.25. 6 ESIMS m/z 380 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 7.32-7.23 (m, 2H), 7.23-7.17 (m, 1H), 7.17-7.10 (m, 2H), 5.26- 5.08 (m, 2H), 4.34-4.20 (m, 1H), 3.54 (s, 3H), 3.10-2.76 (m, 3H), 1.44 (s, 9H), 1.40-1.29 (m, 6H). ¹³C NMR (101 MHz, CDCl₃) δ 172.46, 172.33, 155.04, 138.24, 128.75, 128.50, 126.60, 79.69, 71.70, 52.93, 51.57, 49.30, 34.23, 28.31, 18.60, 17.83. 7 IR (neat) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3361, 2932, [M]⁺ calcd for 7.25-7.21 (m, 2H), 7.20-7.17 1715, 1508, C₂₉H₃₈F₃NO₅, (m, 1H), 7.12-7.03 (m, 6H), 1260 537.2702; found, 5.15-5.08 (m, 1H), 5.08-5.01 537.2704. (m, 1H), 4.37-4.24 (m, 1H), 3.00- 2.90 (m, 1H), 2.73-2.54 (m, 2H), 2.44-2.34 (m, 1H), 1.98-1.90 (m, 1H), 1.83-1.73 (m, 1H), 1.47- 1.32 (m, 5H), 1.43 (s, 9H), 1.26 (d, J = 6.4 Hz, 3H), 0.88 (t, J = 6.9 Hz, 3H) 8 ESIMS m/z 444 ¹H NMR (400 MHz, CDCl₃) δ ([M + Na]⁺⁾ 7.30-7.19 (m, 2H), 6.93-6.83 (m, 3H), 5.15-5.00 (m, 2H), 4.27 (td, J = 6.5, 3.0 Hz, 1H), 4.20 (t, J = 7.3 Hz, 1H), 1.84 (qd, J = 5.7, 2.9 Hz, 1H), 1.81-1.71 (m, 1H), 1.72-1.61 (m, 1H), 1.59-1.50 (m, 1H), 1.44 (s, 9H), 1.41-1.30 (m, 4H), 1.26 (td, J = 6.9, 3.6 Hz, 7H), 0.97 (t, J = 7.4 Hz, 3H), 0.92 (t, J = 7.1 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.52, 158.49, 154.99, 129.47, 120.60, 115.81, 79.33, 72.80, 49.44, 44.79, 31.59, 31.05, 28.34, 25.81, 24.43, 23.19, 18.72, 17.76, 13.99, 10.43. 9 (Thin film) ESIMS m/z 444 ¹H NMR (400 MHz, CDCl₃) δ 3363, 2962, ([M + Na]⁺) 7.30-7.23 (m, 2H), 6.96-6.86 1714, 1493 (m, 3H), 5.20 (dt, J = 11.6, 6.3 Hz, 1H), 5.11 (d, J = 8.1 Hz, 1H), 4.36-4.26 (m, 2H), 2.02-1.91 (m, 1H), 1.79-1.67 (m, 2H), 1.58- 1.47 (m, 1H), 1.45 (s, 9H), 1.38 (d, J = 7.2 Hz, 3H), 1.32 (d, J = 6.4 Hz, 3H), 1.30-1.18 (m, 5H), 0.97 (t, J = 7.4 Hz, 3H), 0.91- 0.82 (m, 3H). 10 (Thin film) ESIMS m/z 478 ¹H NMR (400 MHz, CDCl₃) δ 3340, 2975, ([M + Na]⁺⁾ 7.36-7.28 (m, 2H), 7.26-7.17 1711, 1493 (m, 5H), 6.92-6.86 (m, 1H), 6.73 (dt, J = 7.9, 1.1 Hz, 2H), 5.06 (td, J = 6.5, 4.9 Hz, 1H), 4.99 (d, J = 8.1 Hz, 1H), 4.30 (td, J = 6.5, 2.5 Hz, 1H), 4.20-4.11 (m, 1H), 2.88 (dd, J = 14.5, 6.6 Hz, 1H), 2.75 (dd, J = 14.3, 7.2 Hz, 1H), 2.25 (tdd, J = 7.0, 4.9, 2.5 Hz, 1H), 1.84-1.63 (m, 2H), 1.44 (s, 9H), 1.28 (d, J = 6.4 Hz, 3H), 1.24 (d, J = 7.1 Hz, 3H), 0.95 (t, J = 7.4 Hz, 3H). 11 (Thin film) ESIMS m/z 478 ¹H NMR (400 MHz, CDCl₃) δ 3340, 2976, ([M + Na]⁺⁾ 7.27 (dd, J = 8.7, 7.4 Hz, 2H), 1713, 1493 7.24-7.13 (m, 3H), 7.02-6.92 (m, 3H), 6.88-6.82 (m, 2H), 5.25 (td, J = 5.3, 4.8 Hz, 1H), 5.06 (d, J = 7.9 Hz, 1H), 4.39-4.28 (m, 1H), 4.25 (td, J = 6.5, 3.6 Hz, 1H), 2.88 (dd, J = 13.8, 7.7 Hz, 1H), 2.70 (dd, J = 13.8, 6.5 Hz, 1H), 2.35-2.25 (m, 1H), 1.83-1.67 (m, 2H), 1.45 (s, 9H), 1.43 (d, J = 7.3 Hz, 3H), 1.36 (d, J = 6.5 Hz, 3H), 0.90 (t, J = 7.4 Hz, 3H). 12 ESIMS m/z 398 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 7.26-7.07 (m, 8H), 7.03-6.91 (m, 2H), 5.25-5.16 (m, 1H), 5.06 (d, J = 7.9 Hz, 1H), 4.24 (p, J = 7.3 Hz, 1H), 3.05 (dd, J = 12.4, 5.8 Hz, 1H), 2.99 (dt, J = 8.4, 5.6 Hz, 1H), 2.90 (dd, J = 12.4, 8.1 Hz, 1H), 1.44 (s, 9H), 1.21 (d, J = 6.3 Hz, 3H), 1.14 (d, J = 7.1 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.64, 155.06, 140.38, 139.57, 129.03, 128.97, 128.23, 128.16, 126.74, 126.08, 79.72, 73.41, 53.16, 49.47, 38.50, 28.38, 18.48, 18.42. 13 ESIMS m/z 364 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 7.31-7.24 (m, 2H), 7.22-7.12 (m, 3H), 5.06-4.95 (m, 2H), 4.32- 4.20 (m, 1H), 2.68 (dd, J = 14.3, 5.2 Hz, 1H), 2.52 (dd, J = 14.2, 8.2 Hz, 1H), 2.03-1.89 (m,1H), 1.83-1.73 (m, 1H), 1.45 (s, 9H), 1.36 (d, J = 7.2 Hz, 3H), 1.19 (d, J = 6.5 Hz, 3H), 1.01 (d, J = 6.9 Hz, 3H), 0.95 (d, J = 6.8 Hz, 3H). 14 ESIMS m/z 378.5 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 7.31-7.24 (m, 2H), 7.24-7.13 (m, 3H), 5.17 (p, J = 6.4 Hz, 1H), 4.96 (d, J = 7.9 Hz, 1H), 4.25- 4.08 (m, 1H), 2.66 (ddd, J = 11.0, 7.0, 4.7 Hz, 1H), 1.75-1.57 (m, 2H), 1.53-1.44 (m, 1H), 1.43 (s, 9H), 1.22 (d, J = 6.3 Hz, 3H), 1.12-0.87 (m, 2H), 1.00 (d, J = 7.0 Hz, 3H)., 0.81 (d, J = 4.6 Hz, 3H), 0.80 (d, J = 4.6 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.70, 154.95, 141.29, 128.62, 128.20, 126.52, 79.63, 74.61, 51.41, 49.29, 36.46, 29.44, 28.33, 27.95, 22.74, 22.20, 18.43, 18.37. 15 ESIMS m/z 364 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 7.50-6.96 (m, 5H), 5.26-5.09 (m, 1H), 5.07-4.95 (m, 1H), 4.16 (p, J = 7.5 Hz, 1H), 2.69 (ddd, J = 10.4, 7.0, 4.7 Hz, 1H), 1.75-1.55 (m, 2H), 1.42 (s, 9H), 1.33-1.24 (m, 2H), 1.24-1.20 (m, 3H), 1.16- 1.04 (m, 2H), 0.99 (d, J = 7.2 Hz, 3H), 0.81 (t, J = 7.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.67, 154.95, 141.28, 128.59, 128.18, 126.50, 79.55, 74.58, 51.17, 49.29, 31.42, 29.45, 28.31, 22.60, 18.38, 18.33, 13.88. 16 ESIMS m/z 432 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 7.38-6.84 (m, 9H), 5.26-5.14 (m, 1H), 5.02 (d, J = 8.3 Hz, 1H), 4.31-4.15 (m, 1H), 3.02 (dd, J = 12.6, 5.3 Hz, 1H), 2.94 (dt, J = 8.8, 5.5 Hz, 1H), 2.86 (dd, J = 12.6, 8.8 Hz, 1H), 1.44 (s, 9H), 1.22 (d, J = 5.6 Hz, 3H), 1.12 (d, J = 6.1 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.62, 155.04, 139.87, 138.00, 131.84, 130.33, 128.90, 128.32, 128.23, 126.87, 79.79, 73.34, 53.14, 49.45, 37.83, 28.36, 18.41, 18.41. 17 ESIMS m/z 466.4 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 7.28-7.18 (m, 4H), 7.16-7.04 (m, 3H), 6.77 (dd, J = 8.3, 2.1 Hz, 1H), 5.27-5.15 (m, 1H), 4.98 (d, J = 7.8 Hz, 1H), 4.30-4.17 (m, 1H), 3.08-2.91 (m, 2H), 2.85 (dd, J = 12.6, 8.9 Hz, 1H), 1.44 (s, 9H), 1.22 (d, J = 5.7 Hz, 3H), 1.13 (d, J = 7.2 Hz, 3H). 18 ESIMS m/z 412.5 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺⁾ 7.28-7.20 (m, 2H), 7.22-7.12 (m, 3H), 6.98 (d, J = 8.1 Hz, 2H), 6.88 (d, J = 7.7 Hz, 2H), 5.25- 5.12 (m, 1H), 5.05 (d, J = 8.0 Hz, 1H), 4.32-4.16 (m, 1H), 3.04- 2.93 (m, 2H), 2.87 (dd, J = 11.8, 7.2 Hz, 1H), 2.24 (s, 3H), 1.44 (s, 9H), 1.19 (d, J = 6.3 Hz, 3H), 1.15 (d, J = 7.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.64, 155.05, 140.51, 136.43, 135.48, 129.00, 128.94, 128.89, 128.14, 126.69, 79.72, 73.39, 53.18, 49.46, 38.04, 28.38, 21.00, 18.53, 18.44. 19 ESIMS m/z 416.5 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺⁾ 7.29-7.09 (m, 5H), 6.98-6.88 (m, 2H), 6.88-6.80 (m, 2H), 5.32- 5.13 (m, 1H), 5.05 (d, J = 7.5 Hz, 1H), 4.33-4.15 (m, 1H), 3.03 (dd, J = 12.7, 5.4 Hz, 1H), 2.94 (dt, J = 8.8, 5.5 Hz, 1H), 2.86 (dd, J = 12.7, 8.8 Hz, 1H), 1.44 (s, 9H), 1.22 (d, J = 6.5 Hz, 3H), 1.13 (d, J = 7.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.63, 161.32 (d, J = 244.0 Hz), 155.05, 140.05, 135.17 (d, J = 3.2 Hz), 130.37 (d, J = 7.8 Hz), 128.92, 128.20, 126.81, 114.98 (d, J = 21.1 Hz), 79.76, 73.30, 53.34, 49.46, 37.69, 28.35, 18.43, 18.38. 20 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3354, 2979, ([M + Na]⁺) calcd 7.38-7.23 (m, 5H), 7.12-7.00 2934, 1710, for C₂₆H₃₄FNNaO₅, (m, 2H), 6.99-6.88 (m, 2H), 5.12 1509, 1158, 482.2316; found, (dt, J = 12.1, 4.2 Hz, 2H), 4.49- 1056, 732 483.2313 4.36 (m, 2H), 4.27 (p, J = 7.6 Hz, 1H), 3.38 (d, J = 5.1 Hz, 2H), 2.73-2.55 (m, 2H), 2.13-1.98 (m, 1H), 1.44 (s, 9H), 1.34 (d, J = 7.2 Hz, 3H), 1.29 (d, J = 6.5 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.55, 161.38 (d, J = 243.9 Hz), 155.06, 138.20, 135.54 (d, J = 3.3 Hz), 130.47 (d, J = 7.8 Hz), 128.35, 127.61, 127.60, 115.13 (d, J = 21.2 Hz), 79.71, 73.08, 71.93, 68.23, 49.46, 45.64, 32.67, 28.35, 18.76, 17.29. 21 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3353, 2979, ([M + Na]⁺) calcd 7.37-7.22 (m, 7H), 7.22-7.07 2933, 1712, for C₂₆H₃₅NNaO₅, (m, 3H), 5.23-4.99 (m, 2H), 4.48- 1164, 1063, 464.2407; found, 4.36 (m, 2H), 4.27 (p, J = 7.6 698 464.2416 Hz, 1H), 3.39 (d, J = 5.2 Hz, 2H), 2.68 (d, J = 7.4 Hz, 2H), 2.13 (qt, J = 7.5, 5.1 Hz, 1H), 1.44 (s, 9H), 1.33 (d, J = 7.2 Hz, 3H), 1.29 (d, J = 6.5 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.53, 155.04, 139.96, 138.28, 129.11, 128.36, 128.31, 127.57, 127.52, 126.06, 79.64, 73.03, 72.08, 68.45, 49.43, 45.49, 33.45, 28.34, 18.80, 17.18. 22 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3357, 2977, ([M + Na]⁺) calcd 7.40-7.30 (m, 4H), 7.29-7.21 1711, 1509, for C₂₈H₃₈FNNaO₅, (m, 1H), 7.19-7.09 (m, 2H), 7.01- 1159, 1043, 510.2626; found, 6.88 (m, 2H), 5.40 (qd, J = 6.6, 732 510.2614 2.9 Hz, 1H), 4.89 (d, J = 7.9 Hz, 1H), 4.55-4.37 (m, 2H), 4.11 (dt, J = 15.1, 5.5 Hz, 1H), 3.01 (dd, J = 14.8, 4.9 Hz, 1H), 2.77 (dd, J = 14.8, 7.4 Hz, 1H), 2.26 (ddd, J = 7.7, 4.9, 2.9 Hz, 1H), 1.43 (s, 9H), 1.38-1.32 (m, 6H), 1.29 (s, 3H), 1.11 (d, J = 7.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.40, 161.06 (d, J = 243.6 Hz), 154.97, 139.46, 138.34 (d, J = 3.3 Hz), 130.16 (d, J = 7.6 Hz), 128.27, 127.12, 127.08, 115.02 (d, J = 21.0 Hz), 79.71, 76.94, 72.78, 63.39, 53.30, 49.45, 30.35, 28.32, 24.87, 24.73, 18.36, 17.14. 23 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3354, 2976, ([M + Na]⁺) calcd 7.36-7.29 (m, 4H), 7.29-7.18 1711, 1164, for C₂₈H₃₉NNaO₅, (m, 5H), 7.18-7.11 (m, 1H), 5.41 1043, 732, 492.2720; found, (qd, J = 6.5, 2.8 Hz, 1H), 4.85 (d, 697 492.2712 J = 8.0 Hz, 1H), 4.53-4.37 (m, 2H), 4.12-3.95 (m, 1H), 3.04 (dd, J = 14.7, 4.8 Hz, 1H), 2.81 (dd, J = 14.8, 7.7 Hz, 1H), 2.33 (ddd, J = 7.7, 4.8, 2.8 Hz, 1H), 1.43 (s, 9H), 1.39-1.34 (m, 6H), 1.30 (s, 3H), 1.07 (d, J = 7.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.37, 154.96, 142.73, 139.52, 128.89, 128.29, 128.25, 127.09, 127.08, 125.59, 79.59, 76.97, 72.84, 63.38, 53.01, 49.46, 31.13, 28.33, 24.85, 24.82, 18.33, 17.09. 24 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3353, 2979, ([M + Na]⁺) calcd 7.19-7.04 (m, 2H), 7.03-6.90 2932, 1711, for C₂₀H₃₀FNNaO₅, (m, 2H), 5.13 (d, J = 7.5 Hz, 1H), 1509, 1159, 406.2000; found, 5.11-5.01 (m, 1H), 4.38-4.20 (m, 1062 406.2002 1H), 3.36-3.20 (m, 5H), 2.63 (d, J = 7.4 Hz, 2H), 2.03 (ddt, J = 12.7, 7.6, 5.2 Hz, 1H), 1.45 (s, 9H), 1.40 (d, J = 7.2 Hz, 3H), 1.28 (d, J = 6.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.57, 161.41 (d, J = 243.9 Hz), 155.08, 135.57 (d, J = 3.2 Hz), 130.48 (d, J = 7.8 Hz), 115.17 (d, J = 21.1 Hz), 79.73, 71.86, 70.89, 58.76, 49.50, 45.57, 32.70, 28.36, 18.85, 17.21. 25 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3353, 2977, ([M + Na]⁺) calcd 7.20-7.09 (m, 2H), 7.01-6.88 2939, 1711, for C₂₂H₃₄FNNaO₅, (m, 2H), 5.31 (qd, J = 6.6, 2.9 1509, 1159, 434.2313; found, Hz, 1H), 4.89 (d, J = 7.8 Hz, 1H), 1043 434.2307 4.17-4.00 (m, 1H), 3.18 (s, 3H), 2.88 (dd, J = 14.7, 4.8 Hz, 1H), 2.70 (dd, J = 14.8, 7.7 Hz, 1H), 2.18 (ddd, J = 7.7, 4.9, 2.9 Hz, 1H), 1.44 (s, 9H), 1.32 (d, J = 6.6 Hz, 3H), 1.22 (s, 3H), 1.19 (s, 3H), 1.12 (d, J = 7.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.37, 161.07 (d, J = 243.6 Hz), 154.97, 138.25 (d, J = 3.3 Hz), 130.14 (d, J = 7.7 Hz), 115.01 (d, J = 21.1 Hz), 79.72, 76.40, 72.67, 52.48, 49.46, 48.86, 30.45, 28.33, 24.19, 24.01, 18.40, 17.14. 26 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3432, 2974, ([M + Na]⁺) calcd 7.31-7.12 (m, 5H), 5.35 (qd, J = 1715, 1496, for C₂₄H₃₉NNaO₅, 6.6, 2.8 Hz, 1H), 4.84 (s, 1H), 1366, 1167 444.272; found, 4.12-3.99 (m, 1H), 3.29 (td, J = 444.2723 6.5, 1.0 Hz, 2H), 2.96 (dd, J = 14.7, 4.7 Hz, 1H), 2.74 (dd, J = 14.7, 7.8 Hz, 1H), 2.23 (ddd, J = 7.7, 4.8, 2.8 Hz, 1H), 1.61-1.48 (m, 2H), 1.44 (s, 9H), 1.34 (d, J = 6.5 Hz, 3H), 1.23 (s, 3H), 1.18 (s, 3H), 1.07 (d, J = 7.2 Hz, 3H), 0.92 (t, J = 7.4 Hz, 3H). 27 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3363, 2982, ([M + Na]⁺) calcd 7.32-7.11 (m, 7H), 6.93 (tt, J = 1729, 1682, for C₂₅H₃₃NNaO₅, 7.4, 1.1 Hz, 1H), 6.87-6.80 (m, 1526, 1236, 450.2251; found, 2H), 5.26-5.16 (m, 1H), 5.06 (d, 1156, 1039 450.2235 J = 7.9 Hz, 1H), 4.38-4.19 (m, 1H), 3.97-3.83 (m, 2H), 2.88- 2.70 (m, 2H), 2.29 (ddq, J = 8.5, 6.4, 5.1 Hz, 1H), 1.44 (s, 9H), 1.37 (d, J = 6.5 Hz, 3H), 1.33 (d, J = 7.1 Hz, 3H). 28 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3361, 2979, ([M + Na]⁺) calcd 7.36 (d, J = 2.5 Hz, 1H), 7.32- 1708, 1484, for C₂₅H₃₁Cl₂NNaO₅, 7.22 (m, 2H), 7.23-7.17 (m, 1H), 1464, 1246, 518.1471; found, 7.17-7.14 (m, 2H), 7.12 (dd, J = 1161, 1059 518.147 8.8, 2.6 Hz, 1H), 6.68 (d, J = 8.8 Hz, 1H), 5.27-5.15 (m, 1H), 5.06 (d, J = 7.9 Hz, 1H), 4.42-4.19 (m, 1H), 3.91 (qd, J = 9.4, 4.7 Hz, 2H), 2.88 (dd, J = 13.6, 9.1 Hz, 1H), 2.80 (dd, J = 13.6, 5.9 Hz, 1H), 2.38-2.21 (m, 1H), 1.44 (s, 9H), 1.41 (d, J = 6.5 Hz, 3H), 1.34 (d, J = 7.2 Hz, 3H). 29 ESIMS m/z 448.5 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 7.78-7.71 (m, 1H), 7.67 (dd, J = 7.6, 5.1 Hz, 2H), 7.46-7.34 (m, 3H), 7.25-7.06 (m, 6H), 5.36- 5.19 (m, 1H), 5.01 (d, J = 7.8 Hz, 1H), 4.35-4.21 (m, 1H), 3.30- 3.16 (m, 1H), 3.15-3.01 (m, 2H), 1.45 (s, 9H), 1.25 (d, J = 6.4 Hz, 3H), 1.16 (d, J = 7.2 Hz, 3H). 30 ESIMS m/z 394.5 ([M + H]⁺⁾ 31 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3358, 2979, ([M + Na]⁺) calcd 7.30-7.19 (m, 2H), 7.13-6.98 2934, 1710, for C₂₆H₃₃F₂NNaO₅, (m, 4H), 6.98-6.88 (m, 2H), 5.23- 1509, 1220, 500.2219; found, 4.94 (m, 2H), 4.46-4.33 (m, 2H), 1157, 1063 500.2217 4.28 (t, J = 7.3 Hz, 1H), 3.37 (d, J = 5.1 Hz, 2H), 2.65 (d, J = 7.5 Hz, 2H), 2.13-1.96 (m, 1H), 1.45 (s, 9H), 1.35 (d, J = 7.2 Hz, 3H), 1.28 (d, J = 6.5 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.57, 162.29 (d, J = 245.5 Hz), 161.41 (d, J = 244.1 Hz), 155.06, 135.49 (d, J = 3.3 Hz), 133.97 (d, J = 3.1 Hz), 130.45 (d, J = 7.8 Hz), 129.32 (d, J = 8.1 Hz), 115.20 (d, J = 21.3 Hz), 115.17 (d, J = 21.1 Hz), 79.77, 72.37, 71.88, 68.27, 49.46, 45.59, 32.69, 28.35, 18.79, 17.25. 32 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3359, 2978, ([M + Na]⁺) calcd 7.37-7.22 (m, 2H), 7.20-7.09 1710, 1509, for C₂₈H₃₇F₂NNaO₅, (m, 2H), 7.09-6.98 (m, 2H), 6.98- 1219, 1157, 528.2532; found, 6.89 (m, 2H), 5.40 (qd, J = 6.5, 1042 528.2542 2.8 Hz, 1H), 4.88 (d, J = 7.9 Hz, 1H), 4.49-4.30 (m, 2H), 4.17- 4.02 (m, 1H), 2.97 (dd, J = 14.8, 5.0 Hz, 1H), 2.77 (dd, J = 14.8, 7.4 Hz, 1H), 2.26 (ddd, J = 7.7, 5.0, 2.9 Hz, 1H), 1.43 (s, 9H), 1.37-1.31 (m, 6H), 1.28 (s, 3H), 1.12 (d, J = 7.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.42, 162.02 (d, J = 244.9 Hz), 161.09 (d, J = 243.8 Hz), 154.98, 138.22 (d, J = 3.3 Hz), 135.10 (d, J = 3.2 Hz), 130.14 (d, J = 7.7 Hz), 128.78 (d, J = 8.0 Hz), 115.10 (d, J = 21.3 Hz), 115.05 (d, J = 21.0 Hz), 79.76, 77.06, 72.66, 62.77, 53.17, 49.46, 30.39, 28.33, 24.82, 24.78, 18.36, 17.14. 33 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3357, 2956, ([M + Na]⁺) calcd 7.16-7.04 (m, 2H), 7.02-6.90 (m, 2869, 1714, for C₂₄H₃₈FNNaO₅, 2H), 5.22-4.93 (m, 2H), 4.40- 1510, 1165, 462.2626; found, 4.23 (m, 1H), 3.44-3.21 (m, 4H), 1063 462.2635 2.74-2.53 (m, 2H), 2.07-1.96 (m, 1H), 1.68 (dq, J = 13.4, 6.8 Hz, 1H), 1.45 (m, 10H), 1.43- 1.37 (m, 4H), 1.28 (d, J = 6.5 Hz, 3H), 0.90 (d, J = 1.6 Hz, 3H), 0.89 (d, J = 1.6 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.59, 161.39 (d, J = 243.9 Hz), 155.06, 135.71 (d, J = 3.2 Hz), 130.47 (d, J = 7.7 Hz), 115.12 (d, J = 21.2 Hz), 79.75, 72.07, 69.55, 68.88, 49.48, 45.59, 38.54, 32.72, 28.36, 25.09, 22.64, 22.61, 18.91, 17.18. 34 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3357, 2955, ([M + Na]⁺) calcd 7.31-7.23 (m, 2H), 7.23-7.09 2931, 1714, for C₂₄H₃₉NNaO₅, (m, 3H), 5.10 (qd, J = 6.5, 4.6 1165, 1054, 444.2720; found, Hz, 2H), 4.29 (p, J = 7.6 Hz, 700 444.2711 1H), 3.42-3.26 (m, 4H), 2.66 (d, J = 7.4 Hz, 2H), 2.14-2.03 (m, 1H), 1.69 (tt, J = 13.4, 6.6 Hz, 1H), 1.49-1.42 (m, 11H), 1.39 (d, J = 7.2 Hz, 3H), 1.29 (d, J = 6.5 Hz, 3H), 0.90 (d, J = 1.8 Hz, 3H), 0.89 (d, J = 1.7 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.57, 155.05, 140.14, 129.13, 128.35, 126.03, 79.69, 72.22, 69.50, 69.05, 49.46, 45.44, 38.54, 33.49, 28.36, 25.08, 22.65, 22.61, 18.96, 17.07. 35 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3357.58, ([M + Na]⁺) calcd 7.39 (d, J = 2.6 Hz, 1H), 7.31- 2977.98, for C₂₇H₃₅Cl₂NNaO₅, 7.21 (m, 5H), 7.20-7.16 (m, 1H), 1710.52, 546.1784; found, 7.14 (dd, J = 8.8, 2.6 Hz, 1H), 1472.76, 546.1779 7.02 (d, J = 8.7 Hz, 1H), 5.54 (qd, 1163.16, J = 6.5, 2.9 Hz, 1H), 4.86 (s, 1H), 1046.48 3.25 (dd, J = 14.9, 5.0 Hz, 1H), 2.93 (dd, J = 14.9, 7.3 Hz, 1H), 2.47 (ddd, J = 7.7, 5.0, 2.9 Hz, 1H), 1.46 (d, J = 6.5 Hz, 3H), 1.44 (s, 9H), 1.43 (s, 3H), 1.33 (s, 3H), 1.12 (d, J = 7.2 Hz, 3H). 36 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3361.50, ([M + Na]⁺) calcd 7.13-6.99 (m, 2H), 6.87-6.77 (m, 2975.54, for C₂₃H₃₇NNaO₆, 2H), 5.10 (dtd, J = 11.2, 7.0, 1712.32, 446.2513; found, 6.5, 3.6 Hz, 2H), 4.40-4.21 (m, 1511.62, 446.2506 1H), 3.78 (s, 3H), 3.38-3.22 (m, 1244.78, 4H), 2.60 (d, J = 7.4 Hz, 2H), 1163.20 2.03 (ddt, J = 12.7, 7.6, 5.2 Hz, 1H), 1.56 (dtd, J = 13.9, 7.4, 6.5 Hz, 2H), 1.45 (s, 9H), 1.40 (d, J = 7.2 Hz, 3H), 1.29 (d, J = 6.4 Hz, 3H), 0.91 (t, J = 7.4 Hz, 3H). 37 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3370.66, ([M + Na]⁺) calcd 7.15-7.06 (m, 2H), 6.86-6.77 (m, 2973.75, for C₂₅H₄₁NNaO₆, 2H), 5.34 (qd, J = 6.6, 2.8 Hz, 1713.10, 474.2826; found, 1H), 5.00-4.85 (m, 1H), 4.10 (s, 1511.68, 474.2822 1H), 3.78 (s, 3H), 3.29 (td, J = 1245.81, 6.5, 1.5 Hz, 2H), 2.89 (dd, J = 1165.36 14.8, 4.9 Hz, 1H), 2.75-2.59 (m, 1H), 2.22-2.13 (m, 1H), 1.60- 1.47 (m, 2H), 1.44 (s, 9H), 1.33 (d, J = 6.5 Hz, 3H), 1.22 (s, 3H), 1.17 (s, 3H), 1.15-1.09 (m, 3H), 0.92 (t, J = 7.4 Hz, 3H). 38 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3360.47, ([M + Na]⁺) calcd 7.30-7.22 (m, 2H), 7.22-7.14 2975.23, for C₃₀H₄₃NNaO₆, (m, 3H), 6.95 (dd, J = 8.3, 2.3 Hz, 1712.60, 536.2983; found, 1H), 6.85-6.81 (m, 1H), 6.77 (d, 1501.2, 536.2982 J = 8.3 Hz, 1H), 5.16-4.99 (m, 1247.74, 2H), 4.35-4.19 (m, 1H), 3.93 (d, 1162.84 J = 4.3 Hz, 2H), 3.79 (s, 3H), 3.37-3.15 (m, 4H), 2.54 (d, J = 7.4 Hz, 2H), 2.05-1.91 (m, 1H), 1.61-1.47 (m, 2H), 1.45 (s, 9H), 1.34 (d, J = 7.2 Hz, 3H), 1.26 (d, J = 6.5 Hz, 3H), 0.89 (t, J = 7.4 Hz, 3H). 39 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3355.80, ([M + H]⁺) calcd for 7.30-7.20 (m, 2H), 7.22-7.13 2973.95, C₃₂H₄₇NNaO₆, (m, 3H), 6.99 (dd, J = 8.2, 2.3 Hz, 1712.81, 564.3296; found, 1H), 6.88 (d, J = 2.3 Hz, 1H), 1501.20, 564.3289 6.77 (d, J = 8.3 Hz, 1H), 5.30 (qd, 1248.78, J = 6.6, 2.9 Hz, 1H), 4.92 (s, 1H), 1163.47 4.05 (d, J = 7.7 Hz, 1H), 3.93 (s, 2H), 3.78 (s, 3H), 3.33-3.18 (m, 2H), 2.83 (dd, J = 14.8, 5.2 Hz, 1H), 2.61 (dd, J = 14.8, 7.4 Hz, 1H), 2.12 (ddd, J = 7.2, 5.2, 2.9 Hz, 1H), 1.50 (dtd, J = 13.9, 7.3, 6.4 Hz, 2H), 1.44 (s, 9H), 1.29 (d, J = 6.6 Hz, 3H), 1.18 (s, 3H), 1.12 (s, 3H), 1.05 (d, J = 7.2 Hz, 3H), 0.90 (t, J = 7.4 Hz, 3H). 40 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3369, 2972, ([M + Na]⁺) calcd 7.32-7.03 (m, 10H), 4.96 (qd, 1709, 1494, for C₂₇H₃₇NNaO₄, J = 6.5, 3.0 Hz, 2H), 2.83-2.48 1365, 1157, 462.2615; found, (m, 5H), 2.24-2.12 (m, 2H), 1.46 462.2611 (d, J = 7.7 Hz, 9H), 1.29-1.25 (m, 3H), 1.04-0.87 (m, 6H). 41 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3359, 2980, ([M + Na]⁺) calcd 7.25-7.20 (m, 2H), 6.95-6.81 1705, 1587, for C₂₅H₃₁F₂NNaO₄, (m, 5H), 6.75 (dd, J = 9.9, 2.2 Hz, 1487, 1249, 470.2113; found, 1H), 5.03 (s, 1H), 4.98-4.88 (m, 1162, 470.2116 1H), 4.34-4.23 (m, 1H), 2.76 (d, J = 6.6 Hz, 1H), 2.69-2.47 (m, 4H), 1.45 (s, 9H), 1.42 (d, J = 7.2 Hz, 3H), 1.29-1.24 (m, 3H). 42 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3366, 2976, ([M + Na]⁺) calcd 7.18-7.07 (m, 2H), 6.88-6.77 1713, 1512, for C₂₆H₄₁NNaO₆, (m, 2H), 5.32 (qd, J = 6.5, 2.8 1246, 1165, 486.2826; found, Hz, 1H), 5.07-4.86 (m, 1H), 1039 486.2836 4.20-4.02 (m, 1H), 3.78 (d, J = 2.4 Hz, 3H), 3.28-3.10 (m, 2H), 2.88 (dd, J = 14.7, 4.8 Hz, 1H), 2.67 (dd, J = 14.8, 7.7 Hz, 1H), 2.18 (ddt, J = 7.7, 4.9, 2.7 Hz, 1H), 1.44 (s, 9H), 1.34 (d, J = 6.5 Hz, 3H), 1.21 (s, 3H), 1.17 (s, 3H), 1.14 (d, J = 7.2 Hz, 3H), 1.04-0.91 (m, 1H), 0.57-0.41 (m, 2H), 0.21-0.15 (m, 2H). 43 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + Na]⁺) calcd 7.17-7.12 (m, 2H), 7.08-6.99 for C₂₈H₃₇F₂NNaO₆, (m, 1H), 6.87-6.81 (m, 2H), 6.81- 544.2481; found, 6.71 (m, 2H), 5.51 (qd, J = 6.6, 544.2492 2.9 Hz, 1H), 4.96 (d, J = 7.9 Hz, 1H), 4.25-4.09 (m, 1H), 3.79 (s, 3H), 3.13 (dd, J = 14.9, 5.5 Hz, 1H), 2.85 (dd, J = 14.9, 6.7 Hz, 1H), 2.36 (ddd, J = 6.7, 5.5, 2.9 Hz, 1H), 1.44 (s, 9H), 1.44 (d, J = 6.6 Hz, 3H), 1.39-1.35 (m, 3H), 1.25 (d, J = 2.1 Hz, 3H), 1.19 (d, J = 7.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.55, 158.04 (dd, J = 243.0, 2.4 Hz), 157.76, 155.03, 153.62 (dd, J = 242.2, 3.5 Hz), 142.69 (dd, J = 13.7, 10.8 Hz), 134.31, 129.69, 116.57 (dd, J = 22.8, 10.1 Hz), 113.86, 113.82 (dd, J = 24.2, 1.0 Hz), 110.86 (dd, J = 23.7, 7.4 Hz), 84.85, 79.72, 72.71, 55.28, 53.98, 49.49, 30.34, 28.34, 25.75, 25.66, 18.48, 17.09. 44 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3357, 2979, ([M + Na]⁺) calcd 7.15-6.99 (m, 2H), 6.86-6.76 1712, 1512, for C₂₄H₃₇NNaO₆, (m, 2H), 5.21-5.02 (m, 2H), 4.30 1245, 1163, 458.2513; found, (t, J = 7.4 Hz, 1H), 3.78 (s, 3H), 1057 458.2513 3.39 (dd, J = 9.7, 5.8 Hz, 1H), 3.33 (dd, J = 9.7, 5.1 Hz, 1H), 3.19 (dd, J = 6.8, 1.3 Hz, 2H), 2.61 (d, J = 7.4 Hz, 2H), 2.05 (ddt, J = 12.7, 7.5, 5.2 Hz, 1H), 1.45 (s, 9H), 1.40 (d, J = 7.2 Hz, 3H), 1.29 (d, J = 6.5 Hz, 3H), 1.08-0.95 (m, 1H), 0.57-0.44 (m, 2H), 0.23-0.12 (m, 2H). 45 (Thin film) ¹H NMR (400 MHz, CDCl₃) δ 3357, 2978, 7.30-7.20 (m, 2H), 7.22-7.13 1713, 1501, (m, 3H), 6.95 (dd, J = 8.3, 2.3 Hz, 1249, 1163 1H), 6.86-6.80 (m, 1H), 6.77 (d, J = 8.3 Hz, 1H), 5.18-5.01 (m, 2H), 4.37-4.19 (m, 1H), 3.96 (d, J = 15.1 Hz, 1H), 3.91 (d, J = 15.1 Hz, 1H), 3.78 (s, 3H), 3.34 (dd, J = 9.7, 5.8 Hz, 1H), 3.30 (dd, J = 9.7, 5.1 Hz, 1H), 3.20- 3.10 (m, 2H), 2.55 (d, J = 7.4 Hz, 2H), 2.08-1.92 (m, 1H), 1.45 (s, 9H), 1.34 (d, J = 7.1 Hz, 3H), 1.26 (d, J = 6.6 Hz, 3H), 1.07- 0.90 (m, 1H), 0.56-0.43 (m, 2H), 0.22-0.10 (m, 2H). ¹³C NMR (101 MHz, CDCl₃) δ 172.53, 155.75, 155.05, 141.05, 131.73, 131.16, 129.47, 128.90, 128.23, 127.82, 125.74, 110.40, 79.69, 75.45, 72.19, 68.66, 55.45, 49.43, 45.42, 35.83, 32.64, 28.36, 19.00, 17.11, 10.53, 2.95, 2.89. 46 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3365, 2979, ([M + Na]⁺) calcd 7.10-7.04 (m, 2H), 7.04-6.96 (m, 1738, 1710, for C₂₆H₃₃F₂NNaO₆, 1H), 6.85-6.79 (m, 2H), 6.60- 1512, 1242, 516.2168; found, 6.52 (m, 2H), 5.26-5.14 (m, 1H), 1160 516.2177 5.08 (d, J = 7.9 Hz, 1H), 4.42- 4.21 (m, 1H), 3.92 (d, J = 4.8 Hz, 2H), 3.78 (s, 3H), 2.75 (dd, J = 7.6, 3.8 Hz, 2H), 2.24 (ddq, J = 9.7, 6.6, 4.9 Hz, 1H), 1.44 (s, 9H), 1.38 (d, J = 6.5 Hz, 3H), 1.37 (d, J = 7.3 Hz, 3H). 47 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3374, 2977, ([M + Na]⁺) calcd 7.16-7.06 (m, 2H), 6.91-6.75 1697, 1512, for C₂₂H₃₅NNaO₆, (m, 2H), 5.31 (qd, J = 6.6, 3.3 1246, 1164, 432.2357; found, Hz, 1H), 4.96 (d, J = 7.8 Hz, 1040 432.2364 1H), 4.25-4.07 (m, 1H), 3.78 (s, 3H), 2.81 (dd, J = 14.7, 5.3 Hz, 1H), 2.66 (dd, J = 15.0, 7.7 Hz, 1H), 2.14-2.03 (m, 1H), 1.84 (s, 1H), 1.44 (s, 9H), 1.33 (d, J = 6.6 Hz, 3H), 1.31 (s, 3H), 1.25 (s, 3H), 1.21 (d, J = 7.2 Hz, 3H). 48 ESIMS m/z 336 ¹H NMR (300 MHz, CDCl₃) δ ([M + H]⁺) 7.34-7.19 (m, 3H), 7.17-7.11 (m, 2H), 5.21-5.01 (m, 2H), 4.42-4.22 (m, 1H), 2.63 (ddd, J = 11.0, 8.6, 3.8 Hz, 1H), 1.84 (dqd, J = 13.4, 7.5, 3.9 Hz, 1H), 1.69-1.51 (m, 1H), 1.45 (s, 9H), 1.41 (d, J = 7.2 Hz 3H) 1.04 (d, J = 6.3 Hz, 3H), 0.72 (t, J = 7.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.91, 155.04, 140.84, 128.60, 128.42, 126.76, 79.72, 75.34, 53.05, 49.54, 28.34, 24.58, 18.83, 18.38, 11.84. 49 ESIMS m/z 348 ([M + H]⁺) 50 ESIMS m/z 418 ([M + H]⁺) 51 LCMS m/z 468 ¹H NMR (400 MHz, DMSO-d₆) δ 8.47 (bs, 3H), 7.57 (m, 2H), 7.28 (d, J = 8.2 Hz, 2H), 7.17 (dd, J = 8.6, 5.7 Hz, 2H), 7.08 (t, J = 8.8 Hz, 2H), 5.80 (m, 1H), 5.12 (m, 1H), 5.00 (d, J = 10.2 Hz, 1H), 4.86 (d, J = 16.9 Hz, 1H), 4.39 (bs, 1H), 3.82 (dd, J = 10.5, 3.5 Hz, 1H), 3.62 (dd, J = 10.6, 2.8 Hz, 1H), 3.28 (s, 3H), 3.02-2.89 (m, 1H), 2.80-2.61 (m, 3H), 2.50 (m, 1H, signal obscured by DMSO), 2.04 (m, 1H), 1.27 (d, J = 6.4 Hz, 3H). 52 LCMS m/z 438 ¹H NMR (400 MHz, d6-DMSO) δ 8.30 (bs, 3H), 7.55 (d, J = 7.9 Hz, 2H), 7.24 (d, J = 7.9 Hz, 2H), 7.17 (dd, J = 8.7, 5.6 Hz, 2H), 7.08 (t, J = 8.9 Hz, 2H), 5.75 (m, 1H), 5.10 (m, 1H), 4.98 (dd, J = 10.3, 1.6 Hz, 1H), 4.83 (d, J = 17.2 Hz, 1H), 4.10 (m, 1H), 2.94 (dd, J = 13.6, 4.4 Hz, 1H), 2.73 (m, 2H), 2.65 (m, 1H), 2.46 (m, 1H), 2.05 (m, 1H), 1.36 (d, J = 7.3 Hz, 3H), 1.25 (d, J = 6.4 Hz, 3H). 53 LCMS m/z 424 ¹H NMR (400 MHz, CDCl₃) δ 8.23 (bs, 3H), 7.55 (d, J = 8.0 Hz, 2H), 7.24 (d, J = 7.9 Hz, 2H), 7.18 (dd, J = 8.7, 5.6 Hz, 2H), 7.07 (t, J = 8.8 Hz, 2H), 5.74 (m, 1H), 5.04 (p, J = 6.3 Hz, 1H), 4.98 (dd, J = 10.4, 1.7 Hz, 1H), 4.85 (d, J = 17.1 Hz, 1H), 3.83 (bd, J = 5.5 Hz, 2H), 2.93 (dd, J = 13.5, 4.5 Hz, 1H), 2.74 (dd, J = 14.2, 6.3 Hz, 1H), 2.70-2.60 (m, 2H), 2.46 (m, 1H), 2.03 (m, 1H), 1.25 (d, J = 6.4 Hz, 3H). 54 ESIMS m/z 438.4 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺⁾ 8.93 (bs, 3H), 7.26-7.20 (m, 2H), 7.16-7.11 (m, 1H), 7.10-7.04 (m, 2H), 7.04-6.98 (m, 4H), 5.23-5.13 (m, 1H), 4.15-4.04 (m, 1H), 2.83- 2.75 (m, 1H), 2.70-2.52 (m, 2H), 2.45-2.34 (m, 1H), 1.99-1.91 (m, 1H), 1.77-1.63 (m, 1H), 1.70 (d, J = 7.0 Hz, 3H), 1.39-1.21 (m, 2H), 1.25 (d, J = 6.3 Hz, 3H), 0.85 (t, J = 7.3 Hz, 3H) 55 ESIMS m/z 264 ([M + H]⁺) 56 ESIMS m/z 280 ([M + H]⁺) 57 ESIMS m/z 298 ([M + H]⁺) 58 ESIMS m/z 264 ([M + H]⁺) 59 ESIMS m/z 333 ([M + H]⁺) 60 ESIMS m/z 264.4 ([M + H]⁺⁾ 61 ESIMS m/z 278.4 ([M + H]⁺⁾ 62 ESIMS m/z 322.4 ([M + H]⁺⁾ 63 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3395, 2863, ([M + H]⁺) calcd 8.82 (s, 3H), 7.40-7.17 (m, 5H), 1740, 1508, for C₂₁H₂₇FNO₃, 7.12-6.99 (m, 2H), 6.99-6.83 (m, 1218, 1116, 360.1969; found, 2H), 5.24-5.04 (m, 1H), 4.51- 698 360.1970 4.28 (m, 2H), 4.31-4.11 (m, 1H), 3.33 (d, J = 5.0 Hz, 2H), 2.71- 2.51 (m, 2H), 2.17-1.98 (m, 1H), 1.67 (d, J = 7.0 Hz, 3H), 1.27 (d, J = 6.4 Hz, 3H). 64 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3403, 2976, ([M + H]⁺) calcd 8.66 (d, J = 5.4 Hz, 3H), 7.43- 1737, 1509, for C₂₃H₃₁FNO₃, 7.19 (m, 5H), 7.19-7.06 (m, 2H), 1218, 732 388.2282; found, 6.99-6.85 (m, 2H), 5.44 (qd, J = 388.2281 5.9, 5.4, 2.4 Hz, 1H), 4.41 (s, 2H), 4.02-3.88 (m, 1H), 3.00 (dd, J = 15.0, 5.2 Hz, 1H), 2.76 (dd, J = 15.0, 6.8 Hz, 1H), 2.28-2.19 (m, 1H), 1.36 (dd, J = 11.7, 6.9 Hz, 5H), 1.30 (s, 3H), 1.22 (s, 3H). 65 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3399, 2860, ([M + H]⁺) calcd 8.96-8.63 (m, 3H), 7.36-7.18 1739, 1116, for C₂₁H₂₈NO₃, (m, 7H), 7.18-7.03 (m, 3H), 735, 698 342.2064; found, 5.26-5.10 (m, 1H), 4.50-4.29 342.2063 (m, 2H), 4.20 (q, J = 6.6, 6.2 Hz, 1H), 3.35 (d, J = 5.2 Hz, 2H), 2.78-2.55 (m, 2H), 2.13 (dt, J = 8.7, 5.6 Hz, 1H), 1.65 (d, J = 7.1 Hz, 3H), 1.28 (d, J = 6.4 Hz, 3H). 66 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3400, 2975, ([M + H]⁺) calcd 8.58 (d, J = 5.5 Hz, 3H), 7.39- 1736, 1207, for C₂₃H₃₂NO₃, 7.14 (m, 9H), 7.14-7.05 (m, 1H), 1042, 734, 370.2377; found, 5.46 (qd, J = 6.3, 2.8 Hz, 1H), 697 370.2378 4.43 (s, 2H), 3.92-3.71 (m, 1H), 3.04 (dd, J = 14.9, 4.7 Hz, 1H), 2.80 (dd, J = 14.9, 7.3 Hz, 1H), 2.31 (ddd, J = 7.6, 4.7, 2.8 Hz, 1H), 1.37 (d, J = 6.5 Hz, 3H), 1.32 (s, 3H), 1.28 (d, J = 7.2 Hz, 3H), 1.25 (s, 3H). 67 (Thin film) HRMS-ESI m/z 3384, 2896, ([M + H]⁺) calcd 1737, 1508, for C₁₅H₂₃FNO₃, 1218, 1120 284.1656; found, 284.1659 68 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3400, 2976, ([M + Na]⁺) calcd 8.63 (d, J = 5.4 Hz, 3H), 7.26- 2941, 1737, for C₁₇H₂₆FNNaO₃, 7.06 (m, 2H), 7.04-6.82 (m, 2H), 1509, 1219 334.1789; found, 5.53-5.27 (m, 1H), 3.99 (t, J = 334.1795 6.6 Hz, 1H), 3.15 (s, 3H), 2.86 (dd, J = 14.9, 5.1 Hz, 1H), 2.70 (dd, J = 14.9, 7.0 Hz, 1H), 2.19 (ddt, J = 6.9, 5.0, 2.8 Hz, 1H), 1.39 (d, J = 7.2 Hz, 3H), 1.32 (d, J = 6.5 Hz, 3H), 1.18 (s, 3H), 1.14 (s, 3H). 69 ESIMS m/z 366.3 ([M + H]⁺⁾ 70 ESIMS m/z 312.4 ([M + H]⁺⁾ 71 ESIMS m/z 316.4 ([M + H]⁺⁾ 72 ESIMS m/z 348.4 ([M + H]⁺⁾ 73 ESIMS m/z 295.4 ([M + H]⁺⁾ 74 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 2868, 1740, ([M + H]⁺) calced 8.83 (s, 3H), 7.27-7.14 (m, 2H), 1509, 1220, for C₂₁H₂₆F₂NO₃, 7.11-7.03 (m, 2H), 7.03-6.96 (m, 1115, 824 378.1875; found, 2H), 6.96-6.88 (m, 2H), 5.23- 378.1872 5.08 (m, 1H), 4.48-4.27 (m, 2H), 4.22 (t, J = 6.5 Hz, 1H), 3.32 (d, J = 5.1 Hz, 2H), 2.72-2.51 (m, 2H), 2.16-1.99 (m, 1H), 1.69 (d, J = 7.1 Hz, 3H), 1.26 (d, J = 6.4 Hz, 3H). 75 (Thin film) HRMS-ESI m/z 3488, 3091, ([M + H]⁺) calcd 2981, 1742, for C₂₃H₃₀F₂NO₃, 1238, 1158, 406.2188; found, 1027 406.2196 76 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 2954, 2868, ([M + H]⁺) calced 8.83 (s, 3H), 7.20-7.03 (m, 2H), 1742, 1509, for C₁₉H₃₁FNO₃, 7.03-6.84 (m, 2H), 5.11 (dt, J = 1221, 1110 340.2282; found, 10.8, 5.4 Hz, 1H), 4.16 (s, 1H), 340.2294 3.42-3.19 (m, 4H), 2.63 (d, J = 7.5 Hz, 2H), 2.07 (ddd, J = 14.1, 11.2, 6.3 Hz, 1H), 1.72 (d, J = 7.0 Hz, 3H), 1.65 (dt, J = 13.4, 6.7 Hz, 1H), 1.48-1.33 (m, 2H), 1.28 (d, J = 6.4 Hz, 3H), 0.89 (d, J = 0.8 Hz, 3H), 0.87 (d, J = 0.7 Hz, 3H). 77 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 2953, 2867, ([M + H]⁺) calced 8.95-8.64 (m, 3H), 7.35-7.22 1741, 1238, for C₁₉H₃₂NO₃, (m, 2H), 7.22-7.07 (m, 3H), 5.14 1110, 700 322.2377; found, (qd, J = 6.4, 4.4 Hz, 1H), 4.17 322.2379 (d, J = 6.7 Hz, 1H), 3.42-3.19 (m, 4H), 2.75-2.52 (m, 2H), 2.18- 2.05 (m, 1H), 1.79-1.57 (m, 4H), 1.41 (qd, J = 6.7, 1.4 Hz, 2H), 1.29 (d, J = 6.5 Hz, 3H), 0.89 (d, J = 0.9 Hz, 3H), 0.87 (d, J = 0.9 Hz, 3H). 78 ESIMS m/z 424.4 ([M + H]⁺) 79 ESIMS m/z 262.4 ([M + H]⁺) 80 ESIMS m/z 352.5 ([M + H]⁺) 81 ESIMS m/z 442.7 ([M + H]⁺) 82 ESIMS m/z 312.5 ([M + H]⁺) 83 ESIMS m/z 340.5 ([M + H]⁺) 84 ESIMS m/z 326.5 ([M + H]⁺) 85 ESIMS m/z 348.5 ([M + H]⁺) 86 ESIMS m/z 348.5 ([M + H]⁺) 87 ESIMS m/z 364.6 ([M + H]⁺) 88 ESIMS m/z 422.6 ([M + H]⁺) 89 ESIMS m/z 293.5 ([M + H]⁺) 90 ESIMS m/z 236 ([M + H]⁺) 91 (Thin film) ESIMS m/z 473 ¹H NMR (400 MHz, CDCl₃) δ 3370, 2963, ([M + H]⁺) 12.17 (d, J = 0.6 Hz, 1H), 8.49 (d, 2935, 1733, J = 7.9 Hz, 1H), 7.99 (dd, J = 5.2, 1649, 1528 0.7 Hz, 1H), 7.31-7.22 (m, 2H), 7.23-7.12 (m, 3H), 6.87 (dd, J = 5.3, 1.6 Hz, 1H), 5.18-5.06 (m, 1H), 4.69-4.57 (m, 1H), 3.94 (s, 3H), 3.37-3.27 (m, 2H), 3.19 (ddd, J = 6.9, 5.8, 3.1 Hz, 1H), 2.82 (dd, J = 14.6, 5.9 Hz, 1H), 2.61 (dd, J = 14.6, 7.2 Hz, 1H), 2.22-2.11 (m, 1H), 1.62-1.51 (m, 4H), 1.48 (d, J = 7.1 Hz, 3H), 1.26 (d, J = 6.3 Hz, 3H), 0.91 (t, J = 7.2 Hz, 3H), 0.85 (t, J = 7.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.44, 168.69, 155.37, 148.76, 141.50, 140.47, 130.50, 128.89, 128.33, 125.82, 109.44, 80.79, 73.50, 71.67, 56.07, 48.19, 47.00, 32.06, 24.68, 23.42, 18.30, 17.90, 10.82, 10.56. 92 (Thin film) ESIMS m/z 473 ¹H NMR (400 MHz, CDCl₃) δ 3368, 2963, ([M + H]⁺) 12.16 (d, J = 0.6 Hz, 1H), 8.51 (d, 2936, 1735, J = 7.9 Hz, 1H), 7.98 (d, J = 5.2 1650, 1530 Hz, 1H), 7.31-7.23 (m, 2H), 7.22- 7.07 (m, 3H), 6.86 (dd, J = 5.3, 0.6 Hz, 1H), 5.22 (qd, J = 6.5, 4.1 Hz, 1H), 4.77-4.63 (m, 1H), 3.93 (s, 3H), 3.40 (dt, J = 8.8, 6.4 Hz, 1H), 3.30 (dt, J = 8.8, 6.5 Hz, 1H), 3.17 (td, J = 6.5, 3.8 Hz, 1H), 2.83 (dd, J = 13.8, 7.4 Hz, 1H), 2.64 (dd, J = 13.7, 6.6 Hz, 1H), 2.20-2.12 (m, 1H), 1.64- 1.49 (m, 4H), 1.56 (d, J = 7.2 Hz, 3H), 1.30 (d, J = 6.5 Hz, 3H), 0.96 (t, J = 7.4 Hz, 3H), 0.82 (t, J = 7.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.42, 168.75, 155.38, 148.77, 141.13, 140.48, 130.46, 129.01, 128.35, 125.87, 109.45, 79.84, 72.33, 71.47, 56.07, 48.17, 46.78, 31.65, 23.89, 23.53, 18.40, 17.41, 11.01, 10.18. 93 (Thin film) ESIMS m/z 445 ¹H NMR (400 MHz, CDCl₃) δ 3370, 2963, ([M + H]⁺) 12.17 (d, J = 0.6 Hz, 1H), 8.52 (d, 2936, 1735, J = 7.9 Hz, 1H), 7.99 (d, J = 5.2 1649, 1528 Hz, 1H), 7.32-7.22 (m, 2H), 7.22-7.16 (m, 1H), 7.16-7.12 (m, 2H), 6.90-6.84 (m, 1H), 5.16 (qd, J = 6.4, 4.7 Hz, 1H), 4.78- 4.64 (m, 1H), 3.94 (s, 3H), 3.32 (dd, J = 5.4, 2.2 Hz, 2H), 3.27 (td, J = 6.6, 2.1 Hz, 2H), 2.71- 2.62 (m, 2H), 2.11 (ddt, J = 12.5, 7.0, 5.3 Hz, 1H), 1.56 (d, J = 7.2 Hz, 3H), 1.55-1.50 (m, 2H), 1.32 (d, J = 6.5 Hz, 3H), 0.91 (t, J = 7.4 Hz, 3H). 94 (Thin film) ESIMS m/z 473 ¹H NMR (400 MHz, CDCl₃) δ 3372, 2964, ([M + H]⁺) 12.21 (s, 1H), 8.42 (d, J = 7.8 Hz, 2937, 1736, 1H), 8.00 (d, J = 5.2 Hz, 1H), 1651 7.26 (s, 2H), 7.22-7.14 (m, 3H), 6.87 (d, J = 5.3 Hz, 1H), 5.18- 5.07 (m, 1H), 4.57-4.46 (m, 1H), 3.95 (s, 3H) 3.41-3.26 (m, 2H), 3.20 (td, J = 6.3, 3.5 Hz, 1H), 2.84 (dd, J = 14.6, 5.7 Hz, 1H), 2.63 (dd, J = 14.6, 7.5 Hz, 1H), 2.27- 2.18 (m, 1H), 1.63-1.45 (m, 4H), 1.43 (d, J = 7.2 Hz, 3H), 1.25 (d, J = 6.5 Hz, 3H), 0.94-0.85 (m, 6H). 95 (Thin film) ESIMS m/z 487 ¹H NMR (400 MHz, CDCl₃) δ 2965, 2936, ([M + H]⁺) 12.19 (d, J = 0.6 Hz, 1H), 8.47 (d, 1733, 1650, J = 8.6 Hz, 1H), 7.99 (d, J = 5.2 1527 Hz, 1H), 7.28-7.20 (m, 2H), 7.21- 7.13 (m, 3H), 6.87 (d, J = 5.2 Hz, 1H), 5.19-5.09 (m, 1H), 4.59 (ddd, J = 8.5, 7.3, 5.0 Hz, 1H), 3.95 (d, J = 1.1 Hz, 3H), 3.40- 3.28 (m, 2H), 3.19 (dtd, J = 9.9, 6.4, 3.3 Hz, 1H), 2.81 (dd, J = 14.2, 6.1 Hz, 1H), 2.61 (dd, J = 14.5, 7.1 Hz, 1H), 2.18-2.10 (m, 1H), 2.02-1.87 (m, 1H), 1.85- 1.70 (m, 1H), 1.59-1.44 (m, 4H), 1.26 (d, J = 6.5 Hz, 3H), 0.99 (t, J = 7.4 Hz, 3H), 0.91 (t, J = 7.5 Hz, 3H), 0.84 (t, J = 7.4 Hz, 3H). 96 (Thin film) ESIMS m/z 473 ¹H NMR (400 MHz, CDCl₃) δ 3369, 2962, ([M + H]⁺) 12.19 (d, J = 0.7 Hz, 1H), 8.47 (d, 2936, 1735, J = 7.8 Hz, 1H), 7.99 (d, J = 5.2 1650, 1528 Hz, 1H), 7.30-7.23 (m, 2H), 7.20- 7.13 (m, 3H), 6.87 (d, J = 5.2 Hz, 1H), 5.26-5.18 (m, 1H), 4.66- 4.57 (m, 1H), 3.95 (s, 3H), 3.42 (dt, J = 8.8, 6.4 Hz, 1H), 3.30 (dt, J = 8.8, 6.5 Hz, 1H), 3.21-3.14 (m, 1H), 2.81 (dd, J = 13.8, 7.3 Hz, 1H), 2.68 (dd, J = 13.8, 6.9 Hz, 1H), 2.20 (ddd, J = 10.8, 7.0, 3.8 Hz, 1H), 1.65-1.55 (m, 4H), 1.51 (d, J = 7.2 Hz, 3H), 1.29 (d, J = 6.5 Hz, 3H), 0.96 (t, J = 7.4 Hz, 3H), 0.82 (t, J = 7.4 Hz, 3H). 97 (Thin film) ESIMS m/z 445 ¹H NMR (400 MHz, CDCl₃) δ 3370, 2963, ([M + H]⁺) 12.19 (d, J = 0.6 Hz, 1H), 8.48 (d, 2937, 1736, J = 7.9 Hz, 1H), 7.99 (d, J = 5.2 1649, 1528 Hz, 1H), 7.29-7.24 (m, 2H), 7.22- 7.13 (m, 3H), 6.87 (d, J = 5.2 Hz, 1H), 5.20-5.12 (m, 1H), 4.70- 4.61 (m, 1H), 3.95 (s, 3H), 3.37- 3.31 (m, 2H), 3.31-3.23 (m, 2H), 2.68 (dd, J = 11.4, 7.3 Hz, 2H), 2.15 (dq, J = 14.1, 5.7 Hz, 1H), 1.59-1.54 (m, 2H), 1.53 (d, J = 7.2 Hz, 3H), 1.31 (d, J = 6.4 Hz, 3H), 0.89 (t, J = 7.4 Hz, 3H). 98 (Thin film) ESIMS m/z 459 ¹H NMR (400 MHz, CDCl₃) δ 3370, 2968, ([M + H]⁺) 12.18 (d, J = 0.6 Hz, 1H), 8.52 (d, 2936, 1734, J = 8.6 Hz, 1H), 7.99 (d, J = 5.2 1650, 1527 Hz, 1H), 7.31-7.23 (m, 2H), 7.23- 7.16 (m, 1H), 7.16-7.11 (m, 2H), 6.87 (dd, J = 5.3, 0.6 Hz, 1H), 5.23-5.13 (m, 1H), 4.72-4.63 (m, 1H), 3.95 (s, 3H), 3.34-3.29 (m, 2H), 3.26 (tt, J = 6.6, 3.1 Hz, 2H), 2.67 (dd, J = 7.4, 2.8 Hz, 2H), 2.16-1.98 (m, 2H), 1.88 (dp, J = 14.6, 7.4 Hz, 1H), 1.60-1.48 (m, 2H), 1.32 (d, J = 6.5 Hz, 3H), 1.04 (t, J = 7.5 Hz, 3H), 0.90 (t, J = 7.4 Hz, 3H). 99 (Thin film) ESIMS m/z 459 ¹H NMR (400 MHz, CDCl₃) δ 3365, 2969, ([M + H]⁺) 12.28 (d, J = 0.6 Hz, 1H), 8.56 2937, 1734, (s, 1H), 7.97 (d, J = 5.2 Hz, 1H), 1651, 1527 7.30-7.20 (m, 2H), 7.20-7.16 (m, 1H), 7.16-7.11 (m, 2H), 6.86 (d, J = 5.2 Hz, 1H), 5.21-5.09 (m, 1H), 3.94 (s, 3H), 3.36-3.17 (m, 4H), 2.70-2.61 (m, 2H), 2.10 (q, J = 6.5 Hz, 1H), 1.69 (d, J = 3.8 Hz, 6H), 1.60-1.46 (m, 2H), 1.29 (d, J = 6.5 Hz, 3H), 0.89 (t, J = 7.4 Hz, 3H). 100 (Thin film) ESIMS m/z 487 ¹H NMR (400 MHz, CDCl₃) δ 3365, 2962, ([M + H]⁺) 12.29 (d, J = 0.6 Hz, 1H), 8.48 2936, 1734, (s, 1H), 7.98 (d, J = 5.2 Hz, 1H), 1652, 1527 7.22 (s, 2H), 7.17-7.12 (m, 3H), 6.87 (d, J = 5.2 Hz, 1H), 5.19- 5.08 (m, 1H), 3.94 (s, 3H), 3.31 (td, J = 6.6, 3.7 Hz, 2H), 3.17 (td, J = 6.4, 3.3 Hz, 1H), 2.79 (dd, J = 14.5, 5.9 Hz, 1H), 2.59 (dd, J = 14.5, 7.3 Hz, 1H), 2.20-2.10 (m, 1H), 1.61 (d, J = 6.7 Hz, 6H), 1.23 (d, J = 6.4 Hz, 3H), 0.89 (t, J = 7.4 Hz, 3H), 0.82 (t, J = 7.4 Hz, 3H), 1.60-1.35 (m, 4H). 101 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 12.19 (s, 1H), 8.50 (d, J = 7.8 for C₂₉H₄₃N₂O₅, Hz, 1H), 7.98 (d, J = 5.2 Hz, 1H), 499.3172; found, 7.34-7.22 (m, 2H), 7.22-7.09 (m, 499.3173. 3H), 6.85 (d, J = 5.1 Hz, 1H), 5.18-5.03 (m, 1H), 4.74-4.58 (m, 1H), 3.93 (s, 3H), 2.65-2.49 (m, 2H), 1.72-1.43 (m, 8H), 1.41-1.23 (m, 3H), 1.23 (d, J = 6.4 Hz, 3H), 1.18-0.99 (m, 3H), 0.90-0.78 (m, 9H). ¹³C NMR (101 MHz, CDCl₃) δ 171.69, 168.67, 155.36, 148.76, 142.64, 140.47, 130.51, 128.34, 128.27, 125.67, 125.66, 109.45, 74.04, 56.06, 48.20, 41.06, 40.19, 36.31, 35.70, 30.31, 30.10, 26.08, 24.04, 23.46, 22.31, 18.40, 17.92, 12.49. 102 (Thin film) ESIMS m/z 469 ¹H NMR (400 MHz, CDCl₃) δ 3373, 2957, ([M + H]⁺) 12.16 (d, J = 0.6 Hz, 1H), 8.50 (d, 2934, 1734, J = 7.8 Hz, 1H), 7.99 (d, J = 5.3 1650, 1528 Hz, 1H), 7.32-7.22 (m, 2H), 7.21- 7.10 (m, 3H), 6.87 (d, J = 5.2 Hz, 1H), 5.10-5.00 (m, 1H), 4.72-4.60 (m, 1H), 3.94 (s, 3H), 2.63 (dd, J = 14.2, 5.5 Hz, 1H), 2.49 (dd, J = 14.2, 8.3 Hz, 1H), 2.13-2.03 (m, 1H), 1.68-1.59 (m, 1H), 1.56 (d, J = 7.2 Hz, 3H), 1.54-1.47 (m, 1H), 1.46-1.24 (m, 2H), 1.20 (d, J = 6.4 Hz, 3H), 1.18-1.11 (m, 1H), 0.93 (t, J = 7.4 Hz, 2H), 0.89- 0.77 (m, 2H), 0.69-0.55 (m, 1H), 0.45-0.30 (m, 2H), −0.01-−0.12 (m, 1H). 103 (Thin film) ESIMS m/z 523 ¹H NMR (400 MHz, CDCl₃) δ 3370, 2935, ([M + H]⁺) 12.11 (d, J = 0.6 Hz, 1H), 8.46 1733, 1649, (d, J = 7.9 Hz, 1H), 7.81 (d, J = 1529 5.2 Hz, 1H), 7.25-7.17 (m, 2H), 7.17-7.10 (m, 1H), 7.06-6.90 (m, 6H), 6.75 (d, J = 5.2 Hz, 1H), 5.12 (qd, J = 6.4, 4.4 Hz, 1H), 4.80-4.69 (m, 1H), 3.95-3.92 (m, 1H), 3.91 (s, 3H), 2.88 (dd, J = 13.5, 4.9 Hz, 1H), 2.66 (dd, J = 14.1, 5.7 Hz, 1H), 2.55 (dd, J = 14.1, 8.8 Hz, 1H), 2.24 (dd, J = 13.5, 9.8 Hz, 1H), 2.01-1.87 (m, 2H), 1.85-1.74 (m, 1H), 1.58 (d, J = 7.2 Hz, 3H), 1.27 (d, J = 6.4 Hz, 3H), 0.83 (t, J = 7.4 Hz, 3H). 104 (Thin film) ESIMS m/z 431 ¹H NMR (400 MHz, CDCl₃) δ 3372, 2936, ([M + H]⁺) 12.08 (s, 1H), 8.47 (s, 1H), 7.99 1739, 1650, (d, J = 5.3 Hz, 1H), 7.30-7.24 1533 (m, 2H), 7.22-7.18 (m, 1H), 7.18- 7.13 (m, 2H), 6.87 (d, J = 5.2 Hz, 1H) 5.19 (qd, J = 6.5, 4.6 Hz 1H), 4.23-4.05 (m, 2H), 3.94 (s, 3H), 3.39-3.21 (m, 4H), 2.67 (dd, J = 11.6, 7.3 Hz, 2H), 2.22- 2.11 (m, 1H), 1.55 (dtd, J = 13.9, 7.4, 6.5 Hz, 2H), 1.32 (d, J = 6.4 Hz, 3H), 0.90 (t, J = 7.4 Hz, 3H). 105 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 12.15 (s, 1H), 8.43 (d, J = 7.8 Hz, for C₃₁H₃₈FN₂O₇, 1H), 7.97 (d, J = 5.2 Hz, 1H), 569.2658; found, 7.18 (dd, J = 8.5, 5.5 Hz, 2H), 569.2662 7.06-7.02 (m, 2H), 6.97 (t, J = 8.7 Hz, 2H), 6.86 (d, J = 5.2 Hz, 1H), 6.77 (d, J = 8.6 Hz, 2H), 5.13 (qd, J = 6.4, 4.5 Hz, 1H), 4.60-4.47 (m, 2H), 3.93 (s, 3H), 3.56 (dd, J = 10.0, 5.3 Hz, 1H), 3.47-3.36 (m, 2H), 3.32 (dt, J = 9.4, 7.0 Hz, 1H), 2.98 (dd, J = 14.5, 6.3 Hz, 1H), 2.70 (dd, J = 14.5, 7.1 Hz, 1H), 2.44-2.34 (m, 1H), 2.27 (s, 3H), 1.42 (d, J = 7.2 Hz, 3H), 1.30 (d, J = 6.4 Hz, 3H), 1.13 (t, J = 7.0 Hz, 3H). 106 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3383, 2935, ([M + H]⁺) calcd 12.13 (d, J = 0.6 Hz, 1H), 8.77 (d, 1739, 1650, for C₂₅H₃₄N₂O₇, J = 8.5 Hz, 1H), 8.01 (d, J = 5.2 1527 475.2439; found, Hz, 1H), 7.30-7.24 (m, 2H), 7.22- 475.2441. 7.13 (m, 3H), 6.87 (d, J = 5.2 Hz, 1H), 5.22-5.13 (m, 1H), 4.85 (dt, J = 8.6, 3.3 Hz, 1H), 3.96 (dd, J = 9.5, 3.4 Hz, 1H), 3.93 (s, 3H), 3.74 (dd, J = 9.5, 3.3 Hz, 1H), 3.40 (d, J = 1.0 Hz, 3H), 3.39- 3.22 (m, 4H), 2.73-2.59 (m, 2H), 2.15-2.07 (m, 1H), 1.61-1.47 (m, 2H), 1.31 (d, J = 6.6 Hz, 3H), 0.91 (t, J = 7.4 Hz, 3H). 107 ESIMS m/z 619 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 12.07 (s, 1H), 8.76 (d, J = 8.7 Hz, 1H), 7.88 (d, J = 5.1 Hz, 1H), 7.39 (d, J = 8.0 Hz, 2H), 7.00 (dd, J = 8.4, 5.0 Hz, 4H), 6.91 (t, J = 8.7 Hz, 2H), 6.74 (d, J = 5.1 Hz, 1H), 5.71 (ddd, J = 17.6, 10.1, 8.0 Hz, 1H), 5.18 (m, 1H), 5.01 (dd, J = 10.3, 1.4 Hz, 1H), 4.92-4.79 (m, 2H), 4.01 (dd, J = 9.4, 3.3 Hz, 1H), 3.89 (s, 3H), 3.72 (dd, J = 9.4, 3.4 Hz, 1H), 3.38 (s, 3H), 2.91 (q, J = 9.9 Hz, 1H), 2.75- 2.56 (m, 2H), 2.47 (m, 2H), 1.98 (m, 1H), 1.31 (d, J = 6.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 169.14, 169.04, 161.33 (d, J = 243 Hz), 155.27, 148.74, 144.6, 140.62, 138.73, 135.87 (d, J = 3 Hz), 130.29 (d, J = 7 Hz), 129.39, 127.93 (q, J = 32 Hz), 124.81 (q, J = 4 Hz), 124.36 (q, J = 270 Hz), 116.99, 115.18, (d, J = 21 Hz), 109.38, 72.90, 72.09, 59.38, 55.98, 52.57, 48.35, 45.16, 37.64, 32.39, 17.74. 108 ESIMS m/z 589 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 12.09 (s, 1H), 8.43 (d, J = 7.9 Hz, 1H), 7.87 (d, J = 5.1 Hz, 1H), 7.39 (d, J = 7.9 Hz, 2H), 7.04- 6.96 (m, 4H), 6.91 (t, J = 8.7 Hz, 2H), 6.77 (d, J = 5.1 Hz, 1H), 5.69 (ddd, J = 17.2, 10.3, 8.5 Hz, 1H), 5.17 (m, 1H), 5.03 (dd, J = 10.3, 1.3 Hz, 1H), 4.84 (d, J = 20 Hz, 1H), 4.73 (m, 1H), 3.91 (s, 3H), 2.90 (dd, J = 13.1, 5.1 Hz, 1H), 2.72 (dd, J = 14.1, 6.3 Hz, 1H), 2.60 (dd, J = 14.1, 7.8 Hz, 1H), 2.56-2.48 (m, 1H), 2.46 (m, 1H), 1.97 (m, 1H), 1.56 (d, J = 7.3 Hz, 3H), 1.31 (d, J = 6.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.33, 168.83, 161.34 (d, J = 243 Hz), 155.36, 148.76, 144.44, 140.49, 138.45, 135.83 (d, J = 3 Hz), 130.23, 130.22 (d, J = 7 Hz), 129.32, 127.93 (q, J = 32 Hz), 124.81 (q, J = 4 Hz), 124.36 (q, J = 270 Hz), 116.99, 115.18, (d, J = 21 Hz), 109.40, 72.63, 56.02, 48.13, 45.33, 37.96, 32.69, 18.10, 17.63. 109 ESIMS m/z 575 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 12.02 (bs, 1H), 8.48 (t, J = 5.7 Hz, 1H), 7.91 (d, J = 5.3 Hz, 1H), 7.41 (d, J = 8.0 Hz, 2H), 7.00 (bdd, J = 8.0, 6.4 Hz, 4H), 6.92 (m, 2H), 6.81 (d, J = 5.1 Hz, 1H), 5.69 (ddd, J = 17.1, 10.2, 8.7 Hz, 1H), 5.17 (m, 1H), 5.04 (dd, J = 10.3, 1.3 Hz, 1H), 4.85 (dd, J = 17.1, 0.9 Hz, 1H), 4.24 (dd, J = 18.1, 6.1 Hz, 1H), 4.13 (dd, J = 18.1, 5.8 Hz, 1H), 3.92 (s, 3H), 2.93 (dd, J = 13.4, 5.5 Hz, 1H), 2.73 (dd, J = 14.1, 6.3 Hz, 1H), 2.65-2.52 (m, 2H), 2.43 (m, 1H), 2.02 (m, 1H), 1.31 (d, J = 6.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 169.47, 168.34, 161.33 (d, J = 244.3 Hz), 155.37, 148.71, 144.40, 140.61, 138.31, 135.87 (d, J = 3.3 Hz), 130.25 (d, J = 8.0 Hz), 130.23, 129.36, 128.09 (q, J = 32.3 Hz), 124.91 (q, J = 3.8 Hz), 124.32 (q, J = 270 Hz), 117.25, 115.24 (d, J = 21.1 Hz), 109.50, 73.07, 56.05, 47.81, 45.56, 41.22, 38.27, 32.92, 17.58. 110 ESIMS m/z 621 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 12.06 (s, 1H), 8.74 (d, J = 8.7 Hz, 1H), 7.77 (d, J = 5.1 Hz, 1H), 7.41 (d, J = 8.0 Hz, 2H), 7.10- 7.01 (m, 4H), 6.99-6.90 (m, 2H), 6.65 (d, J = 5.1 Hz, 1H), 5.16- 5.09 (m, 1H), 4.86 (dt, J = 8.7, 3.1 Hz, 1H), 4.05 (dd, J = 9.4, 3.0 Hz, 1H), 3.87 (s, 3H), 3.73 (dd, J = 9.4, 3.1 Hz, 1H), 3.39 (s, 3H), 2.94 (dd, J = 13.4, 4.1 Hz, 1H), 2.64 (dd, J = 13.9, 5.0 Hz, 1H), 2.54 (dd, J = 13.9, 9.5 Hz, 1H), 2.19 (dd, J = 13.3, 10.3 Hz, 1H), 1.93-1.74 (m, 2H), 1.28 (d, J = 6.4 Hz, 3H), 1.28-1.23 (m, 2H), 0.81 (t, J = 7.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 168.92, 168.1, 161.38 (d, J = 242 Hz), 156.68, 149.25, 145.8, 139.52, 136.14 (d, J = 3 Hz), 130.49, 130.39 (d, J = 8 Hz), 129.42, 127.83 (q, J = 31 Hz), 124.87 (q, J = 3 Hz), 124.39 (q, J = 270 Hz), 115.25, (d, J = 21 Hz), 109.24, 73.10, 71.75, 59.38, 56.63, 53.04, 45.51, 40.76, 37.32, 31.41, 23.25, 18.44, 12.38. 111 ESIMS m/z 577 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 11.99 (d, J = 0.6 Hz, 1H), 8.49 (t, J = 5.9 Hz, 1H), 7.82 (d, J = 5.3 Hz, 1H), 7.41 (d, J = 7.9 Hz, 2H), 7.08-6.98 (m, 4H), 6.97-6.91 (m, 2H), 6.73 (d, J = 5.3 Hz, 1H), 5.18-5.10 (m, 1H), 4.30 (dd, J = 18.0, 6.3 Hz, 1H), 4.17 (dd, J = 18.0, 5.8 Hz, 1H), 3.90 (s, 3H), 2.92 (dd, J = 13.4, 5.0 Hz, 1H), 2.64 (dd, J = 13.9, 5.8 Hz, 1H), 2.56 (dd, J = 14.0, 8.7 Hz, 1H), 2.33 (dd, J = 13.4, 9.7 Hz, 1H), 1.90 (m, 1H), 1.79 (m, 1H), 1.37- 1.22 (m, 2H), 1.29 (d, J = 6.4 Hz, 3H), 0.85 (t, J = 7.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 169.51, 168.40, 161.37 (d, J = 243 Hz), 155.28, 148.64, 145.67, 140.54, 136.05 (d, J = 3 Hz), 130.29 (d, J = 8.0 Hz), 130.13, 129.26, 127.93 (q, J = 32 Hz), 124.93 (q, J = 4 Hz), 124.36 (q, J = 270 Hz), 115.27 (d, J = 21 Hz), 109.40, 73.08, 55.99, 45.36, 41.27, 41.00, 37.50, 31.99, 23.17, 18.51, 12.35. 112 IR (neat) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3371, 2936, [M]+ calcd for 12.10 (s, 1H), 8.44 (d, J = 7.8 Hz, 1734, 1650, C₃₁H₃₅F₃N₂O₆, 1H), 7.82 (d, J = 5.2 Hz, 1H), 1529, 1259 588.2447; found, 7.22-7.14 (m, 3H), 7.11-7.04 588.2454. (m, 4H), 6.99-6.95 (m, 2H), 6.75 (d, J = 5.1 Hz, 1H), 5.17-5.09 (m, 1H), 4.78-4.67 (m, 1H), 3.92 (s, 3H), 2.85 (dd, J = 13.5, 5.2 Hz, 1H), 2.71-2.55 (m, 2H), 2.26 (dd, J = 13.5, 9.5 Hz, 1H), 1.98- 1.90 (m, 1H), 1.83-1.72 (m, 1H), 1.57 (d, J = 7.2 Hz, 3H), 1.36- 1.27 (m, 2H), 1.29 (d, J = 6.3 Hz, 3H), 0.84 (t, J = 7.4 Hz, 3H) 113 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 12.17 (s, 1H), 8.53 (d, J = 7.9 Hz, for C₂₃H₃₁N₂O₅, 1H), 7.99 (d, J = 5.2 Hz, 1H), 415.2233; found, 7.33-7.23 (m, 2H), 7.23-7.15 415.2233. (m, 1H), 7.15-7.04 (m, 2H), 6.87 (d, J = 5.2 Hz, 1H), 5.06 (qd, J = 6.4, 3.7 Hz, 1H), 4.83-4.60 (m, 1H), 3.94 (s, 3H), 2.67 (dd, J = 13.6, 6.5 Hz, 1H), 2.50 (dd, J = 13.6, 7.8 Hz, 1H), 1.94-1.79 (m, 1H), 1.57 (d, J = 7.2 Hz, 3H), 1.38-1.28 (m, 4H), 1.24 (d, J = 6.5 Hz, 3H), 0.90-0.80 (m, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.59, 168.75, 155.38, 148.77, 140.67, 140.49, 130.51, 129.08, 128.34, 125.94, 109.44, 73.46, 56.08, 48.19, 44.50, 36.24, 31.50, 20.27, 18.50, 16.19, 14.25. 114 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 12.12 (d, J = 0.6 Hz, 1H), 8.48 (d, for C₂₂H₂₇N₂O₇, J = 7.9 Hz, 1H), 7.99 (d, J = 5.2 431.1818; found, Hz, 1H), 7.30-7.23 (m, 2H), 7.23- 431.1814. 7.18 (m, 1H), 7.16-7.11 (m, 2H), 6.87 (dd, J = 5.2, 0.7 Hz, 1H), 5.43-5.11 (m, 1H), 4.85-4.55 (m, 1H), 3.94 (s, 3H), 3.54 (s, 3H), 2.97-2.81 (m, 3H), 1.52 (d, J = 7.2 Hz, 3H), 1.38 (d, J = 6.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.43, 171.25, 168.76, 155.37, 148.76, 140.51, 138.17, 130.44, 128.76, 128.54, 126.65, 109.48, 72.19, 56.08, 52.97, 51.65, 47.96, 34.29, 18.25, 17.85. 115 (Thin film) ESIMS m/z 473 ¹H NMR (400 MHz, CDCl₃) δ 3372, 2958, ([M + H]⁺) 12.17 (d, J = 0.6 Hz, 1H), 8.44 (d, 1734, 1650, J = 8.0 Hz, 1H), 7.98 (d, J = 5.3 1528 Hz, 1H), 7.28-7.20 (m, 2H), 6.94- 6.81 (m, 4H), 5.17-5.08 (m, 1H), 4.65-4.54 (m, 1H), 4.29 (td, J = 6.5, 3.1 Hz, 1H), 3.94 (s, 3H), 1.91-1.84 (m, 1H), 1.77 (ddd, J = 14.1, 7.5, 6.5 Hz, 1H), 1.71-1.61 (m, 1H), 1.60-1.50 (m, 1H), 1.43 (d, J = 7.2 Hz, 3H), 1.42-1.36 (m, 1H), 1.36-1.32 (m, 1H), 1.31 (d, J = 6.4 Hz, 6H), 0.94 (t, J = 7.4 Hz, 3H), 0.90 (t, J = 7.1 Hz, 3H). 116 (Thin film) ESIMS m/z 473 ¹H NMR (400 MHz, CDCl₃) δ 3371, 2936, ([M + H]⁺) 12.14 (d, J = 0.6 Hz, 1H), 8.49 1734, 1650, (d, J = 7.8 Hz, 1H), 7.99 (d, J = 1528 5.2 Hz, 1H), 7.29-7.20 (m, 2H), 6.95-6.84 (m, 4H), 5.32-5.20 (m, 1H), 4.79-4.64 (m, 1H), 4.36- 4.27 (m, 1H), 3.95 (s, 3H), 2.02- 1.95 (m, 1H), 1.76-1.65 (m, 2H), 1.56 (d, J = 7.1 Hz, 3H), 1.53- 1.45 (m, 1H), 1.34 (d, J = 6.5 Hz, 3H), 1.34-1.16 (m, 5H), 0.95 (t, J = 7.4 Hz, 3H), 0.83 (t, J = 7.1 Hz, 3H). 117 (Thin film) ESIMS m/z 507 ¹H NMR (400 MHz, CDCl₃) δ 3371, 2936, ([M + H]⁺) 12.17 (d, J = 0.6 Hz, 1H), 8.45 1734, 1649, (d, J = 7.9 Hz, 1H), 7.97 (d, J = 1529 5.2 Hz, 1H), 7.34-7.26 (m, 2H), 7.24-7.16 (m, 5H), 6.93-6.84 (m, 2H), 6.76-6.68 (m, 2H), 5.12 (qd, J = 6.4, 4.9 Hz, 1H), 4.62- 4.51 (m, 1H), 4.29 (td, J = 7.0, 2.6 Hz, 1H), 3.93 (s, 3H), 2.89 (dd, J = 14.4, 6.7 Hz, 1H), 2.75 (dd, J = 14.4, 6.9 Hz, 1H), 2.30 (tdd, J = 7.0, 4.9, 2.6 Hz, 1H), 1.83-1.59 (m, 2H), 1.42 (d, J = 7.2 Hz, 3H), 1.31 (d, J = 6.5 Hz, 3H), 0.90 (t, J = 7.3 Hz, 3H). 118 (Thin film) ESIMS m/z 507 ¹H NMR (400 MHz, CDCl₃) δ 3371, 2938, ([M + H]⁺) 12.14 (d, J = 0.6 Hz, 1H), 8.51 1734, 1649, (d, J = 7.9 Hz, 1H), 7.99 (d, J = 1529 5.1 Hz, 1H), 7.28-7.23 (m, 2H), 7.23-7.11 (m, 3H), 7.01-6.90 (m, 3H), 6.90-6.79 (m, 3H), 5.29 (qd J = 6.5, 4.1 Hz, 1H), 4.80- 4.68 (m, 1H), 4.25 (td, J = 6.6, 3.5 Hz, 1H), 3.94 (s, 3H), 2.88 (dd, J = 13.8, 7.7 Hz, 1H), 2.70 (dd, J = 13.8, 6.6 Hz, 1H), 2.36- 2.25 (m, 1H), 1.77-1.66 (m, 2H), 1.60 (d, J = 7.2 Hz, 3H), 1.38 (d, J = 6.5 Hz, 3H), 0.86 (t, J = 7.5 Hz, 3H). 119 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 12.16 (s, 1H), 8.45 (d, J = 8.0 for C₂₆H₂₉N₂O₅, Hz, 1H), 7.99 (d, J = 5.2 Hz, 1H), 449.2076; found, 7.23-6.93 (m, 10H), 6.86 (d, J = 449.2070 5.3 Hz, 1H), 5.31-5.20 (m, 1H), 4.71-4.55 (m, 1H), 3.92 (s, 3H), 3.10-2.97 (m, 2H), 2.94-2.84 (m, 1H), 1.31 (d, J = 7.2 Hz, 3H), 1.24 (d, J = 6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.47, 168.71, 155.41, 148.81, 140.50, 140.19, 139.49, 130.47, 129.00, 128.91, 128.23, 128.13, 126.72, 126.08, 109.50, 73.90, 56.08, 53.09, 48.07, 38.45, 18.43, 18.04. 120 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 12.14 (s, 1H), 8.39 (d, J = 8.1 for C₂₃H₃₁N₂O₅, Hz, 1H), 7.98 (d, J = 5.2 Hz, 1H), 415.2233; found, 7.26-7.13 (m, 5H), 6.86 (d, J = 415.2231. 5.2 Hz, 1H), 5.32-5.10 (m, 1H), 4.63-4.45 (m, 1H), 3.93 (s, 3H), 2.71 (ddd, J = 10.3, 7.1, 4.7 Hz, 1H), 1.74-1.55 (m, 2H), 1.34-1.26 (m, 2H), 1.24 (d, J = 6.3 Hz, 3H), 1.17 (d, J = 7.2 Hz, 3H), 1.14- 1.03 (m, 2H), 0.80 (t, J = 7.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.56, 168.57, 155.36, 148.74, 141.19, 140.42, 130.50, 128.58, 128.19, 126.53, 109.40, 75.09, 56.06, 51.17, 47.97, 31.44, 29.46, 22.62, 18.38, 17.91, 13.89. 121 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 12.13 (s, 1H), 8.42 (d, J = 8.0 for C₂₆H₂₈ClN₂O₅, Hz, 1H), 8.01 (d, J = 5.2 Hz, 483.1686; found, 1H), 7.20-7.04 (m, 7H), 6.95- 483.1691. 6.81 (m, 3H), 5.34-5.17 (m, 1H), 4.71-4.59 (m, 1H), 3.94 (s, 3H), 3.06-2.92 (m, 2H), 2.86 (dd, J = 12.4, 8.6 Hz, 1H), 1.30 (d, J = 7.2 Hz, 3H), 1.25 (d, J = 6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.44, 168.72, 155.42, 148.81, 140.50, 139.66, 137.92, 131.83, 130.44, 130.30, 128.85, 128.32, 128.20, 126.86, 109.49, 73.85, 56.10, 53.07, 48.06, 37.78, 18.41, 17.97. 122 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 12.17 (s, 1H), 8.52 (d, J = 7.8 for C₂₃H₃₁N₂O₅, Hz, 1H), 7.97 (d, J = 5.2 Hz, 415.2233; found, 1H), 7.34-7.21 (m, 2H), 7.21- 415.2232 7.06 (m, 3H), 6.86 (d, J = 5.3 Hz, 1H), 5.05 (qd, J = 6.4, 4.4 Hz, 1H), 4.74-4.57 (m, 1H), 3.93 (s, 3H), 2.67 (dd, J = 14.2, 5.4 Hz, 1H), 2.53 (dd, J = 14.2, 8.1 Hz, 1H), 2.03-1.90 (m, 1H), 1.85-1.75 (m, 1H), 1.53 (d, J = 7.2 Hz, 3H), 1.22 (d, J = 6.4 Hz, 3H), 1.00 (d, J = 6.9 Hz, 3H), 0.92 (d, J = 6.9 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.52, 168.74, 155.37, 148.76, 141.49, 140.47, 130.47, 128.91, 128.35, 125.83, 109.45, 73.32, 56.05, 50.32, 48.20, 32.31, 27.41, 21.41, 19.12, 18.32, 17.58. 123 ¹H NMR (400 MHz, CDCl₃) δ 12.14 (s, 1H), 8.40 (d, J = 8.0 Hz, 1H), 7.99 (d, J = 5.2 Hz, 1H), 7.26-7.14 (m, 5H), 6.86 (d, J = 5.2 Hz, 1H), 5.35-5.10 (m, 1H), 4.57 (dq, J = 8.0, 7.2 Hz, 1H), 3.94 (s, 3H), 2.68 (ddd, J = 10.4, 7.0, 4.6 Hz, 1H), 1.75-1.54 (m, 2H), 1.46 (dp, J = 13.3, 6.7 Hz, 1H), 1.24 (d, J = 6.3 Hz, 3H), 1.19 (d, J = 7.2 Hz, 3H), 1.12- 0.87 (m, 2H), 0.80 (dd, J = 6.6, 5.4 Hz, 6H). ¹³C NMR (101 MHz, CDCl₃) δ 171.56, 168.57, 155.36, 148.75, 141.17, 140.42, 130.50, 128.60, 128.20, 126.54, 109.41, 75.06, 56.06, 51.39, 47.96, 36.46, 29.45, 27.95, 22.72, 22.18, 18.35, 17.93. 124 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3369, 2972, ([M + H]⁺⁾ calcd 12.17 (s, 1H), 8.40 (d, J = 7.9 1730, 1649, for C₂₆H₃₇N₂O₆, Hz, 1H), 7.97 (d, J = 5.2 Hz, 1527, 1263, 473.2649; found, 1H), 7.26-7.06 (m, 5H), 6.85 (d, 1140 473.2646 J = 5.2 Hz, 1H), 5.41 (qd, J = 6.6, 2.9 Hz, 1H), 4.53-4.38 (m, 1H), 3.93 (s, 3H), 3.29 (td, J = 6.5, 2.5 Hz, 2H), 2.96 (dd, J = 14.8, 5.0 Hz, 1H), 2.76 (dd, J = 14.8, 7.4 Hz, 1H), 2.26 (ddd, J = 7.6, 5.1, 2.9 Hz, 1H), 1.60-1.47 (m, 2H), 1.38 (d, J = 6.6 Hz, 3H), 1.24 (d, J = 7.2 Hz, 3H), 1.23 (s, 3H), 1.17 (s, 3H), 0.92 (t, J = 7.4 Hz, 3H). 125 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3368, 2937, ([M + H]⁺⁾ calcd 12.13 (s, 1H), 8.49 (d, J = 8.0 1735, 1648, for C₂₇H₃₁N₂O₆, Hz, 1H), 7.97 (d, J = 5.2 Hz, 1528, 1240, 480.2209; found, 1H), 7.30-7.17 (m, 5H), 7.17- 1148 480.221 7.12 (m, 2H) 6.92 (tt, J = 7.4, 1.1 Hz, 1H), 6.85 (d, J = 4.7 Hz, 1H), 6.83-6.79 (m, 2H), 5.26 (qd, J = 6.4, 5.0 Hz, 1H), 4.78- 4.61 (m, 1H), 3.93 (s, 3H), 3.91- 3.86 (m, 2H), 2.84-2.75 (m, 2H), 2.36-2.25 (m, 1H), 1.50 (d, J = 7.2 Hz, 3H), 1.40 (d, J = 6.5 Hz, 3H). 126 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3369, 2939, ([M + H]⁺⁾ calcd 12.11 (s, 1H), 8.46 (d, J = 7.9 1737, 1649, for C₂₇H₂₉Cl₂N₂O₆, Hz, 1H), 7.96 (d, J = 5.2 Hz, 1H), 1529, 14823, 547.1397; found, 7.35 (d, J = 2.6 Hz, 1H), 7.29- 1465, 1264, 547.1407 7.23 (m, 2H), 7.23-7.17 (m, 1H), 1061 7.16-7.12 (m, 2H), 7.08 (dd, J = 8.8, 2.6 Hz, 1H), 6.86 (d, J = 5.3 Hz, 1H), 6.62 (d, J = 8.8 Hz, 1H), 5.26 (qd, J = 6.4, 5.1 Hz, 1H), 4.77-4.64 (m, 1H), 3.94 (s, 3H), 3.93-3.81 (m, 2H), 2.87 (dd, J = 13.6, 9.0 Hz, 1H), 2.80 (dd, J = 13.6, 6.0 Hz, 1H), 2.40-2.23 (m, 1H), 1.53 (d, J = 7.2 Hz, 3H), 1.44 (d, J = 6.4 Hz, 3H). 127 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 12.11 (d, J = 0.6 Hz, 1H), 8.41 for C₂₆H₂₇Cl₂N₂O₅ (d, J = 7.9 Hz, 1H), 8.01 (d, J = 517.1297; found, 5.2 Hz, 1H), 7.20 (d, J = 8.2 Hz, 517.1286 1H), 7.19-7.14 (m, 3H), 7.11- 7.06 (m, 2H), 7.05 (d, J = 2.1 Hz, 1H), 6.89 (dd, J = 5.2, 0.7 Hz, 1H), 6.76 (dd, J = 8.2, 2.1 Hz, 1H), 5.29-5.20 (m, 1H), 4.70- 4.53 (m, 1H), 3.95 (s, 3H), 3.07- 2.91 (m, 2H), 2.90-2.77 (m, 1H), 1.31 (d, J = 7.2 Hz, 3H), 1.25 (d, J = 6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.41, 168.76, 155.44, 148.83, 140.52, 139.73, 139.19, 132.06, 130.84, 130.41, 130.08, 128.81, 128.44, 128.31, 127.04, 109.52, 73.77, 56.10, 52.80, 48.08, 37.54, 18.36, 17.93. 128 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 12.15 (d, J = 0.6 Hz, 1H), 8.44 for C₂₇H₃₁N₂O₅, (d, J = 8.0 Hz, 1H), 8.01 (d, J = 463.2233; found, 5.2 Hz, 1H), 7.22-7.11 (m, 5H), 463.2214 7.02-6.96 (m, 2H), 6.90-6.83 (m, 3H), 5.28-5.18 (m, 1H), 4.71- 4.57 (m, 1H), 3.94 (s, 3H), 3.06- 2.93 (m, 2H), 2.93-2.81 (m, 1H), 2.26 (s, 3H), 1.32 (d, J = 7.2 Hz, 3H), 1.23 (d, J = 6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.48, 168.67, 155.41, 148.80, 140.47, 140.33, 136.34, 135.51, 130.50, 128.94, 128.85, 128.11, 126.67, 109.46, 73.89, 56.08, 53.11, 48.05, 37.99, 20.98, 18.43, 18.10. 129 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 12.13 (d, J = 0.6 Hz, 1H), 8.42 for C₂₆H₂₈FN₂O₅, (d, J = 8.0 Hz, 1H), 8.01 (d, J = 467.1982; found, 5.2 Hz, 1H), 7.20-7.13 (m, 3H), 467.1976 7.12-7.06 (m, 2H), 6.93-6.82 (m, 5H), 5.36-5.18 (m, 1H), 4.73- 4.52 (m, 1H), 3.94 (s, 3H), 3.02 (dd, J = 12.7, 5.5 Hz, 1H), 2.95 (dt, J = 8.8, 5.6 Hz, 1H), 2.85 (dd, J = 12.6, 8.7 Hz, 1H), 1.30 (d, J = 7.2 Hz, 3H), 1.25 (d, J = 6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.46, 168.71, 161.33 (d, J = 244.0 Hz), 155.43, 148.81, 140.49, 139.84, 135.08 (d, J = 3.2 Hz), 130.46, 130.34 (d, J = 7.8 Hz), 128.87, 128.17, 126.80, 114.99 (d, J = 21.1 Hz), 109.49, 73.81, 56.09, 53.29, 48.06, 37.66, 18.44, 17.98. 130 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calced 12.16 (d, J = 0.6 Hz, 1H), 8.45 for C₃₀H₃₁FN₂O₅ (d, J = 8.0 Hz, 1H), 8.01 (d, J = 499.2233; found, 5.2Hz, 1H), 7.79-7.71 (m, 1H), 499.2220 7.71-7.62 (m, 2H), 7.45-7.34 (m, 3H), 7.21-7.08 (m, 6H), 6.87 (dd, J = 5.3, 0.7 Hz, 1H), 5.37-5.23 (m, 1H), 4.76-4.56 (m, 1H), 3.93 (s, 3H), 3.22 (dd, J = 12.1, 4.8 Hz, 1H), 3.16-3.01 (m, 2H), 1.32 (d, J = 7.2 Hz, 3H), 1.27 (d, J = 6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.48, 168.71, 155.42, 148.82, 140.49, 140.09, 137.01, 133.42, 132.01, 130.50, 128.92, 128.17, 127.77, 127.52, 127.47, 127.47, 127.45, 126.76, 125.84, 125.25, 109.48, 74.05, 56.08, 53.02, 48.09, 38.61, 18.46, 18.08. 131 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3369, 2938, ([M + H]⁺) calcd 12.16 (d, J = 0.6 Hz, 1H), 8.49 1509, 1242, for C₂₈H₃₂FN₂O₆, (d, J = 7.9 Hz, 1H), 7.99 (dd, J = 1218, 730 511.2239; found, 12.1, 5.2 Hz, IH), 7.41-7.17 (m, 511.2217 4H), 7.16-7.00 (m, 2H), 7.00- 6.88 (m, 2H), 6.86 (d, J = 5.2 Hz, 1H), 5.18 (qd, J = 6.5, 5.0 Hz, 1H), 4.78-4.62 (m, 1H), 4.40 (d, J = 2.9 Hz, 2H), 3.93 (d, J = 2.0 Hz, 3H), 3.36 (d, J = 5.1 Hz, 2H), 2.64 (t, J = 7.2 Hz, 2H), 2.14- 2.02 (m, 1H), 1.93 (dddd, J = 31.1, 13.0, 6.7, 5.3 Hz, 1H), 1.50 (d, J = 7.2 Hz, 3H), 1.31 (d, J = 6.5 Hz, 3H). 132 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3367, 2937, ([M + H]⁺) calcd 12.17 (d, J = 0.6 Hz, 1H), 8.51 1527, 1452, for C₂₈H₃₃N₂O₆, (d, J = 7.9 Hz, 1H), 7.99 (dd, J = 1262, 699 493.2333; found, 11.6, 5.2 Hz, 1H), 7.43-7.22 (m, 493.2310 6H), 7.22-7.05 (m, 3H), 6.92- 6.77 (m, 1H), 5.20 (qd, J = 6.4, 4.9 Hz, 1H), 4.75-4.62 (m, 1H), 4.49-4.33 (m, 2H), 3.92 (d, J = 1.5 Hz, 3H), 3.39 (d, J = 5.2 Hz, 2H), 2.76-2.65 (m, 2H), 2.29- 2.08 (m, 1H), 2.03-1.82 (m, 1H), 1.50 (d, J = 7.2 Hz, 3H), 1.32 (d, J = 6.5 Hz, 3H). 133 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3368, 2976, ([M + H]⁺) calcd 12.14 (d, J = 0.6 Hz, 1H), 8.39 1732, 1528, for C₃₀H₃₆FN₂O₆, (d, J = 7.9 Hz, 1H), 7.98 (dd, J = 1262, 1218, 539.2552; found, 21.4, 5.2 Hz, 1H), 7.40-7.21 (m, 730 539.2542 4H), 7.18-7.06 (m, 2H), 7.00- 6.79 (m, 3H), 5.46 (qd, J = 6.6, 2.8 Hz, 1H), 4.58-4.36 (m, 3H), 3.93 (d, J = 1.5 Hz, 3H), 3.01 (dd, J = 14.9, 5.3 Hz, 1H), 2.78 (dd, J = 14.9, 7.0 Hz, 1H), 2.29 (ddd, J = 7.0, 5.3, 2.9 Hz, 1H), 2.04- 1.80 (m, 1H), 1.38 (d, J = 6.6 Hz, 3H), 1.35 (s, 3H), 1.30 (d, J = 7.2 Hz, 3H), 1.26 (s, 3H). 134 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3368, 2975, ([M + H]⁺) calcd 12.16 (d, J = 0.6 Hz, 1H), 8.40 1731, 1528, for C₃₀H₃₇N₂O₆, (d, J = 7.9 Hz, 1H), 7.96 (d, J = 1263, 1040, 521.2646; found, 5.2 Hz, 1H), 7.33 (d, J = 4.4 Hz, 730 521.2619 4H), 7.30-7.03 (m, 6H), 6.90-6.77 (m, 1H), 5.47 (qd, J = 6.6, 2.9 Hz, 1H), 4.52-4.39 (m, 3H), 3.92 (s, 2H), 3.04 (dd, J = 14.8, 5.0 Hz, 1H), 2.82 (dd, J = 14.8, 7.4 Hz, 1H), 2.37 (ddd, J = 7.7, 5.1, 2.9 Hz, 1H), 2.03-1.82 (m, 1H), 1.40 (d, J = 6.6 Hz, 3H), 1.36 (s, 3H), 1.29 (s, 3H), 1.23 (d, J = 7.2 Hz, 3H). 135 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3368, 2936, ([M + H]⁺) calcd 12.15 (d, J = 0.6 Hz, 1H), 8.51 1734, 1648, for C₂₂H₂₈FN₂O₆, (d, J = 7.9 Hz, 1H), 7.98 (d, J = 1241, 1217, 435.1926; found, 5.2 Hz, 1H), 7.17-7.03 (m, 2H), 728 435.1928 7.03-6.91 (m, 2H), 6.91-6.79 (m, 1H), 5.13 (qd, J = 6.5, 4.7 Hz, 1H), 4.78-4.64 (m, 1H), 3.94 (d, J = 3.8 Hz, 3H), 3.26 (d, J = 8.6 Hz, 4H), 2.63 (d, J = 7.3 Hz, 2H), 2.11-1.85 (m, 2H), 1.57 (d, J = 7.2 Hz, 3H), 1.31 (d, J = 6.5 Hz, 3H). 136 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3369, 2976, ([M + H]⁺) calcd 12.13 (d, J = 0.6 Hz, 1H), 8.39 2941, 1731, for C₂₄H₃₂FN₂O₆, (d, J = 7.9 Hz, 1H), 8.05-7.92 1509, 1218, 463.2239; found, (m, 1H), 7.19-7.06 (m, 2H), 6.99- 728 463.2237 6.77 (m, 2H), 5.37 (qd, J = 6.6, 2.8 Hz, 1H), 4.57-4.45 (m, 1H), 3.94 (s, 3H), 3.17 (s, 3H), 2.87 (dd, J = 14.8, 5.1 Hz, 1H), 2.71 (dd, J = 14.8, 7.3 Hz, 1H), 2.29- 2.14 (m, 1H), 2.03-1.84 (m, 1H), 1.35 (d, J = 6.6 Hz, 3H), 1.31 (d, J = 7.2 Hz, 3H), 1.21 (s, 3H), 1.17 (s, 3H). 137 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 12.16 (d, J = 0.7 Hz, 1H), 8.40 for C₂₄H₃₃N₂O₆, (d, J = 7.9 Hz, 1H), 7.96 (d, J = 445.2338; found, 5.2 Hz, 1H), 7.31-7.07 (m, 5H), 445.2335 6.85 (dd, J = 5.3, 0.7 Hz, 1H), 5.38 (qd, J = 6.5, 2.9 Hz, 1H), 4.53-4.39 (m, 1H), 3.93 (s, 3H), 3.19 (s, 3H), 2.90 (dd, J = 14.7, 4.9 Hz, 1H), 2.74 (dd, J = 14.7, 7.6 Hz, 1H), 2.29 (ddd, J = 7.7, 4.9, 2.8 Hz, 1H), 1.36 (d, J = 6.6 Hz, 3H), 1.24 (d, J = 7.2 Hz, 3H), 1.22 (s, 3H), 1.19 (s, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.35, 168.62, 155.33, 148.71, 142.50, 140.43, 130.49, 128.80, 128.27, 125.62, 109.42, 76.47, 73.30, 56.05, 52.06, 48.89, 48.07, 31.20, 24.35, 23.98, 17.86, 17.12. 138 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3373, 2939, ([M + H]⁺) calcd 12.15 (d, J = 0.6 Hz, 1H), 8.49 2872, 1736, for C₂₈H₃₁F₂N₂O₆, (d, J = 7.9 Hz, 1H), 7.99 (dd, J = 1529, 1219, 529.2145; found, 13.4, 5.2 Hz, 1H), 7.27-7.19 (m, 824 529.2152 2H), 7.10-6.97 (m, 3H), 6.97- 6.89 (m, 2H), 6.89-6.81 (m, 1H), 5.18 (qd, J = 6.5, 5.0 Hz, 1H), 4.76-4.62 (m, 1H), 4.42-4.29 (m, 2H), 3.92 (s, 3H), 3.35 (d, J = 5.1 Hz, 2H), 2.75-2.53 (m, 2H), 2.09 (ddq, J = 8.3, 6.7, 5.2 Hz, 1H), 2.04-1.81 (m, 1H), 1.52 (d, J = 7.2 Hz, 3H), 1.31 (d, J = 6.4 Hz, 3H). 139 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3369, 2976, ([M + H]⁺) calcd 12.13 (s, 1H), 8.38 (d, J = 7.9 1732, 1528, for C₃₀H₃₅F₂N₂O₆, Hz, 1H), 7.96 (d, J = 5.2 Hz, 1218, 729 557.2458; found, 1H), 7.36-7.20 (m, 2H), 7.20- 557.2471 7.06 (m, 2H), 7.06-6.95 (m, 2H), 6.94-6.87 (m, 2H), 5.45 (qd, J = 6.5, 2.8 Hz, 1H), 4.59-4.46 (m, 1H), 4.45-4.32 (m, 2H), 3.93 (d, J = 2.0 Hz, 3H), 2.96 (dd, J = 14.8, 5.3 Hz, 1H), 2.78 (dd, J = 14.9, 7.0 Hz, 1H), 2.29 (ddd, J = 7.0, 5.4, 2.8 Hz, 1H), 1.93 (dddd, J = 31.2, 13.0, 7.3, 5.9 Hz, 1H), 1.36 (d, J = 6.6 Hz, 3H), 1.33 (s, 3H), 1.30 (d, J = 7.2 Hz, 3H), 1.26 (s, 3H). 140 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3373, 2954, ([M + H]⁺) calcd 12.15 (d, J = 0.6 Hz, 1H), 8.51 2868, 1736, for C₂₆H₃₆FN₂O₆, (d, J = 7.9 Hz, 1H), 7.99 (d, J = 1509, 1263, 491.2552; found, 5.2 Hz, 1H), 7.16-7.02 (m, 2H), 1219 491.2558 7.03-6.90 (m, 2H), 6.87 (dd, J = 5.2, 0.6 Hz, 1H), 5.13 (qd, J = 6.5, 4.7 Hz, 1H), 4.80-4.62 (m, 1H), 3.94 (s, 3H), 3.45-3.19 (m, 4H), 2.63 (d, J = 7.4 Hz, 2H), 2.13- 1.94 (m, 1H), 1.76-1.61 (m, 1H), 1.57 (d, J = 7.2 Hz, 3H), 1.47- 1.36 (m, 2H), 1.31 (d, J = 6.5 Hz, 3H), 0.90 (d, J = 1.7 Hz, 3H), 0.88 (d, J = 1.6 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.38, 168.77, 161.39 (d, J = 243.8 Hz), 155.40, 148.79, 140.51, 135.64 (d, J = 3.2 Hz), 130.46, 130.45 (d, J = 7.8 Hz), 115.12 (d, J = 21.2 Hz), 109.47, 72.58, 69.55, 68.82, 56.08, 48.18, 45.58, 38.51, 32.68, 25.08, 22.64, 22.60, 18.43, 17.11. 141 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3370, 2954, ([M + H]⁺) calcd 12.17 (d, J = 0.6 Hz, 1H), 8.53 2868, 1736, for C₂₆H₃₇N₂O₆, (d, J = 7.9 Hz, 1H), 7.98 (d, J = 1528, 1263 473.2646; found, 5.2 Hz, 1H), 7.27 (tt, J = 7.1, 1.0 473.2649 Hz, 2H), 7.23-7.16 (m, 1H), 7.16- 7.09 (m, 2H), 6.86 (dd, J = 5.2, 0.6 Hz, 1H), 5.16 (qd, J = 6.5, 4.7 Hz, 1H), 4.80-4.62 (m, 1H), 3.94 (s, 3H), 3.45-3.20 (m, 4H), 2.76- 2.56 (m, 2H) 2.16-2.05 (m, 1H), 1.69 (dp, J = 13.4, 6.6 Hz, 1H), 1.56 (d, J = 7.2 Hz, 3H), 1.47-1.36 (m, 2H), 1.32 (d, J = 6.5 Hz, 3H), 0.90 (d, J = 1.8 Hz, 3H), 0.88 (d, J = 1.8 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.39, 168.73, 155.37, 148.77, 140.49, 140.05, 130.48, 129.11, 128.35, 126.05, 109.45, 72.73, 69.50, 68.98, 56.06, 48.15, 45.43, 38.52, 33.47, 25.07, 22.65, 22.60, 18.47, 17.03. 142 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3366, 2978, ([M + H]⁺) calcd 12.14 (s, 1H), 8.40 (d, J = 7.9 1732, 1648, for C₂₉H₃₃Cl₂N₂O₆, Hz, 1H), 7.97 (d, J = 5.2 Hz, 1473, 1261 575.171; found, 1H), 7.39 (d, J = 2.6 Hz, 1H), 575.171 7.30-7.18 (m, 4H), 7.18-7.11 (m, 2H), 7.01 (d, J = 8.8 Hz, 1H), 6.86 (d, J = 5.2 Hz, 1H), 5.60 (qd, J = 6.5, 2.9 Hz, 1H), 4.56- 4.44 (m, 1H), 3.94 (s, 3H), 3.24 (dd, J = 14.9, 5.2 Hz, 1H), 2.93 (dd, J = 14.9, 7.0 Hz, 1H), 2.51 (ddd, J = 7.0, 5.2, 3.0 Hz, 1H), 1.49 (d, J = 6.5 Hz, 3H), 1.43 (s, 3H), 1.31 (s, 3H), 1.29 (d, J = 7.2 Hz, 3H). 143 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3372, 2936, ([M + H]⁺) calcd 12.17 (s, 1H), 8.53 (d, J = 7.9 1734, 1512, for C₂₅H₃₅N₂O₇, Hz, 1H), 7.99 (d, J = 5.2 Hz, 1242 475.2439; found, 1H), 7.04 (d, J = 8.6 Hz, 2H), 475.2429 6.87 (d, J = 5.2 Hz 1H) 6.81 (d, J = 8.6 Hz, 2H), 5.15 (qd, J = 6.5, 4.7 Hz, 1H), 4.71 (p, J = 7.3 Hz, 1H), 3.94 (s, 3H), 3.79 (s, 3H), 3.38-3.16 (m, 4H), 2.60 (d, J = 7.4 Hz, 2H), 2.09-2.01 (m, 1H), 2.01-1.85 (m, 1H), 1.57 (d, J = 7.2 Hz, 4H), 1.31 (d, J = 6.4 Hz, 3H), 0.91 (t, J = 7.4 Hz, 3H). 144 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3371, 2971, ([M + H]⁺) calcd 12.17 (s, 1H), 8.43 (d, J = 7.9 Hz, 1731, 1649, for C₂₇H₃₉N₂O₇, 1H), 7.97 (d, J = 5.2 Hz, 1H), 1511, 1243 503.2752; found, 7.08 (d, J = 8.6 Hz, 1H), 6.85 (d, 503.2736 J = 5.3 Hz, 1H), 6.78 (d, J = 8.6 Hz, 1H), 5.40 (qd, J = 6.6, 2.9 Hz, 1H), 4.50 (p, J = 7.3 Hz, 1H), 3.94 (s, 3H), 3.77 (s, 3H), 3.36- 3.15 (m, 2H), 2.89 (dd, J = 14.8, 5.1 Hz, 1H), 2.69 (dd, J = 14.8, 7.2 Hz, 1H), 2.24-2.14 (m, 1H), 2.05-1.84 (m, 2H), 1.61-1.44 (m, 2H), 1.36 (d, J = 6.6 Hz, 3H), 1.30 (d, J = 7.2 Hz, 3H), 1.22 (s, 3H), 1.16 (s, 3H), 0.92 (t, J = 7.4 Hz, 3H). 145 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3371, 2935, ([M + H]⁺) calcd 12.17 (s, 1H), 8.52 (d, J = 7.9 1733, 1649, for C₃₂H₄₁N₂O₇, Hz, 1H), 7.99 (d, J = 5.2 Hz, 1528, 1244 565.2908; found, 1H), 7.29-7.22 (m, 2H), 7.22- 565.2913 7.12(m, 3H), 6.94 (dd, J = 8.3, 2.3 Hz, 1H), 6.85 (d, J = 5.2 Hz, 1H), 6.82 (d, J = 2.5 Hz, 1H), 6.77 (d, J = 8.3 Hz, 1H), 5.19- 5.05 (m, 1H), 4.76-4.54 (m, 1H), 3.93 (s, 5H), 3.79 (s, 3H), 3.35- 3.16 (m, 4H), 2.55 (d, J = 7.4 Hz, 2H), 2.06-1.83 (m, 3H), 1.50 (d, J = 7.2 Hz, 3H), 1.29 (d, J = 6.5 Hz, 3H), 0.89 (t, J = 7.4 Hz, 3H). 146 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3371, 2971, ([M + H]⁺) calcd 12.19 (s, 1H), 8.42 (d, J = 8.0 1732, 1650, for C₃₄H₄₅N₂O₇, Hz, 1H), 7.96 (d, J = 5.2 Hz, 1528, 1245 593.3221; found, 1H), 7.30-7.22 (m, 2H), 7.21- 593.3227 7.13 (m, 3H), 6.97 (dd, J = 8.4, 2.3 Hz, 1H), 6.87 (d, J = 2.3 Hz, 1H), 6.83 (d, J = 5.2 Hz 1H) 6.74 (d, J = 8.4 Hz, 1H), 5.36 (qd, J = 6.5, 2.7 Hz, 1H), 4.46 (p, J = 7.3 Hz, 1H), 3.97-3.88 (m, 5H), 3.77 (s, 3H), 3.33-3.19 (m, 2H), 2.83 (dd, J = 14.8, 5.4 Hz, 1H), 2.64 (dd, J = 8.2, 7.6 Hz, 1H), 2.02- 1.85 (m, 1H), 1.57-1.44 (m, 2H), 1.33 (d, J = 6.6 Hz, 3H), 1.21 (d, J = 7.1 Hz, 3H), 1.18 (s, 3H), 1.12 (s, 3H), 0.90 (t, J = 7.4 Hz, 3H). 147 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3371, 2937, ([M + H]⁺) calcd 12.16 (d, J = 0.6 Hz, 1H), 8.51 1734.22, for C₂₇H₃₁N₂O₅, (d, J = 7.9 Hz, 1H), 8.01-7.98 1648.72, 464.226; found, (m, 1H), 7.25-7.00 (m, 10H), 1527, 1452, 464.2262 6.87 (d, J = 5.2 Hz, 1H), 4.97 1262 (td, J = 6.6, 3.1 Hz, 1H), 4.72 (p, J = 7.2 Hz, 1H), 3.94 (d, J = 4.4 Hz, 3H), 2.83-2.46 (m, 5H), 1.58 (d, J = 7.2 Hz, 3H), 1.29 (d, 3H). 148 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3373, 2963, ([M + Na]⁺) calcd 12.19 (d, J = 0.6 Hz, 1H), 8.55 1729, 1651, for C₂₉H₃₄N₂NaO₅, (d, J = 9.8 Hz, 1H), 8.00 (d, J = 1526, 1262 513.236; found, 5.2 Hz, 1H), 7.30-7.01 (m, 10H), 513.2364 6.88 (d, J = 5.1 Hz, 1H), 5.03- 4.95 (m, 1H), 4.66 (dd, J = 9.3, 4.6 Hz, 1H), 3.95 (s, 3H), 2.80- 2.68 (m, 2H), 2.67-2.47 (m, 4H), 1.28 (d, J = 6.5 Hz, 3H), 1.08 (d, J = 6.9 Hz, 3H), 1.06 (d, J = 6.9 Hz, 3H). 149 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3372.52, ([M + H]⁺) calcd 12.18 (s, 1H), 8.50 (t, J = 10.2 2935, 1730, for C₂₈H₃₃N₂O₅, Hz, 1H), 8.09-7.94 (m, 1H), 1649, 1527, 478.2416; found, 7.37-6.97 (m, 10H), 6.87 (d, J = 1452, 1260 478.2423 5.3 Hz, 1H), 4.97 (ddtt, J = 16.4, 9.9, 6.6, 3.3 Hz, 1H), 4.68 (ddd, J = 8.6, 7.3, 5.2 Hz, 1H), 3.95 (s, 3H), 3.71 (t, J = 6.9 Hz, 1H), 3.34 (dd, J = 7.2, 5.3 Hz, 1H), 2.79-2.47 (m, 4H), 2.23 (dtd, J = 17.3, 7.1, 3.1 Hz, 1H), 1.28 (d, J = 6.5 Hz, 3H), 1.26 (d, J = 6.5 Hz, 3H). 150 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 12.13 (d, J = 0.6 Hz, 1H), 8.48 for C₂₇H₂₉F₂N₂O₅, (d, J = 8.0 Hz, 1H), 8.01 (dd, 499.2039; found, J = 5.2, 0.6 Hz, 1H), 7.25-7.16 499.2043 (m, 2H), 6.92-6.70 (m, 7H), 4.95 (dt, J = 6.9, 3.5 Hz, 1H), 4.78-4.65 (m, 1H), 3.95 (d, J = 1.1 Hz, 3H), 2.83-2.43 (m, 5H), 1.59 (d, J = 7.2 Hz, 3H), 1.28 (d, J = 6.5 Hz, 3H). 151 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3369, 2939, ([M + H]⁺) calcd 12.13 (s, 1H), 8.48 (d, J = 7.7 1733, 1648, for C₂₇H₂₉F₂N₂O₅ Hz, 1H), 7.99 (d, J = 5.2 Hz, 1H), 1508, 1453, 499.2039; found, 7.11-6.85 (m, 9H), 4.95 (qd, J = 1218 499.2046 6.7, 3.0 Hz, 1H), 4.72 (p, J = 7.2 Hz, 1H), 3.95 (s, 3H), 2.71 (dd, J = 14.2, 6.7 Hz, 1H), 2.58 (dd, J = 13.8, 7.4 Hz, 1H), 2.55-2.40 (m, 2H), 2.13-2.04 (m, 1H), 1.59 (d, J = 7.0 Hz, 3H), 1.27 (d, J = 6.5 Hz, 3H). 152 ESIMS m/z 523.7 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺⁾ 12.16 (s, 1H), 8.51 (d, J = 7.9 Hz, 1H), 8.00 (d, J = 5.2 Hz, 1H), 7.17 (ddd, J = 11.9, 8.2, 7.5 Hz, 2H), 6.87 (d, J = 5.2 Hz, 1H), 6.76-6.57 (m, 7H), 4.99 (dd, J = 6.5, 3.0 Hz, 1H), 3.94 (s, 3H), 3.78 (s, 3H), 3.77 (s, 3H), 2.78- 2.46 (m, 5H), 1.59 (d, J = 7.2 Hz, 3H), 1.28 (d, J = 6.5 Hz, 3H). 153 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 12.38-11.99 (m, 1H), 8.51 (d, for C₃₀H₃₇N₂O₇, J = 8.4 Hz, 1H), 8.00 (d, J = 5.2 537.2595; found, Hz, 1H), 7.17 (dt, J = 12.7, 7.9 537.259 Hz, 2H), 6.87 (d, J = 5.2 Hz, 1H), 6.72 (tdd, J = 8.4, 2.6, 1.2 Hz, 3H), 6.64 (dt, J = 3.8, 1.9 Hz, 2H), 6.59 (t, J = 2.0 Hz, 1H), 5.00 (qd, J = 6.4, 3.0 Hz, 1H), 4.68 (ddd, J = 8.6, 7.3, 5.2 Hz, 1H), 3.95 (s, 3H), 3.78 (d, J = 1.0 Hz, 3H), 3.76 (s, 3H), 2.78- 2.43 (m, 5H), 2.06 (ddd, J = 14.1, 7.4, 5.2 Hz, 1H), 1.90 (dt, J = 14.2, 7.3 Hz, 1H), 1.28 (dd, J = 6.4, 1.8 Hz, 3H), 1.06 (t, J = 7.4 Hz, 3H). ¹³C NMR (126 MHz, CDCl₃) δ 170.72, 169.02, 159.66, 159.59, 155.41, 148.77, 141.80, 141.67, 140.54, 130.49, 129.40, 129.33, 121.46, 121.27, 114.93, 114.91, 111.27, 111.19, 109.47, 72.60, 56.07, 55.14, 55.11, 53.46, 46.59, 35.95, 35.58, 25.78, 16.56, 9.89. 154 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 12.17 (d, J = 0.6 Hz, 1H), 8.52 for C₂₉H₃₅N₂O₇, (d, J = 7.9 Hz, 1H), 7.99 (d, J = 523.2439; found, 5.2 Hz, 1H), 7.07-6.91 (m, 4H), 523.2419 6.89-6.75 (m, 4H), 5.04-4.91 (m, 1H), 4.79-4.66 (m, 1H), 3.95 (s, 4H), 3.78 (s, 3H), 3.77 (s, 3H), 2.70-2.42 (m, 4H), 2.08 (td, J = 7.1, 2.8 Hz, 1H), 1.59 (d, J = 7.2 Hz, 3H), 1.26 (d, 3H). ¹³C NMR (126 MHz, CDCl₃) δ 171.43, 168.78, 157.93, 157.90, 155.40, 148.79, 140.51, 132.24, 132.04, 130.48, 130.00, 129.95, 129.79, 113.86, 113.81, 109.47, 72.67, 56.08, 55.23, 48.20, 47.10, 34.87, 34.57, 18.52, 16.41. 155 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 12.20 (s, 1H), 8.52 (d, J = 8.8 for C₃₀H₃₇N₂O₇, Hz, 1H), 8.06-7.93 (m, 1H), 537.2595; found, 7.10-6.71 (m, 8H), 5.03-4.91 537.2585 (m, 1H), 4.68 (ddd, J = 8.5, 7.2, 5.2 Hz, 1H), 3.95 (s, 3H), 3.78 (s, 3H), 3.77 (s, 3H), 2.72-2.41 (m, 5H), 2.10-1.97 (m, 1H), 1.95- 1.82 (m, 1H), 1.26 (d, J = 6.5, 1.9 Hz, 3H), 1.06 (t, J = 7.4 Hz, 3H). ¹³C NMR (126 MHz, CDCl₃) δ 171.43, 168.78, 157.93, 157.90, 155.40, 148.79, 140.51, 132.24, 132.04, 130.48, 129.95, 129.79, 113.86, 113.81, 109.47, 72.67, 56.08, 55.23 (2C), 48.20, 47.10, 34.87, 34.57, 18.52, 16.41. 156 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3371, 2975, ([M + H]⁺) calcd 12.17 (s, 1H), 8.42 (d, J = 7.9 1731, 1528, for C₂₈H₃₉N₂O₇, Hz, 1H), 7.97 (d, J = 5.1 Hz, 1244, 1038 515.2752; found, 1H), 7.17-7.01 (m, 2H), 6.86 515.2732 (d, J = 5.2 Hz, 1H), 6.81-6.74 (m, 2H), 5.38 (qd, J = 6.4, 2.6 Hz, 1H), 4.56-4.45 (m, 1H), 3.94 (s, 3H), 3.77 (s, 3H), 3.25- 3.13 (m, 2H), 2.88 (dd, J = 14.8, 5.1 Hz, 1H), 2.69 (dd, J = 14.8, 7.5 Hz, 1H), 2.21 (ddd, J = 7.7, 5.2, 2.8 Hz, 1H), 1.38 (d, J = 6.5 Hz, 3H), 1.31 (d, J = 7.2 Hz, 3H), 1.20 (s, 3H), 1.16 (s, 3H), 1.03-0.92 (m, 1H), 0.55- 0.43 (m, 2H), 0.22-0.14 (m, 2H). 157 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3368, 2979, ([M + H]⁺) calcd 12.15 (s, 1H), 8.45 (d, J = 7.9 1732, 1649, for C₃₀H₃₅F₂N₂O₇, Hz, 1H), 7.96 (d, J = 5.2 Hz, 1501, 1243 573.2402; found, 1H), 7.18-7.10 (m, 2H), 7.07- 573.2407 6.98 (m, 1H), 6.85 (d, J = 5.3 Hz, 1H), 6.80 (d, J = 8.6 Hz, 2H), 6.79-6.69 (m, 2H), 5.57 (qd, J = 6.6, 2.9 Hz, 1H), 4.68- 4.49 (m, 1H), 3.94 (s, 3H), 3.78 (s, 3H), 3.12 (dd, J = 14.9, 5.7 Hz, 1H), 2.87 (dd, J = 14.9, 6.5 Hz, 1H), 2.40 (td, J = 6.1, 2.9 Hz, 1H), 1.48 (d, J = 6.6 Hz, 3H), 1.37 (s, 3H), 1.37 (d, J = 7.1 Hz, 3H), 1.23 (s, 3H). 158 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3370, 2936, ([M + H]⁺⁾ calcd 12.17 (s, 1H), 8.52 (d, J = 7.9 1734, 1649, for C₂₆H₃₅N₂O₇, Hz, 1H), 7.98 (d, J = 5.2 Hz, 1512, 1243 487.2400; found, 1H), 7.16-7.00 (m, 2H), 6.87 (d, 487.2439 J = 5.2 Hz, 1H), 6.85-6.75 (m, 2H), 5.16 (qd, J = 6.4, 4.6 Hz, 1H), 4.83-4.62 (m, 1H), 3.94 (s, 3H), 3.78 (s, 3H), 3.38 (dd, J = 9.8, 5.9 Hz, 1H), 3.32 (dd, J = 9.7, 5.1 Hz, 1H), 3.19 (dd, J = 9.3, 5.7 Hz, 1H), 3.15 (dd, J = 9.3, 5.7 Hz, 1H), 2.74-2.46 (m, 2H), 2.15-2.00 (m, 1H), 1.57 (d, J = 7.2 Hz, 3H), 1.32 (d, J = 6.5 Hz, 3H), 1.08-0.91 (m, 1H), 0.58- 0.38 (m, 2H), 0.28-0.09 (m, 2H). 159 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3367, 2936, ([M + H]⁺) calcd 12.17 (s, 1H), 8.52 (d, J = 7.7 Hz, 1734, 1649, for C₃₃H₄₁N₂O₇, 1H), 7.98 (d, J = 5.2 Hz, 1H), 1528, 1452, 577.2905; found, 7.29-7.23 (m, 2H), 7.22-7.16 (m, 1244 577.2905 2H), 7.08 (dd, J = 21.8, 7.6 Hz, 1H), 6.95 (dd, J = 8.3, 2.2 Hz, 1H) 6.89-6.82 (m, 1H), 6.86- 6.80 (m, 2H), 6.77 (d, J = 8.3 Hz, 1H), 5.17-5.06 (m, 1H), 4.76- 4.62 (m, 1H), 4.09-3.86 (m, 5H), 3.79 (s, 3H), 3.39-3.25 (m, 2H), 3.17-3.07 (m, 2H), 2.55 (d, J = 7.4 Hz, 1H), 2.08-1.93 (m, 1H), 1.50 (d, J = 7.2 Hz, 3H), 1.29 (d, J = 6.5 Hz, 3H), 1.00-0.91 (m, 1H), 0.51-0.42 (m, 2H), 0.22- 0.09 (m, 2H). 160 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3373, 2938, ([M + H]⁺) calcd 12.11 (s, 1H), 8.47 (d, J = 8.0 1736, 1649, for C₂₈H₃₁F₂N₂O₇, Hz, 1H), 7.97 (d, J = 5.2 Hz, 1512, 1244, 545.2092; found, 1H), 7.12-7.01 (m, 2H), 6.99 1154 545.2094 (ddd, J = 10.6, 8.9, 5.3 Hz, 1H), 6.86 (d, J = 5.2 Hz, 1H), 6.84- 6.78 (m, 2H), 6.55 (ddt, J = 8.9, 7.8, 3.1 Hz, 1H), 6.47 (ddd, J = 9.7, 6.7, 3.0 Hz, 1H), 5.23 (qd, J = 6.5, 4.8 Hz, 1H), 4.82-4.65 (m, 1H), 3.94 (s, 3H), 3.93-3.84 (m, 2H), 3.78 (s, 3H), 2.82-2.65 (m, 2H), 2.31-2.21 (m, 1H), 1.55 (d, J = 7.2 Hz, 3H), 1.41 (d, J = 6.5 Hz, 3H). 161 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 12.15 (s, 1H), 8.51 (d, J = 7.9 for C₂₁H₂₇N₂O₅, Hz, 1H), 8.00 (d, J = 5.2 Hz, 387.1920; found, 1H), 7.37-7.09 (m, 5H), 6.87 (d, 387.1919 J = 5.2 Hz, 1H), 5.14 (dq, J = 8.3, 6.3 Hz, 1H), 4.72 (p, J = 7.3 Hz, 1H), 3.94 (s, 3H), 2.66 (ddd, J = 10.8, 8.3, 3.9 Hz, 1H), 1.92-1.77 (m, 1H), 1.69-1.51 (m, 1H), 1.57 (d, J = 7.2 Hz, 3H), 1.08 (d, J = 6.3 Hz, 3H), 0.72 (t, J = 7.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.74, 168.72, 155.40, 148.81, 140.73, 140.46, 130.56, 128.62, 128.41, 126.77, 109.46, 75.79, 56.06, 52.94, 48.20, 24.50, 18.40, 18.22, 11.82. 162 (Thin film) ESIMS m/z 517 ¹H NMR (400 MHz, CDCl₃) δ 3380, 2936, ([M + H]⁺) 8.39 (d, J = 7.8 Hz, 1H), 8.28 (d, 1736, 1676, J = 5.4 Hz, 1H), 7.32-7.22 (m, 1503 2H), 7.21-7.16 (m, 1H), 7.16- 7.12 (m, 2H), 6.94 (d, J = 5.4 Hz, 1H), 5.76 (d, J = 2.3 Hz, 2H), 5.20-5.09 (m, 1H), 4.79- 4.68 (m, 1H), 3.91 (s, 3H), 3.34 (dd, J = 5.4, 2.8 Hz, 2H), 3.31- 3.24 (m, 2H), 2.72-2.63 (m, 2H), 2.07 (s, 3H), 1.61-1.55 (m, 3H), 1.55-1.52 (m, 3H), 1.31 (d, J = 6.5 Hz, 3H), 0.91 (t, J = 7.4 Hz, 3H). 163 (Thin film) ESIMS m/z 545 ¹H NMR (400 MHz, CDCl₃) δ 3383, 2930, ([M + H]⁺) 8.32-8.25 (m, 2H), 7.30-7.21 1736, 1677, (m, 2H), 7.22-7.12 (m, 3H), 6.95 1503 (d, J = 5.4 Hz, 1H), 5.76 (d, J = 3.9 Hz, 2H), 5.16-5.05 (m, 1H), 4.64-4.54 (m, 1H), 3.91 (s, 3H), Hz 3.33 (td, J = 6.6, 2.8, 2H), 3.21 (td, J = 6.8, 6.4, 3.4 Hz, 1H), 2.83 (dd, J = 14.6, 5.9 Hz, 1H), 2.63 (dd, J = 14.5, 7.4 Hz, 1H), 2.26-2.17 (m, 1H), 2.08 (s, 3H), 1.63-1.43 (m, 4H), 1.42 (d, J = 7.1 Hz, 3H), 1.24 (d, J = 6.4 Hz, 3H), 0.89 (t, J = 7.4 Hz, 6H). 164 (Thin film) ESIMS m/z 559 ¹H NMR (400 MHz, CDCl₃) δ 3380, 2956, ([M + H]⁺) 8.36 (d, J = 8.4 Hz, 1H), 8.27 (d, 1733, 1678, J = 5.3 Hz, 1H), 7.29-7.22 (m, 1502 2H), 7.22-7.13 (m, 3H), 6.94 (d, J = 5.4 Hz, 1H), 5.75 (d, J = 4.5 Hz, 2H), 5.16-5.08 (m, 1H), 4.70- 4.61 (m, 1H), 3.91 (s, 3H), 3.32 (t, J = 6.6 Hz, 2H), 3.19 (td, J = 6.4, 3.1 Hz, 1H), 2.81 (dd, J = 14.5, 6.1 Hz, 1H), 2.63 (dd, J = 14.5, 7.2 Hz, 1H), 2.23-2.08 (m, 1H), 2.07 (s, 3H), 2.02-1.87 (m, 1H), 1.82-1.70 (m, 1H), 1.63- 1.41 (m, 4H), 1.25 (d, J = 6.5 Hz, 3H), 0.97 (t, J = 7.4 Hz, 3H), 0.90 (t, J = 7.5 Hz, 3H), 0.86 (t, J = 7.4 Hz, 3H). 165 (Thin film) ESIMS m/z 545 ¹H NMR (400 MHz, CDCl₃) δ 3382, 2936, ([M + H]⁺) 8.36 (d, J = 7.6 Hz, 1H), 8.27 (d, 1736, 1677, J = 5.4 Hz, 1H), 7.28-7.23 (m, 1503 2H), 7.22-7.13 (m, 3H), 6.95 (d, J = 5.4 Hz, 1H), 5.76 (d, J = 3.9 Hz, 2H), 5.24-5.16 (m, 1H), 4.72- 4.63 (m, 1H), 3.91 (s, 3H), 3.41 (dt, J = 8.8, 6.4 Hz, 1H), 3.31 (dt, J = 8.8, 6.5 Hz, 1H), 3.18 (td, J = 6.4, 3.9 Hz, 1H), 2.81 (dd, J = 13.8, 7.3 Hz, 1H), 2.69 (dd, J = 13.7, 6.7 Hz, 1H), 2.24-2.15 (m, 1H), 2.08 (s, 3H), 1.65-1.51 (m, 4H), 1.49 (d, J = 7.2 Hz, 3H), 1.28 (d, J = 6.5 Hz, 3H), 0.96 (t, J = 7.4 Hz, 3H), 0.82 (t, J = 7.4 Hz, 3H). 166 (Thin film) ESIMS m/z 517 ¹H NMR (400 MHz, CDCl₃) δ 3381, 2937, ([M + H]⁺⁾ 8.36 (d, J = 7.7 Hz, 1H), 8.28 (d, 1737, 1676, J = 5.3 Hz, 1H), 7.31-7.22 (m, 1503 2H), 7.22-7.13 (m, 3H), 6.95 (d, J = 5.4 Hz, 1H), 5.76 (d, J = 3.9 Hz, 2H) 5.20-5.10 (m, 1H), 4.77- 4.65 (m, 1H), 3.91 (s, 3H), 3.41- 3.21 (m, 4H), 2.68 (qd, J = 13.5, 7.3 Hz, 2H), 2.20-2.09 (m, 1H), 2.07 (s, 3H), 1.54 (s, 2H), 1.50 (d, J = 7.2 Hz, 3H), 1.30 (d, J = 6.5 Hz, 3H), 0.90 (t, J = 7.4 Hz, 3H). 167 (Thin film) ESIMS m/z 531 ¹H NMR (400 MHz, CDCl₃) δ 3379, 2936, ([M + H]⁺) 8.40 (d, J = 8.2 Hz, 1H), 8.28 (d, 1734, 1678, J = 5.4 Hz, 1H), 7.32-7.23 (m, 1502 2H), 7.22-7.10 (m, 3H), 6.94 (d, J = 5.4 Hz, 1H), 5.76 (d, J = 5.0 Hz, 2H), 5.21-5.11 (m, 1H), 4.72 (ddd, J = 8.3, 6.8, 5.3 Hz, 1H), 3.91 (s, 3H), 3.37-3.31 (m, 2H), 3.31-3.21 (m, 2H), 2.68 (dd, J = 7.4, 4.8 Hz, 2H), 2.15-2.08 (m, 1H), 2.07 (s, 3H), 2.06-1.97 (m, 1H), 1.92-1.81 (m, 1H), 1.62- 1.48 (m, 2H), 1.31 (d, J = 6.5 Hz, 3H), 1.02 (t, J = 7.5 Hz, 3H), 0.91 (t, J = 7.4 Hz, 3H). 168 (Thin film) ESIMS m/z 545 ¹H NMR (400 MHz, CDCl₃) δ 3381, 2936, ([M + H]⁺) 8.36 (d, J = 7.7 Hz, 1H), 8.27 1734, 1676, (d, J = 5.4 Hz, 1H), 7.31-7.22 1502 (m, 2H), 7.22-7.13 (m, 3H), 6.94 (d, J = 5.4 Hz, 1H), 5.75 (d, J = 1.7 Hz, 2H), 5.16-5.05 (m, 1H), 4.71-4.62 (m, 1H), 3.91 (s, 3H), 3.33 (td, J = 6.6, 0.8 Hz, 2H), 3.21 (td, J = 6.4, 3.0 Hz, 2H), 2.82 (dd, J = 14.5, 6.2 Hz, 1H), 2.62 (dd, J = 14.5, 7.2 Hz, 1H), 2.19-2.11 (m, 1H), 2.07 (s, 3H), 1.64-1.46 (m, 3H), 1.46 (d, J = 7.1 Hz, 3H), 1.25 (d, J = 6.5 Hz, 3H), 0.93-0.84 (m, 6H). 169 (Thin film) ESIMS m/z 545 ¹H NMR (400 MHz, CDCl₃) δ 3382, 2936, ([M + H]⁺) 8.40 (d, J = 7.8 Hz, 1H), 8.27 (d, 1736, 1676, J = 5.4 Hz, 1H), 7.31-7.22 (m, 1503 2H), 7.21-7.08 (m, 4H), 6.94 (d, J = 5.4 Hz, 1H), 5.75 (d, J = 4.2 Hz, 2H), 5.25-5.14 (m, 1H), 4.78- 4.67 (m, 1H), 3.91 (s, 3H), 3.40 (dt, J = 8.8, 6.4 Hz, 1H), 3.31 (dt, J = 8.9, 6.5 Hz, 1H), 3.18 (td, J = 6.5, 3.8 Hz, 1H), 2.83 (dd, J = 13.8, 7.4 Hz, 1H), 2.65 (dd, J = 13.8, 6.6 Hz, 1H), 2.07 (s, 3H), 1.65-1.53 (m, 4H), 1.54 (d, J = 7.1 Hz, 3H), 1.29 (d, J = 6.5 Hz, 3H), 0.97 (t, J = 7.4 Hz, 3H), 0.83 (t, J = 7.4 Hz, 3H). 170 (Thin film) ESIMS m/z 559 ¹H NMR (400 MHz, CDCl₃) δ 3378, 2936, ([M + H]⁺) 8.37 (s, 1H), 8.26 (d, J = 5.4 Hz, 1735, 1679, 1H), 7.24-7.20 (m, 2H), 7.19- 1505 7.12 (m, 3H), 6.93 (d, J = 5.4 Hz, 1H), 5.73 (d, J = 0.8 Hz, 2H), 5.18-5.07 (m, 1H), 3.90 (s, 3H), 3.38-3.26 (m, 2H), 3.25-3.15 (m, 1H), 2.79 (dd, J = 14.4, 6.0 Hz, 1H), 2.62 (dd, J = 14.4, 7.3 Hz, 1H), 2.18-2.11 (m, 2H), 2.06 (s, 3H), 1.60 (d, J = 12.4 Hz, 6H), 1.54-1.44 (m, 3H), 1.24 (d, J = 6.4 Hz, 3H), 0.89 (t, J = 7.4 Hz, 3H), 0.84 (t, J = 7.4 Hz, 3H). 171 (Thin film) ESIMS m/z 531 ¹H NMR (400 MHz, CDCl₃) δ 3378, 2936, ([M + H]⁺) 8.43 (s, 1H), 8.25 (d, J = 5.4 Hz, 1734, 1678, 1H), 7.29-7.22 (m, 2H), 7.20- 1504 7.13 (m, 4H), 6.93 (d, J = 5.4 Hz, 1H), 5.74 (s, 2H), 5.19-5.08 (m, 1H), 3.90 (s, 3H), 3.39-3.20 (m, 4H), 2.67 (t, J = 7.3 Hz, 2H), 2.16-2.08 (m, 1H), 2.06 (s, 3H), 1.68 (d, J = 6.9 Hz, 6H), 1.54 (dt, J = 7.7, 6.8 Hz, 1H), 1.29 (d, J = 6.4 Hz, 3H), 0.90 (t, J = 7.4 Hz, 3H). 172 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.57 (d, J = 7.9 Hz, 1H), 8.32 (d, for C₃₁H₄₅N₂O₆, J = 5.4 Hz, 1H), 7.32-7.24 (m, 541.3277; found, 2H), 7.23-7.11 (m, 3H), 6.98 (d, 541.3282. J = 5.5 Hz, 1H), 5.14-5.01 (m, 1H), 4.74-4.58 (m, 1H), 3.89 (s, 3H), 2.65-2.48 (m, 2H), 2.40 (s, 3H), 1.71-1.51 (m, 5H), 1.47 (d, J = 7.1 Hz, 3H), 1.40-1.23 (m, 3H), 1.21 (d, J = 6.5 Hz, 3H), 1.18-1.08 (m, 2H), 1.02 (ddd, J = 13.9, 8.5, 4.7 Hz, 1H), 0.93- 0.78 (m, 9H). ¹³C NMR (101 MHz, CDCl₃) δ 172.27, 168.91, 162.32, 159.45, 146.66, 142.70, 141.58, 137.50, 128.35, 128.27, 125.63, 109.74, 73.76, 56.27, 48.20, 41.04, 40.18, 36.37, 35.70, 30.35, 30.18, 26.08, 24.05, 23.50, 22.30, 20.77, 18.81, 17.91, 12.49. 173 (Thin film ) ESIMS m/z 541 ¹H NMR (400 MHz, CDCl₃) δ 3381, 2934 ([M + H]⁺) 8.39 (d, J = 7.6 Hz, 1H), 8.28 (d, 1735, 1678, J = 5.4 Hz, 1H), 7.31-7.23 (m, 1503 2H), 7.20-7.09 (m, 3H), 6.95 (d, J = 5.5 Hz, 1H), 5.75 (d, J = 4.4 Hz, 2H), 5.03 (qd, J = 6.4, 5.1 Hz, 1H), 4.76-4.63 (m, 1H), 3.91 (s, 3H), 2.63 (dd, J = 14.1, 5.6 Hz, 1H), 2.50 (dd, J = 14.2, 8.5 Hz,1H), 2.07 (s, 3H), 2.03- 1.91 (m, 1H), 1.71-1.59 (m, 2H), 1.54 (d, J = 7.1 Hz, 3H), 1.48- 1.24 (m, 2H), 1.19 (d, J = 6.4 Hz, 3H), 0.94 (t, J = 7.3 Hz, 3H), 0.91-0.78 (m, 1H), 0.63 (dtt, J = 10.6, 6.3, 2.7 Hz, 1H), 0.43-0.32 (m, 2H), −0.02-−0.09 (m, 2H). 174 (Thin film) ESIMS m/z 595 ¹H NMR (400 MHz, CDCl₃) δ 3382, 2935, ([M + H]⁺) 8.38 (d, J = 7.7 Hz, 1H), 8.11 (d, 1733, 1676, J = 5.3 Hz, 1H), 7.26-7.18 (m, 1508 2H), 7.19-7.12 (m, 1H), 7.08- 6.99 (m, 4H), 6.98-6.89 (m, 2H), 6.86 (d, J = 5.4 Hz, 1H), 5.74 (d, J = 1.5 Hz, 2H), 5.11 (qd, J = 6.4, 4.3 Hz, 1H), 4.80-4.69 (m, 1H), 3.89 (s, 3H), 2.94 (dd, J = 13.5, 4.8 Hz, 1H), 2.66 (dd, J = 14.1, 5.6 Hz, 1H), 2.57 (dd, J = 14.1, 8.7 Hz, 1H), 2.26 (dd, J = 13.4, 9.8 Hz, 1H), 2.07 (s, 3H), 1.97-1.88 (m, 1H), 1.86-1.75 (m, 1H), 1.55 (d, J = 7.2 Hz, 3H), 1.37-1.29 (m, 2H), 1.27 (d, J = 6.4 Hz, 3H), 0.84 (t, J = 7.3 Hz, 3H). 175 (Thin film) ESIMS m/z 503 ¹H NMR (400 MHz, CDCl₃) δ 3384, 2937, ([M + H]⁺) 8.31-8.26 (m, 2H), 7.30-7.25 1753, 1678, (m, 2H), 7.22-7.14 (m, 3H), 6.96 1510 (d, J = 5.4 Hz, 1H), 5.76 (s, 2H), 5.17 (qd, J = 6.5, 4.7 Hz, 1H), 4.15 (dd, J = 6.7, 5.5 Hz, 2H), 3.91 (s, 3H), 3.39-3.22 (m, 4H), 2.68 (dd, J = 12.9, 7.3 Hz, 2H), 2.21-2.10 (m, 1H), 2.08 (s, 3H), 1.61-1.50 (m, 2H), 1.31 (d, J = 6.6 Hz, 3H), 0.90 (t, J = 7.4 Hz, 3H). 176 (Thin film) ESIMS m/z 473 ¹H NMR (400 MHz, CDCl₃) δ 3386, 2937, ([M + H]⁺) 8.48 (t, J = 5.4 Hz, 1H), 8.33 (d, 1770, 1677, J = 5.5 Hz, 1H), 7.30-7.24 (m, 1511 2H), 7.22-7.13 (m, 3H), 7.01 (d, J = 5.5 Hz, 1H), 5.17 (qd, J = 6.5, 4.6 Hz, 1H) 4.12 (t, J = 5.8 Hz, 2H), 3.91 (s, 3H), 3.41-3.20 (m, 4H), 2.67 (dd, J = 11.8, 7.3 Hz, 2H), 2.40 (s, 3H), 2.20-2.09 (m, 1H), 1.60-1.49 (m, 2H), 1.31 (d, J = 6.5 Hz, 3H), 0.90 (t, J = 7.4 Hz, 3H). 177 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.29 (d, J = 7.9 Hz, 1H), 8.26 (d, for C₃₄H₄₂FN₂O₉, J = 5.3 Hz, 1H), 7.23-7.13 (m, 641.2869; found, 2H), 7.05-7.01 (m, 2H), 7.02- 641.2867 6.91 (m, 3H), 6.76 (d, J = 8.6 Hz, 2H), 5.77-5.70 (m, 2H), 5.11 (qd, J = 6.4, 4.4 Hz, 1H), 4.58 (p, J = 7.2 Hz, 1H), 4.54-4.51 (m, 1H), 3.90 (s, 3H), 3.56 (dd, J = 10.0, 5.3 Hz, 1H), 3.46-3.39 (m, 2H), 3.39-3.29 (m, 1H), 2.98 (dd, J = 14.5, 6.4 Hz, 1H), 2.72 (dd, J = 14.5, 7.1 Hz, 1H), 2.37 (tdd, J = 6.9, 4.5, 2.6 Hz, 1H), 2.27 (s, 3H), 2.06 (s, 3H), 1.40 (d, J = 7.1 Hz, 3H), 1.29 (d, J = 6.4 Hz, 3H), 1.13 (t, J = 7.0 Hz, 3H). 178 ESIMS m/z 661 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 8.82 (d, J = 8.4 Hz, 1H), 8.22- 8.13 (m, 1H), 7.40 (d, J = 8.0 Hz, 2H), 7.02 (m, 4H), 6.94-6.85 (m, 3H), 5.71 (m, 1H), 5.13 (m, 1H), 5.00 (dd, J = 10.2, 1.6 Hz, 1H), 4.89-4.77 (m, 2H), 3.97 (dd, J = 9.4, 3.1 Hz, 1H), 3.88 (s, 3H), 3.68 (dd, J = 9.4, 3.4 Hz, 1H), 3.35 (s, 3H), 2.94 (q, J = 9.3 Hz, 1H), 2.71 (dd, J = 13.9, 6.9 Hz, 1H), 2.59 (dd, J = 14.0, 7.5 Hz, 1H), 2.52-2.44 (m, 2H), 2.37 (s, 3H), 1.97 (m, 1H), 1.29 (d, J = 6.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 169.58, 168.88, 162.8, 161.30 (d, J = 242 Hz), 159.4, 146.66, 144.87, 141.17, 138.96, 137.61, 136.07 (d, J = 3 Hz), 130.35 (d, J = 8 Hz), 129.46, 127.89 (q, J = 31 Hz), 124.78 (q, J = 3 Hz), 124.39 (q, J = 270 Hz), 116.86, 115.14, (d, J = 21 Hz), 109.71, 72.58, 72.49, 59.35, 56.25, 52.80, 48.49, 45.14, 37.54, 32.27, 20.71, 17.71. 179 ESIMS m/z 631 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 8.50 (d, J = 7.4 Hz, 1H), 8.17 (d, J = 5.4 Hz, 1H), 7.40 (d, J = 7.9 Hz, 2H), 7.05-6.96 (m, 4H), 6.96-6.85 (m, 3H), 5.69 (ddd, J = 17.2, 10.2, 8.3 Hz, 1H), 5.12 (m, 1H), 5.01 (dd, J = 10.4, 1.4 Hz, 1H), 4.83 (d, J = 16.3 Hz, 1H), 4.72 (m, 1H), 3.89 (s, 3H), 2.92 (dd, J = 12.5, 4.2 Hz, 1H), 2.72 (dd, J = 14.1, 6.5 Hz, 1H), 2.63- 2.42 (m, 3H), 2.38 (s, 3H), 1.95 (m, 1H), 1.52 (d, J = 7.3 Hz, 3H), ¹³C NMR (101 MHz, CDCl₃) δ 171.89, 168.91, 162.48, 161.31 (d, J = 242 Hz), 159.49, 146.54, 144.69, 141.22, 138.68, 137.60, 136.00 (d, J = 3 Hz), 130.30 (d, J = 7 Hz), 129.38, 127.99 (q, J = 31 Hz), 124.83 (q, J = 4 Hz), 124.35 (q, J = 270 Hz), 117.04, 115.19, (d, J = 21 Hz), 109.73, 72.28, 56.27, 48.29, 48.24, 45.24, 37.81, 32.57, 20.73, 18.38, 17.65. 180 ESIMS m/z 617 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 8.53 (t, J = 5.6 Hz, 1H), 8.22 (d, J = 5.5 Hz, 1H), 7.41 (d, J = 8.0 Hz, 2H), 7.05-6.97 (m, 4H), 6.97-6.88 (m, 3H), 5.70 (ddd, J = 17.1, 10.2, 8.7 Hz, 1H), 5.13 (m, 1H), 5.03 (dd, J = 10.3, 1.3 Hz, 1H), 4.85 (d, J = 17.1 Hz, 1H), 4.27-4.05 (m, 2H), 3.89 (s, 3H), 2.94 (dd, J = 13.4, 5.5 Hz, 1H), 2.72 (dd, J = 14.1, 6.4 Hz, 1H), 2.65-2.51 (m, 2H), 2.50- 2.41 (m, 1H), 2.39 (s, 3H), 1.99 (m, 1H), 1.30 (d. J = 6.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 168.91, 168.87, 163.15, 161.32 (d, J = 243 Hz), 159.50, 146.63, 144.59, 141.14, 138.48, 137.60, 135.94 (d, J = 3 Hz), 130.0 (d, J = 8 Hz), 129.41, 128.02 (q, J = 32 Hz), 124.89 (q, J = 4 Hz), 124.35 (q, J = 270 Hz), 117.12, 115.21, (d, J = 21 Hz), 109.85, 72.76, 56.27, 47.93, 45.41, 41.56, 38.18, 32.88, 20.72, 17.73. 181 ESIMS m/z 663 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 8.81 (d, J = 8.0 Hz, 1H), 8.06 (d, J = 4.8 Hz, 1H), 7.44 (d, J = 8.0 Hz, 2H), 7.15-7.02 (m, 4H), 6.99-6.89 (m, 2H), 6.82 (d, J = 5.5 Hz, 1H), 5.10-5.06 (m, 1H), 4.85 (dt, J = 8.5, 3.1 Hz, 1H), 3.99 (dd, J = 9.3, 3.1 Hz, 1H), 3.87 (s, 3H), 3.69 (dd, J = 9.4, 3.3 Hz, 1H), 3.37 (s, 3H), 2.99 (dd, J = 13.4, 3.8 Hz, 1H), 2.63 (dd, J = 13.9, 5.0 Hz, 1H), 2.54 (dd, J = 13.6, 9.7 Hz, 1H), 2.37 (s, 3H), 2.21 (dd, J = 13.4, 10.4 Hz, 1H), 1.85 (dd, J = 9.3, 5.0 Hz, 2H), 1.36-1.20 (m, 2H), 1.27 (d, J = 6.0 Hz, 3H) 0.82 (t, J = 7.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 169.75, 168.86, 162.80, 161.34 (d, J = 243.8 Hz), 159.32, 146.58, 146.17, 141.05, 137.55, 136.38 (d, J = 3.2 Hz), 130.45 (d, J = 7.7 Hz), 129.48, 127.79 (q, J = 32.2 Hz), 124.84 (q, J = 3.7 Hz) 124.44 (q, J = 270 Hz), 115.18 (d, J = 21.1 Hz), 109.60, 72.78, 72.45, 59.30, 56.21, 52.87, 45.58, 40.74, 37.29, 31.25, 23.32, 20.70, 18.35, 12.38. 182 ESIMS m/z 633 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 8.47 (d, J = 6.4 Hz, 1H), 8.05 (d, J = 5.2 Hz, 1H), 7.43 (d, J = 8.0 Hz, 2H), 7.08-7.02 (m, 4H), 6.99- 6.88 (m, 2H), 6.84 (d, J = 5.4 Hz, 1H), 5.07 (m, 1H), 4.72 (p, J = 7.2 Hz, 1H), 3.87 (s, 3H), 2.95 (dd, J = 13.5, 4.6 Hz, 1H), 2.62 (dd, J = 13.8, 5.5 Hz, 1H), 2.55 (dd, J = 13.9, 9.0 Hz, 1H), 2.36 (s, 3H), 2.26 (dd, J = 13.2, 10.2 Hz, 1H), 1.94-1.75 (m, 2H), 1.55 (d, J = 7.3 Hz, 3H), 1.37- 1.21 (m, 2H), 1.26 (d, J = 6.4 Hz, 3H), 0.83 (t, J = 7.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.00, 168.88, 162.49, 161.34 (d, J = 242 Hz), 159.43, 146.45, 146.00, 141.07, 137.56, 136.30 (d, J = 3 Hz), 130.37 (d, J = 8.0 Hz), 129.37, 127.85 (q, J = 32.0 Hz), 124.88 (q, J = 4.0 Hz), 124.41 (q, J = 270.0 Hz), 115.21 (d, J = 21.0 Hz), 109.63, 72.40, 56.23, 48.32, 45.52, 40.84, 37.33, 31.59, 23.26, 20.71, 18.38, 18.32, 12.40. 183 ESIMS m/z 619 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 8.53 (t, J = 5.7 Hz, 1H), 8.11 (d, J = 5.4 Hz, 1H), 7.42 (d, J = 7.9 Hz, 2H), 7.08 (d, J = 7.9 Hz, 2H), 7.05-6.99 (m, 2H), 6.97-6.91 (m, 2H), 6.88 (d, J = 5.4 Hz, 1H), 5.14-5.06 (m, 1H), 4.21 (qd, J = 19.7, 18.9, 6.5 Hz, 2H), 3.88 (s, 3H), 2.95 (dd, J = 13.4, 4.9 Hz, 1H), 2.59 (qd, J = 14.0, 7.3 Hz, 2H), 2.38 (s, 3H), 2.33 (dd, J = 13.3, 9.5 Hz, 1H), 1.93-1.84 (m, 1H), 1.84-1.75 (m, 1H), 1.37- 1.22 (m, 2H), 1.27 (d, J = 6.4 Hz, 3H), 0.84 (t, J = 7.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 168.97, 168.91, 163.16, 161.35 (d, J = 244.1 Hz), 159.44, 146.53, 145.89, 141.00, 137.58, 136.17 (d, J = 3.1 Hz), 130.34 (d, J = 7.8 Hz, 129.36, 127.86 (q, J = 32.2 Hz), 124.93 (q, J = 3.8 Hz), 124.4 (q, J = 270.0 Hz), 115.24 (d, J = 21.1 Hz), 109.77, 72.79, 56.24, 45.41, 41.62, 40.96, 37.53, 31.96, 23.21, 20.71, 18.54, 12.40. 184 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.41 (d, J = 7.8 Hz, 1H), 8.27 for C₂₆H₃₅N₂O₇, (d, J = 5.4 Hz, 1H), 7.31-7.21 487.2444; found, (m, 2H), 7.21-7.15 (m, 1H), 487.2441. 7.15-7.08 (m, 2H), 6.94 (d, J = 5.4 Hz, 1H), 5.81-5.71 (m, 2H), 5.04 (qd, J = 6.5, 3.7 Hz, 1H), 4.79-4.68 (m, 1H), 3.91 (s, 3H), 2.69 (dd, J = 13.6, 6.4 Hz, 1H), 2.50 (dd, J = 13.6, 7.8 Hz, 1H), 2.07 (s, 3H), 1.91-1.79 (m, 1H), 1.54 (d, J = 7.1 Hz, 3H), 1.41- 1.25 (m, 4H), 1.23 (d, J = 6.5 Hz, 3H), 0.91-0.80 (m, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.27, 170.28, 163.01, 160.31, 145.70, 144.04, 142.54, 140.77, 129.10, 128.31, 125.90, 109.56, 89.61, 73.09, 56.18, 48.40, 44.52, 36.23, 31.49, 20.89, 20.28, 18.73, 16.18, 14.26. 185 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.36 (d, J = 7.8 Hz, 1H), 8.28 for C₂₅H₃₁N₂O₉, (d, J = 5.4 Hz, 1H), 7.32-7.23 503.2029; found, (m, 2H), 7.23-7.17 (m, 1H), 503.2026. 7.17-7.07 (m, 2H), 6.95 (d, J = 5.4 Hz, 1H), 5.75 (d, J = 0.8 Hz, 2H), 5.27-5.17 (m, 1H), 4.84- 4.62 (m, 1H), 3.91 (s, 3H), 3.54 (s, 3H), 3.02-2.80 (m, 3H), 2.07 (s, 3H), 1.49 (d, J = 7.2 Hz, 3H), 1.37 (d, J = 6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.50, 171.89, 170.28, 163.02, 160.28, 145.72, 144.01, 142.42, 138.27, 128.77, 128.50, 126.60, 109.60, 89.54, 71.91, 56.19, 52.97, 51.63, 48.18, 34.23, 20.87, 18.41, 17.83. 186 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.53 (d, J = 6.3 Hz, 1H), 8.33 for C₂₄H₂₉N₂O₈, (d, J = 5.5 Hz, 1H), 7.30-7.23 473.1924; found, (m, 2H), 7.23-7.18 (m, 1H), 473.1925. 7.17-7.12 (m, 2H), 7.00 (d, J = 5.5 Hz, 1H), 5.33-5.15 (m, 1H), 4.79-4.61 (m, 1H), 3.89 (s, 3H), 3.53 (s, 3H), 2.99-2.81 (m, 3H), 2.39 (s, 3H), 1.47 (d, J = 7.2 Hz, 3H), 1.36 (d, J = 6.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.47, 171.77, 168.89, 162.44, 159.46, 146.69, 141.47, 138.30, 137.51, 128.79, 128.50, 126.59, 109.81, 71.91, 56.29, 52.96, 51.62, 47.97, 34.17, 20.74, 18.55, 17.77. 187 IR (neat) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3376, 2934, [M]+ calcd for 8.37 (d, J = 7.6 Hz, 1H), 8.11 1735, 1678, C₃₄H₃₉F₃N₂O₈, (d, J = 5.4 Hz, 1H), 7.24-7.14 1507, 1260 660.2659; found, (m, 3H), 7.12-7.05 (m, 4H), 660.2658. 7.02-6.97 (m, 2H), 6.86 (d, J = 5.4 Hz, 1H), 5.78-5.71 (m, 2H), 5.17-5.08 (m, 1H), 4.79-4.68 (m, 1H), 3.89 (s, 3H), 2.91 (dd, J = 13.5, 5.1 Hz, 1H), 2.72-2.56 (m, 2H), 2.27 (dd, J = 13.4, 9.5 Hz, 1H), 2.07 (s, 3H), 1.97-1.90 (m, 1H), 1.84-1.74 (m, 1H), 1.54 (d, J = 7.3 Hz, 3H), 1.37-1.28 (m, 2H), 1.28 (d, J = 6.4 Hz, 3H), 0.85 (t, J = 7.3 Hz, 3H) 188 (Thin film) ESIMS m/z 545 ¹H NMR (400 MHz, CDCl₃) δ 3384, 2936, ([M + H]⁺) 8.32 (d, J = 7.8 Hz, 1H), 8.27 1736, 1677, (d, J = 5.3 Hz, 1H), 7.26-7.21 1493 (m, 2H), 6.94 (d, J = 5.4 Hz, 1H), 6.90 (tt, J = 7.4, 1.1 Hz, 1H), 6.87-6.82 (m, 2H), 5.74 (d, J = 1.6 Hz, 2H), 5.17-5.05 (m, 1H), 4.67-4.57 (m, 1H), 4.28 (td, J = 6.4, 3.1 Hz, 1H), 3.91 (s, 3H), 2.07 (s, 3H), 1.88 (qd, J = 6.5, 5.7, 2.3 Hz, 1H), 1.83-1.71 (m, 1H), 1.71-1.61 (m, 1H), 1.61- 1.50 (m, 1H), 1.46 (td, J = 6.3, 3.5 Hz, 1H), 1.41 (d, J = 7.2 Hz, 3H), 1.39-1.31 (m, 4H), 1.30 (d, J = 6.4 Hz, 3H), 0.95 (t, J = 7.4 Hz, 3H), 0.90 (t, J = 7.2 Hz, 3H). 189 (Thin film) ESIMS m/z 545 ¹H NMR (400 MHz, CDCl₃) δ 3382, 2935, ([M + H]⁺⁾ 8.39 (d, J = 7.8 Hz, 1H), 8.28 1735, 1677, (d, J = 5.3 Hz, 1H), 7.32-7.21 1494 (m, 2H), 6.99-6.85 (m, 4H), 5.75 (d, J = 3.2 Hz, 2H), 5.23 (qd, J = 6.5, 5.2 Hz, 1H), 4.80- 4.67 (m, 1H), 4.33 (td, J = 6.2, 3.9 Hz, 1H), 3.91 (s, 3H), 2.08 (s, 3H), 2.03-1.95 (m, 1H), 1.78- 1.67 (m, 2H), 1.58-1.45 (m, 1H), 1.53 (d, J = 7.1 Hz, 3H), 1.43- 1.35 (m, 1H), 1.34 (d, J = 6.4 Hz, 3H), 1.32-1.18 (m, 4H), 0.96 (t, J = 7.4 Hz, 3H), 0.84 (t, J = 7.1 Hz, 3H) 190 (Thin film) ESIMS m/z 515 ¹H NMR (400 MHz, CDCl₃) δ 3384, 2936, ([M + H]⁺) 8.57 (d, J = 7.7 Hz, 1H), 8.33 (d, 1771, 1677, J = 5.5 Hz, 1H), 7.31-7.20 (m, 1507 2H), 7.01 (d, J = 5.4 Hz, 1H), 6.95-6.84 (m, 3H), 5.22 (qd, J = 6.4, 5.2 Hz, 1H), 4.76-4.65 (m, 1H), 4.33 (td, J = 6.2, 4.0 Hz, 1H), 3.91 (s, 3H), 2.40 (s, 3H), 2.02-1.94 (m, 1H), 1.79- 1.65 (m, 2H), 1.51 (d, J = 7.1 Hz, 3H), 1.58-1.44 (m, 1H), 1.42- 1.35 (m, 1H), 1.32 (d, J = 6.4 Hz, 3H), 1.31-1.17 (m, 4H), 0.95 (t, J = 7.4 Hz, 3H), 0.84 (t, J = 7.0 Hz, 3H). 191 (Thin film) ESIMS m/z 579 ¹H NMR (400 MHz, CDCl₃) δ 3383, 2975, ([M + H]⁺) 8.30 (d, J = 8.6 Hz, 1H), 8.28 (d, 1735, 1676, J = 5.4 Hz, 1H), 7.34-7.25 (m, 1494 2H), 7.25-7.16 (m, 5H), 6.95 (d, J = 5.4 Hz, 1H), 6.93-6.85 (m, 1H), 6.75-6.70 (m, 2H), 5.75 (d, J = 1.1 Hz, 2H), 5.11 (qd, J = 6.4, 4.8 Hz, 1H), 4.67-4.54 (m, 1H), 4.29 (ddd, J = 7.0, 5.9, 2.6 Hz, 1H), 3.91 (s, 3H), 2.89 (dd, J = 14.4, 6.8 Hz, 1H), 2.77 (dd, J = 14.4, 6.9 Hz, 1H), 2.35-2.25 (m, 1H), 2.06 (s, 3H), 1.83-1.62 (m, 2H), 1.41 (d, J = 7.1 Hz, 3H), 1.30 (d, J = 6.5 Hz, 3H), 0.91 (t, J = 7.4 Hz, 3H). 192 (Thin film) ESIMS m/z 579 ¹H NMR (400 MHz, CDCl₃) δ 3383, 2939, ([M + H]⁺) 8.41 (d, J = 7.7 Hz, 1H), 8.27 (d, 1735, 1676, J = 5.3 Hz, 1H), 7.29-7.24 (m, 1493 2H), 7.23-7.12 (m, 3H), 7.02- 6.90 (m, 4H), 6.87-6.81 (m, 2H), 5.76 (d, J = 3.6 Hz, 2H), 5.27 (qd, J = 6.5, 4.2 Hz, 1H), 4.82- 4.69 (m, 1H), 4.27 (td, J = 6.6, 3.5 Hz, 1H), 3.91 (s, 3H), 2.88 (dd, J = 13.7, 7.6 Hz, 1H), 2.71 (dd, J = 13.7, 6.6 Hz, 1H), 2.36- 2.25 (m, 1H), 2.08 (s, 3H), 1.80- 1.67 (m, 2H), 1.58 (d, J = 7.2 Hz, 3H), 1.37 (d, J = 6.5 Hz, 3H), 0.88 (t, J = 7.4 Hz, 3H). 193 (Thin film) ESIMS m/z 549 ¹H NMR (400 MHz, CDCl₃) δ 3383, 2938, ([M + H]⁺) 8.49 (d, J = 7.2 Hz, 1H), 8.32 (d, 1771, 1734, J = 5.4 Hz, 1H), 7.32-7.27 (m, 1676 2H), 7.25-7.16 (m, 5H), 6.99 (d, J = 5.5 Hz, 1H), 6.88 (tt, J = 7.3, 1.1 Hz, 1H), 6.74-6.68 (m, 2H), 5.10 (qd, J = 6.5, 4.9 Hz, 1H), 4.66-4.53 (m, 1H), 4.28 (ddd, J = 7.1, 5.8, 2.7 Hz, 1H), 3.90 (s, 3H), 2.88 (dd, J = 14.4, 6.9 Hz, 1H), 2.75 (dd, J = 14.4, 6.8 Hz, 1H), 2.39 (s, 3H), 2.34-2.25 (m, 1H), 1.84-1.58 (m, 2H), 1.40 (d, J = 7.1 Hz, 3H), 1.29 (d, J = 6.5 Hz, 3H), 0.89 (t, J = 7.4 Hz, 3H). 194 (Thin film) ESIMS m/z 549 ¹H NMR (400 MHz, CDCl₃j) δ 3384, 2978, ([M + H]⁺) 8.57 (d, J = 7.3 Hz, 1H), 8.32 1771, 1734, (d, J = 5.4 Hz, 1H), 7.29-7.23 1677 (m, 2H), 7.23-7.12 (m, 3H), 7.02-6.96 (m, 3H), 6.94 (tt, J = 7.4, 1.1 Hz, 1H), 6.86-6.78 (m, 2H), 5.24 (qd, J = 6.5, 4.1 Hz, 1H), 4.81-4.66 (m, 1H), 4.26 (td, J = 6.6, 3.5 Hz, 1H), 3.91 (s, 3H), 2.88 (dd, J = 13.7, 7.5 Hz, 1H), 2.70 (dd, J = 13.7, 7.4 Hz, 1H), 2.39 (s, 3H), 2.33-2.25 (m, 1H), 1.78-1.66 (m, 2H), 1.56 (d, J = 7.2 Hz, 3H), 1.35 (d, J = 6.5 Hz, 3H), 0.87 (t, J = 7.4 Hz, 3H). 195 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.33 (d, J = 7.8 Hz, 1H), 8.28 (d, for C₂₉H₃₃N₂O₇, J = 5.4 Hz, 1H), 7.22-6.98 (m, 521.2288; found, 10H), 6.95 (d, J = 5.4 Hz, 1H), 521.2283. 5.82-5.70 (m, 2H), 5.24 (qd, J = 6.3, 5.1 Hz, 1H), 4.74-4.61 (m, 1H), 3.90 (s, 3H), 3.11-2.98 (m, 2H), 2.91 (dd, J = 12.4, 8.0 Hz, 1H), 2.05 (s, 3H), 1.29 (d, J = 7.2 Hz, 3H), 1.23 (d, J = 6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.12, 170.22, 162.95, 160.32, 145.68, 144.04, 142.50, 140.26, 139.57, 128.99, 128.95, 128.18, 128.09, 126.66, 126.01, 109.59, 89.54, 73.60, 56.17, 53.09, 48.29, 38.41, 20.83, 18.36, 18.27. 196 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.51 (d, J = 7.8 Hz, 1H), 8.34 (d, for C₂₈H₃₁N₂O₆, J = 5.4 Hz, 1H), 7.22-6.98 (m, 491.2182; found, 11H), 5.21 (qd, J = 6.3, 5.0 Hz, 491.2182. 1H), 4.72-4.57 (m, 1H), 3.89 (s, 3H), 3.14-2.96 (m, 2H), 2.91 (dd, J = 12.4, 8.0 Hz, 1H), 2.37 (s, 3H), 1.30 (d, J = 7.2 Hz, 3H), 1.20 (d, J = 6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.99, 168.83, 162.39, 159.50, 146.65, 141.49, 140.21, 139.62, 137.54, 129.01, 128.99, 128.17, 128.05, 126.65, 126.00, 109.81, 73.51, 56.26, 53.03, 48.12, 38.34, 20.69, 18.36, 18.31. 197 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.46 (d, J = 8.3 Hz, 1H), 8.32 for C₂₅H₃₃N₂O₆, (d, J = 5.4 Hz, 1H), 7.33-7.14 457.2338; found, (m, 5H), 6.99 (d, J = 5.5 Hz, 457.2345 1H), 5.20 (p, J = 6.4 Hz, 1H), 4.58 (dq, J = 8.2, 7.2 Hz, 1H), 3.89 (s, 3H), 2.70 (ddd, J = 10.3, 6.9, 4.9 Hz, 1H), 2.38 (s, 3H), 1.75-1.56 (m, 2H), 1.33- 1.23 (m, 2H), 1.22 (d, J = 6.3 Hz, 3H), 1.13 (d, J = 7.2 Hz, 3H), 1.12-0.99 (m, 2H), 0.81 (t, J = 7.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.13, 168.87, 162.28, 159.44, 146.64, 141.56, 141.22, 137.47, 128.65, 128.17, 126.50, 109.73, 74.81, 56.27, 51.11, 47.97, 31.39, 29.48, 22.61, 20.73, 18.32, 18.30, 13.90. 198 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.41 (d, J = 7.8 Hz, 1H), 8.31 for C₂₇H₃₇N₂O₆, (d, J = 5.4 Hz, 1H), 7.29-7.12 485.2651; found, (m, 5H), 6.97 (d, J = 5.5 Hz, 485.2647 1H), 5.19 (p, J = 6.4 Hz, 1H), 4.59 (dq, J = 8.2, 7.2 Hz, 1H), 3.86 (s, 3H), 2.93 (hept, J = 7.0 Hz, 1H), 2.70 (ddd, J = 10.2, 6.9, 4.9 Hz, 1H), 1.76-1.58 (m, 2H), 1.35 (d, J = 7.0 Hz, 6H), 1.29-1.23 (m, 2H), 1.21 (d, J = 6.3 Hz, 3H), 1.13 (d, J = 7.2 Hz, 3H), 1.12-1.04 (m, 2H), 0.81 (t, J = 7.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 174.65, 172.22, 162.27, 159.41, 146.55, 141.95, 141.23, 137.63, 128.67, 128.16, 126.50, 109.58, 74.73, 56.27, 51.10, 47.94, 33.93, 31.40, 29.48, 22.60, 18.80, 18.35, 18.32, 13.89. 199 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.43-8.14 (m, 2H), 7.31-7.21 for C₂₆H₃₅N₂O₇, (m, 2H), 7.22-7.11 (m, 3H), 487.2444; found, 6.94 (d, J = 5.4 Hz, 1H), 5.86- 487.2437 5.60(m, 2H), 5.31-5.14 (m, 1H), 4.75-4.49 (m, 1H), 3.90 (s, 3H), 2.71 (ddd, J = 10.3, 7.0, 4.6 Hz, 1H), 2.06 (s, 3H), 1.73-1.58 (m, 2H), 1.37-1.19 (m, 2H), 1.24 (d, J = 6.3 Hz, 3H), 1.17-1.04 (m, 2H), 1.14 (d, J = 7.1 Hz, 3H). 0.81 (t, J = 7.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.23, 170.23, 162.87, 160.26, 145.68, 143.96, 142.56, 141.28, 128.62, 128.18, 126.49, 109.54, 89.55, 74.79, 56.17, 51.14, 48.18, 31.40, 29.46, 22.60, 20.85, 18.35, 18.12, 13.89. 200 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.34 (d, J = 7.8 Hz, 1H), 8.26 (d, for C₂₈H₃₉N₂O₇, J = 5.4 Hz, 1H), 7.27-7.15 (m, 515.2764; found, 5H), 6.94 (d, J = 5.4 Hz, 1H), 515.2759 5.76 (q, J = 6.4 Hz, 2H), 5.33- 5.10 (m, 1H), 4.65-4.51 (m, 1H), 3.88 (s, 3H), 2.72 (ddd, J = 10.3, 7.0, 4.7 Hz, 1H), 2.54 (hept, J = 7.0 Hz, 1H), 1.76-1.55 (m, 2H), 1.32-1.21 (m, 2H), 1.24 (d, J = 6.3 Hz, 3H), 1.20-1.02 (m, 2H), 1.14 (d, J = 7.2 Hz, 3H), 1.14 (d, J = 7.0 Hz, 6H), 0.81 (t, J = 7.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 176.19, 172.23, 162.84, 160.25, 145.53, 144.19, 142.19, 141.27, 128.62, 128.17, 126.48, 109.48, 89.91, 74.77, 56.12, 51.13, 48.17, 33.84, 31.39, 29.46, 22.60, 18.66, 18.34, 18.12, 13.88. 201 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.49 (d, J = 7.9 Hz, 1H), 8.34 (d, for C₂₈H₃₀ClN₂O₆, J = 5.4 Hz, 1H), 7.19-7.07 (m, 525.1792; found, 7H), 7.01 (d, J = 5.5 Hz, 1H), 525.1785 6.94-6.85 (m, 2H), 5.21 (qd, J = 6.3, 5.1 Hz, 1H), 4.73-4.60 (m, 1H), 3.90 (s, 3H), 3.02 (dd, J = 12.5, 5.4 Hz, 1H), 2.94 (dt, J = 8.7, 5.3 Hz, 1H), 2.86 (dd, J = 12.5, 8.7 Hz, 1H), 2.37 (s, 3H), 1.28 (d, J = 7.2 Hz, 3H), 1.23- 1.17 (m, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.01, 168.88, 162.45, 159.54, 146.66, 141.47, 139.73, 138.13, 137.60, 131.77, 130.37, 128.99, 128.30, 128.16, 126.82, 109.83, 73.45, 56.30, 53.01, 48.16, 37.67, 20.74, 18.32, 18.32. 202 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺⁾ calcd 8.44 (d, J = 7.7 Hz, 1H), 8.33 for C₃₀H₃₄ClN₂O₆, (d, J = 5.4 Hz, 1H), 7.17-7.08 553.2105; found, (m, 7H), 6.99 (d, J = 5.4 Hz, 553.2106 1H), 6.92 (d, J = 8.4 Hz, 2H), 5.19 (qd, J = 6.3, 5.0 Hz, 1H), 4.73-4.61 (m, 1H), 3.87 (s, 3H), 3.02 (dd, J = 12.3, 5.3 Hz, 1H), 2.97-2.83 (m, 3H), 1.34 (d, J = 4.7 Hz, 3H), 1.32 (d, J = 4.7 Hz, 3H), 1.29 (d, J = 7.2 Hz, 3H), 1.18 (d, J = 6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 174.66, 172.10, 162.43, 159.52, 146.56, 141.82, 139.73, 138.16, 137.79, 131.75, 130.39, 129.02, 128.28, 128.14, 126.80, 109.68, 73.34, 56.31, 53.00, 48.13, 37.69, 33.95, 18.80, 18.78, 18.34. 203 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.45-8.14 (m, 2H), 7.24-7.14 for C₂₉H₃₂ClN₂O₇, (m, 3H), 7.14-7.09 (m, 4H), 555.1898; found, 6.99-6.94 (m, 1H), 6.93-6.84 555.1895 (m, 2H), 5.85-5.63 (m, 2H), 5.28-5.09 (m, 1H), 4.66 (p, J = 7.3 Hz, 1H), 3.90 (s, 3H), 3.03 (dd, J = 12.6, 5.4 Hz, 1H), 2.96 (dt, J =8.9, 5.4 Hz, 1H), 2.87 (dd, J = 12.6, 8.8 Hz, 1H), 2.06 (s, 3H), 1.28 (d, J = 7.1 Hz, 3H), 1.23 (d, J = 6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.12, 170.25, 163.00, 160.33, 145.68, 142.46, 139.76, 138.06, 131.77, 130.34, 130.34, 128.93, 128.29, 128.19, 126.82, 109.63, 89.58, 73.54, 56.20, 53.06, 48.32, 37.72, 22.65, 20.86, 18.35, 18.20. 204 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.37 (d, J = 7.8 Hz, 1H), 8.28 for C₃₁H₃₆ClN₂O₇, (d, J = 5.3 Hz, 1H), 7.23-7.08 583.2211; found, (m, 7H), 6.95 (d, J = 5.4 Hz, 583.2206 1H), 6.93-6.85 (m, 2H), 5.83- 5.70 (m, 2H), 5.28-5.15 (m, 1H), 4.72-4.59 (m, 1H), 3.88 (s, 3H), 3.03 (dd, J = 12.6, 5.4 Hz, 1H), 2.96 (dt, J = 8.9, 5.4 Hz, 1H), 2.87 (dd, J = 12.6, 8.8 Hz, 1H), 2.54 (hept, J = 7.0 Hz, 1H), 1.28 (d, J = 7.2 Hz, 3H), 1.23 (d, J = 6.3 Hz, 3H), 1.13 (d, J = 7.0 Hz, 6H). ¹³C NMR (101 MHz, CDCl₃) δ 176.22, 172.12, 162.96, 160.32, 145.55, 144.33, 142.09, 139.76, 138.06, 131.77, 130.34, 128.93, 128.29, 128.18, 126.81, 109.55, 89.96, 73.53, 56.14, 53.06, 48.32, 37.72, 33.85, 18.68, 18.34, 18.21. 205 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.56 (s, 1H), 8.31 (d, J = 5.4 Hz, for C₂₅H₃₃N₂O₆, 1H), 7.32-7.23 (m, 2H), 7.20- 457.2339; found, 7.09 (m, 3H), 6.99 (d, J = 5.5 Hz, 457.2329 1H), 5.02 (qd, J = 6.4, 4.4 Hz, 1H), 4.68 (dq, J = 8.1, 7.2 Hz, 1H), 3.90 (s, 3H), 2.66 (dd, J = 13.9, 5.5 Hz, 1H), 2.54 (dd, J = 14.2, 8.1 Hz, 1H), 2.39 (s, 3H), 1.97 (ddq, J = 10.7, 6.9, 3.5 Hz, 1H), 1.82-1.73 (m, 1H), 1.50 (d, J = 7.1 Hz, 3H), 1.20 (d, J = 6.4 Hz, 3H), 1.00 (d, J = 6.9 Hz, 3H), 0.92 (d, J = 6.8 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.09, 168.90, 162.40, 159.46, 146.64, 141.57, 141.53, 137.52, 128.96, 128.34, 125.79, 109.75, 72.98, 56.28, 50.38, 48.26, 32.26, 27.32, 21.51, 20.75, 19.07, 18.71, 17.64. 206 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.39 (d, J = 7.8 Hz, 1H), 8.27 for C₂₆H₃₅N₂O₇, (d, J = 5.3 Hz, 1H), 7.35-7.22 487.2444; found, (m, 2H), 7.22-7.07 (m, 3H), 487.2419 6.94 (d, J = 5.3 Hz, 1H), 5.85- 5.64 (m, 2H), 5.04 (qd, J = 6.4, 4.5 Hz, 1H), 4.83-4.58 (m, 1H), 3.90 (s, 3H), 2.67 (dd, J = 14.2, 5.4 Hz, 1H), 2.55 (dd, J = 14.2, 8.0 Hz, 1H), 2.07 (s, 3H), 2.04- 1.91 (m, 1H), 1.84-1.74 (m, 1H), 1.51 (d, J = 7.1 Hz, 3H), 1.21 (d, J = 6.4 Hz, 3H), 1.00 (d, J = 6.9 Hz, 3H), 0.94 (d, J = 6.9 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.21, 170.27, 162.98, 160.30, 145.68, 144.05, 142.51, 141.58, 128.93, 128.34, 125.80, 109.56, 89.62, 73.00, 56.18, 50.36, 48.42, 32.33, 27.38, 21.46, 20.87, 19.12, 18.60, 17.64. 207 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3380, 2973, ([M + H]⁺) calcd 8.27 (d, J = 5.4 Hz, 1H), 8.25 1756, 1731, for C₂₉H₄₁N₂O₈, (d, J = 5.4 Hz, 1H), 7.25-7.16 1676, 1501, 545.2857; found, (m, 4H), 7.16-7.09 (m, 1H), 1201 545.2857 6.93 (d, J = 5.4 Hz, 1H), 5.74 (s, 1H), 5.74 (s, 1H), 5.39 (qd, J = 6.7, 2.9 Hz, 1H), 4.59-4.44 (m, 1H), 3.90 (s, 3H), 3.36-3.20 (m, 2H), 2.96 (dd, J = 14.7, 5.2 Hz, 1H), 2.77 (dd, J = 14.7, 7.2 Hz, 1H), 2.26 (ddd, J = 7.2, 5.2, 2.8 Hz, 1H), 2.07 (s, 3H), 1.53 (h, J = 7.4 Hz, 2H), 1.36 (d, J = 6.6 Hz, 3H), 1.23 (d, J = 7.0 Hz, 3H), 1.23 (s, 3H), 1.16 (s, 3H), 0.92 (t, J = 7.4 Hz, 3H). 208 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3382, 2937, ([M + H]⁺) calcd 8.36 (d, J = 7.8 Hz, 1H), 8.25 1739, 1676, for C₃₀H₃₅N₂O₈, (d, J = 5.4 Hz, 1H), 7.31-7.11 1497, 1201 551.2388; found, (m, 7H), 6.96-6.90 (m, 2H), 551.2389 6.86-6.80 (m, 2H), 5.75 (d, J = 6.4 Hz, 1H), 5.73 (d, J = 6.4 Hz, 1H), 5.24 (qd, J = 6.5, 5.0 Hz, 1H), 4.81-4.65 (m, 1H), 3.96-3.85 (m, 2H), 3.90 (s, 3H), 2.83-2.78 (m, 2H), 2.38-2.25 (m, 1H), 2.06 (s, 3H), 1.48 (d, J = 7.1 Hz, 3H), 1.39 (d, J = 6.5 Hz, 3H). 209 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3384, 2939, ([M + H]⁺) calcd 8.33 (d, J = 7.7 Hz, 1H), 8.24 1739, 1677, for C₃₀H₃₃Cl₂N₂O₈, (d, J = 5.4 Hz, 1H), 7.35 (d, 1506, 1465, 619.1608; found, J = 2.5 Hz, 1H), 7.31-7.22 (m, 1202 619.1617 2H), 7.23-7.13 (m, 3H), 7.09 (dd, J = 8.8, 2.6 Hz, 1H), 6.93 (d, J = 5.4 Hz, 1H), 6.66 (d, J = 8.8 Hz, 1H), 5.74 (s, 2H), 5.23 (qd, J = 6.4, 5.1 Hz, 1H), 4.72 (p, J = 7.3 Hz, 1H), 3.98-3.84 (m, 2H), 3.91 (s, 3H), 2.88 (dd, J = 13.6, 8.9 Hz, 1H), 2.81 (dd, J = 13.6, 6.0 Hz, 1H), 2.33 (ddd, J = 10.7, 9.3, 5.2 Hz, 1H), 2.07 (s, 3H), 1.49 (d, J = 7.2 Hz, 3H), 1.43 (d, J = 6.5 Hz, 3H). 210 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.47 (d, J = 8.1 Hz, 1H), 8.32 for C₂₆H₃₅N₂O₆, (d, J = 5.4 Hz, 1H), 7.27-7.21 471.2495; found, (m, 2H), 7.23-7.13 (m, 3H), 471.2475 6.99 (d, J = 5.5 Hz, 1H), 5.26- 5.11 (m, 1H), 4.59 (dq, J = 8.2, 7.2 Hz, 1H), 3.89 (s, 3H), 2.67 (ddd, J = 10.3, 6.7, 4.7 Hz, 1H), 2.38 (s, 3H), 1.74-1.59 (m, 2H), 1.51-1.41 (m, 1H), 1.21 (d, J = 6.3 Hz, 3H), 1.15 (d, J = 7.1 Hz, 3H), 1.12-0.99 (m, 1H), 0.99- 0.94 (m, 1H), 0.81 (d, J = 4.8 Hz, 3H), 0.79 (d, J = 4.8 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.13, 168.87, 162.28, 159.44, 146.64, 141.56, 141.21, 137.47, 128.67, 128.17, 126.51, 109.73, 74.78, 56.27, 51.34, 47.97, 36.49, 29.41, 27.94, 22.73, 22.21, 20.74, 18.33, 18.30. 211 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.41 (d, J = 8.1 Hz, 1H), 8.31 for C₂₈H₃₉N₂O₆, (d, J = 5.4 Hz, 1H), 7.27-7.21 499.2808; found, (m, 2H), 7.21-7.12 (m, 3H), 499.2791 6.97 (d, J = 5.4 Hz, 1H), 5.20 (p, J = 6.4 Hz, 1H), 4.60 (dq, J = 8.2, 7.1 Hz, 1H), 3.87 (s, 3H), 2.93 (hept, J = 7.0 Hz, 1H), 2.67 (ddd, J = 10.2, 6.8, 4.8 Hz, 1H), 1.76-1.59 (m, 2H), 1.53-1.42 (m, 1H), 1.35 (d, J = 7.0 Hz, 6H), 1.21 (d, J = 6.3 Hz, 3H), 1.15 (d, J = 7.1 Hz, 3H), 1.11-1.03 (m, 1H), 1.00-0.94 (m, 1H), 0.81 (d, J = 4.7 Hz, 3H), 0.79 (d, J = 4.7 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 174.66, 172.23, 162.27, 159.41, 146.55, 141.95, 141.22, 137.63, 128.68, 128.17, 126.50, 109.57, 74.71, 56.27, 51.33, 47.94, 36.49, 33.94, 29.42, 27.94, 22.73, 22.21, 18.80, 18.39, 18.30. 212 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.45 (d, J = 8.6 Hz, 1H), 8.32 for C₂₈H₃₉N₂O₇, (d, J = 5.4 Hz, 1H), 7.27-7.21 515.2757; found, (m, 2H), 7.21-7.15 (m, 3H), 515.2750 6.99 (d,J = 5.5 Hz, 1H), 5.20 (p, J = 6.4 Hz, 1H), 4.58 (dq, J = 8.2, 7.2 Hz, 1H), 3.88 (s, 3H), 3.80 (t, J = 6.6 Hz, 2H), 3.39 (s, 3H), 2.97 (t, J = 6.6 Hz, 2H), 2.67 (ddd, J = 10.3, 6.7, 4.7 Hz, 1H), 1.75-1.55 (m, 2H), 1.55-1.39 (m, 1H), 1.21 (d, J = 6.3 Hz, 3H), 1.14 (d, J = 7.2 Hz, 3H), 1.10-1.01 (m, 1H), 1.00-0.92 (m, 1H), 0.81 (d, J = 4.8 Hz, 3H), 0.79 (d, J = 4.8 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.15, 169.40, 162.24, 159.45, 146.70, 141.59, 141.21, 137.32, 128.67, 128.18, 126.51, 109.73, 74.76, 67.58, 58.75, 56.30, 51.34, 47.96, 36.49, 34.63, 29.42, 27.94, 22.73, 22.21, 18.33, 18.30. 213 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.28 (d, J = 7.9 Hz, 1H), 8.27 for C₂₇H₃₇N₂O₇, (d, J = 5.3 Hz, 1H), 7.28-7.22 501.2601; found, (m, 2H), 7.23-7.14 (m, 3H), 501.2584 6.94 (d, J = 5.4 Hz, 1H), 5.84- 5.67 (m, 2H), 5.26-5.14 (m, 1H), 4.71-4.52 (m, 1H), 3.90 (s, 3H), 2.68 (ddd, J = 10.3, 6.9, 4.6 Hz, 1H), 2.06 (s, 3H), 1.77-1.55 (m, 2H), 1.53-1.41 (m, 1H), 1.23 (d, J = 6.3 Hz, 3H), 1.15 (d, J = 7.1 Hz, 3H), 1.07 (ddt, J = 13.4, 10.8, 6.0 Hz, 1H), 1.01-0.90 (m, 1H), 0.81 (d, J = 5.2 Hz, 3H), 0.79 (d, J = 5.1 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.23, 170.23, 162.86, 160.26, 145.68, 143.96, 142.55, 141.26, 128.63, 128.18, 126.49, 109.53, 89.55, 74.77, 56.17, 51.37, 48.18, 36.47, 29.42, 27.94, 22.72, 22.19, 20.86, 18.32, 18.16. 214 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.34 (d, J = 7.8 Hz, 1H), 8.26 for C₂₉H₄₁N₂O₇, (d, J = 5.3 Hz, 1H), 7.28-7.22 529.2914; found, (m, 2H), 7.22-7.14 (m, 3H), 529.2880 6.94 (d, J = 5.4 Hz, 1H), 5.76 (q, J = 6.4 Hz, 2H), 5.21 (p, J = 6.4 Hz, 1H), 4.68-4.52 (m, 1H), 3.88 (s, 3H), 2.69 (ddd, J = 10.4, 6.9, 4.7 Hz, 1H), 2.54 (hept, J = 7.0 Hz, 1H), 1.76-1.55 (m, 2H), 1.52-1.41 (m, 1H), 1.23 (d, J = 6.3 Hz, 3H), 1.16 (d, J = 7.4 Hz, 3H), 1.14 (d, J = 7.1 Hz, 6H), 1.10-1.02 (m, 1H), 1.01-0.90 (m, 1H), 0.81 (d, J = 5.2 Hz, 3H), 0.79 (d, J = 5.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 176.20, 172.23, 162.84, 160.25, 145.54, 144.19, 142.19, 141.26, 128.63, 128.18, 126.49, 109.48, 89.91, 74.74, 56.12, 51.36, 48.17, 36.46, 33.83, 29.41, 27.93, 22.72, 22.19, 18.66, 18.31, 18.15. 215 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.29 (d, J = 8.0 Hz, 1H), 8.27 for C₂₉H₄₁N₂O₈, (d, J = 5.4 Hz, 1H), 7.27-7.21 545.2863; found, (m, 2H), 7.22-7.14 (m, 3H), 545.2854 6.94 (d, J = 5.4 Hz, 1H), 5.93- 5.73 (m, 2H), 5.25-5.16 (m, 1H), 4.67-4.52 (m, 1H), 4.09 (s, 2H), 3.89 (s, 3H), 3.58 (q, J = 7.0 Hz, 2H), 2.68 (ddd, J = 10.4, 6.9, 4.7 Hz, 1H), 1.76- 1.56 (m, 2H), 1.53-1.41 (m, 1H), 1.23 (d, J = 6.3 Hz, 3H), 1.22 (t, J = 7.0 Hz, 3H), 1.15 (d, J = 7.1 Hz, 3H), 1.11-1.02 (m, 1H), 0.95 (dddd, J = 13.3, 10.9, 7.3, 5.0 Hz, 1H), 0.81 (d, J = 5.2 Hz, 3H), 0.79 (d, J = 5.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.21, 170.03, 162.81, 160.19, 145.73, 143.94, 142.41, 141.26, 128.63, 128.19, 126.50, 109.62, 89.60, 74.80, 67.78, 67.17, 56.21, 51.37, 48.17, 36.47, 29.41, 27.94, 22.73, 22.19, 18.32, 18.15, 15.00. 216 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.48 (d, J = 7.7 Hz, 1H), 8.35 for C₂₈H₂₉Cl₂N₂O₆, (d, J = 5.4 Hz, 1H), 7.24-7.14 559.1402; found, (m, 4H), 7.10 (dd, J = 6.5, 2.9 559.1384 Hz, 3H), 7.02 (d, J = 5.5 Hz, 1H), 6.80 (dd, J = 8.2, 2.1 Hz, 1H), 5.20 (qd, J = 6.3, 5.0 Hz, 1H), 4.75-4.53 (m, 1H), 3.90 (s, 3H), 3.02-2.90 (m, 2H), 2.85 (dd, J = 12.3, 8.5 Hz, 1H), 2.37 (s, 3H), 1.30 (d, J = 7.2 Hz, 3H), 1.19 (d, J = 6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.97, 168.86, 162.50, 159.56, 146.67, 141.42, 139.98, 139.25, 137.62, 132.00, 130.91, 130.05, 129.97, 128.97, 128.53, 128.23, 126.97, 109.88, 73.35, 56.31, 52.70, 48.22, 37.40, 20.74, 18.28, 18.22. 217 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.43 (d, J = 7.9 Hz, 1H), 8.34 for C₃₀H₃₃Cl₂N₂O₆, (d, J = 5.4 Hz, 1H), 7.20 (d, 587.1715; found, J = 8.3 Hz, 1H), 7.17-7.13 (m, 587.1712 3H), 7.13-7.08 (m, 3H), 7.00 (d, J = 5.4 Hz, 1H), 6.81 (dd, J = 8.2, 2.1 Hz, 1H), 5.19 (qd, J = 6.3, 4.8 Hz, 1H), 4.76- 4.54 (m, 1H), 3.88 (s, 3H), 3.03-2.76 (m, 4H), 1.38-1.27 (m, 9H), 1.17 (d, J = 6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 174.66, 172.07, 162.49, 159.55, 146.56, 141.77, 140.02, 139.26, 137.82, 131.99, 130.92, 130.04, 129.96, 129.01, 128.58, 128.22, 126.96, 109.72, 73.24, 56.32, 52.71, 48.17, 37.43, 33.95, 18.80, 18.30, 18.25. 218 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.35-8.24 (m, 2H), 7.23-7.16 for C₂₉H₃₁Cl₂N₂O₇, (m, 4H), 7.14-7.09 (m, 2H), 589.1508; found, 7.07 (d, J = 2.1 Hz, 1H), 6.96 589.1490 (d, J = 5.4 Hz, 1H), 6.79 (dd, J = 8.2, 2.1 Hz, 1H), 5.79-5.67 (m, 2H), 5.29-5.18 (m, 1H), 4.72-4.60 (m, 1H), 3.91 (s, 3H), 3.08-2.91 (m, 2H), 2.86 (dd, J = 12.4, 8.7 Hz, 1H), 2.06 (s, 3H), 1.29 (d, J = 7.2 Hz, 3H), 1.23 (d, J = 6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.08, 170.25, 163.03, 160.35, 145.70, 144.09, 142.41, 139.89, 139.29, 131.98, 130.87, 130.05, 129.98, 128.90, 128.50, 128.27, 126.98, 109.65, 89.55, 73.46, 56.21, 52.76, 48.36, 37.45, 20.85, 18.29, 18.13. 219 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.36 (d, J = 7.8 Hz, 1H), 8.28 for C₃₁H₃₅Cl₂N₂O₇, (d, J = 5.3 Hz, 1H), 7.24-7.15 617.1821; found, (m, 4H), 7.15-7.09 (m, 2H), 617.1795 7.07 (d, J = 2.0 Hz, 1H), 6.95 (d, J = 5.4 Hz, 1H), 6.79 (dd, J = 8.2, 2.1 Hz, 1H), 5.82-5.67 (m, 2H), 5.29-5.18 (m, 1H), 4.74-4.58 (m, 1H), 3.88 (s, 3H), 3.09-2.91 (m, 2H), 2.85 (dd, J = 12.4, 8.7 Hz, 1H), 2.54 (hept, J = 7.0 Hz, 1H), 1.29 (d, J = 7.2 Hz, 3H), 1.23 (d, J = 6.3 Hz, 3H), 1.13 (d, J = 7.0 Hz, 6H). ¹³C NMR (101 MHz, CDCl₃) δ 176.22, 172.08, 163.01, 160.33, 145.56, 144.32, 142.06, 139.90, 139.29, 131.98, 130.87, 130.04, 129.97, 128.90, 128.50, 128.27, 126.97, 109.60, 89.93, 73.45, 56.15, 52.76, 48.36, 37.44, 33.84, 18.66, 18.28, 18.13. 220 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.51 (d, J = 7.9 Hz, 1H), 8.33 for C₂₉H₃₃N₂O₆, (d, J = 5.4 Hz, 1H), 7.21-7.13 505.2338; found, (m, 5H), 7.03-6.94 (m, 3H), 505.2328 6.92-6.84 (m, 2H), 5.20 (qd, J = 6.2, 4.7 Hz, 1H), 4.72-4.59 (m, 1H), 3.88 (s, 3H), 3.06-2.93 (m, 2H), 2.88 (dd, J = 11.9, 7.2 Hz, 1H), 2.38 (s, 3H), 1.30 (d, J = 7.2 Hz, 3H), 1.19 (d, J = 6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.05, 168.90, 162.41, 159.51, 146.68, 141.54, 140.39, 137.57, 136.51, 135.45, 129.05, 128.93, 128.89, 128.08, 126.65, 109.81, 73.53, 56.29, 53.09, 48.15, 37.93, 21.00, 20.75, 18.46, 18.39. 221 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.33 (d, J = 7.8 Hz, 1H), 8.28 for C₃₀H₃₅N₂O₇, (d, J = 5.4 Hz, 1H), 7.23-7.13 535.2444; found, (m, 5H), 7.01-6.92 (m, 3H), 535.2447 6.92-6.86 (m, 2H), 5.82-5.67 (m, 2H), 5.26-5.17 (m, 1H), 4.75-4.61 (m, 1H), 3.90 (s, 3H), 3.07-2.95 (m, 2H), 2.88 (dd, J = 11.5, 6.9 Hz, 1H), 2.25 (s, 3H), 2.05 (s, 3H), 1.30 (d, J = 7.2 Hz, 3H), 1.22 (d, J = 6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.16, 170.26, 162.95, 160.32, 145.70, 144.04, 142.53, 140.42, 136.45, 135.45, 129.00, 128.91, 128.86, 128.10, 126.64, 109.60, 89.57, 73.61, 56.19, 53.13, 48.31, 37.96, 20.99, 20.87, 18.40, 18.34. 222 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.31 (d, J = 7.9 Hz, 1H), 8.29 for C₂₉H₃₂FN₂O₇, (d, J = 5.4 Hz, 1H), 7.22-7.09 539.2193; found, (m, 5H), 6.99-6.89 (m, 3H), 539.2190 6.90-6.78 (m, 2H), 5.87-5.64 (m, 2H), 5.34-5.19 (m, 1H), 4.77-4.56 (m, 1H), 3.90 (s, 3H), 3.04 (dd, J = 12.7, 5.4 Hz, 1H), 2.95 (dt, J = 8.9, 5.5 Hz, 1H), 2.87 (dd, J = 12.7, 8.8 Hz, 1H), 2.05 (s, 3H), 1.28 (d, J = 7.2 Hz, 3H), 1.24 (d, J = 6.3 Hz, 3H). 223 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.38 (d, J = 7.8 Hz, 1H), 8.28 for C₃₁H₃₆FN₂O₇, (d, J = 5.4 Hz, 1H), 7.25-7.07 567.2506; found, (m, 5H), 6.99-6.88 (m, 3H), 567.2496 6.88-6.78 (m, 2H) 5.84-5.69 (m, 2H), 5.33-5.17 (m, 1H), 4.73-4.58(m, 1H), 3.88 (s, 3H), 3.04 (dd, J = 12.8, 5.4 Hz, 1H), 2.96 (dt, J = 8.8, 5.5 Hz, 1H), 2.87 (dd, J = 12.7, 8.8 Hz, 1H), 2.54 (hept, J = 7.0 Hz, 1H), 1.28 (d, J = 7.2 Hz, 3H), 1.23 (d, J = 6.3 Hz, 3H), 1.13 (d, J = 7.0 Hz, 6H). 224 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.52 (d, J = 7.6 Hz, 1H), 8.32 (d, for C₃₂H₃₃N₂O₆, J = 5.4 Hz, 1H), 7.81-7.62 (m, 541.2338; found, 3H), 7.45 (s, 1H), 7.43-7.34 (m, 541.2336 2H), 7.22-7.09 (m, 6H), 6.96 (d, J = 5.5 Hz, 1H), 5.32-5.21 (m, 1H), 4.75-4.59 (m, 1H), 3.86 (s, 3H), 3.28-3.16 (m, 1H), 3.15- 3.02 (m, 2H), 2.37 (s, 3H), 1.31 (d, J = 7.2 Hz, 3H), 1.22 (d, J = 6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.07, 168.92, 162.47, 159.53, 146.69, 141.53, 140.16, 137.60, 137.20, 133.46, 132.02, 129.06, 128.14, 127.76, 127.54, 127.54, 127.52, 127.51, 126.74, 125.83, 125.24, 109.83, 73.67, 56.29, 52.98, 48.21, 38.53, 20.78, 18.45, 18.41. 225 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.34 (d, J = 7.8 Hz, 1H), 8.27 for C₃₃H₃₅N₂O₇, (d, J = 5.3 Hz, 1H), 7.77-7.63 571.2444; found, (m, 3H), 7.46-7.33 (m, 3H), 571.2448 7.23-7.06 (m, 6H), 6.92 (d, J = 5.4 Hz, 1H), 5.81-5.69 (m, 2H), 5.36-5.23 (m, 1H), 4.77-4.60 (m, 1H), 3.87 (s, 3H), 3.23 (dd, J = 11.7, 4.3 Hz, 1H), 3.16- 3.02 (m, 2H), 2.04 (s, 3H), 1.31 (d, J = 7.2 Hz, 3H), 1.25 (d, J = 6.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.17, 170.27, 163.00, 160.33, 145.72, 144.07, 142.52, 140.19, 137.13, 133.43, 132.01, 129.00, 128.16, 127.75, 127.52, 127.51, 127.48, 126.73, 125.82, 125.24, 109.62, 89.59, 73.76, 56.19, 53.02, 48.36, 38.58, 20.87, 18.43, 18.33. 226 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.40 (d, J = 7.8 Hz, 1H), 8.27 for C₃₅H₃₉N₂O₇, (d, J = 5.3 Hz, 1H), 7.77-7.71 599.2757; found, (m, 1H), 7.71-7.61 (m, 2H), 599.2756 7.46-7.33 (m, 3H), 7.22-7.08 (m, 6H), 6.91 (d, J = 5.4 Hz, 1H), 5.78 (q, J = 6.4 Hz, 2H), 5.34-5.22 (m, 1H), 4.81-4.63 (m, 1H), 3.85 (s, 3H), 3.23 (dd, J = 11.7, 4.3 Hz, 1H), 3.17- 3.02 (m, 2H), 2.53 (hept, J = 7.0 Hz, 1H), 1.31 (d, J = 7.2 Hz, 3H), 1.25 (d, J = 6.3 Hz, 3H), 1.13 (d, J = 7.0 Hz, 6H). ¹³C NMR (101 MHz, CDCl₃) δ 176.24, 172.18, 162.98, 160.32, 145.57, 144.32, 142.17, 140.20, 137.14, 133.43, 132.01, 129.00, 128.16, 127.75, 127.52, 127.51, 127.49, 126.73, 125.82, 125.23, 109.55, 89.97, 73.76, 56.14, 53.03, 48.36, 38.58, 33.86, 18.69, 18.42, 18.34. 227 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3382, 2937, ([M + H]⁺) calcd 8.55 (d, J = 7.8 Hz, 1H), 8.32 1676, 1507, for C₃₀H₃₅N₂O₇, (d, J = 5.4 Hz, 1H), 7.37-7.22 1175, 732, 535.2439; found, (m, 7H), 7.22-7.08 (m, 3H), 699 535.2441 7.02-6.96 (m, 1H), 5.17 (qd, J = 6.5, 4.8 Hz, 1H), 4.76-4.61 (m, 1H), 4.51-4.30 (m, 2H), 3.90 (s, 3H), 3.39 (d, J = 5.2 Hz, 2H), 2.73-2.65 (m, 2H), 2.39 (s, 3H), 2.21-2.07 (m, 1H), 1.46 (d, J = 7.1 Hz, 3H), 1.30 (d, J = 6.5 Hz, 3H). 228 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3381, 2938, ([M + H]⁺) calcd 8.67-8.41 (m, 1H), 8.31 (d, J = 1770, 1676, for C₃₀H₃₄FN₂O₇, 5.5 Hz, 1H), 7.43-7.20 (m, 5H), 1508, 1175, 553.2345; found, 7.10-7.02 (m, 2H), 6.99 (d, J = 731 553.2358 5.5 Hz, 1H), 6.97-6.89 (m, 2H), 5.14 (qd, J = 6.4, 4.9 Hz, 1H), 4.77-4.61 (m, 1H), 4.48-4.33 (m, 2H), 3.90 (s, 3H), 3.45-3.31 (m, 2H), 2.71-2.59 (m, 2H), 2.38 (s, 3H), 2.07 (tq, J = 7.6, 5.1 Hz, 1H), 1.46 (d, J = 7.2 Hz, 3H), 1.29 (d, J = 6.5 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.89, 168.89, 162.44, 161.37 (d, J = 243.8 Hz), 159.49, 146.66, 141.52, 138.24, 137.55, 135.60 (d, J = 3.2 Hz), 130.49 (d, J = 7.8 Hz), 128.35, 127.63, 127.59, 115.10 (d, J = 21.1 Hz), 109.78, 73.08, 72.10, 68.24, 56.29, 48.18, 45.64, 32.63, 20.75, 18.63, 17.23. 229 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3382, 2978, ([M + H]⁺) calcd 8.45 (d, J = 7.9 Hz, 1H), 8.28 1770, 1508, for C₃₂H₃₈FN₂O₇, (d, J = 5.5 Hz, 1H), 7.37-7.29 1175, 1041, 581.2658; found, (m, 3H), 7.29-7.22 (m, 1H), 733 581.2662 7.15-7.08 (m, 2H), 6.98 (d, J = 5.5 Hz, 1H), 6.93-6.85 (m, 2H), 5.42 (qd, J = 6.6, 2.8 Hz, 1H), 4.61-4.50 (m, 1H), 4.50-4.33 (m, 2H), 3.90 (s, 3H), 2.99 (dd, J = 14.8, 5.5 Hz, 1H), 2.78 (dd, J = 14.8, 6.8 Hz, 1H), 2.42-2.34 (m, 3H), 2.34-2.23 (m, 1H), 2.21-2.15 (m, 1H), 1.35 (d, J = 6.5 Hz, 3H), 1.33 (s, 3H), 1.28 (d, J = 7.2 Hz, 3H), 1.26-1.23 (m, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.90, 168.90, 162.35, 161.04 (d, J = 243.3 Hz), 159.47, 146.59, 141.49, 139.51, 138.24 (d, J = 3.1 Hz), 137.54, 130.12 (d, J = 7.6 Hz), 128.26, 127.11, 114.96 (d, J = 21.1 Hz), 109.74, 72.94, 63.38, 56.28, 53.80, 53.12, 48.14, 30.36, 29.28, 24.93, 24.84, 20.74, 18.23, 17.24. 230 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3382, 2977, ([M + H]⁺) calcd 8.45 (d, J = 7.9 Hz, 1H), 8.30 1771, 1507, for C₃₂H₃₉N₂O₇, (d, J = 5.4 Hz, 1H), 7.33 (d, J = 1175, 1040, 563.2752; found, 4.4 Hz, 4H), 7.29-7.16 (m, 5H), 731 563.2759 7.16-7.07 (m, 1H), 6.98 (d, J = 5.5 Hz, 1H), 5.44 (qd, J = 6.5, 2.8 Hz, 1H), 4.58-4.40 (m, 3H), 3.90 (s, 3H), 3.03 (dd, J = 14.8, 5.3 Hz, 1H) 2.81 (dd, J = 14.7, 7.1 Hz, 1H), 2.42-2.31 (m, 4H), 1.37 (d, J = 6.6 Hz, 3H), 1.34 (s, 3H), 1.30-1.16 (m, 6H). ¹³C NMR (101 MHz, CDCl₃) δ 171.96, 168.90, 162.32, 159.43, 146.61, 142.63, 141.58, 139.58, 137.49, 128.86, 128.28, 128.25, 127.12, 127.06, 125.58, 109.70, 73.09, 63.38, 56.27, 52.86, 48.12, 31.18, 29.27, 24.94, 24.88, 20.75, 18.23, 17.24. 231 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3381, 2983, ([M + H]⁺) calcd 8.65-8.42 (m, 1H), 8.32 (d, J = 1770, 1676, for C₂₄H₃₀FN₂O₇, 5.4 Hz, 1H), 7.17-7.04 (m, 1508, 1176, 477.2032; found, 2H), 7.04-6.88 (m, 3H), 5.09 731 477.2035 (qd, J = 6.5, 4.6 Hz, 1H), 4.78- 4.63 (m, 1H), 3.91 (s, 3H), 3.36-3.17 (m, 5H), 2.62 (d, J = 7.5 Hz, 2H), 2.39 (s, 3H), 2.03 (tq, J = 7.4, 5.2 Hz, 1H), 1.52 (d, J = 7.2 Hz, 3H), 1.28 (d, J = 6.5 Hz, 3H). 232 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3380, 2977, ([M + H]⁺) calcd 8.45 (d, J = 7.9 Hz, 1H), 8.28 1770, 1676, for C₂₆H₃₄FN₂O₇, (d, J = 5.5 Hz, 1H), 7.21-7.04 1508, 1175, 505.2345; found, (m, 2H), 6.98 (d, J = 5.5 Hz, 1040, 730 505.2351 1H), 6.96-6.81 (m, 2H), 5.33 (qd, J = 6.5, 2.8 Hz, 1H), 4.61- 4.48 (m, 1H), 3.90 (s, 3H), 3.16 (s, 3H), 2.85 (dd, J = 14.8, 5.3 Hz, 1H), 2.71 (dd, J = 14.8, 7.1 Hz, 1H), 2.38 (s, 3H), 2.24- 2.15 (m, 1H), 1.36-1.23 (m, 6H), 1.20 (s, 3H), 1.15 (s, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.88, 168.90, 162.35, 161.05 (d, J = 243.2 Hz), 159.47, 146.59, 141.49, 138.13 (d, J = 3.3 Hz), 137.54, 130.11 (d, J = 7.7 Hz), 114.95 (d, J = 21.0 Hz), 109.75, 72.82, 56.28, 52.25, 48.85, 48.14, 30.47, 29.28, 24.31, 24.09, 20.74, 18.24, 17.23. 233 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3376, 2979, ([M + H]⁺) calcd 8.37 (d, J = 7.8 Hz, 1H), 8.26 1773, 1508, for C₃₃H₄₀FN₂O₉, (d, J = 5.4 Hz, 1H), 7.39-7.22 1126, 952, 627.2712; found, (m, 5H), 7.15-7.01 (m, 2H), 733 627.2724 7.01-6.88 (m, 3H), 5.83 (d, J = 0.9 Hz, 2H), 5.23-5.11 (m, 1H), 4.77-4.62 (m, 1H), 4.49- 4.31 (m, 2H), 4.10 (s, 2H), 3.90 (s, 3H), 3.59 (q, J = 7.0 Hz, 2H), 3.38 (d, J = 5.1 Hz, 2H), 2.73-2.60 (m, 2H), 2.09 (tq, J = 7.5, 5.1 Hz, 1H), 1.48 (d, J = 7.2 Hz, 3H), 1.30 (d, J = 6.4 Hz, 3H), 1.27-1.18 (m, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.01, 170.06, 162.98, 161.38 (d, J = 243.8 Hz), 160.24, 145.75, 144.03, 142.35, 138.22, 135.57 (d, J = 3.2 Hz), 130.48 (d, J = 7.8 Hz), 128.36, 127.62, 127.59, 115.12 (d, J = 21.2 Hz), 109.68, 89.63, 73.09, 72.14, 68.25, 67.80, 67.19, 56.22, 48.36, 45.65, 32.64, 18.54, 17.25, 15.01. 234 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3379, 2978, ([M + H]⁺) calcd 8.39 (d, J = 7.8 Hz, 1H), 8.26 1735, 1676, for C₃₃H₄₁N₂O₉, (d, J = 5.3 Hz, 1H), 7.39-7.22 1503, 1126, 609.2807; found, (m, 7H), 7.22-7.08 (m, 3H), 952, 700 609.2815 6.94 (d, J = 5.4 Hz, 1H), 5.89- 5.77 (m, 2H), 5.18 (qd, J = 6.5, 4.9 Hz, 1H), 4.77-4.62 (m, 1H), 4.51-4.35 (m, 2H), 4.10 (s, 2H), 3.90 (s, 3H), 3.59 (q, J = 7.0 Hz, 2H), 3.41 (d, J = 5.2 Hz, 2H), 2.75-2.66 (m, 2H), 2.21- 2.10 (m, 1H), 1.48 (d, J = 7.2 Hz, 3H), 1.31 (d, J = 6.5 Hz, 3H), 1.22 (t, J = 7.0 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.02, 170.06, 162.95, 160.22, 145.76, 144.00, 142.40, 139.99, 138.32, 129.14, 128.37, 128.33, 127.59, 127.53, 126.06, 109.66, 89.63, 73.05, 72.30, 68.46, 67.80, 67.18, 56.21, 48.34, 45.52, 33.45, 18.60, 17.17, 15.01. 235 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3387, 2977, ([M + H]⁺) calcd 8.33-8.25 (m, 1H), 8.23 (d, J = 1736, 1677, for C₃₅H₄₄FN₂O₉, 5.4 Hz, 1H), 7.39-7.29 (m, 4H), 1508, 1129 655.3025; found, 7.29-7.21 (m, 1H), 7.17-7.08 655.3028 (m, 2H), 6.97-6.84 (m, 3H), 5.81 (s, 2H), 5.44 (qd, J = 6.6, 2.3 Hz, 1H), 4.61-4.49 (m, 1H), 4.49-4.38 (m, 2H), 4.09 (s, 2H), 3.90 (s, 3H), 3.59 (q, J = 7.0 Hz, 2H), 3.00 (dd, J = 14.8, 5.4 Hz, 1H), 2.79 (dd, J = 14.9, 6.8 Hz, 1H), 2.28 (ddd, J = 6.8, 5.4, 2.9 Hz, 1H), 1.37 (d, J = 6.5 Hz, 3H), 1.34 (s, 3H), 1.28 (d, J = 7.2 Hz, 3H), 1.26 (d, J = 1.4 Hz, 3H), 1.22 (t, J = 7.0 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.99, 170.07, 162.89, 161.05 (d, J = 243.6 Hz), 160.23, 145.69, 144.06, 142.29, 139.50, 138.31 (d, J = 3.2 Hz), 130.11 (d, J = 7.7 Hz), 128.27, 127.09, 114.97 (d, J = 21.0 Hz), 109.64, 89.65, 76.99, 72.98, 67.79, 67.19, 63.38, 56.21, 53.20, 48.31, 30.32, 29.28, 24.95, 24.80, 18.09, 17.21, 15.00. 236 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3377, 2976, ([M + H]⁺) calcd 8.35-8.18 (m, 2H), 7.33 (d, J = 1731, 1676, for C₃₅H₄₅N₂O₉, 4.4 Hz, 4H), 7.29-7.16 (m, 5H), 1502, 1128, 637.3120; found, 7.16-7.07 (m, 1H), 6.93 (d, J = 953, 732 637.3126 5.4 Hz, 1H), 5.81 (s, 2H), 5.45 (qd, J = 6.5, 2.9 Hz, 1H), 4.56- 4.39 (m, 3H), 4.09 (s, 2H), 3.89 (s, 3H), 3.59 (q, J = 7.0 Hz, 2H), 3.04 (dd, J = 14.8, 5.2 Hz, 1H), 2.83 (dd, J = 14.8, 7.1 Hz, 1H), 2.40-2.31 (m, 1H), 1.38 (d, J = 6.5 Hz, 3H), 1.35 (s, 3H), 1.28 (s, 3H), 1.26-1.19 (m, 6H). ¹³C NMR (101 MHz, CDCl₃) δ 172.03, 170.05, 162.86, 160.20, 145.71, 143.98, 142.69, 142.42, 139.58, 128.86, 128.28, 128.26, 127.11, 127.06, 125.58, 109.61, 89.65, 73.11, 67.79, 67.18, 63.39, 56.20, 52.93, 48.29, 31.13, 29.28, 24.92, 24.90, 18.09, 17.20, 15.01. 237 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3379, 2980, ([M + H]⁺) calcd 8.39 (d, J = 7.7 Hz, 1H), 8.27 1735, 1675, for C₂₇H₃₆FN₂O₉, (d, J = 5.4 Hz, 1H), 7.15-7.03 1508, 1125, 551.2399; found, (m, 2H), 7.03-6.91 (m, 3H), 952 551.2402 5.83 (d, J = 0.7 Hz, 2H), 5.16- 5.03 (m, 1H), 4.71 (p, J = 7.2 Hz, 1H), 4.10 (s, 2H), 3.91 (s, 3H), 3.59 (q, J = 7.0 Hz, 2H), 3.36-3.19 (m, 5H), 2.68-2.59 (m, 2H), 2.04 (ddt, J = 12.5, 7.2, 5.2 Hz, 1H), 1.54 (d, J = 7.2 Hz, 3H), 1.30 (d, J = 6.5 Hz, 3H), 1.23 (t, J = 7.0 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.04, 170.07, 163.00, 161.40 (d, J = 243.8 Hz), 160.24, 145.76, 144.03, 142.36, 135.58 (d, J = 3.3 Hz), 130.48 (d, J = 7.8 Hz), 115.15 (d, J = 21.1 Hz), 109.69, 89.63, 72.07, 70.87, 67.80, 67.20, 58.76, 56.23, 48.38, 45.56, 32.66, 18.62, 17.16, 15.01. 238 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3379, 2977, ([M + H]⁺) calcd 8.28 (d, J = 7.8 Hz, 1H), 8.23 1731, 1676, for C₂₉H₄₀FN₂O₉, (d, J = 5.4 Hz, 1H), 7.20-7.07 1508, 1157, 579.2712; found, (m, 2H), 6.98-6.83 (m, 3H), 953 579.2728 5.82 (s, 2H), 5.40-5.31 (m, 1H), 4.58-4.47 (m, 1H), 4.10 (s, 2H), 3.90 (s, 3H), 3.59 (q, J = 7.0 Hz, 2H), 3.17 (s, 3H), 2.87 (dd, J = 14.8, 5.2 Hz, 1H), 2.80-2.66 (m, 1H), 2.29- 2.13 (m, 1H), 1.34 (d, J = 6.6 Hz, 3H), 1.28 (d, J = 7.2 Hz, 3H), 1.23 (t, J = 7.0 Hz, 3H), 1.21 (s, 3H), 1.16 (s, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.97, 170.07, 162.89, 161.05 (d, J = 243.4 Hz), 160.23, 145.69, 144.04, 142.30, 138.20 (d, J = 3.2 Hz), 130.10 (d, J = 7.6 Hz), 114.95 (d, J = 21.1 Hz), 109.65, 89.65, 76.45, 72.86, 67.79, 67.19, 56.22, 52.34, 48.86, 48.31, 30.42, 24.27, 24.09, 18.10, 17.20, 15.00. 239 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3376, 2983, ([M + H]⁺) calcd 8.36 (d, J = 7.7 Hz, 1H), 8.26 1736, 1676, for C₃₁H₃₆FN₂O₈, (d, J = 5.3 Hz, 1H), 7.40-7.20 1508, 1201, 583.2450; found, (m, 5H), 7.12-7.01 (m, 2H), 969, 731 583.2452 6.93 (ddd, J = 8.7, 7.0, 2.1 Hz, 3H), 5.82-5.70 (m, 2H), 5.16 (qd, J = 6.5, 4.9 Hz, 1H), 4.71 (p, J = 7.3 Hz, 1H), 4.51-4.33 (m, 2H), 3.90 (s, 3H), 3.38 (d, J = 5.1 Hz, 2H), 2.66 (d, J = 7.5 Hz, 2H), 2.07 (s, 4H), 1.48 (d, J = 7.2 Hz, 3H), 1.30 (d, J = 6.5 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.03, 170.27, 163.03, 161.38 (d, J = 243.8 Hz), 160.31, 145.71, 144.05, 142.50, 138.22, 135.57 (d, J = 3.3 Hz), 130.48 (d, J = 7.8 Hz), 128.35, 127.62, 127.59, 115.12 (d, J = 21.2 Hz), 109.59, 89.58, 73.08, 72.11, 68.25, 56.19, 48.37, 45.65, 32.65, 20.87, 18.54, 17.25. 240 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3380, 2983, ([M + H]⁺) calcd 8.38 (d, J = 7.8 Hz, 1H), 8.27 1735, 1675, for C₃₁H₃₇N₂O₈, (d, J = 5.3 Hz, 1H), 7.38-7.22 1503, 1201, 565.2544; found, (m, 7H), 7.22-7.06 (m, 3H), 968, 731 565.2551 6.94 (d, J = 5.4 Hz, 1H), 5.75 (d, J = 1.8 Hz, 2H), 5.18 (qd, J = 6.4, 4.8 Hz, 1H), 4.79- 4.64 (m, 1H), 4.50-4.32 (m, 2H), 3.90 (s, 3H), 3.41 (d, J = 5.2 Hz, 2H), 2.7 (dd, J = 7.5, 2.0 Hz, 2H), 2.21-2.10 (m, 1H), 2.07 (s, 3H), 1.48 (d, J = 7.2 Hz, 3H), 1.31 (d, J = 6.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.05, 170.27, 163.00, 160.29, 145.71, 144.02, 142.55, 139.99, 138.32, 129.14, 128.37, 128.33, 127.59, 127.53, 126.06, 109.56, 89.59, 73.05, 72.27, 68.46, 56.18, 48.35, 45.53, 33.46, 20.88, 18.61, 17.18. 241 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3377, 2978, ([M + H]⁺) calcd 8.32-8.18 (m, 2H), 7.39-7.29 1731, 1676, for C₃₃H₄₀FN₂O₈, (m, 4H), 7.29-7.19 (m, 1H), 1508, 1201, 611.2763; found, 7.17-7.07 (m, 2H), 6.98-6.83 1041 611.2765 (m, 3H), 5.74 (s, 2H), 5.44 (qd, J = 6.5, 2.9 Hz, 1H), 4.62-4.50 (m, 1H), 4.50-4.37 (m, 2H), 3.90 (s, 3H), 3.00 (dd, J = 14.8, 5.4 Hz, 1H), 2.79 (dd, J = 14.9, 6.9 Hz, 1H), 2.28 (ddd, J = 6.9, 5.5, 2.9 Hz, 1H), 2.07 (s, 3H), 1.37 (d, J = 6.5 Hz, 3H), 1.34 (s, 3H), 1.28 (d, J = 7.1 Hz, 3H), 1.26 (s, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.02, 170.28, 162.94, 161.05 (d, J = 243.4 Hz), 160.32, 145.65, 144.08, 142.45, 139.51, 138.31 (d, J = 3.3 Hz), 130.12 (d, J = 7.7 Hz), 128.27, 127.09, 114.97 (d, J = 21.1 Hz), 109.55, 89.62, 77.00, 72.97, 63.38, 56.18, 53.20, 48.32, 30.33, 29.28, 24.94, 24.80, 20.87, 18.10, 17.22. 242 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3381, 2978, ([M + H]⁺) calcd 8.31-8.20 (m, 2H), 7.33 (d, J = 1731, 1675, for C₃₃H₄₁N₂O₈, 4.3 Hz, 4H), 7.29-7.16 (m, 5H), 1502, 1201, 593.2857; found, 7.16-7.08 (m, 1H), 6.93 (d, J = 1041, 730 593.2861 5.4 Hz, 1H), 5.80-5.67 (m, 2H), 5.45 (qd, J = 6.5, 2.9 Hz, 1H), 4.58-4.39 (m, 3H), 3.90 (s, 3H), 3.04 (dd, J = 14.8, 5.2 Hz, 1H), 2.83 (dd, J = 14.8, 7.2 Hz, 1H), 2.36 (ddd, J = 7.1, 5.2, 2.9 Hz, 1H), 2.06 (s, 3H), 1.38 (d, J = 6.6 Hz, 3H), 1.35 (s, 3H), 1.29 (s, 3H), 1.23 (d, J = 7.2 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.06, 170.27, 162.91, 160.28, 145.66, 144.01, 142.69, 142.58, 139.58, 128.86, 128.28, 128.25, 127.10, 127.06, 125.58, 109.50, 89.62, 77.06, 73.09, 63.38, 56.16, 52.92, 48.30, 31.14, 24.92, 24.89, 20.87, 18.10, 17.21. 243 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3381, 2983, ([M + H]⁺) calcd 8.37 (d, J = 7.7 Hz, 1H), 8.27 1735, 1674, for C₂₅H₃₂FN₂O₈, (d, J = 5.3 Hz, 1H), 7.16-7.03 1508, 1201, 507.2137; found, (m, 2H), 7.03-6.88 (m, 3H), 969 507.2139 5.80-5.71 (m, 2H), 5.10 (qd, J = 6.4, 4.7 Hz, 1H), 4.80-4.66 (m, 1H), 3.91 (s, 3H), 3.39-3.18 (m, 5H), 2.72-2.50 (m, 2H), 2.14-1.95 (m, 4H), 1.54 (d, J = 7.2 Hz, 3H), 1.30 (d, J = 6.5 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.07, 170.28, 163.05, 161.40 (d, J = 243.8 Hz), 160.32, 145.71, 144.06, 142.52, 135.59 (d, J = 3.2 Hz), 130.48 (d, J = 7.7 Hz), 115.15 (d, J = 21.1 Hz), 109.59, 89.59, 72.04, 70.88, 58.76, 56.19, 48.39, 45.56, 32.67, 20.88, 18.63, 17.17. 244 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3381, 2978, ([M + H]⁺) calcd 8.33-8.25 (m, 1H), 8.24 (d, J = 1732, 1676, for C₂₇H₃₆FN₂O₈, 5.4 Hz, 1H), 7.19-7.07 (m, 2H), 1509, 1202, 535.2450; found, 7.00-6.83 (m, 3H), 5.74 (s, 2H), 1042 535.2450 5.35 (qd, J = 6.5, 2.9 Hz, 1H), 4.60-4.48 (m, 1H), 3.91 (s, 3H), 3.17 (s, 3H), 2.87 (dd, J = 14.8, 5.3 Hz, 1H), 2.72 (dd, J = 14.8, 7.1 Hz, 1H), 2.26-2.16 (m, 1H), 2.07 (s, 3H), 1.34 (d, J = 6.6 Hz, 3H), 1.29 (d, J = 7.2 Hz, 3H), 1.21 (s, 3H), 1.17 (s, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.99, 170.28, 162.94, 161.05 (d, J = 243.4 Hz), 160.32, 145.65, 144.08, 142.45, 138.20 (d, J = 3.3 Hz), 130.11 (d, J = 7.7 Hz), 114.96 (d, J = 21.0 Hz), 109.56, 89.62, 76.46, 72.84, 56.18, 52.35, 48.86, 48.32, 30.44, 24.27, 24.08, 20.87, 18.11, 17.21. 245 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.26 (d, J = 7.7 Hz, 1H), 8.25 for C₂₇H₃₇N₂O₈, (d, J = 5.4 Hz, 1H), 7.37-7.08 517.2550; found, (m, 5H), 6.93 (d, J = 5.3 Hz, 517.2555 1H), 5.82-5.66 (m, 2H), 5.36 (qd, J = 6.6, 2.9 Hz, 1H), 4.55- 4.45 (m, 1H), 3.90 (s, 3H), 3.19 (s, 3H), 2.90 (dd, J = 14.7, 5.0 Hz, 1H), 2.75 (dd, J = 14.7, 7.4 Hz, 1H), 2.29 (ddd, J = 7.7, 5.1, 2.9 Hz, 1H), 2.07 (s, 3H), 1.35 (d, J = 6.5 Hz, 3H), 1.24 (d, J = 7.2 Hz, 3H), 1.22 (s, 3H), 1.19 (s, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.02, 170.26, 162.91, 160.28, 145.67, 144.01, 142.56, 128.84, 128.27, 128.25, 125.59, 109.52, 89.61, 76.52, 72.95, 56.18, 52.04, 48.88, 48.30, 31.25, 24.39, 24.05, 20.87, 18.11, 17.20. 246 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3382, 2939, ([M + H]⁺) calcd 8.52 (d, J = 7.8 Hz, 1H), 8.31 1771, 1676, for C₃₀H₃₃F₂N₂O₇, (d, J = 5.4 Hz, 1H), 7.32-7.17 1509, 1218 571.2250; found, (m, 2H), 7.11-6.98 (m, 5H), 571.2266 6.97-6.89 (m, 2H), 5.14 (qd, J = 6.4, 4.9 Hz, 1H), 4.77-4.62 (m, 1H), 4.45-4.27 (m, 2H), 3.90 (s, 3H), 3.35 (dd, J = 5.2, 1.6 Hz, 2H), 2.69-2.59 (m, 2H), 2.38 (s, 3H), 2.07 (ddq, J = 8.2, 6.7, 5.1 Hz, 1H), 1.48 (d, J = 7.2 Hz, 3H), 1.28 (d, J = 6.4 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.90, 168.89, 162.47, 162.27 (d, J = 245.6 Hz), 161.39 (d, J = 244.0 Hz), 159.50, 146.66, 141.49, 137.56, 135.54 (d, J = 3.3 Hz), 134.00 (d, J = 3.2 Hz), 130.47 (d, J = 7.8 Hz), 129.31 (d, J = 8.1 Hz), 115.18 (d, J = 21.4 Hz), 115.13 (d, J = 21.1 Hz), 109.80, 72.34, 72.01, 68.30, 56.29, 48.19, 45.58, 32.66, 20.74, 18.61, 17.20. 247 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3382, 2979, ([M + H]⁺) calcd 8.44 (d, J = 7.9 Hz, 1H), 8.28 (d, 1770, 1676, for C₃₂H₃₇F₂N₂O₇, J = 5.4 Hz, 1H), 7.34-7.20 (m, 1509, 1218 599.2563; found, 3H), 7.16-7.07 (m, 2H), 7.07- 599.2579 6.95 (m, 3H), 6.95-6.82 (m, 2H), 5.41 (qd, J = 6.5, 2.8 Hz, 1H), 4.61-4.47 (m, 1H), 4.39 (q, J = 11.0 Hz, 2H), 3.90 (s, 3H), 2.94 (dd, J = 14.8, 5.6 Hz, 1H), 2.78 (dd, J = 14.8, 6.8 Hz, 1H), 2.37 (s, 3H), 1.34 (d, J = 6.6 Hz, 3H), 1.32 (s, 3H), 1.28 (d, J = 7.2 Hz, 3H), 1.24 (s, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.89, 168.90, 162.37, 162.01 (d, J = 244.8 Hz), 161.06 (d, J = 243.5 Hz), 159.48, 146.59, 141.47, 138.10 (d, J = 3.2 Hz), 137.55, 135.14 (d, J = 3.0 Hz), 130.09 (d, J = 7.7 Hz), 128.81 (d, J = 8.0 Hz), 115.08 (d, J = 21.3 Hz), 114.99 (d, J = 21.1 Hz), 109.76, 77.14, 72.79, 62.75, 56.29, 52.94, 48.15, 30.42, 24.89, 24.86, 20.74, 18.20, 17.23. 248 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3382, 2954, ([M + H]⁺) calcd 8.57 (d, J = 7.9 Hz, 1H), 8.32 (d, 1771, 1677, for C₃₈H₃₉N₂O₇, J = 5.4 Hz, 1H), 7.34-7.23 (m, 1506, 1175 515.2752; found, 2H), 7.23-7.07 (m, 3H), 7.00 (d, 515.2764 J = 5.5 Hz, 1H), 5.12 (qd, J = 6.5, 4.6 Hz, 1H), 4.71 (dq, J = 8.0, 7.1 Hz, 1H), 3.90 (s, 3H), 3.40-3.25 (m, 4H), 2.71-2.61 (m, 2H), 2.39 (s, 3H), 2.09 (ddt, J = 9.8, 5.2, 3.3 Hz, 1H), 1.76-1.62 (m, 1H), 1.52 (d, J = 7.2 Hz, 3H), 1.48-1.38 (m, 2H), 1.29 (d, J = 6.4 Hz, 3H), 0.90 (d, J = 1.7 Hz, 3H), 0.88 (d, J = 1.7 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 171.95, 168.90, 162.42, 159.47, 146.67, 141.57, 140.17, 137.52, 129.15, 128.33, 126.01, 109.75, 72.39, 69.48, 69.04, 56.28, 48.18, 45.45, 38.54, 33.47, 25.07, 22.67, 22.60, 20.75, 18.81, 17.03. 249 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3382, 2938, ([M + H]⁺⁾ calcd 8.35 (d, J = 7.7 Hz, 1H), 8.26 1736, 1676, for C₃₁H₃₅F₂N₂O₈, (d, J = 5.3 Hz, 1H), 7.32-7.19 1508, 1219, 601.2356; found, (m, 2H), 7.13-6.98 (m, 4H), 1202, 827 601.2360 6.98-6.87 (m, 3H), 5.75 (d, J = 0.9 Hz, 2H), 5.15 (qd, J = 6.5, 4.9 Hz, 1H), 4.71 (p, J = 7.2 Hz, 1H), 4.46-4.27 (m, 2H), 3.91 (s, 3H), 3.37 (d, J = 5.2 Hz, 2H), 2.78-2.52 (m, 2H), 2.13-2.00 (m, 4H), 1.49 (d, J = 7.2 Hz, 3H), 1.30 (d, J = 6.5 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.04, 170.27, 163.04, 162.27 (d, J = 245.5 Hz), 161.39 (d, J = 244.0 Hz), 160.32, 145.71, 144.07, 142.47, 135.51 (d, J = 3.3 Hz), 133.99 (d, J = 3.1 Hz), 130.45 (d, J = 7.8 Hz), 129.31 (d, J = 8.1 Hz), 115.19 (d, J = 21.3 Hz), 115.14 (d, J = 21.1 Hz), 109.60, 89.59, 72.35, 72.01, 68.29, 56.19, 48.37, 45.60, 32.68, 20.87, 18.53, 17.22. 250 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3381, 2979, ([M + H]⁺) calcd 8.31-8.19 (m, 2H), 7.32-7.23 1733, 1676, for C₃₃H₃₉F₂N₂O₈, (m, 2H), 7.17-7.07 (m, 2H), 1508, 1202, 629.2669; found, 7.07-6.97 (m, 2H), 6.97-6.84 1041, 827 629.2686 (m, 3H), 5.73 (s, 2H), 5.43 (qd, J = 6.5, 2.8 Hz, 1H), 4.61- 4.49 (m, 1H), 4.40 (q, J = 11.0 Hz, 2H), 3.90 (s, 3H), 2.96 (dd, J = 14.8, 5.5 Hz, 1H), 2.79 (dd, J = 14.8, 6.8 Hz, 1H), 2.28 (ddd, J = 6.8, 5.5, 2.8 Hz, 1H), 2.07 (s, 3H), 1.35 (d, J = 6.6 Hz, 3H), 1.33 (s, 3H), 1.29 (d, J = 7.2 Hz, 3H), 1.26 (d, J = 1.0 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.01, 170.28, 162.95, 162.00 (d, J = 244.8 Hz), 161.06 (d, J = 243.6 Hz), 160.32, 145.65, 144.09, 142.42, 138.17 (d, J = 3.3 Hz), 135.13 (d, J = 3.1 Hz), 130.09 (d, J = 7.7 Hz), 128.78 (d, J = 8.0 Hz), 115.08 (d, J = 21.3 Hz), 114.99 (d, J = 21.1 Hz), 109.56, 89.62, 77.11, 72.81, 62.75, 56.18, 53.04, 48.33, 30.38, 24.87, 24.85, 20.87, 18.08, 17.21. 251 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3381, 2955, ([M + H]⁺) calcd 8.38 (d, J = 7.7 Hz, 1H), 8.27 1736, 1677, for C₂₉H₄₀FN₂O₈, (d, J = 5.4 Hz, 1H), 7.15-7.03 1509, 1202, 563.2763; found, (m, 2H), 7.03-6.89 (m, 3H), 1003 563.2769 5.80-5.69 (m, 2H), 5.11 (qd, J = 6.5, 4.6 Hz, 1H), 4.79-4.66 (m, 1H), 3.91 (s, 3H), 3.39- 3.24 (m, 4H), 2.64 (d, J = 7.0 Hz, 2H), 2.14-1.96 (m, 4H), 1.76-1.61 (m, 1H),1.54 (d, J = 7.2 Hz, 3H), 1.49-1.38 (m, 2H), 1.30 (d, J = 6.5 Hz, 3H), 0.90 (d, J = 1.6 Hz, 3H), 0.88 (d, J = 1.6 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.07, 170.27, 163.03, 161.37 (d, J = 243.7 Hz), 160.31, 145.70, 144.06, 142.53, 135.74 (d, J = 3.2 Hz), 130.48 (d, J = 7.7 Hz), 115.10 (d, J = 21.1 Hz), 109.57, 89.59, 72.24, 69.54, 68.90, 56.19, 48.38, 45.59, 38.53, 32.68, 25.08, 22.65, 22.60, 20.88, 18.66, 17.12. 252 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3382, 2953, ([M + H]⁺) calcd 8.39 (d, J = 7.8 Hz, 1H), 8.27 1735, 1676, for C₂₉H₄₁N₂O₈, (d, J = 5.4 Hz, 1H), 7.32-7.23 1503, 1201, 545.2857; found, (m, 2H), 7.23-7.09 (m, 3H), 1003, 969 545.2871 6.94 (d, J = 5.4 Hz, 1H), 5.79- 5.69 (m, 2H), 5.14 (qd, J = 6.5, 4.6 Hz, 1H), 4.80-4.66 (m, 1H), 3.91 (s, 3H), 3.41-3.27 (m, 4H), 2.75-2.59 (m, 2H), 2.16-2.01 (m, 4H), 1.74-1.64 (m, 1H), 1.54 (d, J = 7.2 Hz, 3H), 1.47- 1.38 (m, 2H), 1.31 (d, J = 6.4 Hz, 3H), 0.90 (d, J = 1.7 Hz, 3H), 0.88 (d, J = 1.7 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.09, 170.27, 163.00, 160.30, 145.71, 144.03, 142.58, 140.16, 129.15, 128.35, 126.02, 109.55, 89.60, 72.40, 69.50, 69.05, 56.18, 48.37, 45.46, 38.54, 33.48, 25.08, 22.67, 22.61, 20.88, 18.72, 17.05. 253 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3383, 2979, ([M + H]⁺) calcd 8.37 (d, J = 7.8 Hz, 1H), 8.26 1735, 1676, for C₃₃H₃₉F₂N₂O₉, (dd, J = 5.4, 1.0 Hz, 1H), 7.33- 1508, 1219, 645.2618; found, 7.16 (m, 3H), 7.16-6.84 (m, 1127, 828 645.2625 6H), 5.82 (d, J = 0.9 Hz, 2H), 5.22-5.05 (m, 1H), 4.77-4.62 (m, 1H), 4.46-4.26 (m, 2H), 4.10 (s, 2H), 3.90 (s, 3H), 3.59 (qd, J = 7.0, 1.0 Hz, 2H), 3.36 (d, J = 5.1 Hz, 2H), 2.74-2.56 (m, 2H), 2.15-1.99 (m, 1H), 1.49 (dd, J = 7.2, 1.0 Hz, 3H), 1.30 (dd, J = 6.4, 1.0 Hz, 3H), 1.22 (td, J = 7.1, 1.0 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.02, 170.07, 163.00, 162.28 (d, J = 245.5 Hz), 161.40 (d, J = 244.0 Hz), 160.25, 145.76, 144.05, 142.32, 135.50 (d, J = 3.3 Hz), 133.98 (d, J = 3.2 Hz), 130.45 (d, J = 7.7 Hz), 129.31 (d, J = 8.0 Hz), 115.19 (d, J = 21.4 Hz), 115.15 (d, J = 21.2 Hz), 109.70, 89.64, 72.36, 72.04, 68.30, 67.80, 67.20, 56.23, 48.37, 45.60, 32.66, 18.52, 17.21, 15.01. 254 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3377, 2981, ([M + H]⁺⁾ calcd 8.31-8.22 (m, 2H), 7.38 (d, J = 1755, 1732, for C₃₂H₃₇Cl₂N₂O₈, 2.6 Hz, 1H), 7.26 (s, 1H), 7.23 1675, 1501, 647.1921; found, (d, J = 6.0 Hz, 3H), 7.17-7.11 1473, 1200 647.1925 (m, 2H), 7.02 (d, J = 8.8 Hz, 1H), 6.94 (d, J = 5.4 Hz, 1H), 5.76-5.72 (m, 2H), 5.58 (qd, J = 6.6, 3.0 Hz, 1H), 4.61-4.47 (m, 1H), 3.91 (s, 3H), 3.24 (dd, J = 14.9, 5.3 Hz, 1H), 2.94 (dd, J = 14.9, 6.8 Hz, 1H), 2.50 (ddd, J = 6.9, 5.3, 2.9 Hz, 1H), 2.07 (s, 3H), 1.48 (d, J = 6.5 Hz, 3H), 1.42 (s, 3H), 1.31 (s, 3H), 1.28 (d, J = 7.2 Hz, 3H) 255 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3380, 2981, ([M + H]⁺⁾ calcd 8.38 (d, J = 7.8 Hz, 1H), 8.27 1733, 1675, for C₂₆H₃₃N₂O₇, (d, J = 5.4 Hz, 1H), 7.29-7.20 1499, 1200 485.2282; found, (m, 2H), 7.20-7.13 (m, 1H), 485.2284 7.13-7.09 (m, 2H), 6.94 (d, J = 5.3 Hz, 1H), 5.82-5.70 (m, 2H), 5.11-4.99 (m, 1H), 4.81-4.78 (m, 1H), 4.77-4.68 (m, 1H), 4.67 (dt, J = 1.8, 0.8 Hz, 1H), 3.91 (s, 3H), 2.82 (dd, J = 13.6, 5.5 Hz, 1H), 2.65 (dd, J = 13.5, 9.5 Hz, 1H), 2.55 (dt, J = 9.5, 5.8 Hz, 1H), 2.07 (s, 3H), 1.72-1.62 (m, 3H), 1.53 (d, J = 7.1 Hz, 3H), 1.29 (d, J = 6.4 Hz, 3H). 256 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3378, 2936, ([M + H]⁺) calcd 8.39 (d, J = 7.8 Hz, 1H), 8.27 1734, 1675, for C₂₈H₃₉N₂O₉, (d, J = 5.4 Hz, 1H), 7.12-7.01 1511, 1201 547.265; found, (m, 2H), 6.95 (d, J = 5.4 Hz, 547.2687 1H), 6.89-6.73 (m, 2H), 5.76 (d, J = 6.4 Hz, 1H), 5.74 (d, J = 6.4 Hz, 1H), 5.13 (qd, J = 6.5, 4.7 Hz, 1H), 4.73 (p, J = 7.3 Hz, 1H), 3.91 (s, 3H), 3.78 (s, 3H), 3.39- 3.19 (m, 4H), 2.70-2.52 (m, 2H), 2.13-1.96 (m, 1H), 2.07 (s, 3H), 1.62- 1.49 (m, 2H), 1.54 (d, J = 7.2 Hz, 3H), 1.31 (d, J = 6.5 Hz, 3H), 0.91 (t, J = 7.4 Hz, 3H). 257 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3377, 2974, ([M + H]⁺) calcd 8.30 (d, J = 7.8 Hz, 1H), 8.25 1751, 1732, for C₃₀H₄₃N₂O₉, (d, J = 5.4 Hz, 1H), 7.16-7.05 1675, 1511, 575.2963; found, (m, 2H), 6.93 (d, J = 5.4 Hz, 1202 575.3002 1H), 6.84-6.73 (m, 2H), 5.77- 5.71 (m, 2H), 5.38 (qd, J = 6.6, 2.8 Hz, 1H), 4.55 (p, J = 7.2 Hz, 1H), 3.90 (s, 3H), 3.77 (s, 3H), 3.28 (td, J = 6.5, 2.9 Hz, 2H), 2.89 (dd, J = 14.8, 5.3 Hz, 1H), 2.70 (dd, J = 14.9, 7.0 Hz, 1H), 2.19 (ddt, J = 7.2, 3.4, 1.8 Hz, 1H), 2.07 (s, 3H), 1.53 (h, J = 7.1 Hz, 2H), 1.35 (d, J = 6.6 Hz, 3H), 1.29 (d, J = 7.2 Hz, 3H), 1.21 (s, 3H), 1.15 (s, 3H), 0.92 (t, J = 7.4 Hz, 3H). 258 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3376, 2936, ([M + H]⁺⁾ calcd 8.39 (d, J = 7.8 Hz, 1H), 8.27 1735, 1676, for C₃₅H₄₅N₂O₉, (d, J = 5.4 Hz, 1H), 7.26 (dd, 1502, 1202 637.312; found, J = 8.0, 6.8 Hz, 2H), 7.22-7.14 637.313 (m, 3H), 6.98-6.91 (m, 2H), 6.83 (d, J = 2.2 Hz 1H), 6.77 (d, J = 8.3 Hz, 1H), 5:82-5.62 (m, 2H), 5.19-5.02 (m, 1H), 4.78-4.56 (m, 1H), 3.93 (d, J = 4.7 Hz, 2H), 3.90 (s, 3H), 3.79 (s, 3H), 3.36-3.15 (m, 4H), 2.63-2.53 (m, 2H), 2.07 (s, 3H), 2.03-1.93 (m, 1H), 1.58-1.50 (m, 2H), 1.48 (d, J = 7.1 Hz, 3H), 1.28 (d, J = 6.4 Hz, 3H), 0.89 (t, J = 7.4 Hz, 3H). 259 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3382, 2974, ([M + H]⁺) calcd 8.30 (d, J = 7.8 Hz, 1H), 8.24 1757, 1733, for C₃₇H₄₉N₂O₉, (d, J = 5.4 Hz, 1H), 7.30-7.21 1676, 1502, 665.3433; found, (m, 2H), 7.21-7.13 (m, 3H), 1202 665.3449 6.98 (dd, J = 8.3, 2.3 Hz, 1H), 6.90 (d, J = 5.4 Hz, 1H), 6.88 (d, J = 2.2 Hz, 1H), 6.74 (d, J = 8.3 Hz, 1H), 5.75 (d, J = 6.5 Hz, 1H), 5.73 (d, J = 6.5 Hz, 1H), 5.35 (qd, J = 6.6, 2.8 Hz, 1H), 4.53 (p, J = 7.2 Hz, 1H), 3.92 (s, 2H), 3.89 (s, 3H), 3.77 (s, 3H), 3.31-3.19 (m, 2H), 2.83 (dd, J = 14.8, 5.6 Hz, 1H), 2.64 (dd, J = 14.8, 6.9 Hz, 1H), 2.19-2.10 (m, 1H), 2.06 (s, 3H), 1.50 (h, J = 7.1 Hz, 2H), 1.32 (d, J = 6.5 Hz, 3H), 1.22 (d, J = 7.0 Hz, 3H), 1.18 (s, 3H), 1.12 (s, 3H), 0.90 (t, J = 7.4 Hz, 3H). 260 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3377, 2937, ([M + H]⁺) calcd 8.56 (s, 1H), 8.33 (d, J = 5.4 1770, 1733, for C₂₉H₃₃N₂O₆, Hz, 1H), 7.32-6.99 (m, 11H), 1676, 1507, 505.2333; found, 4.95 (qd, J = 6.5, 3.1 Hz, 1H), 1200, 1174 505.2341 4.77-4.67 (m, 1H), 3.91 (s, 3H), 2.82-2.46 (m, 4H), 2.39 (s, 3H), 2.23-2.13 (m, 1H), 1.54 (d, J = 7.2 Hz, 3H), 1.26 (d, J = 6.3 Hz, 3H). 261 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3382, 2965, ([M + H]⁺) calcd 8.56 (s, 1H), 8.33 (d, J = 5.6 1771, 1732, for C₃₁H₃₇N₂O₆, Hz, 1H), 7.31-6.98 (m, 11H), 1682, 1506, 533.2646; found, 5.01-4.92 (m, 1H), 4.66 (dd, 1199, 1174 533.2649 J = 9.3, 4.6 Hz, 1H), 3.91 (s, 3H), 2.81-2.47 (m, 5H), 2.16 (dd, J = 7.9, 5.1 Hz, 1H), 1.26 (d, J = 6.5 Hz, 3H), 1.04 (dd, J = 6.9, 1.6 Hz, 6H), 1.00 (d, J = 6.9 Hz, 3H). 262 IR (thin flim) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3376, 2936, ([M + H]⁺) calcd 8.54 (d, J = 7.6 Hz, 1H), 8.32 1771, 1732, for C₃₀H₃₅N₂O₆, (d, J = 5.3 Hz, 1H), 7.31-6.95 1677, 1507, 519.249; found, (m, 11H), 5.97 (d, J = 9.7 Hz, 1199. 519.2491 1H), 5.04-4.87 (m, 2H), 4.77- 4.50 (m, 2H), 3.91 (s, 3H), 2.82-2.47 (m, 5H), 2.39 (s, 3H), 1.30-1.21 (m, 6H). 263 IR (thin flim) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3383, 2940, ([M + H]⁺) calcd 8.51 (s, 1H), 8.33 (d, J = 5.4 1770, 1734, for C₂₉H₃₁F₂N₂O₆, Hz, 1H), 7.26-7.15 (m, 2H), 1676, 1588, 541.2145; found, 7.03-6.99 (m, 1H), 6.93-6.68 1508, 1202, 541.2145 (m, 6H), 5.02-4.85 (m, 1H), 1176 4.81-4.56 (m, 1H), 3.92 (s, 3H), 2.79-2.43 (m, 5H), 2.38 (s, 3H), 1.55 (d, J = 7.2 Hz, 3H), 1.26 (d, J = 6.5 Hz, 3H). 264 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3382, 2940, ([M + H]⁺⁾ calcd 8.52 (s, 1H), 8.32 (d, J = 5.4 1770, 1733, for C₂₉H₃₁F₂N₂O₆, Hz, 1H), 7.11-6.88 (m, 9H), 1674, 1507, 541.2145; found, 4.96-4.87 (m, 1H), 4.76-4.62 1217, 1175. 541.2156 (m, 1H), 3.93 (d, J = 8.3 Hz, 3H), 2.74-2.40 (m, 5H), 2.38 (d, J = 0.9 Hz, 3H), 1.54 (d, J = 7.2 Hz, 3H), 1.25 (d, J = 6.6 Hz, 3H). 265 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3383, 2938, ([M + H]⁺⁾ calcd 8.38 (d, J = 7.8 Hz, 1H), 8.27 1735, 1755, for C₃₀H₃₅N₂O₇, (d, J = 5.4 Hz, 1H), 7.30-7.03 1676, 1504, 535.2439; found, (m, 10H), 6.95 (d, J = 5.4 Hz, 1202, 1041, 535.2451 1H), 5.80-5.71 (m, 2H), 5.07- 1004 4.91 (m, 1H), 4.83-4.62 (m, 1H), 3.91 (s, 3H), 2.80-2.47 (m, 5H), 2.07 (s, 3H), 1.56 (d, J = 7.2 Hz, 3H), 1.28 (d, J = 6.4 Hz, 3H). 266 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3382, 2964, ([M + H]⁺⁾ calcd 8.44 (d, J = 9.5 Hz, 1H), 8.27 1757, 1733, for C₃₂H₃₉N₂O₇, (d, J = 5.4 Hz, 1H), 7.31-7.01 1681, 1503, 563.2752; found, (m, 10H), 6.95 (d, J = 5.4 Hz, 1312, 1202 563.2759 1H), 5.77 (d, J = 6.4 Hz, 1H) 5.74 (d, J = 6.4 Hz, 1H), 4.98 (ddt, J = 9.7, 6.4, 3.3 Hz, 1H), 4.71 (dd, J = 9.3, 4.6 Hz, 1H), 3.91 (s, 3H), 2.80-2.47 (m, 5H), 2.38-2.24 (m, 1H), 2.06 (s, 3H), 1.27 (d, J = 6.5 Hz, 3H), 1.12-0.95 (m, 6H). 267 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3378, 2939, ([M + H]⁺⁾ calcd 8.35 (d, J = 7.8 Hz, 1H), 8.28 1735, 1675, for C₃₀H₃₃F₂N₂O₇, (dd, J = 5.4, 1.7 Hz, 1H), 7.21 1585, 1504, 571.225; found, (ddt, J = 13.7, 8.0, 4.0 Hz, 1487, 1248, 571.2263 2H), 6.96 (d, J = 5.4 Hz, 1H), 1202 6.95-6.69 (m, 6H), 5.78-5.73 (m, 2H), 4.94 (qd, J = 6.4, 3.0 Hz, 1H), 4.71 (dt, J = 19.5, 7.4 Hz, 1H), 3.92 (s, 3H), 2.87-2.41 (m, 5H), 2.07 (s, 3H), 1.56 (d, J = 7.2 Hz, 3H), 1.28 (d, J = 5.5 Hz, 3H). 268 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3383, 2939, ([M + H]⁺) calcd 8.35 (d, J = 7.7 Hz, 1H), 8.27 1735, 1676, for C₃₀H₃₃F₂N₂O₇, (d, J = 5.4 Hz, 1H), 7.11-6.87 1508, 1218, 571.225; found, (m, 9H), 5.75 (s, 2H), 4.94 (tt, 1203 571.225 J = 7.0, 3.5 Hz, 1H), 4.73 (dq, J = 14.7, 7.3 Hz, 1H), 2.76- 2.41 (m, 5H), 2.17 (s, 3H), 2.07 (s, 3H), 1.56 (d, J = 7.2 Hz, 3H), 1.27 (d, J = 6.5 Hz, 3H). 269 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3377, 2936, ([M + H]⁺) calcd 8.40 (d, J = 8.6 Hz, 1H), 8.27 1756, 1734, for C₃₁H₃₇N₂O₇, (d, J = 5.2 Hz, 1H), 7.29-7.02 1678, 1503, 549.2595; found, (m, 10H), 6.95 (d, J = 5.5 Hz, 1202 549.2601 1H), 5.80-5.72 (m, 2H), 4.98 (dd, J = 6.6, 2.9 Hz, 1H), 4.72 (dt, J = 7.0, 1.7 Hz, 1H), 3.91 (s, 3H), 2.81-2.47 (m, 5H), 2.07 (s, 3H), 2.05-1.75 (m, 2H), 1.26 (d, J = 4.0 Hz, 3H), 1.04 (t, J = 7.4 Hz, 3H). 270 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.55 (s, 1H), 8.33 (d, J = 5.4 for C₃₁H₃₇N₂O₈, Hz, 1H), 7.17 (dt, J = 13.6, 565.2544; found, 7.9 Hz, 2H), 7.00 (d, J = 5.4 565.2533 Hz, 1H), 6.77-6.58 (m, 6H), 4.96 (dd, J = 6.5, 2.9 Hz, 1H), 4.82-4.64 (m, 1H), 3.91 (s, 3H), 3.78 (s, 3H), 3.76 (s, 3H), 2.74 (dd, J = 14.1, 6.4 Hz, 1H), 2.67-2.45 (m, 4H), 2.38 (s, 3H) 1.55 (d, 3H) 1.26 (d, J = 64 Hz, 3H). ¹³C NMR (126 MHz, CDCl₃) δ 171.94, 168.92, 162.48, 159.64, 159.58, 159.49, 146.68, 141.93, 141.80, 141.53, 137.55, 129.37, 129.32, 121.51, 121.33, 114.92, 114.88, 111.31, 111.23, 109.78, 72.27, 56.28, 55.14, 55.12, 48.26, 46.64, 31.59, 22.66, 20.75, 16.54, 14.12. 271 ESIMS m/z 579.3 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 8.55 (s, 1H), 8.33 (d, J = 5.4 Hz, 1H), 7.17 (dt, J = 14.2, 7.9 Hz, 2H), 7.00 (d, J = 5.5 Hz, 1H), 6.76-6.59 (m, 6H), 5.05- 4.92 (m, 1H), 4.75-4.62 (m, 1H), 3.91 (s, 3H), 3.78 (s, 3H), 3.76 (s, 3H), 2.73 (dd, J = 14.1, 6.6 Hz, 1H), 2.55 (dtd, J = 27.9, 13.7, 7.1 Hz, 4H), 2.38 (s, 3H), 2.08-1.95 (m, 1H), 1.88 (dq, J = 14.1, 7.2 Hz, 1H), 1.26 (d, J = 6.5 Hz, 3H), 1.03 (t, J = 7.5 Hz, 3H). ¹³C NMR (126 MHz, CDCl₃) δ 171.25, 168.91, 162.67, 159.64, 159.57, 159.50, 146.69, 141.95, 141.83, 141.59, 137.54, 129.37, 129.30, 121.51, 121.32, 114.90, 114.89, 111.33, 111.22, 109.76, 72.22, 56.28, 55.14, 55.12, 53.47, 46.68, 31.59, 22.66, 20.76, 16.60, 14.13, 9.77. 272 ESIMS m/z 565.3 ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) 8.56 (s, 1H), 8.33 (d, J = 5.4 Hz, 1H), 7.08-6.93 (m, 5H), 6.85-6.76 (m, 4H), 4.94 (dd, J = 6.5, 3.0 Hz, 1H), 4.72 (dd, J = 7.9, 7.1 Hz, 1H), 3.91 (s, 3H), 3.79 (s, 3H), 3.77 (s, 3H), 2.71-2.42 (m, 4H), 2.39 (s, 3H), 2.10-2.01 (m, 1H), 1.54 (d, J = 7.2 Hz, 3H), 1.25 (d, J = 1.7 Hz, 3H). ¹³C NMR (126 MHz, CDCl₃) δ 171.99, 168.93, 162.46, 159.49, 157.89, 157.86, 146.67, 141.54, 137.54, 132.37, 132.17, 129.99, 129.82, 113.83, 113.78, 109.77, 72.28, 56.29, 55.23, 55.22, 48.24, 47.16, 34.86, 34.53, 29.27, 20.76, 16.42. 273 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.56 (s, 1H), 8.32 (d, J = 5.5 for C₃₀H₃₉N₂O₇, Hz, 1H), 7.07-6.92 (m, 5H), 537.2595; found, 6.86-6.73 (m, 4H), 4.96 (dt, 537.2574 J = 8.6, 4.3 Hz, 1H), 4.75-4.56 (m, 1H), 3.91 (s, 3H), 3.79 (s, 3H), 3.77 (s, 3H), 2.71-2.41 (m, 5H), 2.39 (s, 3H), 2.07- 1.96 (m, 1H), 1.87 (tq, J = 13.7, 7.3, 6.7 Hz, 1H), 1.24 (d, J = 6.5 Hz, 3H), 1.02 (t, J = 7.5 Hz, 3H). 274 HRMS-ESI m/z ¹H NMR (300 MHz, CDCl₃) δ ([M + H]⁺⁾ calcd 8.38 (d, J = 7.8 Hz, 1H), 8.28 for C₃₂H₃₉N₂O₉, (d, J = 5.4 Hz, 1H), 7.18 (dt, 595.2658; found, J = 10.4, 7.9 Hz, 2H), 6.95 (d, 595.265 J = 5.4 Hz, 1H), 6.77-6.58 (m, 6H), 5.79-5.70 (m, 2H), 4.97 (qd, J = 6.4, 3.0 Hz, 1H), 4.85-4.61 (m, 1H), 3.91 (s, 3H), 3.79 (s, 3H), 3.77 (s, 3H), 2.81-2.45 (m, 5H), 2.18 (t, J = 7.2 Hz, 1H), 2.07 (s, 3H), 1.57 (d, J = 7.3 Hz, 3H), 1.28 (d, J = 6.5 Hz, 3H). ¹³C NMR (126 MHz, CDCl₃) δ 171.29, 168.92, 162.64, 159.49, 157.89, 157.85, 146.67, 141.59, 137.53, 132.39, 132.19, 130.00, 129.81, 113.83, 113.76, 109.75, 72.23, 56.29, 55.22, 55.21, 53.44, 47.19, 34.85, 34.56, 31.59, 20.77, 16.47, 9.76. 275 HRMS-ESI m/z ¹H NMR (300 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.40 (d, J = 8.3 Hz, 1H), 8.28 for C₃₃H₄₁N₂O₉, (d, J = 5.4 Hz, 1H), 7.23-7.11 609.2807; found, (m, 2H), 6.95 (d, J = 5.4 Hz, 609.2822. 1H), 6.76-6.58 (m, 7H), 5.79- 5.71(m, 2H), 4.99 (dt, J = 6.7, 3.4 Hz, 1H), 4.72 (ddd, J = 8.3, 7.0, 5.3 Hz, 1H), 3.91 (s, 3H), 3.79 (s, 3H), 3.76 (s, 3H), 2.81-2.45 (m, 4H), 2.25-2.13 (m, 1H), 2.06 (s, 3H), 1.95- 1.78 (m, 1H), 1.27 (d, J = 6.5 Hz, 3H), 1.05 (t, J = 7.5 Hz, 3H). ¹³C NMR (126 MHz, CDCl₃) δ 171.42, 170.28, 163.24, 160.36, 159.64, 159.58, 145.70, 144.10, 142.50, 141.92, 141.79, 129.38, 129.31, 121.49, 121.32, 114.92, 114.89, 111.28, 111.20, 109.56, 89.65, 72.27, 56.18, 55.14, 55.11, 53.63, 46.64, 35.95, 35.59, 25.91, 20.87, 16.57, 9.87. 276 ESIMS m/z 595.7 ¹H NMR (300 MHz, CDCl₃) δ ([M + H]⁺⁾ 8.39 (d, J = 7.7 Hz, 1H), 8.27 (d, J = 5.4 Hz, 1H), 7.09-6.98 (m, 2H), 7.02-6.91 (m, 3H), 6.86-6.72 (m, 4H), 5.77 (d, J = 6.4 Hz, 1H), 5.74 (d, J = 6.4 Hz, 1H), 4.96 (qd, J = 6.6, 3.2 Hz, 1H), 4.83-4.67 (m, 1H), 3.91 (s, 3H), 3.79 (s, 3H), 3.77 (s, 3H), 2.68 (dd, J = 14.2, 6.8 Hz, 1H), 2.55 (q, J = 6.1 Hz, 2H), 2.46 (dd, J = 13.7, 6.6 Hz, 1H), 2.07 (s, 3H), 2.17- 2.00 (m, 1H), 1.60-1.53 (m, 3H), 1.26 (d, J = 6.5 Hz, 3H). ¹³C NMR (126 MHz, CDCl₃) δ 172.14, 170.30, 163.03, 160.32, 157.91, 157.88, 145.70, 144.08, 142.53, 132.35, 132.16, 129.98, 129.82, 113.84, 113.79, 109.56, 89.62, 72.32, 56.19, 55.23 (2C), 48.41, 47.15, 34.87, 34.56, 20.89, 18.77, 16.43. 277 (Thin film) ESIMS m/z 609.8 ¹H NMR (300 MHz, CDCl₃) δ 3380, 2935, ([M + H]⁺⁾ 8.41 (d, J = 8.2 Hz, 1H), 8.27 1755, 1732, (d, J = 5.3 Hz, 1H), 7.08-6.93 1676, 1510, (m, 5H), 6.85-6.75 (m, 4H), 1243, 1200 5.75 (s, 2H), 4.97 (dd, J = 6.4, 3.0 Hz, 1H), 4.78-4.65 (m, 1H), 3.91 (s, 3H), 3.79 (d, J = 0.7 Hz, 3H), 3.77 (s, 3H), 2.74- 2.39 (m, 5H), 2.07 (s, 3H), 2.07-1.96 (m, 1H), 1.87 (dt, J = 14.1, 7.3 Hz, 1H), 1.26 (d, J = 6.5 Hz, 3H), 1.04 (t, J = 7.5 Hz, 3H). 278 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3382, 2977, ([M + H]⁺) calcd 8.29 (d, J = 8.0 Hz, 1H), 8.25 1756, 1731, for C₃₁H₄₃N₂O₉, (d, J = 5.4 Hz, 1H), 7.12-7.06 1675, 1510, 587.2963; found, (m, 2H), 6.93 (d, J = 5.3 Hz, 1201, 1038 587.2958 1H), 6.83-6.71 (m, 2H), 5.76- 5.72 (m, 2H), 5.36 (qd, J = 6.7, 2.8 Hz, 1H), 4.62-4.50 (m, 1H), 3.90 (s, 3H), 3.77 (s, 3H), 3.27-3.11 (m, 2H), 2.87 (dd, J = 14.7, 5.3 Hz, 1H), 2.70 (dd, J = 14.8, 7.2 Hz, 1H), 2.24- 2.14 (m, 1H), 2.07 (s, 3H), 1.36 (d, J = 6.5 Hz, 3H), 1.30 (d, J = 7.2 Hz, 3H), 1.20 (s, 3H), 1.16 (s, 3H), 1.03-0.91 (m, 1H), 0.55-0.42 (m, 2H), 0.22-0.12 (m, 2H). 279 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3377, 2983, ([M + H]⁺) calcd 8.32 (d, J = 7.8 Hz, 1H), 8.25 1734, 1677, for C₃₃H₃₉F₂N₂O₉, (d, J = 5.4 Hz, 1H), 7.14 (d, J = 1501, 1245 645.2618; found, 8.6 Hz, 2H), 7.08-6.97 (m, 1H), 645.2621 6.93 (d, J = 5.5 Hz, 1H), 6.80 (d, J = 8.7 Hz 2H), 6.78-6.68 (m, 2H), 5.77-5.71 (m, 2H), 5.55 (qd, J = 6.5, 2.9 Hz, 1H), 4.69-4.54 (m, 1H), 3.91 (s, 3H), 3.78 (s, 3H), 3.12 (dd, J = 14.9, 5.8 Hz, 1H), 2.87 (dd, J = 14.9, 6.3 Hz, 1H), 2.38 (td, J = 6.1, 2.9 Hz, 1H), 2.07 (s, 3H), 1.46 (d, J = 6.6 Hz, 3H), 1.37 (s, 3H), 1.35 (d, J = 7.3 Hz, 3H), 1.22 (s, 3H). 280 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3386, 2936, ([M + H]⁺⁾ calcd 8.23 (d, J = 7.7 Hz, 1H), 8.11 1738, 1676, for C₂₉H₃₉N₂O₉, (d, J = 5.4 Hz, 1H), 6.95-6.86 1509, 1244, 559.265; found, (m, 2H), 6.79 (d, J = 5.4 Hz, 1201, 1037 559.265 1H), 6.71-6.57 (m, 2H), 5.67- 5.51(m, 2H), 4.98 (qd, J = 6.4, 4.6 Hz, 1H), 4.57 (p, J = 7.2 Hz, 1H), 3.75 (s, 3H), 3.62 (s, 3H), 3.23 (dd, J = 9.7, 5.8 Hz, 1H), 3.17 (dd, J = 9.7, 5.2 Hz, 1H), 3.08-2.94 (m, 2H), 2.52- 2.38 (m, 2H), 1.96-1.86 (m, 1H), 1.91 (s, 3H), 1.38 (d, J = 7.2 Hz, 3H), 1.15 (d, J = 6.5 Hz, 3H), 0.92-0.77 (m, 1H), 0.39-0.28 (m, 2H), 0.07-−0.06 (m, 2H). 281 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3380, 2936, ([M + H]⁺⁾ calcd 8.38 (d, J = 7.8 Hz, 1H), 8.27 1734, 1675, for C₃₆H₄₅N₂O₉, (d, J = 5.4 Hz, 1H), 7.30-7.22 1501, 1200, 649.312; found, (m, 3H), 7.21-7.15 (m, 2H), 1002 649.3135 6.99-6.91 (m, 2H), 6.83 (d, J = 2.2 Hz, 1H), 6.77 (d, J = 8.3 Hz, 1H), 5.82-5.70 (m, 2H), 5.14-5.06 (m, 1H), 4.77-4.63 (m, 1H), 3.98-3.91 (m, 2H), 3.90 (s, 3H), 3.79 (s, 3H), 3.36 (dd, J = 9.7, 5.8 Hz, 1H), 3.31 (dd, J = 9.7, 5.1 Hz, 1H), 3.18- 3.07 (m, 2H), 2.64-2.47 (m, 2H), 2.07 (s, 3H), 2.05-1.95 (m, 1H), 1.48 (d, J = 7.1 Hz, 3H), 1.28 (d, J = 6.5 Hz, 3H), 1.04-0.92 (m, 1H), 0.54-0.36 (m, 2H), 0.18-0.10 (m, 2H). 282 (Thin film) HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ 3380, 2939, ([M + H]⁺) calcd 8.33 (d, J = 7.8 Hz, 1H), 8.25 1736, 1674, for C₃₁H₃₄F₂N2 (d, J = 5.4 Hz, 1H), 7.07 (d, J = 1510, 1200 O9, 617.2305; 8.6 Hz, 2H), 6.99 (ddd, J = found, 617.2313 10.7, 8.9, 5.3 Hz, 1H), 6.94 (d, J = 5.4 Hz, 1H), 6.85-6.78 (m, 2H), 6.59-6.47 (m, 2H), 5.74 (s, 2H), 5.21 (qd, J = 6.4, 4.7 Hz, 1H), 4.73 (p, J = 7.2 Hz, 1H), 3.97-3.86 (m, 2H), 3.91 (s, 3H), 3.78 (s, 3H), 2.82-2.69 (m, 2H), 2.33-2.21 (m, 1H), 2.06 (s, 3H), 1.51 (d, J = 7.2 Hz, 3H), 1.40 (d, J = 6.5 Hz, 3H). 283 HRMS-ESI m/z ¹H NMR (400 MHz, CDCl₃) δ ([M + H]⁺) calcd 8.55 (d, J = 8.1 Hz, 1H), 8.33 for C₂₃H₂₉N₂O₆, (d, J = 5.4 Hz, 1H), 7.30-7.25 429.2025; found, (m, 2H), 7.25-7.18 (m, 1H), 429.2029 7.17-7.09 (m, 2H), 7.00 (d, J = 5.5 Hz, 1H), 5.12 (dq, J = 8.3, 6.4 Hz, 1H), 4.72 (p, J = 7.3 Hz, 1H), 3.89 (s, 3H), 2.65 (ddd, J = 11.6, 8.2, 3.9 Hz, 1H), 2.39 (s, 3H), 1.92-1.78 (m, 1H), 1.67-1.54 (m, 1H), 1.52 (d, J = 7.2 Hz, 3H), 1.06 (d, J = 6.3 Hz, 3H), 0.72 (t, J = 7.3 Hz, 3H). ¹³C NMR (101 MHz, CDCl₃) δ 172.27, 168.83, 162.39, 159.48, 146.65, 141.62, 140.86, 137.53, 128.62, 128.38, 126.70, 109.77, 75.49, 56.26, 52.95, 48.21, 24.49, 20.71, 18.68, 18.23, 11.83. *Cmpd. No. - Compound Number *¹H NMR were run at 400 MHz unless noted otherwise *¹³C NMR were run at 101 MHz unless noted otherwise *¹⁹F NMR were run at 376 MHz unless noted otherwise

TABLE 3 Biological Testing Rating Scale Rating Table for Biological Activity % Disease Control Rating 80-100 A More than 0-Less than 80 B Not Tested C No activity noticed in this bioassay D

TABLE 4 Biological Activity - High-Volume Cereal Activity at 100 ppm PUCCRT* SEPTTR* Cmpd. No. 1DP* 3DC* 1DP* 3DC* 91 A A B A 92 A A A A 93 A A B A 94 A A B B 95 A A B B 96 A A A B 97 B B B B 98 A A A A 99 B B D B 100 B D D B 101 A B A D 102 A A B A 103 A B A B 104 D B D B 105 A B B B 106 B B D B 107 B D D D 108 A D D B 109 B D D D 110 A D D D 112 B D B D 113 A A B A 114 B B D B 115 A A D A 116 B A B B 117 A A A B 118 B A A B 119 D D D B 120 D B D B 121 A B A B 122 B D D D 123 D B D A 125 B B B B 126 B D B D 127 B D B B 128 A D A B 129 A B A B 130 A D A B 131 A B A B 132 A A B A 133 A D B B 134 A B A B 135 A B B B 136 B B D A 137 D B D B 138 D D D D 139 B D B B 140 D B B B 141 B B A B 143 A B A B 145 B D A B 146 B D B B 147 A D A D 148 B D B D 149 A D A D 150 A D A D 151 A D A D 152 A B D D 153 A D B B 154 A D A D 155 D D D D 160 A D B D 162 A A A A 163 A A B B 164 A A A A 165 B A A B 166 A A B B 167 A A A A 168 A A A A 169 A A A A 170 B D B B 171 D B B B 172 C C C C 173 C C C C 174 C C C C 175 C C C C 176 C C C C 177 C C C C 178 C C C C 179 C C C C 180 C C C C 181 C C C C 182 C C C C 183 C C C C 184 C C C C 185 C C C C 186 C C C C 187 C C C C 188 C C C C 189 C C C C 190 C C C C 191 C C C C 192 C C C C 193 C C C C 194 C C C C 195 C C C C 196 C C C C 197 C C C C 198 C C C C 199 C C C C 200 C C C C 201 C C C C 202 C C C C 203 C C C C 204 C C C C 205 C C C C 206 C C C C 207 C C C C 208 C C C C 209 C C C C 210 C C C C 211 C C C C 212 C C C C 213 C C C C 214 C C C C 215 C C C C 216 C C C C 217 C C C C 218 C C C C 219 C C C C 220 C C C C 221 C C C C 222 C C C C 223 C C C C 224 C C C C 225 C C C C 226 C C C C 227 C C C C 228 C C C C 229 C C C C 230 C C C C 231 C C C C 232 C C C C 233 C C C C 234 C C C C 235 C C C C 236 C C C C 237 C C C C 238 C C C C 239 C C C C 240 C C C C 241 C C C C 242 C C C C 243 C C C C 244 C C C C 245 C C C C 246 C C C C 247 C C C C 248 C C C C 249 C C C C 250 C C C C 251 C C C C 252 C C C C 253 C C C C 254 C C C C 255 C C C C 256 C C C C 257 C C C C 258 C C C C 259 C C C C 260 C C C C 261 C C C C 262 C C C C 263 C C C C 264 C C C C 265 C C C C 266 C C C C 267 C C C C 268 C C C C 269 C C C C 270 C C C C 271 C C C C 272 C C C C 273 C C C C 274 C C C C 275 C C C C 276 C C C C 277 C C C C 278 C C C C 279 C C C C 280 C C C C 281 C C C C 282 C C C C 283 C C C C 284 A A B D *PUCCRT—Wheat Brown Rust (Puccinia triticina) *SEPTTR—Wheat Leaf Blotch (Zymoseptoria tritici) *1DP—1 Day Protectant *3DC—Day Curative

TABLE 5 Biological Activity - Low-Volume Cereal Activity at 121.5 g/H PUCCRT* SEPTTR* Cmpd. No. 1DP* 3DC* 1DP* 3DC* 91 C C C C 92 C C C C 93 C C C C 94 C C C C 95 C C C C 96 C C C C 97 C C C C 98 C C C C 99 C C C C 100 C C C C 101 C C C C 102 C C C C 103 C C C C 104 C C C C 105 C C C C 106 C C C C 107 C C C C 108 C C C C 109 C C C C 110 C C C C 112 C C C C 113 C C C C 114 C C C C 115 C C C C 116 C C C C 117 C C C C 118 C C C C 119 C C C C 120 C C C C 121 C C C C 122 C C C C 123 C C C C 125 C C C C 126 C C C C 127 C C C C 128 C C C C 129 C C C C 130 C C C C 131 C C C C 132 C C C C 133 C C C C 134 C C C C 135 C C C C 136 C C C C 137 C C C C 138 C C C C 139 C C C C 140 C C C C 141 C C C C 143 C C C C 145 C C C C 146 C C C C 147 C C C C 148 C C C C 149 C C C C 150 C C C C 151 C C C C 152 C C C C 153 C C C C 154 C C C C 155 C C C C 160 C C C C 162 A A A A 163 C C C C 164 A A B B 165 C C C C 166 C C C C 167 A A A B 168 A A A B 169 A A A A 170 C C C C 171 C C C C 172 A B B B 173 A B A A 174 A B A B 175 A A D B 176 A B D D 177 A B A B 178 B B B B 179 A D B A 180 B D B D 181 A B B B 182 B B D D 183 B D D D 184 A A A A 185 B B B D 186 D D B D 187 B B B B 188 A A A A 189 A A A B 190 A A A A 191 A A A A 192 A A A A 193 A A A B 194 A B A A 195 A A A A 196 A B A A 197 A A A A 198 B B A A 199 A A A A 200 A A A A 201 B B A B 202 B B A A 203 A B A A 204 B B A A 205 A A A A 206 A A A A 207 A A A A 208 A B A B 209 B D B B 210 A B A A 211 B D A A 212 A A A A 213 A A A A 214 A A A A 215 A A A A 216 B B A B 217 D D B B 218 B B A B 219 B B B B 220 B B A A 221 A B A A 222 A D A A 223 A B A A 224 B D B B 225 B B B B 226 B D B B 227 B B A B 228 B B A B 229 B D A B 230 A B A A 231 B B B B 232 B D B B 233 A B B B 234 A A B A 235 A B A B 236 A B A B 237 A A B B 238 A B B B 239 A B A B 240 A A B A 241 A B A A 242 A A A A 243 A A B B 244 A A B A 245 A A D B 246 B B A B 247 B D B B 248 A B D B 249 A B A B 250 B B B D 251 A B B A 252 A A A A 253 A B A B 254 A B A A 255 A A B A 256 A A D D 257 A D D B 258 B B B B 259 B D D B 260 A B A B 261 A B B B 262 A B B D 263 B B B B 264 B D B D 265 A B A B 266 A B B D 267 B D B B 268 A A B B 269 A B A A 270 A B B D 271 B D B D 272 B B A D 273 B B A B 274 A B B D 275 A B B D 276 A D A B 277 A B A D 278 A B B B 279 A B B A 280 A A B A 281 A B B A 282 A D B B 283 A A B A 284 C C C C *PUCCRT—Wheat Brown Rust (Puccinia triticina) *SEPTTR—Wheat Leaf Blotch (Zymoseptoria tritici) *1DP—1 Day Protectant *3DC—3 Day Curative

TABLE 6 Biological Activity - Disease Control at 25 ppm PHAKPA* Cmpd. No. 1DP* 3DC* 169 A B 240 A B 242 B D *PHAKPA—Asian Soybean Rust (Phakopsora pachyrhizi) *1DP—1 Day Protectant *3DC—3 Day Curative 

What is claimed is:
 1. A compound of Formula I

wherein X is hydrogen or C(O)R₅; Y is hydrogen, C(O)R₅, or Q; Q is

R₁ is CH₂OCH₃, or hydrogen or alkyl, where alkyl is optionally substituted with 0, 1 or multiple R₈; R₂ is methyl; R₃ is chosen from C(O)OCH₃ or alkyl, alkenyl, or aryl, each optionally substituted with 0, 1 or multiple R₈; R₄ is chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R₈; R₅ is alkoxy, optionally substituted with 0, 1, or multiple R₈; R₆ is chosen from hydrogen or alkoxy, where alkoxy is optionally substituted with 0, 1, or multiple R₈; R₇ is chosen from hydrogen, C(O)R₉, or CH₂OC(O)R₉; R₈ is chosen from hydrogen, alkyl, aryl, halo, alkenyl, or phenoxy, each optionally substituted with 0, 1, or multiple R₁₀, R₉ is chosen from alkyl, alkoxy, or aryl, each optionally substituted with 0, 1, or multiple R₈; R₁₀ is chosen from alkyl, aryl, halo, haloalkyl, haloaryl, alkenyl, or alkoxy; and R₁₁ is chosen from hydrogen or methyl.
 2. A compound according to claim 1, wherein X and Y are hydrogen.
 3. A compound according to claim 2, wherein R₁ and R₁₁ are independently chosen from hydrogen or methyl.
 4. A compound according to claim 2, wherein R₃ is independently chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R₈.
 5. A compound according to claim 2, wherein R₁ and R₁₁ are independently chosen from hydrogen or methyl, and R₃ is independently chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R₈.
 6. A compound according to claim 1, wherein X is C(O)R₅ and Y is hydrogen.
 7. A compound according to claim 6, wherein R₁ and R₁₁ are independently chosen from hydrogen or methyl.
 8. A compound according to claim 6, wherein R₃ is independently chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R₈.
 9. A compound according to claim 6, wherein R₁ and R₁₁ are independently chosen from hydrogen or methyl, and R₃ is independently chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R₈.
 10. A compound according to claim 1, wherein X is hydrogen and Y is Q.
 11. A compound according to claim 10, wherein R₇ is hydrogen.
 12. A compound according to claim 11, wherein R₆ is OCH₃.
 13. A compound according to claim 12, wherein R₁ and R₁₁ are independently chosen from hydrogen or methyl.
 14. A compound according to claim 12, wherein R₃ is independently chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R₈.
 15. A compound according to claim 12, wherein R₁ and R₁₁ are independently chosen from hydrogen or methyl, and R₃ is independently chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R₈.
 16. A compound according to claim 10, wherein R₇ is C(O)R₉, or CH₂OC(O)R₉.
 17. A compound according to claim 16, wherein R₁ and R₁₁ are independently chosen from hydrogen or methyl.
 18. A compound according to claim 16, wherein R₃ is independently chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R₈.
 19. A compound according to claim 16, wherein R₁ and R₁₁ are independently chosen from hydrogen or methyl, and R₃ is independently chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R₈. 